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Subacute Lymphocytic Thyroiditis

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81. Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies Treatment (PDQ®): Health Professional Version

and Other Myeloid Malignancies in Children Approximately 20% of childhood leukemias are of myeloid origin and they represent a spectrum of hematopoietic malignancies.[ ] The majority of myeloid leukemias are acute, and the remainder include chronic and/or subacute myeloproliferative disorders such as chronic myelogenous leukemia and juvenile myelomonocytic leukemia. Myelodysplastic syndromes occur much less frequently in children than in adults and almost invariably represent clonal, preleukemic (...) antigens on AML cells should be used at the time of initial diagnostic workup, along with a battery of lineage-specific T-lymphocyte and B-lymphocyte markers to help distinguish AML from ALL and acute leukemias of ambiguous lineage. The expression of various cluster determinant (CD) proteins that are relatively lineage-specific for AML include CD33, CD13, CD14, CDw41 (or platelet antiglycoprotein IIb/IIIa), CD15, CD11B, CD36, and antiglycophorin A. Lineage-associated B-lymphocytic antigens CD10, CD19

2015 PDQ - NCI's Comprehensive Cancer Database

82. Scintimun - besilesomab

blood), there was decreased platelet aggregation. Concentrations of 18 µg/ml and higher caused haemolysis, increased the proportion of segmented neutrophils and decreased lymphocytes. PTP was not found to be mutagenic in a reverse mutation test at any concentration tested (10 to 2500 µg/plate), either in the presence or absence of metabolic activation, nor clastogenic in a micronucleus test in mice at an intraperitoneal dose of 30mg/kg. For protein A, mice were given a single intravenous dose at 10

2010 European Medicines Agency - EPARs

83. Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effect of GSK2646264 in Cutaneous Lupus Erythematosus Subjects

Recruitment Status : Completed First Posted : October 7, 2016 Last Update Posted : August 13, 2018 Sponsor: GlaxoSmithKline Information provided by (Responsible Party): GlaxoSmithKline Study Details Study Description Go to Brief Summary: This study is designed to examine safety, tolerability, pharmacokinetics, pharmacodynamics and clinical effect of repeat dosing of GSK2646264 in patients with subacute and chronic cutaneous lupus erythematosus (CLE) lesions and in acute CLE like lesions induced (...) included are platelet count, red blood cell (RBC) count, hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), neutrophils, lymphocytes, monocytes, eosinophils, basophils. Number of participants with abnormal hematology parameters in Group B [ Time Frame: Approximately 12 weeks ] The hematology parameters included are platelet count, RBC count, hemoglobin, hematocrit, MCV, MCH, neutrophils, lymphocytes, monocytes, eosinophils, basophils. Number of participants

2016 Clinical Trials

84. Myeloid Leukemia, Childhood Acute/Other Childhood Myeloid Malignancies

rate increased over the same time from less than 20% to 68% for children younger than 15 years and from less than 20% to 57% for adolescents aged 15 to 19 years.[ ] Characteristics of Myeloid Leukemias and Other Myeloid Malignancies in Children Approximately 20% of childhood leukemias are of myeloid origin and they represent a spectrum of hematopoietic malignancies.[ ] The majority of myeloid leukemias are acute, and the remainder include chronic and/or subacute myeloproliferative disorders (...) - + + - - - - PAS - - ± ± + - + Immunophenotypic evaluation The use of monoclonal antibodies to determine cell-surface antigens of AML cells is helpful to reinforce the histologic diagnosis. Various lineage-specific monoclonal antibodies that detect antigens on AML cells should be used at the time of initial diagnostic workup, along with a battery of lineage-specific T-lymphocyte and B-lymphocyte markers to help distinguish AML from ALL and acute leukemias of ambiguous lineage. The expression of various cluster

