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Subcutaneous Fat Necrosis

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1. Subcutaneous Fat Necrosis and Hypercalcemia After Therapeutic Hypothermia in Patients With Hypoxic-ischemic Encephalopathy: A Case Series (PubMed)

Subcutaneous Fat Necrosis and Hypercalcemia After Therapeutic Hypothermia in Patients With Hypoxic-ischemic Encephalopathy: A Case Series Therapeutic hypothermia (TH) is provided to newborns with moderate to severe hypoxic-ischemic encephalopathy (HIE) to improve survival and long-term neurodevelopmental outcomes. Although the benefits certainly outweigh the risks associated with therapeutic hypothermia, it is important to be mindful of potential rare side effects in the background of asphyxia (...) -related injury to various body organs. One of those side effects includes subcutaneous fat necrosis (SCFN) that can occur in term newborns after perinatal hypoxia-ischemia or other stressing factors such as systemic hypothermia. It is usually a self-limited condition, however, in some cases, it can lead to severe hypercalcemia. We report three such cases of SCFN in newborns with HIE treated with TH. Due to potential long-term complications, such as metastatic calcifications, caregivers should

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2018 Cureus

2. Neonatal subcutaneous fat necrosis with hypercalcemia treatment using calcitonin (PubMed)

Neonatal subcutaneous fat necrosis with hypercalcemia treatment using calcitonin Subcutaneous fat necrosis of newborn is a form of noninfectious panniculitis. It is an uncommon condition and mostly occurs in full-term infants within first weeks of life that have had a significant condition such as hypoxic-ischemic encephalopathy at the time of birth. Subcutaneous fat necrosis of newborn is usually a self-limiting condition but may be associated with hypercalcemia, which may lead to life (...) threatening levels. Hypercalcemia is a significant reason of subcutaneous fat necrosis and needs an intervention involving hyperhydration, calcitonin, diuretics, steroids and sometimes bisphosphonate in resistant cases. Here, we have reported the case of a term infant who developed extensive subcutaneous fat necrosis in the first week of life after significant perinatal hypoxic injury. Her condition was complicated by hypercalcemia resistant to prolonged medical treatment with hyperhydration, diuretic

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2018 Saudi medical journal

3. Zoledronic acid for neonatal subcutaneous fat necrosis (PubMed)

Zoledronic acid for neonatal subcutaneous fat necrosis Subcutaneous fat necrosis (SFN) in infants producing severe hypercalcemia is a life-threatening emergency. Pathophysiology may include enhanced gastrointestinal calcium absorption and bone resorption. We treated an infant with SFN and serum calcium of 15 mg/dL with prednisolone and low-dose zoledronic acid. Serum calcium promptly normalized without rebound hypocalcemia, and redosing of zoledronic acid was not necessary.

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2017 Clinical Case Reports

4. Hypocalcemia Associated with Subcutaneous Fat Necrosis of the Newborn: Case Report and Literature Review (PubMed)

Hypocalcemia Associated with Subcutaneous Fat Necrosis of the Newborn: Case Report and Literature Review Subcutaneous fat necrosis of the newborn (SCFNN) is a rare benign inflammatory disorder of the adipose tissue but may be complicated by hypercalcemia or less frequently, hypocalcemia, resulting in morbidity and mortality. Here we report the case of a neonate with subcutaneous fat necrosis who surprisingly developed hypocalcemia instead of hypercalcemia. A full-term female neonate

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2017 Oman medical journal

5. Subcutaneous encapsulated fat necrosis (PubMed)

Subcutaneous encapsulated fat necrosis We have described subcutaneous encapsulated fat necrosis, which is benign, usually asymptomatic and underreported. Images have only been published on two earlier occasions, in which the necrotic nodules appear "pearly" than the cloudy yellow surface in present case. The presented image may help future surgeons to establish the diagnosis peroperatively.

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2016 Clinical Case Reports

6. Subcutaneous Fat Necrosis

Subcutaneous Fat Necrosis Subcutaneous Fat Necrosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Subcutaneous Fat Necrosis (...) Subcutaneous Fat Necrosis Aka: Subcutaneous Fat Necrosis II. Epidemiology May appear up to 1 month of age III. Signs Erythematous s or s IV. Distribution Cheeks or buttocks V. Associations Rarely associated with VI. Course Most lesions resolve spontaneously VII. Management Fluctuant lesions may be aspirated Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Subcutaneous Fat Necrosis." Click on the image (or right click) to open the source

2018 FP Notebook

7. Subcutaneous fat necrosis in neonates after therapeutic hypothermia – report of two cases (PubMed)

Subcutaneous fat necrosis in neonates after therapeutic hypothermia – report of two cases 27279827 2016 06 09 2018 11 13 1642-395X 33 2 2016 Apr Postepy dermatologii i alergologii Postepy Dermatol Alergol Subcutaneous fat necrosis in neonates after therapeutic hypothermia - report of two cases. 152-4 10.5114/ada.2016.59164 Szpecht Dawid D Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland. Bagnosz-Magnuszewska Alina A Department of Neonatology, Poznan University

