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Subcutaneous Fat Necrosis

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181. Anoplasty for Post-hemorrhoidectomy Low Anal Stenosis: A New Technique. (PubMed)

patients treated over a period of 20 years. The data were prospectively recorded by the author. The essence of this simple procedure is mobilizing the anal mucosa to the dentate line via a vertical incision and mobilizing the adjacent perianal skin and subcutaneous fat to allow a completely tension-free approximation of the perianal skin and the anal mucosa which are sutured together transversely. A tension-releasing incision is made in the perianal region which is left to heal by secondary (...) Anoplasty for Post-hemorrhoidectomy Low Anal Stenosis: A New Technique. Post-hemorrhoidectomy anal stenosis though rare is very disturbing and devastating complication. Many surgical procedures have been described, but despite good results, many complications can ensue like flap necrosis, mucosal ectropion, and restenosis.We report a new simple technique for repair of severe/moderate anal stenosis which requires no extensive flap mobilization or many sutures.This is a personal series of 65

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2018 World Journal of Surgery

182. Health Outcomes After Participating in Exercise (HOPE)

[ Time Frame: Baseline ] Fat and whole body and appendicular lean mass will be measured by dual-energy X-ray absorptiometry (DXA). DXA will also be used to analyze bone mineral density (BMD) using specific scans of the anterior-posterior (AP) spine (L1-L4) and proximal femur. Thigh and body fat distribution [ Time Frame: Baseline ] Thigh inter-muscular adipose tissue (IMAT), subcutaneous and visceral abdominal fat (SAT and VAT, respectively), and pericardial fat will be measured by computed (...) : Baseline ] Grip strength will be measured twice in each hand using an isometric hydraulic hand dynamometer and the mean value from the stronger hand used. Body mass index [ Time Frame: Baseline ] Body mass index (kg/m2) will be calculated using measured height and weight. Anthropometric measures [ Time Frame: Baseline ] Anthropometric measures of fat distribution will be assessed by circumference measurements of the waist, hip, and thigh using a tape measure. Body composition and bone mineral density

2018 Clinical Trials

183. Dysplastic Lipoma: A Distinctive Atypical Lipomatous Neoplasm With Anisocytosis, Focal Nuclear Atypia, p53 Overexpression, and a Lack of MDM2 Gene Amplification by FISH: A Report of 66 Cases Demonstrating Occasional Multifocality and a Rare Association Wi (PubMed)

Dysplastic Lipoma: A Distinctive Atypical Lipomatous Neoplasm With Anisocytosis, Focal Nuclear Atypia, p53 Overexpression, and a Lack of MDM2 Gene Amplification by FISH: A Report of 66 Cases Demonstrating Occasional Multifocality and a Rare Association Wi In our routine and consultative pathology practices, we have repeatedly encountered an unusual subcutaneous fatty tumor with notable anisocytosis, single-cell fat necrosis, and patchy, often mild, adipocytic nuclear atypia. Because (...) fatty tumor variant that has p53 overexpression and RB1 gene abnormalities and lacks MDM2 gene amplification by FISH. These tumors have a strong male predominance and a notable tendency to involve the subcutaneous tissue of the shoulders, upper back and posterior neck. Multifocality is frequent (18.9% of patients with follow-up information), and there is a rare association with retinoblastoma. This tumor warrants separation from ordinary lipoma with fat necrosis, fat-rich spindle cell lipoma

2018 American Journal of Surgical Pathology

184. Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients. (PubMed)

, but it is thought to result from lipolysis and fat necrosis with secondary tissue inflammation induced by pancreatic enzymes. Histopathology shows subcutaneous lobular fat necrosis with anuclear adipocytes (called ghost cells) surrounded by a mixed inflammatory infiltrate. Focal calcification may also be seen. The treatment is directed to the underlying disorder, which may result in regression of skin lesions.We present two cases of pancreatic panniculitis with similar clinical, laboratory (...) , and histopathological features associated with different internal malignancy. The first case, after extensive investigations showed the presence of a pancreatic carcinoma with multiple liver metastases and a poor prognosis. The second one instead is the first case in literature where painful subcutaneous nodules of the legs were the early manifestation of a neuroendocrine carcinoma of the adrenal gland.Although subcutaneous fat necrosis usually occurs late in the course of a malignancy, recognition

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2018 BMC Gastroenterology

185. Optimal timing of initial debridement for necrotizing soft tissue infection: A practice management guideline from the Eastern Association for the Surgery of Trauma.