2012 PDQ - NCI's Comprehensive Cancer Database

85. Thymoma and Thymic Carcinoma

. Nephrotic syndrome. Parahypopituitarism. Pernicious anemia. Aplastic anemia. Polymyositis. Rheumatoid arthritis. Sarcoidosis. Scleroderma. Sensorimotor radiculopathy. Sjögren syndrome. Stiff-person syndrome. Systemic lupus erythematosus. Thyroiditis. Ulcerative colitis. Prognosis and Survival Although the oncologic prognosis of thymoma is reported to be more favorable in patients with myasthenia gravis than in patients without myasthenia gravis,[ , ] data are conflicting as to whether the presence (...) (2): 123-33, 2001. Montella L, Masci AM, Merkabaoui G, et al.: B-cell lymphopenia and hypogammaglobulinemia in thymoma patients. Ann Hematol 82 (6): 343-7, 2003. Cucchiara BL, Forman MS, McGarvey ML, et al.: Fatal subacute cytomegalovirus encephalitis associated with hypogammaglobulinemia and thymoma. Mayo Clin Proc 78 (2): 223-7, 2003. Morgenthaler TI, Brown LR, Colby TV, et al.: Thymoma. Mayo Clin Proc 68 (11): 1110-23, 1993. Souadjian JV, Enriquez P, Silverstein MN, et al.: The spectrum

2012 PDQ - NCI's Comprehensive Cancer Database

86. Evaluation of Sleep Apnea Related Inflammation With CRP, ESR and Neutrophil toLymphocyte Ratio

, diabetes mellitus, dyslipidemia, cardiovascular disease or hypertension, chronic inflammatory processes, thyroid dysfunction, chronic hepatic disease, renal failure, any acute- subacute infectious disease within past 2 months, if data are incomplete such as blood sample testing results, if they were unable to perform complete PSG testing. Contacts and Locations Go to No Contacts or Locations Provided More Information Go to Layout table for additonal information Responsible Party: Hakan Korkmaz (...) of nocturnal sleep disturbance and associated systemic inflammation and presence of comorbidities. Recently, novel inflammatory biomarkers, such as neutrophil to lymphocyte ratio (NLR) have been proposed as an indicator of systemic inflammation. To our knowledge, NLR has not been studied in OSAS. We conducted the present study to evaluate the association between OSAS and inflammatory markers CRP, ESR and NLR. Condition or disease Intervention/treatment Obstructive Sleep Apnea Other: Evaluation of Sleep

2014 Clinical Trials

87. The Approach to the Painful Joint (Diagnosis)

The synovial membrane is the principal site of inflammation in persons with rheumatoid arthritis (RA) and many other inflammatory arthritides. [ ] Synovitis is characterized pathologically by the following: Neovascularization Infiltration of the synovium with lymphocytes, plasma cells, and macrophages Synovial lining cell hyperplasia These cause synovial proliferation, clinically manifested by warmth, tenderness, and a boggy consistency of the soft tissues overlying the involved joint. The inflamed (...) and the inner aspect of the thigh. Tenderness can be elicited by local palpation of the adductor muscles, especially near their insertion on the front of the pelvis. Pain is increased by passive abduction of the thighs and active adduction against resistance. Treatment of adductor tendinitis consists of rest and ice packs during the acute phase. NSAIDs, ultrasonography, and progressive stretching exercises are used in the subacute phase. Local corticosteroid injections are reserved for patients resistant

2014 eMedicine.com

88. Benign Vulvar Lesions (Follow-up)

contraceptives with antiandrogenic properties might trigger the early onset of lichen sclerosus in susceptible young women. [ ] Investigative studies aimed toward identifying an infection-causing agent (eg, spirochetes, viruses) have yielded inconclusive results. Lichen sclerosus has been weakly linked to autoimmune diseases and genetic factors. Approximately 21% of patients have an autoimmune disease, most commonly a thyroid disorder. Familial occurrence is also well recognized. Forty-four percent (...) is classified into systemic, subacute, chronic, or discoid forms. Genital involvement is uncommon, and vulvar manifestations have seldom been described. In one study, vulvar lesions were found in 2 (5%) of 42 women affected by the chronic form. Darier disease Darier disease is a heritable disorder of keratinization transmitted as an autosomal dominant trait. Altered keratinization is a result of the disruption of desmosomal proteins with consequent tonofilament detachment and acantholysis because

