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Subclinical Hyperthyroidism

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1. Hemostasis in Overt and Subclinical Hyperthyroidism Full Text available with Trip Pro

Hemostasis in Overt and Subclinical Hyperthyroidism There are contradictory results on the effect of hyperthyroidism on hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). The present review focuses on hemostatic changes in overt and subclinical hyperthyroidism.A systematic literature search was conducted employing MEDLINE database. The following words were used for the search: Hyperthyroidism; thyrotoxicosis (...) ; Graves disease; goiter, nodular; hemostasis; blood coagulation factors; blood coagulation disorders; venous thromboembolism; bleeding; fibrinolysis. The articles that were related to hyperthyroidism and hemostasis are used in this manuscript.Hyperthyroidism, either overt or subclinical, renders a hypercoagulable state, although there are several studies with contradictory findings in the literature. Hypercoagulability may be caused by an increase in the level of various coagulation factors

2017 International journal of endocrinology and metabolism

2. Thyroid hormones treatment for subclinical hypothyroidism Full Text available with Trip Pro

Thyroid hormones treatment for subclinical hypothyroidism Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline | The BMJ Intended for healthcare professionals Username * Password * Edition: Search form Search Search Thyroid hormones... Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline (Published 14 May 2019) Cite this as: BMJ 2019;365:l2006 Visual summary of recommendation or No thyroid hormones Thyroid hormones (...) Levothyroxine Interventions compared Recommendation Population Adults with subclinical hypothyroidism Does not apply to: May not apply to: Including: Women who are or trying to become pregnant Patients with no symptoms (diagnosed after screening) Patients with non-specific symptoms Patients with severe symptoms Patients with TSH above 20 mIU/L Young adults (such as <30 years) Elevated levels of thyroid stimulating hormone (TSH) Normal free T4 (thyroxine) levels We recommend against thyroid hormone therapy

2019 BMJ Rapid Recommendations

3. Subclinical Hyperthyroidism

Subclinical Hyperthyroidism Subclinical Hyperthyroidism Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Subclinical Hyperthyroidism (...) Subclinical Hyperthyroidism Aka: Subclinical Hyperthyroidism From Related Chapters II. Definition Euthyroid patient with TSH suppression Low but detectable TSH: 0.1 to 0.4 mIU/L Suppressed TSH: <0.1 mIU/L (greatest association with adverse effects, esp. >65 years old) III. Epidemiology in U.S. (study included patients over age 12 years old) TSH <0.4 mIU/L: 3.2% TSH <0.1 mIU/L: 0.7% More common in older agults Prevalance in age over 70 years approaches 15% in deficient regions IV. Causes Over-treatment

2018 FP Notebook

4. Helping physicians fatigued by TSH Screening and Subclinical Hypothyroidism

hypothyroidism (in the developed world) is 4-10%, with 2- 6% of these developing overt hypothyroidism. Subclinical hyperthyroidism prevalence is ~2% with 1-2% of these developing overt hyperthyroidism. 2,11 o 40% subclinical hypothyroidism revert to normal over ~2.5 years. 12 o Symptoms are often poor predictors. Example: one study found ~18% of euthyroid, ~22% subclinical hyperthyroid, ~26% overt hypothyroid patients reported =4 symptoms of hypothyroidism. 13 • Canadian Task Force on Preventive Health Care (...) Helping physicians fatigued by TSH Screening and Subclinical Hypothyroidism Tools for Practice is proudly sponsored by the Alberta College of Family Physicians (ACFP). ACFP is a provincial, professional voluntary organization, representing more than 4,800 family physicians, family medicine residents, and medical students in Alberta. Established over sixty years ago, the ACFP strives for excellence in family practice through advocacy, continuing medical education and primary care research

2019 Tools for Practice

5. Screening and treatment of subclinical hypothyroidism or hyperthyroidism

Screening and treatment of subclinical hypothyroidism or hyperthyroidism Screening and treatment of subclinical hypothyroidism or hyperthyroidism Screening and treatment of subclinical hypothyroidism or hyperthyroidism Rugge B, Balshem H, Sehgal R, Relevo R, Gorman P, Helfand M Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Rugge B (...) , Balshem H, Sehgal R, Relevo R, Gorman P, Helfand M. Screening and treatment of subclinical hypothyroidism or hyperthyroidism. Rockville: Agency for Healthcare Research and Quality (AHRQ). Comparative Effectiveness Review No. 24. 2011 Authors' conclusions Currently there are no studies that evaluate the benefits and harms of screening for subclinical thyroid dysfunction in the primary care setting. Studies of treatment tend to be small and of short duration, and they have failed to demonstrate