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2016 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

8. Neutrophil-rich subcutaneous fat necrosis of the newborn: A potential mimic of infection. (PubMed)

Neutrophil-rich subcutaneous fat necrosis of the newborn: A potential mimic of infection. The inflammatory infiltrate seen in biopsy specimens obtained from patients with subcutaneous fat necrosis of the newborn (SCFN) has classically been described as consisting mostly of histiocytes. However, we encountered patients with SCFN whose biopsy specimens revealed mostly neutrophils, prompting infection to be an initial consideration.We sought to describe cases of SCFN in which neutrophils formed

2016 Journal of American Academy of Dermatology

9. Breast panniculitis with liquefactive fat necrosis: A case report (PubMed)

Breast panniculitis with liquefactive fat necrosis: A case report Panniculitis is a group of heterogeneous disorders characterized by inflammation of the subcutaneous adipose tissue. Panniculitis of breast tissue as the initial manifestation has rarely been reported and is often misdiagnosed. Breast panniculitis may cause substantial morbidity and early diagnosis and treatment are important for the prognosis of the disease. The present study has reported a case of panniculitis with inflammation

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2018 Experimental and therapeutic medicine

10. Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register. (PubMed)

Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register. Neonates with hypoxic ischaemic encephalopathy (HIE) are routinely treated with therapeutic hypothermia (TH) for 72 h in order to improve neurological outcome. Subcutaneous fat necrosis (SCFN) is an adverse event occurring in neonates with HIE.We analyzed risk factors for SCFN regarding demographic factors, cooling methods and deviation from target (...) % in neonates without SCFN. Neonates with SCFN showed 3.6% of all measured temperatures below target temperature range compared to 12.7% in neonates without SCFN.Subcutaneous fat necrosis in the neonate with HIE undergoing TH is a potential adverse event that seems to occur independently from the whole-body cooling method applied and proportion of temperature measurements outside target temperature range. In this cohort, moderate overcooling associated with moderate hypothermia (33.0-34.0 °C) does not seem

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2015 BMC Pediatrics

11. Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register (PubMed)

Subcutaneous fat necrosis in neonates with hypoxic ischaemic encephalopathy registered in the Swiss National Asphyxia and Cooling Register Neonates with hypoxic ischaemic encephalopathy (HIE) are routinely treated with therapeutic hypothermia (TH) for 72 h in order to improve neurological outcome. Subcutaneous fat necrosis (SCFN) is an adverse event occurring in neonates with HIE.We analyzed risk factors for SCFN regarding demographic factors, cooling methods and deviation from target (...) % in neonates without SCFN. Neonates with SCFN showed 3.6% of all measured temperatures below target temperature range compared to 12.7% in neonates without SCFN.Subcutaneous fat necrosis in the neonate with HIE undergoing TH is a potential adverse event that seems to occur independently from the whole-body cooling method applied and proportion of temperature measurements outside target temperature range. In this cohort, moderate overcooling associated with moderate hypothermia (33.0-34.0 °C) does not seem

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2015 BMC pediatrics

12. Severe hypercalcaemia due to subcutaneous fat necrosis: presentation, management and complications. (PubMed)

Severe hypercalcaemia due to subcutaneous fat necrosis: presentation, management and complications. Subcutaneous fat necrosis (SCFN) is a rare form of panniculitis in infants that generally occurs following birth trauma, meconium aspiration, or therapeutic cooling. Severe hypercalcaemia occurs in a subset of patients, but data on its presentation, management and outcomes are limited. This report details the clinical course and complications of infants treated for severe hypercalcaemia (peak

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2014 Archives of Disease in Childhood. Fetal and Neonatal Edition

13. Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review (PubMed)

Neonatal Hypercalcemia Secondary to Subcutaneous Fat Necrosis Successfully Treated with Pamidronate: A Case Series and Literature Review Subcutaneous fat necrosis (SCFN) is a noninfectious panniculitis that occurs in term infants who experience significant distress in the 1st weeks of life, including hypoxic ischemic encephalopathy (HIE). Since the introduction of therapeutic hypothermia for HIE, there have been a few published case reports of SCFN, following this modality of treatment

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2014 AJP Reports

14. Subcutaneous Fat Necrosis of the Newborn (Treatment)

Subcutaneous Fat Necrosis of the Newborn (Treatment) Subcutaneous Fat Necrosis of the Newborn Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA4MTkxMC10cmVhdG1lbnQ= processing > Subcutaneous Fat Necrosis of the Newborn Treatment & Management Updated: May 15, 2018 Author: Sungat K Grewal; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Subcutaneous Fat Necrosis of the Newborn Treatment Medical Care Subcutaneous fat necrosis of the newborn (SFNN) is usually a self-limited process that does not require treatment. Interventions have focused on the prevention of subcutaneous fat necrosis of the newborn in the setting