2014 eMedicine.com

89. Urticaria, Chronic (Diagnosis)

disease associated with chronic idiopathic urticaria: 2 case reports. J Investig Allergol Clin Immunol . 2009. 19(1):54-6. . Ryhal B, DeMera RS, Shoenfeld Y, Peter JB, Gershwin ME. Are autoantibodies present in patients with subacute and chronic urticaria?. J Investig Allergol Clin Immunol . 2001. 11 (1):16-20. . Kasumagic-Halilovic E, Beslic N, Ovcina-Kurtovic N. Thyroid Autoimmunity in Patients with Chronic Urticaria. Med Arch . 2017 Feb. 71 (1):29-31. . Palma-Carlos AG, Palma-Carlos ML. Chronic (...) in hereditary angioedema), and C1-esterase inhibitor (associated with hereditary angioedema) functional assays may be performed Thyroid function testing and antithyroid microsomal and peroxidase antibody titers: Patients with urticaria unresponsive to antihistamines or steroids may have elevated titers [ ] ; the plasma thyrotropin level (TSH) helps screen for thyroid dysfunction Chronic Urticaria (CU) Index: A nonspecific measure of basophil histamine release, which, if positive, may indicate the presence

2014 eMedicine.com

91. HIV-1 Encephalopathy and AIDS Dementia Complex (Diagnosis)

infiltration has been identified in patients with latent or inactive HIV infection of the brain due to restoration of T-cell function with HAART, leading to an intense inflammatory reaction with an influx of CD8 + lymphocytes. The influx of the CD8 cells may cause macrophage activation and control of infection but can also present with a subacute or acute encephalopathy. The imbalance between CD8 + /CD4 + cells may cause worsening of the HIV encephalopathy and can also produce an acute demyelinating (...) to the advent of highly active antiretroviral therapy (HAART), dementia was a common source of morbidity and mortality in HIV-infected patients. It was usually observed in the late stages of acquired immunodeficiency syndrome (AIDS), when CD4 + lymphocyte counts fall below 200 cells/mL, and was seen in up to 50% of patients prior to their deaths. [ ] In 1986, the term AIDS dementia complex (ADC) was introduced to describe a unique constellation of neurobehavioral findings. [ , ] HIV associated

2014 eMedicine.com

92. Hepatitis, Viral (Diagnosis)

lymphocytic sialadenitis, autoimmune thyroiditis, , lichen planus, and Mooren corneal ulcer. Some cases of can be attributed to HCV infection. Previous Next: Patient Education Refer patients with infectious hepatitis to their primary care providers for further counseling specific to their disease; the precise etiologic virus is unlikely to be known at the time of discharge from the emergency department. Counsel patients regarding the importance of follow-up care to monitor for evidence of disease (...) experience several relapses during the course of a year. Less than 1% of cases result in fulminant hepatic failure (FHF). HAV infection does not persist and does not lead to chronic hepatitis. Hepatitis B Hepatitis B virus (HBV) may be directly cytopathic to hepatocytes. However, immune system–mediated cytotoxicity plays a predominant role in causing liver damage. The immune assault is driven by human leukocyte antigen (HLA) class I–restricted CD8 cytotoxic T lymphocytes that recognize hepatitis B core