Optimal timing of initial debridement for necrotizing soft tissue infection: A practice management guideline from the Eastern Association for the Surgery of Trauma. Necrotizing soft tissue infections (NSTI) are rare, life-threatening, soft-tissue infections characterized by rapidly spreading inflammation and necrosis of the skin, subcutaneous fat, and fascia. While it is widely accepted that delay in surgical debridement contributes to increased mortality, there are currently no practice

2018 The journal of trauma and acute care surgery

186. Inhibition of ghrelin o-acyltransferase attenuated lipotoxicity by inducing autophagy via AMPK–mTOR pathway (PubMed)

GOAT exerted in NAFLD, and its potential association with autophagy.Human LO2 cells were pretreated with siRNA-GOAT to induce liver steatosis using free fatty acids (FFAs). A chronic NAFLD model was established by feeding male mice C57bl/6 with high-fat diet (HFD) for 56 days with GO-CoA-Tat administrated subcutaneously. Lipid droplets were identified by Oil Red O stains. Body weight (BW) of mice was measured every week. Autophagy, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), serum

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2018 Drug design, development and therapy

187. The therapeutic effects of bee venom on some metabolic and antioxidant parameters associated with HFD-induced non-alcoholic fatty liver in rats (PubMed)

The therapeutic effects of bee venom on some metabolic and antioxidant parameters associated with HFD-induced non-alcoholic fatty liver in rats The present study was designed to investigate the therapeutic effects of bee venom (BV) on high-fat diet (HFD)-induced non-alcoholic fatty liver (NAFL) in rats at different levels. Histological manifestations, hepatic lipid content, liver function tests, glucose homeostasis, lipid abnormalities, adipocytokines, lipid peroxidation, disturbed glutathione (...) and antioxidant enzymes systems and dysregulation of Nrf2 transcription factor were assessed. In the present study, the NAFL rats were subcutaneously treated with BV with different doses (0.01, 0.05, 0.1 mg/kg). The results indicated that BV treatment completely normalized the lipid profile values of NAFL rats. Fasting blood sugar, insulin level and homeostatic model assessment of insulin resistance significantly decreased. BV treated rats showed a significantly lower level of all liver enzymes and bilirubin

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2018 Experimental and therapeutic medicine

188. Enhanced Preoperative Deep Inferior Epigastric Artery Perforator Flap Planning with a 3D-Printed Perforasome Template: Technique and Case Report (PubMed)

Enhanced Preoperative Deep Inferior Epigastric Artery Perforator Flap Planning with a 3D-Printed Perforasome Template: Technique and Case Report Optimizing preoperative planning is widely sought in deep inferior epigastric artery perforator (DIEP) flap surgery. One reason for this is that rates of fat necrosis remain relatively high (up to 35%), and that adjusting flap design by an improved understanding of individual perforasomes and perfusion characteristics may be useful in reducing the risk (...) of fat necrosis. Imaging techniques have substantially improved over the past decade, and with recent advances in 3D printing, an improved demonstration of imaged anatomy has become available. We describe a 3D-printed template that can be used preoperatively to mark out a patient's individualized perforasome for flap planning in DIEP flap surgery. We describe this "perforasome template" technique in a case of a 46-year-old woman undergoing immediate unilateral breast reconstruction with a DIEP flap

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2018 Plastic and Reconstructive Surgery Global Open

189. Safety, tolerability, and efficacy evaluation of the SlimME device for circumference reduction (PubMed)

and high intensity regimens (4.4 ± 1.5 and 4.9 ± 1.4, respectively). Mean SAT temperatures did not exceed 48.4 ± 2.5°C and were effectively maintained throughout the maintenance phase of the treatment session. Low-energy fluence led to localized fat coagulative necrotic lesions, surrounded by subacute rim of inflammation, while high-energy fluence induced fat coagulative necrosis alongside granulomatous panniculitis, which resolved within 90 days.The tested uniform ultrasound regimens elicited SAT (...) temperature elevations, with a subsequent energy-dependent increase in degree of fat necrosis. At the same time, the unique design spared the surrounding tissue from thermal damage and was associated with minimal discomfort. Taken together, the SlimME device constitutes an effective tool for destruction of stubborn hypodermal fat deposits. Lasers Surg. Med. © 2018 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.© 2018 The Authors. Lasers in Surgery and Medicine Published

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2018 Lasers in surgery and medicine

