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Stimulant Use Disorder

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41. Using Directional Deep Brain Stimulation to Co-activate the Subthalamic Nucleus and Zona Incerta for Overlapping Essential Tremor/Parkinson's Disease Symptoms Full Text available with Trip Pro

Using Directional Deep Brain Stimulation to Co-activate the Subthalamic Nucleus and Zona Incerta for Overlapping Essential Tremor/Parkinson's Disease Symptoms This index case report describes a novel programming approach that utilizes the 8-contact directional Deep Brain Stimulation (DBS) lead to effectively control the akinesia, rigidity and tremor of Parkinson's Disease (PD), as well as a severe kinetic tremor of Essential Tremor (ET), in a patient with overlapping symptoms of both PD and ET (...) targeting the STN. Both intraoperatively and post-operatively, omnidirectional, and directional electrode review resulted in significant akinesia, rigidity, and as well as resting tremor control but failed to sufficiently improve the kinetic tremor. As electrode 2B was shown to be the most efficacious with the largest therapeutic window, a bipolar directional montage on a single segmented contact was tried with the idea of possibly further extending the axial asymmetry of the directional stimulation

2018 Frontiers in neurology

42. Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis Full Text available with Trip Pro

Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis Background: Current ulcerative colitis (UC) treatments are focused on symptom management primarily via immune suppression. Despite the current arsenal of immunosuppressant treatments, the majority of patients with UC still experience disease progression. Importantly, aggressive long-term inhibition of immune function comes with consequent risk, such as serious (...) colitis that develops in Muc2 deficient mice, were used to assess whether QBECO treatment could ameliorate gastrointestinal disease. A small exploratory 16-week QBECO open-label trial was subsequently conducted to test the safety and tolerability of this approach and also to determine whether similar improvements in clinical disease and histopathology could be demonstrated in patients with moderate-to-severe UC. Results: QBECO treatment successfully reduced inflammation and promoted mucosal

2018 Frontiers in immunology

43. Use of basal and TRH‐stimulated plasma growth hormone concentrations to differentiate between primary hypothyroidism and nonthyroidal illness in dogs Full Text available with Trip Pro

Use of basal and TRH‐stimulated plasma growth hormone concentrations to differentiate between primary hypothyroidism and nonthyroidal illness in dogs A low plasma total thyroxine (TT4 ) concentration in combination with a plasma TSH concentration within reference range does not distinguish between hypothyroidism and nonthyroidal illness (NTI) in dogs. Hypothyroidism is associated with TSH-releasing hormone (TRH)-induced increased release of growth hormone (GH).Basal and TRH-induced plasma GH (...) concentrations can be used to distinguish hypothyroid dogs from NTI dogs.Twenty-one dogs with signs consistent with hypothyroidism, a low plasma TT4 concentration, and a plasma TSH concentration within reference interval.Case control study. Thyroid scintigraphy was performed to classify dogs as having hypothyroidism or NTI. All dogs underwent a TRH stimulation test with measurement of plasma concentrations of GH and TSH before and 30 and 45 minutes after IV administration of TRH.Eleven of the dogs were

2018 Journal of Veterinary Internal Medicine

44. Adaptive deep brain stimulation for Parkinson’s disease using motor cortex sensing Full Text available with Trip Pro

Adaptive deep brain stimulation for Parkinson’s disease using motor cortex sensing Contemporary deep brain stimulation (DBS) for Parkinson's disease is delivered continuously, and adjustments based on patient's changing symptoms must be made manually by a trained clinician. Patients may be subjected to energy intensive settings at times when they are not needed, possibly resulting in stimulation-induced adverse effects, such as dyskinesia. One solution is 'adaptive' DBS, in which stimulation (...) is modified in real time based on neural signals that co-vary with the severity of motor signs or of stimulation-induced adverse effects. Here we show the feasibility of adaptive DBS using a fully implanted neural prosthesis.We demonstrate adaptive deep brain stimulation in two patients with Parkinson's disease using a fully implanted neural prosthesis that is enabled to utilize brain sensing to control stimulation amplitude (Activa PC  +  S). We used a cortical narrowband gamma (60-90 Hz) oscillation

2018 Journal of neural engineering

45. The Use of Footstep Sounds as Rhythmic Auditory Stimulation for Gait Rehabilitation in Parkinson’s Disease: A Randomized Controlled Trial Full Text available with Trip Pro