2011 Health Technology Assessment (HTA) Database.

6. Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism

Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism | Effective Health Care Program Search Effective Health Care website Submit search Toggle navigation Select site to search Search Effective Health Care website Submit search Screening and Treatment of Subclinical Hypothyroidism or Hyperthyroidism Mar. 10, 2010 Nov. 14, 2011 Systematic Review May. 2, 2012 Disposition of Comments Report Screening (...) and Treatment of Subclinical Hypothyroidism or Hyperthyroidism Systematic Review Archived November 14, 2011 1.5 MB Related Files Archived : This report is greater than 3 years old. Findings may be used for research purposes, but should not be considered current. People using assistive technology may not be able to fully access information in these files. For additional assistance, please . Structured Abstract Objectives This report focused on four questions: Does screening for subclinical thyroid

2011 Effective Health Care Program (AHRQ)

7. Hyperthyroidism

, such as in Graves' disease. Secondary hyperthyroidism occurs when thyrotoxicosis is caused by abnormal stimulation of a normal thyroid gland, such as by a TSH-secreting pituitary tumour. Subclinical hyperthyroidism is diagnosed when TSH is suppressed but FT4 and FT3 concentrations are within the normal reference range. The complications of hyperthyroidism include: Graves' orbitopathy. Thyroid storm (thyrotoxic crisis). Atrial fibrillation. Heart failure. Reduced bone mineral density. Increased mortality rate (...) (ESR) and C-reactive protein (CRP) should be checked if subacute thyroiditis is suspected. Management of hyperthyroidism includes: Admission as a medical emergency if a person has symptoms of thyroid storm. Referral of all people with overt hyperthyroidism to an endocrinologist, the urgency depending on clinical judgement. Possible interim treatment with a beta-blocker to provide relief of adrenergic symptoms (if present and appropriate). Referral of people with persistent subclinical

2019 NICE Clinical Knowledge Summaries

8. The natural history of subclinical hyperthyroidism in Graves' disease - the rule of thirds. (Abstract)

The natural history of subclinical hyperthyroidism in Graves' disease - the rule of thirds. There is little information regarding the natural history of subclinical hyperthyroidism (SH) due to Graves' disease (GD).A prospective analysis was conducted of patients with SH due to GD between 2007 and 2013 with at least 12 months of follow-up. SH was diagnosed if serum thyrotropin (TSH) was below the laboratory reference range (0.4-4.0 mIU/L) and when thyroid hormones were normal. GD was confirmed (...) by either a raised TSH receptor antibody (TRAb) level or uniform uptake on Technetium scan.Forty-four patients (89% female, 16% current smokers, and 5% with active Graves' orbitopathy) were diagnosed with SH due to GD. Over the follow-up period (median 32 months), approximately one third (34%) of the cohort progressed to overt hyperthyroidism, one third (34%) normalized their thyroid function, slightly less than one third (30%) remained in the SH state, while one person became hypothyroid. Multivariate

2016 Thyroid

9. Hypokalaemic Periodic Paralysis in a Patient with Subclinical Hyperthyroidism: A Rare Case Full Text available with Trip Pro

Hypokalaemic Periodic Paralysis in a Patient with Subclinical Hyperthyroidism: A Rare Case Thyrotoxic Periodic Paralysis (TPP) is an uncommon disorder. Though many cases of hypokalaemic periodic paralysis are reported in overt hyperthyroidism, hypokalaemic paralysis in subclinical hyperthyroidism is very rare. Subclinical hyperthyroidism is characterised by circulating TSH levels below reference range and normal thyroid hormone levels. We describe a case of 32-year-old Asian male who presented (...) to the emergency department with acute onset weakness and hypokalaemia with no previous history of thyroid disorder or any signs and symptoms suggestive of hyperthyroidism. He was subsequently diagnosed with Graves' disease with subclinical hyperthyroidism.

2016 Journal of clinical and diagnostic research : JCDR

10. Electrocardiographic and scintigraphic evaluation of patients with subclinical hyperthyroidism during workout Full Text available with Trip Pro

Electrocardiographic and scintigraphic evaluation of patients with subclinical hyperthyroidism during workout Subclinical hyperthyroidism (sHT) was found to be associated with elevated heart rate, blood pressure and increased risk of extrasystoles. However, the full clinical relevance of morphological and functional implications of sHT on the cardiovascular system is still a matter of debate. The aim of the study was to prospectively assess the influence of endogenous sHT on exercise capacity

2016 Endocrine

11. Evaluation of endothelial function in exogenous subclinical hyperthyroidism and the effect of treatment Full Text available with Trip Pro