2014 eMedicine.com

15. Subcutaneous Fat Necrosis of the Newborn (Overview)

Subcutaneous Fat Necrosis of the Newborn (Overview) Subcutaneous Fat Necrosis of the Newborn: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA4MTkxMC1vdmVydmlldw (...) == processing > Subcutaneous Fat Necrosis of the Newborn Updated: May 15, 2018 Author: Sungat K Grewal; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Subcutaneous Fat Necrosis of the Newborn Overview Background Subcutaneous fat necrosis of the newborn (SFNN) is an uncommon disorder characterized by firm, mobile, erythematous nodules and plaques over the trunk, arms, buttocks, thighs, and cheeks of full-term newborns. [ , ] The nodules and plaques appear in the first

2014 eMedicine.com

16. Subcutaneous Fat Necrosis of the Newborn (Follow-up)

Subcutaneous Fat Necrosis of the Newborn (Follow-up) Subcutaneous Fat Necrosis of the Newborn Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA4MTkxMC10cmVhdG1lbnQ= processing > Subcutaneous Fat Necrosis of the Newborn Treatment & Management Updated: May 15, 2018 Author: Sungat K Grewal; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Subcutaneous Fat Necrosis of the Newborn Treatment Medical Care Subcutaneous fat necrosis of the newborn (SFNN) is usually a self-limited process that does not require treatment. Interventions have focused on the prevention of subcutaneous fat necrosis of the newborn in the setting

2014 eMedicine.com

17. Subcutaneous Fat Necrosis of the Newborn (Diagnosis)

Subcutaneous Fat Necrosis of the Newborn (Diagnosis) Subcutaneous Fat Necrosis of the Newborn: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA4MTkxMC1vdmVydmlldw (...) == processing > Subcutaneous Fat Necrosis of the Newborn Updated: May 15, 2018 Author: Sungat K Grewal; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Subcutaneous Fat Necrosis of the Newborn Overview Background Subcutaneous fat necrosis of the newborn (SFNN) is an uncommon disorder characterized by firm, mobile, erythematous nodules and plaques over the trunk, arms, buttocks, thighs, and cheeks of full-term newborns. [ , ] The nodules and plaques appear in the first

2014 eMedicine.com

18. Review of the Mechanisms and Effects of Noninvasive Body Contouring Devices on Cellulite and Subcutaneous Fat (PubMed)

Review of the Mechanisms and Effects of Noninvasive Body Contouring Devices on Cellulite and Subcutaneous Fat Today, different kinds of non-invasive body contouring modalities, including cryolipolysis, radiofrequency (RF), low-level laser therapy (LLLT), and high-intensity focused ultrasound (HIFU) are available for reducing the volume of subcutaneous adipose tissue or cellulite. Each procedure has distinct mechanisms for stimulating apoptosis or necrosis adipose tissue. In addition (...) to the mentioned techniques, some investigations are underway for analyzing the efficacy of other techniques such as whole body vibration (WBV) and extracorporeal shockwave therapy (ESWT). In the present review the mechanisms, effects and side effects of the mentioned methods have been discussed. The effect of these devices on cellulite or subcutaneous fat reduction has been assessed.We searched pubmed, google scholar and the cochrane databases for systemic reviews, review articles, meta-analysis

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2016 International journal of endocrinology and metabolism

19. Fish oil prevents changes induced by a high‐fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes (PubMed)

Fish oil prevents changes induced by a high‐fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes Fish oil (FO), rich in omega-3 polyunsaturated fatty acids, has beneficial effects on changes induced by obesity and partially prevents associated comorbidities. The effects of FO on adipocytes from different adipose tissue depots in high-fat (HF) diet induced obese mice have not been uninvestigated. This is the first study to examine the effects of FO (...) on changes in metabolism and adipokine production in adipocytes from s.c. (inguinal; ING) or visceral (retroperitoneal; RP) white adipose depots in a HF diet-induced obese mice. Unlike most studies performed previously, FO supplementation was initiated 4 weeks before the induction of obesity. HF diet caused marked changes in ING (glucose uptake and secretion of adiponectin, tumour necrosis factor-α and interleukin-6 in ING) and RP (lipolysis, de novo lipogenesis and secretion of pro-inflammatory

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2016 The Journal of physiology

20. Surgical management of subcutaneous fat necrosis of the newborn required due to a lack of improvement: a very rare case. (PubMed)

Surgical management of subcutaneous fat necrosis of the newborn required due to a lack of improvement: a very rare case. Subcutaneous fat necrosis of the newborn (ScFN) is an uncommon and transient disease characterized by defined areas of fat necrosis and overlying cutaneous nodule lesions. It usually becomes apparent within the first 6 weeks of life in full-term or post-term infants. It is caused by generalized and/or local tissue hypoperfusion. The skin lesions of ScFN tend generally (...) to improve spontaneously in a few weeks. We present a full-term newborn with birth distress. After therapeutic hypothermia, she presented voluminous and numerous subcutaneous fat necrosis with extensive calcifications. Surgical management was decided at her ninth month because of a total lack of regression. Hypercalcaemia, the most threatening complication, appeared only after this delayed surgery.© 2013 British Association of Dermatologists.

2013 British Journal of Dermatology

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