190. Acellular Adipose Tissue (AAT) for Soft Tissue Reconstruction

Collaborators: U.S. Army Medical Research and Materiel Command Armed Forces Institute of Regenerative Medicine Information provided by (Responsible Party): Johns Hopkins University Study Details Study Description Go to Brief Summary: Although other methods (e.g., autologous fat transfer, dermal-/collagen-based fillers) for soft tissue reconstruction exist, each has distinct disadvantages leaving room for improvement in this treatment area. Investigators in the Elisseeff Laboratory (Johns Hopkins University (...) Department of Biomedical Engineering) have recently generated a novel tissue-derived material to create instructive matrices for soft tissue reconstruction called Acellular Adipose Tissue (AAT). This material takes advantage of the inherent bioactivity and unique mechanical properties of subcutaneous adipose tissue. Investigators' preclinical data suggest that AAT is safe for use in small and large animals; investigators' clinical (Phase I) data suggest that AAT is safe for use in humans. These data

2018 Clinical Trials

191. IORT Following Breast Conserving Surgery for Early Stage Breast Cancer Registry

for subcutaneous tissue as well as cosmetic result. The RTOG/EORTC late radiation morbidity scoring schema on subcutaneous tissue is as follows: GRADE 1: Slight induration (fibrosis) and loss of subcutaneous fat GRADE 2: Moderate fibrosis but asymptomatic; slight field contracture; <10% linear reduction GRADE 3: Severe induration and loss of subcutaneous tissue; field contracture > 10% linear measurement GRADE 4: Necrosis Acute Toxicity [ Time Frame: 3 months ] Acute radiation toxicity will be scored (...) consequences; skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from involved site; skin graft indicated Other acute toxicity will also be scored per the CTCAE v4.03 scale and will be rated on the relation to radiation therapy (definitely related, probably related, possibly related, unlikely related, unrelated) Disease Free Survival [ Time Frame: 5 yeras ] Disease Free Survival Overall Survival [ Time Frame: 5 years ] Overall Survival Eligibility Criteria Go to Information from

2018 Clinical Trials

192. Adipose Tissue and Serum Inflammation in GH Deficiency

adipose tissue and serum inflammation in patients with GH deficiency before and after GH therapy. The investigators will obtain subcutaneous adipose tissue by biopsy in patients with active GH deficiency planning to undergo therapy for GH deficiency. Concurrently serum samples will be taken for analysis of levels of inflammatory markers and adipokines. After treatment for 12 months with a normal levels of Insulin-like growth factor 1 (IGF-1), a marker of GH deficiency, patients will have a repeat (...) and are planning to initiate a therapy. Drug: Growth Hormone Patients will receive growth hormone replacement therapy as per standard clinical care during this study. Other Name: GH Control group Healthy subjects matched to the GH deficiency subjects for age (+/- 5 years), gender and total fat mass (+/- 4%). Outcome Measures Go to Primary Outcome Measures : Visceral Adipose Tissue (VAT) mass [ Time Frame: Baseline to 12 months of GH therapy ] Visceral adipose tissue mass as measured by tota body magnetic

2018 Clinical Trials

193. Researching an Effect of GLP-1 Agonist on Liver STeatosis (REALIST)

to other GLP-1 receptor agonists. Reduction in body weight was observed in patients treated with Dulaglutide, irrespective of nausea and/or vomiting.The search for a direct effect of Dulaglutide on liver fat overload in patients with type2 diabetes is required before considering the effectiveness of this treatment in NASH in diabetic populations. No current GLP-1 study has been designed with a control group with the same weight loss than as in the treatment group. Primary objective: The investigators (...) Detailed Description: This is a multicentre, open, prospective, randomized, controlled dietary reinforcement study. Treatment Group: dulaglutide (TRULICITY®) subcutaneous administration, one weekly injection, in a dose of 1.5 mg of dulaglutide in combinaison with reinforced dietary monitoring as same as control group. Control group: reinforced dietary monitoring with frequent dietary consultations, based on AHA recommendations: All patients are monitored in the same way for dietary reinforcement

2018 Clinical Trials

194. GammaPod Registry and Quality of Life Nomogram

a questionnaire. Number of participants with treatment related adverse events as assessed by CTCAE v4.0 post one year from treatment [ Time Frame: ~1.5 years ] The evaluation of long-term toxicity at one year to assess the presence of subcutaneous fibrosis, and fat necrosis. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study