Evaluation of endothelial function in exogenous subclinical hyperthyroidism and the effect of treatment Subclinical hyperthyroidism (SHy) is a widespread condition in which cardiovascular manifestations are frequently occur, but there is still a debate about the vascular responsiveness in it. Measuring flow-mediated dilation (FMD) and intimae-media thickness (IMT) are used to evaluate endothelial function in these patients.Twenty-five patients with a diagnosis of exogenous SHy and 25 full (...) , respectively. The mean of FMD in healthy people was dramatically higher than the subclinical hyperthyroid patients (P < 0.001) but no statistically significant difference was found for IMT (P = 0.459). After intervention in the case group, FMD was meaningfully increased (P < 0.001) but IMT of common carotid artery was not considerably changed (P = 0.491).This study demonstrated that FMD decreased in exogenous subclinical hyperthyroid patients which could be partially restored by treatment. These findings

2016 Advanced biomedical research

12. Hyperthyroidism and papillary thyroid carcinoma in thyrotropin receptor D633H mutant mice. (Abstract)

this model, both subclinical and overt hyperthyroidism was observed, depending on the age, sex, and genotype. Homozygous mice presented hyperthyroidism at two months of age, while heterozygous animals showed only suppressed thyrotropin. Interestingly, at six months of age, thyroid hormone concentrations in all mutant mice were analogous to wild-type mice, and they showed colloid goiter with flattened thyrocytes. Strikingly, at one year of age, nearly all homozygous mice presented large papillary thyroid (...) Hyperthyroidism and papillary thyroid carcinoma in thyrotropin receptor D633H mutant mice. Constitutively active thyrotropin receptor (TSHR) mutations are the most common etiology of non-autoimmune hyperthyroidism (NAH). Thus far, the functionality of these mutations has been tested in vitro, but the in vivo models are lacking.To understand the pathophysiology of NAH, the patient-derived constitutively active TSHR D633H mutation was introduced into the murine Tshr by homologous recombination.In

2018 Thyroid

13. Echocardiographic evolution of pulmonary hypertension in female patients with hyperthyroidism Full Text available with Trip Pro

groups: groups A (overt hyperthyroidism), B (recurrent disease), and C (subclinical forms). We performed echocardiography to determine echocardiographically estimated systolic pulmonary arterial pressure (eePAP), CO, and PVR before and at 3, 6, and 12 months after treatment with thyroid suppression therapy and beta-blockers.In our study group we documented PH of various severities in 73 patients (51.4%). Increased CO, induced mostly by hyperthyroidismspecific tachycardia, was frequently detected (...) Echocardiographic evolution of pulmonary hypertension in female patients with hyperthyroidism The objective of this study was to highlight the impact of increased cardiac output (CO) and/or pulmonary vascular resistance (PVR) on the occurrence and evolution of pulmonary hypertension (PH) in hyperthyroidism and to follow their evolution in patients under therapy.Our study group consisted of 142 women with hyperthyroidism of different severities and etiologies. We divided our patients into three

2018 Anatolian journal of cardiology

14. A patient-specific treatment model for Graves’ hyperthyroidism Full Text available with Trip Pro

predictions with data from four patients.When there is no MMI treatment, there is a unique asymptotically stable hyperthyroid state. After the initiation of MMI treatment, the hyperthyroid state moves towards subclinical hyperthyroidism and then euthyroidism.We can use the model to describe or test and predict patient treatment schedules. More specifically, we can fit the model to individual patients' data including loading and maintenance doses and describe the mechanism, hyperthyroidism→euthyroidism (...) A patient-specific treatment model for Graves’ hyperthyroidism Graves' is disease an autoimmune disorder of the thyroid gland caused by circulating anti-thyroid receptor antibodies (TRAb) in the serum. TRAb mimics the action of thyroid stimulating hormone (TSH) and stimulates the thyroid hormone receptor (TSHR), which results in hyperthyroidism (overactive thyroid gland) and goiter. Methimazole (MMI) is used for hyperthyroidism treatment for patients with Graves' disease.We have developed

2018 Theoretical biology & medical modelling

15. Validity and Reliability of the Korean Version of the Hyperthyroidism Symptom Scale Full Text available with Trip Pro