The Use of Footstep Sounds as Rhythmic Auditory Stimulation for Gait Rehabilitation in Parkinson’s Disease: A Randomized Controlled Trial The use of rhythmic auditory stimulation (RAS) has been proven useful in the management of gait disturbances associated with Parkinson's disease (PD). Typically, the RAS consists of metronome or music-based sounds (artificial RAS), while ecological footstep sounds (ecological RAS) have never been used for rehabilitation programs.The aim of this study (...) was to compare the effects of a rehabilitation program integrated either with ecological or with artificial RAS.An observer-blind, randomized controlled trial was conducted to investigate the effects of 5 weeks of supervised rehabilitation integrated with RAS. Thirty-eight individuals affected by PD were randomly assigned to one of the two conditions (ecological vs. artificial RAS); thirty-two of them (age 68.2 ± 10.5, Hoehn and Yahr 1.5-3) concluded all phases of the study. Spatio-temporal parameters

2018 Frontiers in neurology Controlled trial quality: uncertain

46. Does the use of epiduroscopic lysis of adhesions reduce the need for spinal cord stimulation in failed back surgery syndrome: a short term pilot study? (Abstract)

Does the use of epiduroscopic lysis of adhesions reduce the need for spinal cord stimulation in failed back surgery syndrome: a short term pilot study? Persistent low back pain after initially successful surgery that is not attributed to structural deficits is called failed back surgery syndrome (FBSS). When conservative and minimal invasive therapy fail, the recommended treatment is spinal cord stimulation (SCS). Because epidural fibrosis can be a contributing factor in the majority of FBSS (...) patients, lumbosacral epiduroscopic lysis of adhesions may be considered as a less invasive alternative treatment option. We hypothesized that the use of epiduroscopic lysis of adhesions could reduce the need for SCS.A pilot study was performed in 35 consecutive patients with FBSS who underwent epiduroscopic lysis of adhesions. SCS was considered if epiduroscopic lysis of adhesions gave less than 50% global perceived effect (GPE) improvement after 15 months of follow-up. The GPE was measured 1 week

2018 Pain Practice

47. Conditioned Pain Modulation Using Painful Cutaneous Electrical Stimulation or Simply Habituation? (Abstract)

Conditioned Pain Modulation Using Painful Cutaneous Electrical Stimulation or Simply Habituation? Cold pressor test was recently reported to significantly reduce painful cutaneous electrical stimulation (PCES)-induced pain and corresponding evoked potentials (PCES-EPs), but whether this reduction is an effect of conditioned pain modulation (CPM) remains unknown. To what extent these findings are confounded by habituation is also unknown. We thus compared the effect of CPM and habituation (...) on PCES-induced pain and PCES-EPs and analysed whether increased attention by a random change of electric stimulation would intensify this possible habituation effect.Three custom-built concentric surface electrodes were used to induce a pain intensity of 60 on a 0-100 numerical rating scale (NRS) among 29 healthy subjects (age 20-35y, 16 females). PCES-EPs (including P0N1 and N1P1 amplitudes, N1 latencies) were assessed over Cz. Group A received 14 min of electrical stimulation with constant

2018 European Journal of Pain

48. Transcranial Magnetic Stimulation for Treatment of Methamphetamine Use Disorder

-dependent patients. Condition or disease Intervention/treatment Phase Amphetamine Use Disorders Device: sham TBS Device: real mPFC cTBS Device: real dlPFC iTBS Device: real dlPFC iTBS + real mPFC cTBS Not Applicable Detailed Description: The limbic circuit and executive control circuit are two important frontal-striatal neural circuits associated with drug dependence. Previous studies showed increased functional activity within the limbic neural circuit (e.g. medial prefrontal cortex and ventral (...) Transcranial Magnetic Stimulation for Treatment of Methamphetamine Use Disorder Transcranial Magnetic Stimulation for Treatment of Methamphetamine Use Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

49. Impact of Central Nervous System Stimulant Medication Use on Growth in Pediatric Populations with Attention-Deficit/Hyperactivity Disorder: A Review. (Abstract)

Impact of Central Nervous System Stimulant Medication Use on Growth in Pediatric Populations with Attention-Deficit/Hyperactivity Disorder: A Review. Central nervous system stimulants are a commonly used first-line treatment option for attention-deficit/hyperactivity disorder (ADHD). Stimulants are generally well tolerated, with anorexia and insomnia the most common adverse effects. However, there are some concerns with long-term use of stimulants, such as potential growth delay. Historically (...) , data regarding this long-term adverse effect have been conflicting. In this article, we review the newer data surrounding the effects of central nervous system stimulants on growth parameters in children with ADHD. We conducted a literature search of the PubMed database; only articles using ADHD criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition; Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision; and Diagnostic and Statistical

2018 Pharmacotherapy

50. Treatment of Chronic Back and Chest Pain in a Patient with Sickle Cell Disease Using Spinal Cord Stimulation Full Text available with Trip Pro