2018 Clinical Trials

195. Color Doppler Ultrasonography to Evaluate Hypoechoic Areas in Pressure Ulcers: A Report of Two Cases (PubMed)

Color Doppler Ultrasonography to Evaluate Hypoechoic Areas in Pressure Ulcers: A Report of Two Cases Ultrasound (US) is frequently used for evaluating inflammation of subcutaneous tissue caused by pressure ulcers (PUs), but color Doppler mode (CDM) helps to better identify inflammatory edema in subcutaneous fat and necrotic tissue in PUs. We report two cases where inflammatory edema in subcutaneous fat and necrotic tissue in PUs are identified using small US equipment with CDM. Case 1 - An 82 (...) -year-old male presented with cerebral infarction and a Category III PU in the sacral region. B-mode gray-scale US imaging (B-mode imaging) revealed a thickened layer of subcutaneous fat with fat lobules and homogeneous cobblestone appearance with fluid accumulation within the echo-free space. CDM did not identify any color signal (CS) in hypoechoic areas. Case 2 - A 29-year-old female presented with cytopenia and decreased renal function with a Category IV PU with undermining in the coccyx region

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2018 Journal of medical ultrasound

196. Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men (PubMed)

tumor necrosis factor receptors (sTNFR) I and II, and homeostatic model assessment of insulin resistance (HOMA-IR), higher adiponectin, less visceral fat, and more subcutaneous fat. Among HIV-uninfected normal weight men and obese men (regardless of HIV serostatus), metabolic health was associated only with higher levels of adiponectin, less visceral fat, and lower HOMA-IR values. In multivariate analyses restricted to HIV-infected men, lower hs-CRP, sTNFRI, sTNFRII, and HOMA-IR and higher

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2018 Mediators of inflammation

197. Impact of Ketone Bodies and Epigallocatechin Gallate in Multiple Sclerosis

as perioxidation marker. It is based on the reaction of thiobarbituric with malondialdehyde, product of the splitting of hydroperoxides, thus forming a color that can be measured directly. Its analysis is used for its good practicability and simplicity, but it lacks sensitivity, so it is recommended, to increase it, to use fluorometric or chromatographic procedures. Tumor necrosis factor alfa (TNF-alpha) [ Time Frame: 0-4 months ] Plasma concentrations of inflammatory markers (IL-6 and TNF-a) were determined (...) the exercise and the corresponding deficiency according to the scales of RD 1971/1999 or the AMA disability assessment tables. The results of the assessment can be displayed on the screen and printed on a report card. Body diameters [ Time Frame: 0-4 months ] Distance taken in projection, between two anatomical points and measured in centimeters (cm), through a pachymeter. Body perimeters [ Time Frame: 0-4 months ] They are indicators of body fat and protein reserves, so they are useful to know

2018 Clinical Trials

198. Necrotizing Fasciitis of Thoracic and Abdominal Wall with Emphysematous Pyelonephritis and Retroperitoneal Abscess (PubMed)

necrosis of fat and fascia due to deep-seated infection of subcutaneous tissue. It has a fulminant course with considerable mortality. Diabetes Mellitus is a common predisposing factor. The combined occurrence of emphysematous pyelonephritis and necrotizing fasciitis is extremely unusual. Early recognition and management is mandatory to avoid mortality. We report a case of a 53-year-old female, a known case of Type II diabetes mellitus, who presented with necrotizing fasciitis of thoracic and abdominal

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2018 Journal of clinical imaging science

199. Adipose‐Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization (PubMed)

types of exosomes isolated from the supernatants of ex vivo subcutaneous AT and visceral AT (VAT) explants that were derived from wild-type mice and high-fat diet (HFD)-induced obese mice were effectively taken up by RAW264.7 macrophages. Both treatment with wild-type VAT exosomes and HFD-VAT exosomes, but not subcutaneous AT exosomes, markedly facilitated macrophage foam cell generation through the downregulation of ATP-binding cassette transporter (ABCA1 and ABCG1)-mediated cholesterol efflux (...) . Decreased expression of liver X receptor-α was also observed. Among the 4 types of exosomes, only HFD-VAT exosomes significantly induced M1 phenotype transition and proinflammatory cytokine (tumor necrosis factor α and interleukin 6) secretion in RAW264.7 macrophages, which was accompanied by increased phosphorylation of NF-κB-p65 but not the cellular expression of NF-κB-p65 or IκB-α. Furthermore, systematic intravenous injection of HFD-VAT exosomes profoundly exacerbated atherosclerosis

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2018 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

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