2014 eMedicine.com

93. Multifocal Choroidopathy Syndromes (Diagnosis)

of patients with MCP. Other infections that have been associated with MCP include , , , , Toxocara canis, and . [ , , , , ] Despite this, many investigators still believe that MCP results from an underlying autoimmune mechanism, possibly triggered by an infectious agent. Histopathologic studies of ocular specimens from patients with MCP have revealed a predominant B-lymphocyte and plasma cell infiltrate of the choroid and choriocapillaris. [ ] In addition, a deposition of compliment and immunoglobulins (...) lesion, there is a fairly rapid flattening of the well-demarcated dome-shaped lesion accompanied by thickening of the IS/OS junction and hyperreflectivity of the outer nuclear layer. Within about 2 weeks, the lesion evolves into stage 2, a subacute phase, with a distinct separation of the IS/OS junction and RPE layer visible with mild subretinal fluid accumulation present. The hyperreflectivity of the outer nuclear layer begins to fade and the layer thins at this stage. In Stage 3, the late phase

2014 eMedicine.com

94. Nonneoplastic Epithelial Disorders of the Vulva (Diagnosis)

contraceptives with antiandrogenic properties might trigger the early onset of lichen sclerosus in susceptible young women. [ ] Investigative studies aimed toward identifying an infection-causing agent (eg, spirochetes, viruses) have yielded inconclusive results. Lichen sclerosus has been weakly linked to autoimmune diseases and genetic factors. Approximately 21% of patients have an autoimmune disease, most commonly a thyroid disorder. Familial occurrence is also well recognized. Forty-four percent (...) is classified into systemic, subacute, chronic, or discoid forms. Genital involvement is uncommon, and vulvar manifestations have seldom been described. In one study, vulvar lesions were found in 2 (5%) of 42 women affected by the chronic form. Darier disease Darier disease is a heritable disorder of keratinization transmitted as an autosomal dominant trait. Altered keratinization is a result of the disruption of desmosomal proteins with consequent tonofilament detachment and acantholysis because

2014 eMedicine.com

95. Paraneoplastic Syndromes (Diagnosis)

, neoplastic hypoalbuminemia, which is also related to reduced albumin synthesis. Gastrointestinal syndromes Gastrointestinal paraneoplastic disorders are related to production of molecules that affect the motility and secretory activity of the digestive tract, as follows: Medullary thyroid carcinomas (MTCs) may produce several prostaglandins (PGs) (eg, PGE2 and PGF2) that lead to malabsorption and, consequently, unavailability of nutrients Malignancies of the digestive system, especially those (...) enzymes into the bloodstream, leading to adipose nodular necrosis of subcutaneous tissues; this condition is characterized by painful pink to dark-reddish nodules under the skin; these nodules often ulcerate, causing leakage of an oily material Flushes can be observed in patients with acute leukemias, mastocytosis, carcinoids, medullary thyroid cancer, or pancreatic carcinomas that secrete vasoactive substances, mainly prostaglandins (alpha, E1, E2, F2, I2) Dermic melanosis results from melanin

2014 eMedicine.com

96. Paraneoplastic Autonomic Neuropathy (Diagnosis)

paraneoplastic neurological syndromes include: Encephalomyelitis Limbic encephalitis Subacute cerebellar degeneration Opsoclonus-myoclonus Subacute sensory neuronopathy Chronic gastrointestinal pseudo-obstruction Lambert-Eaton myasthenic syndrome (LEMS) Dermatomyositis The most common non-classical paraneoplastic neurological syndromes include: Brainstem encephalitis Optic neuritis Cancer- or melanoma-associated retinopathy Stiff person syndrome Necrotizing myelopathy Motor neuron diseases Acute sensorimotor (...) neuropathies (ie, Guillain-Barre syndrome or brachial neuritis) Subacute/chronic sensorimotor neuropathies Neuropathies associated with paraproteinemia or vasculitis Autonomic neuropathies Myasthenia gravis Acquired neuromyotonia Acute necrotizing myopathy Patients with a definite PNS include those with the following: A classical syndrome and cancer that develops within 5 years of the diagnosis of the neurological disorder, regardless of the presence of paraneoplastic antibodies, A nonclassical syndrome