Treatment of Chronic Back and Chest Pain in a Patient with Sickle Cell Disease Using Spinal Cord Stimulation 29911986 2018 12 07 1308-5263 35 4 2018 Nov 13 Turkish journal of haematology : official journal of Turkish Society of Haematology Turk J Haematol Treatment of Chronic Back and Chest Pain in a Patient with Sickle Cell Disease Using Spinal Cord Stimulation 307-308 10.4274/tjh.2017.0447 Yürük Damla D 0000-0002-0799-3434 Bursa Yüksek İhtisas Training and Research Hospital, Clinic (...) of Algology, Bursa, Turkey Aşık İbrahim İ 0000-0002-5830-5179 Ankara University Faculty of Medicine, Department of Algology, Bursa, Turkey eng Journal Article Orak Hücre Hastasında Kronik Sırt ve Göğüs Ağrısının Spinal Kord Stimülatörü ile Tedavisi 2018 06 18 Turkey Turk J Haematol 9606065 1300-7777 Chronic pain Sickle cell disease Spinal cord stimulation 2018 6 19 6 0 2018 6 19 6 0 2018 6 19 6 0 ppublish 29911986 10.4274/tjh.2017.0447 PMC6256825 Neurosurgery. 2006 Mar;58(3):481-96; discussion 481-96

2018 Turkish Journal of Hematology

51. Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder

the participant is assigned to the active or sham condition. Primary Purpose: Treatment Official Title: A Double-Blind, Randomized, Controlled Trial, Utilizing Accelerated Repetitive Transcranial Magnetic Stimulation (rTMS) as a Tool to Decrease Pain and Craving in Hospitalized Patients With Opiate Use Disorder Actual Study Start Date : September 28, 2018 Estimated Primary Completion Date : June 1, 2020 Estimated Study Completion Date : June 1, 2020 Resource links provided by the National Library of Medicine (...) Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder Repetitive Transcranial Magnetic Stimulation for Opiate Use Disorder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Repetitive

2018 Clinical Trials

52. A Review of Brain Stimulation Methods to Treat Substance Use Disorders Full Text available with Trip Pro

A Review of Brain Stimulation Methods to Treat Substance Use Disorders Substance use disorders (SUDs) are a leading cause of disability worldwide. While several pharmacological and behavioral treatments for SUDs are available, these may not be effective for all patients. Recent studies using non-invasive neuromodulation techniques including Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct Current Stimulation (tDCS), and Deep Brain Stimulation (DBS) have shown promise (...) similar results. Results are most encouraging when stimulation is targeted to the Dorsolateral Prefrontal Cortex (DLPFC).Short-term treatment with rTMS and tDCS may have beneficial effects on drug craving and consumption. Future studies should focus on extending therapeutic benefits by increasing stimulation frequency and duration of treatment.The utility of these methods in SUD treatment and prevention are unclear, and warrants further study using randomized, controlled designs. (Am J Addict 2018;27

2018 The American Journal on Addictions

53. Nucleus Accumbens Deep Brain Stimulation in Patients with Substance Use Disorders and Delay Discounting Full Text available with Trip Pro

Nucleus Accumbens Deep Brain Stimulation in Patients with Substance Use Disorders and Delay Discounting Deep brain stimulation (DBS) of the nucleus accumbens (NAc) shows first promising results in patients with severe substance use disorder (SUD), a patient group known to have deficits in self-control. One facet of self-control is the ability to forego smaller sooner rewards in favor of larger later rewards (delay discounting, DD). The NAc has been suggested to integrate motivational

2018 Brain sciences

54. Managing opioid use disorder in primary care: PEER simplified guideline

that, similar to other chronic diseases, management of OUD be performed in primary care as part of the continuum of care for patients with OUD. Diagnosis of OUD The diagnostic criteria in the DSM-IV and DSM-5 are the Table 1. Estimated effects of treatments in opioid use disorder with GRADE rating of evidence TOPIC INTERVENTION VS CONTROL OUTCOME ESTIMATED BENEFIT, % FOLLOW-UP RANGE NNT OR NNH GRADE QUALITY OF EVIDENCE INTERVENTION CONTROL Primary care Primary care vs specialty care Treatment retention 86 (...) in male patients -Methadone can cause sweating, which can also be a withdrawal symptom • For patients with chronic pain, first stabilize the OUD before managing pain -Pain outcomes might improve as OUD stabilizes • OAT can still be used in the context of polysubstance use disorder (eg, OUD and stimulant use disorder) • If patients are employed in safety-sensitive jobs, check employer standards for urine drug testing and pharmacotherapeutic management • If a urine drug test result is negative