Validity and Reliability of the Korean Version of the Hyperthyroidism Symptom Scale Thyrotoxicosis is a common disease resulting from an excess of thyroid hormones, which affects many organ systems. The clinical symptoms and signs are relatively nonspecific and can vary depending on age, sex, comorbidities, and the duration and cause of the disease. Several symptom rating scales have been developed in an attempt to assess these symptoms objectively and have been applied to diagnosis (...) or to evaluation of the response to treatment. The aim of this study was to assess the reliability and validity of the Korean version of the hyperthyroidism symptom scale (K-HSS).Twenty-eight thyrotoxic patients and 10 healthy subjects completed the K-HSS at baseline and after follow-up at Seoul National University Bundang Hospital. The correlation between K-HSS scores and thyroid function was analyzed. K-HSS scores were compared between baseline and follow-up in patient and control groups. Cronbach's α

2018 Endocrinology and Metabolism

16. Association between subclinical thyroid dysfunction and depressive symptoms in the Korean adult population: The 2014 Korea National Health and Nutrition Examination Survey. Full Text available with Trip Pro

without overt thyroid disease were included in this study. Serum thyroid stimulating hormone (TSH), serum free thyroxine (fT4), and depressive symptoms were analyzed based on the Patient Health Questionnaire (PHQ9).The percentages of subjects with subclinical hypothyroidism and subclinical hyperthyroidism were 3.3% and 2.6%, respectively. The percentages of subjects with moderate (10-14 points), moderately severe (15-19 points), and severe (≥20 points) depression according to the distribution of PHQ-9 (...) scores were 4.7%, 1.1%, and 0.3%, respectively. TSH, fT4, and the percentage of patients with subclinical hypothyroidism were not significantly associated with PHQ-9 score. However, the percentage of patients with subclinical hyperthyroidism increased significantly with PHQ9 score (P = 0.002). Subjects with subclinical hyperthyroidism had higher PHQ-9 scores than those with normal thyroid function (mean ± standard error [SE], 4.2 ± 0.5 vs. 2.7 ± 0.1 points, P = 0.010). More subjects with subclinical

2018 PLoS ONE

17. Subclinical thyroid dysfunction is associated with adverse prognosis in heart failure patients with reduced ejection fraction. Full Text available with Trip Pro

Subclinical thyroid dysfunction is associated with adverse prognosis in heart failure patients with reduced ejection fraction. Subclinical thyroid dysfunction whose typical patterns include subclinical hypothyroidism and subclinical hyperthyroidism, has been indicated to be associated with an increased risk of heart failure (HF). However, the relationship between subclinical thyroid dysfunction and the clinical outcomes of HF patients is uncertain. This meta-analysis was conducted to assess (...) ). Subclinical hyperthyroid can increase the risk of all-cause mortality without heterogeneity (HR 1.31, 95% CI 1.10-1.55, I2 = 25.5%, P = 0.225) but have no influence on the risk of cardiac death and/or hospitalization (HR 1.03, 95% CI 0.87-1.23, I2 = 0.0%, P = 0.958). These significant adverse associations were also retained in subgroup analysis. Sensitivity analysis demonstrated the stability of the results of our meta-analysis.Both subclinical hypothyroidism and subclinical hyperthyroidism are associated

2019 BMC Cardiovascular Disorders

18. Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies. Full Text available with Trip Pro

. We will ask corresponding authors of studies that meet our inclusion criteria to collaborate by providing IPD. Our primary outcome will be depressive symptoms at the first available individual follow-up, measured on a validated scale. We will convert all the scores to the Beck Depression Inventory scale. For each cohort, we will estimate the mean difference of depressive symptoms between participants with subclinical hypothyroidism or hyperthyroidism and control adjusted for depressive symptoms (...) Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies. Prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms have yielded conflicting findings, possibly because of differences in age, sex, thyroid-stimulating hormone cut-off levels or degree of baseline depressive symptoms. Analysis of individual participant data (IPD) may help

2019 BMJ open

19. Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Full Text available with Trip Pro

Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) The association between subclinical thyroid dysfunctions and autonomic modulation changes has been described by many studies with conflicting results. We aimed to analyze the association between subclinical hyperthyroidism (SCHyper), subclinical hypothyroidism (SCHypo), and heart rate variability (HRV) using the baseline from ELSA-Brasil. SCHyper

2018 Brazilian Journal of Medical and Biological Research

20. Thyroxin in Subclinical Hypothyroidism

Thyroxin in Subclinical Hypothyroidism Thyroxin in Subclinical Hypothyroidism - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Thyroxin in Subclinical Hypothyroidism The safety and scientific validity (...) of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03712683 Recruitment Status : Completed First Posted : October 19, 2018 Last Update Posted : October 29, 2018 Sponsor: Hawler Medical University Information provided by (Responsible Party): Ariana Jawad, Hawler Medical University Study Details Study Description Go to Brief Summary: Subclinical

2018 Clinical Trials

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