2014 eMedicine.com

97. Oral Manifestations of Systemic Diseases (Diagnosis)

systemic evaluation, including referral for and biopsy with histopathologic correlation. The most common histologic findings in both oral and intestinal Crohn disease are noncaseating granulomas and both acute and chronic inflammation with lymphocytic and giant cell perivascular infiltrates. Also see . Pyostomatitis vegetans Although relatively rare, most PSV cases occur concurrently with either Crohn disease or UC. [ ] As such, PSV is considered a specific finding of IBD, and its presence can precede (...) based on clinical presentation. Reticular LP, the most common form, presents as white papules or plaques on a bed of erythema with Wickham striae. [ , ] The buccal mucosa, tongue, and gingivae may be involved. It is generally asymptomatic. [ ] Other less common forms of LP include erosive LP, erythematous (or atrophic) LP, and papular (or plaquelike) LP. [ , ] Rarely, bullous LP may be observed. [ ] Histology reveals a bandlike lymphocytic infiltrate with a saw-tooth appearance of the rete ridges

2014 eMedicine.com

98. Optic Neuritis, Adult (Diagnosis)

Classically, patients with optic neuritis are young, are often female, and have subacute vision loss associated with pain on eye movement. The patient’s history may reveal the following signs and symptoms of optic neuritis: Preceding viral illness Rapidly developing impairment of vision in 1 eye or, less commonly, both eyes: During an acute attack [ ] Dyschromatopsia (change in color perception) in the affected eye: Occasionally may be more prominent than the decreased vision [ ] Retro-orbital or ocular (...) of patients with optic neuritis See for more detail. Diagnosis The following blood tests can be performed when optic neuropathies other than optic neuritis are suspected: Erythrocyte sedimentation rate Thyroid function tests Antinuclear antibodies Angiotensin-converting enzyme Rapid plasma reagin Mitochondrial deoxyribonucleic acid (DNA) mutation studies Magnetic resonance imaging (MRI) is highly sensitive for and specific in the assessment of inflammatory changes in the optic nerves, and for central

2014 eMedicine.com

99. Hyperthyroidism (Diagnosis)

thyroid hormone. A typical nuclear scintigraphy scan shows no radioactive iodine uptake (RAIU) in the thyrotoxic phase of the disease (see the images below). Thyroid hormone levels can be highly elevated in this condition. Absence of iodine 123 (123I) radioactive iodine uptake in patient with thyrotoxicosis and subacute painless or lymphocytic thyroiditis. Laboratory studies at time of scan demonstrated the following: thyroid-stimulating hormone (TSH), less than 0.06 mIU/mL; total thyroxine (T4), 21.2 (...) . This patient also had optic nerve dysfunction and chemosis (conjunctival edema) from thyroid-related orbitopathy. Color flow ultrasonogram in patient with Graves disease. Generalized hypervascularity is visible throughout gland (note red areas), which often can be heard as hum or bruit with stethoscope. Absence of iodine 123 (123I) radioactive iodine uptake in patient with thyrotoxicosis and subacute painless or lymphocytic thyroiditis. Laboratory studies at time of scan demonstrated the following: thyroid

2014 eMedicine.com

100. Hypertrophic Osteoarthropathy (Diagnosis)

of lymphocytes and vascular hyperplasia are responsible for thickening of the vessel walls. Electron microscopy reveals Weibel-Palade bodies and prominent Golgi complexes, confirming structural vessel wall damage. [ ] Vast numbers of arteriovenous anastomoses may also be seen in the nail bed. [ ] Periosteum Subperiosteal new bone formation exists along the distal diaphysis of tubular bones, progressing proximally over time. The irregular periosteal proliferation affects predominantly the distal ends of long (...) of the subsynovial blood vessels and mild lining-layer hyperplasia may occur. [ , ] The edematous synovium becomes mildly infiltrated with lymphocytes, plasma cells, and occasional polymorphonuclear leukocytes, but the results from immunohistologic studies are negative. Electron-dense subendothelial deposits are present in vessel walls. [ , , ] In a study of a patient with primary hypertrophic osteoarthropathy and chronic arthritis, Lauter et al found multilayered basement laminae around small subsynovial blood

2014 eMedicine.com

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