2019 CPG Infobase

55. Opioid use disorder

Opioid use disorder Opioid use disorder - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Opioid use disorder Last reviewed: February 2019 Last updated: January 2019 Summary Heroin and prescription opioid misuse is a major health concern. From a diagnostic perspective, it is imperative that the physician understands the criteria for opioid use disorder. Comorbid medical and psychiatric illnesses, as well as other (...) substance use disorders, should be assessed. Physicians should be aware of methods for screening and detection of opioid use in clinical settings. Evidence-based treatments include detoxification, maintenance therapy, and psychosocial and supportive therapies. Treatment requires a multidisciplinary approach, is long term, and involves modifying deeply ingrained behaviours through the use of medications and psychosocial treatments. Definition An opioid is a synthetic or natural agent that stimulates

2019 BMJ Best Practice

56. Canadian guidelines on opioid use disorder among older adults

and rarely > 7 days. [GRADE Quality: Moderate; Strength: Strong] RECOMMENDATION #2: In most circumstances, avoid prescribing opioids for older adults with CNCP . For severe pain that is not responsive to non- opioid therapy in patients without a history of substance use disorder and without active mental illness, a trial of opioid treatment may be considered. Consider obtaining a second opinion before prescribing long-term opioid therapy. After explaining the risks and benefits to the patient, prescribe (...) , with an emphasis on signs of intoxication or withdrawal and the sequelae of substance use. Laboratory and other investigations (including urine drug tests) should be performed as appropriate for the medical conditions identified. Reassessment is essential and should be conducted episodically throughout long-term care. [GRADE Quality: Moderate; Strength: Strong]7 Canadian Guidelines on Opioid Use Disorder Among Older Adults QUESTION E: In older adults with or at risk for an OUD, what considerations

2019 CPG Infobase

57. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation for the Treatment of Patients with Parkinson's Disease

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation for the Treatment of Patients with Parkinson's Disease cns.org ');//]]> × To support the neurosurgery community in these unprecedented times, the CNS is offering complimentary online education. . Register today for the only neurosurgery meeting you can’t miss! Register today for the only neurosurgery meeting you can’t miss! Register today (...) for the only neurosurgery meeting you can’t miss! Register today for the only neurosurgery meeting you can’t miss! Register today for the only neurosurgery meeting you can’t miss! We're Sorry. We cannot find the page you requested. The file you are looking for may have been moved. You can or . The CNS Mission: Enhancing health and improving lives through the advancement of neurosurgical education and scientific exchange Get Involved Associated CNS Websites Connect With Us 10 North Martingale Road, Suite

2017 Congress of Neurological Surgeons

58. Systematic review with meta-analysis: Stimulant medication for ADHD not associated with subsequent substance use disorders

Systematic review with meta-analysis: Stimulant medication for ADHD not associated with subsequent substance use disorders Stimulant medication for ADHD not associated with subsequent substance use disorders | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password (...) For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Stimulant medication for ADHD not associated with subsequent substance use disorders Article Text Aetiology Systematic review with meta-analysis Stimulant medication for ADHD

2014 Evidence-Based Medicine

59. Letter to the editor: Clinical Use, Quality of Life and Cost-Effectiveness of Spinal Cord Stimulation Used to Treat Patients with Failed Back Surgery Syndrome Full Text available with Trip Pro

Letter to the editor: Clinical Use, Quality of Life and Cost-Effectiveness of Spinal Cord Stimulation Used to Treat Patients with Failed Back Surgery Syndrome 28874987 2018 11 13 1976-1902 11 4 2017 Aug Asian spine journal Asian Spine J Letter to the editor: Clinical Use, Quality of Life and Cost-Effectiveness of Spinal Cord Stimulation Used to Treat Patients with Failed Back Surgery Syndrome. 675-676 10.4184/asj.2017.11.4.675 Scalone Luciana L Research Centre on Public Health, University

2017 Asian spine journal

60. Response to: Clinical Use, Quality of Life and Cost-Effectiveness of Spinal Cord Stimulation Used to Treat Failed Back Surgery Syndrome Full Text available with Trip Pro

Response to: Clinical Use, Quality of Life and Cost-Effectiveness of Spinal Cord Stimulation Used to Treat Failed Back Surgery Syndrome 28874988 2018 11 13 1976-1902 11 4 2017 Aug Asian spine journal Asian Spine J Response to: Clinical Use, Quality of Life and Cost-Effectiveness of Spinal Cord Stimulation Used to Treat Failed Back Surgery Syndrome. 677-678 10.4184/asj.2017.11.4.677 Waszak Przemyslaw Maciej PM Janusz Korczak Memorial Voivodeship Hospital, Słupsk, Poland. Department of Hygiene

2017 Asian spine journal

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