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Stimulant Use Disorder

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30661. Efficacy and safety of modafinil film-coated tablets in children and adolescents with or without prior stimulant treatment for attention-deficit/hyperactivity disorder: pooled analysis of 3 randomized, double-blind, placebo-controlled studies. (PubMed)

Efficacy and safety of modafinil film-coated tablets in children and adolescents with or without prior stimulant treatment for attention-deficit/hyperactivity disorder: pooled analysis of 3 randomized, double-blind, placebo-controlled studies. This report evaluated the efficacy and tolerability of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder (ADHD), diagnosed using DSM-IV-TR criteria, who did or did not receive prior treatment (...) analysis extends previous findings that modafinil was well tolerated and improved the symptoms and behaviors of ADHD at school and at home as assessed by teachers, parents, and clinicians and improved patients' overall clinical condition. Improvements were shown regardless of history of stimulant use.

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2006 Primary care companion to the Journal of clinical psychiatry Controlled trial quality: uncertain

30662. Relative benefits of stimulant therapy with OROS methylphenidate versus mixed amphetamine salts extended release in improving the driving performance of adolescent drivers with attention-deficit/hyperactivity disorder. (PubMed)

Relative benefits of stimulant therapy with OROS methylphenidate versus mixed amphetamine salts extended release in improving the driving performance of adolescent drivers with attention-deficit/hyperactivity disorder. Automobile accidents are the leading cause of death among adolescents, and collisions are 2 to 4 times more likely to occur among adolescents with attention-deficit/hyperactivity disorder. Studies have demonstrated that stimulants improve driving performance. This study compared (...) 2 long-acting stimulant medications during daytime and evening driving evaluations.Adolescent drivers with attention-deficit/hyperactivity disorder were compared on a driving simulator after taking 72 mg of OROS methylphenidate, 30 mg of mixed amphetamine salts extended release, or placebo in a randomized, double-blind, placebo-controlled, crossover study design. During laboratory testing, adolescents drove a driving simulator at 5:00 pm, 8:00 pm, and 11:00 pm. Driving performance was rated

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2006 Pediatrics Controlled trial quality: uncertain

30663. [Use of drugs in attention deficit hyperactivity disorders]. (PubMed)

[Use of drugs in attention deficit hyperactivity disorders]. Attention deficit hyperactivity disorder (ADHD) is a neurological disorder which is common in the childhood and can be caused by exogenous and endogenous factors, that are responsible for cerebral disorder. This disorder presents a functional alteration of the motor, perceptive, cognition systems and conduct disorders compromising the learning of children with an adequate intellectual potential. The authors study the action (...) of stimulants and antidepressive drugs in the ADHD, using as measure of efficacy the motor persistence tests.

1997 Arquivos de neuro-psiquiatria

30664. Practical recommendations for the use of acupuncture in the treatment of temporomandibular disorders based on the outcome of published controlled studies. (PubMed)

Practical recommendations for the use of acupuncture in the treatment of temporomandibular disorders based on the outcome of published controlled studies. The objective is to analyse the treatment procedures used in the individual studies to identify any similarities of therapeutic approaches and subsequently present recommendations for a standard acupuncture procedure for the treatment of temporomandibular disorders (TMD).Literature searches performed by the Royal Society of Medicine (...) counted as one.All publications were analysed for the following information: acupuncture points used, type of stimulation, number of treatments, duration of the individual treatment and the interval between the individual treatments.Acupuncture has in three out of three randomised controlled trials (RCT) proved effective for the treatment of TMD. The following local acupuncture points are recommended for the treatment of TMD: ST-6, ST-7, SI-18, GV-20, GB-20, BL-10. As a distant point LI-4

2001 Oral diseases

30665. Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: a reanalysis using drug-placebo and drug-drug response curve methodology. (PubMed)

Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: a reanalysis using drug-placebo and drug-drug response curve methodology. Because methylphenidate (MPH) is currently the most widely prescribed medication for attention deficit hyperactivity disorder (ADHD), several studies have used this as the touch-stone for evaluating the efficacy of a newer stimulant, Adderall. In a parallel-groups study of MPH (n = 20), Adderall (n = 20), and placebo (n = 18), Pliszka et (...) al. (2000) reported that both medications were superior to placebo in improving parent, teacher, and clinician ratings of ADHD and associated behaviors. Compared with MPH, Adderall led to significantly more improvements in teacher and clinician ratings. The present study extends these results by addressing the issue of clinical significance using drug-placebo and drug-drug response curve analyses of the same data. The goal of this method is to answer the following questions about drug-placebo

2001 Journal of Child and Adolescent Psychopharmacology

30666. Guanfacine use in children with attention deficit hyperactivity disorder. (PubMed)

Guanfacine use in children with attention deficit hyperactivity disorder. The role of guanfacine in ADHD remains unclear. It may be reasonable to initiate a trial of guanfacine in a patient who has not responded to or cannot tolerate other agents due to adverse effects or drug dependence, or in a patient who develops motor tics. However, large placebo-controlled, double-blind, comparative trials involving guanfacine, stimulants, and/or TCAs are necessary to fully determine the role (...) of guanfacine in the treatment of ADHD. Presently, behavioral modification is considered a first-line therapy and may be sufficient in mild cases of ADHD. Pharmacologic intervention or a combination of pharmacotherapy and behavioral modification should be tried in patients who cannot be adequately controlled with nonpharmacologic treatment. The stimulants still are considered first-line pharmacotherapy; however, guanfacine may have a role as a second- or third-line agent in patients who do not respond

1997 The Annals of pharmacotherapy

30667. Sequential use of norethisterone and natural progesterone in pre-menopausal bleeding disorders. (PubMed)

Sequential use of norethisterone and natural progesterone in pre-menopausal bleeding disorders. Sequential treatment with norethisterone (NET) or natural micronized progesterone (NMP) was administered randomly to 80 consecutive patients attending our clinic because of cycle disorders. The endometrial morphology indicated a need for progestogen therapy in all cases and the endometrium was hyperplastic in half of the women before therapy. Hyperplastic changes disappeared during the first three (...) cycles of treatment with both NET and NMP, the duration of treatment being 6 months. However, the carry-over effect of both progestogens was short: three months after treatment was discontinued a proliferative or hyperplastic endometrial pattern recurred in 24% and 10% of cases, respectively. Whereas NET decreased oestradiol, follicle-stimulating hormone, luteinizing hormone and sex-hormone-binding globulin levels (P less than 0.001) no changes were seen during NMP treatment. High-density-lipoprotein

1990 Maturitas Controlled trial quality: uncertain

30668. Visuo-spatial attention processes in panic disorder with agoraphobia: a pilot study using a visual target discrimination task. (PubMed)

Visuo-spatial attention processes in panic disorder with agoraphobia: a pilot study using a visual target discrimination task. Panic attacks can be observed in a wide range of situations, but most common are those providing complex and unstructured stimulations, suggesting an impairment in attentional processing of visuo-spatial information. This study evaluated agoraphobics' attentional processing of neutral (i.e., not anxiety-provoking) visuo-spatial stimulation. Twelve patients suffering (...) from panic attacks with agoraphobia were compared with 22 normal controls on a computerized visual target discrimination task specifically designed for this study. Psychometric measures assessed the phobic avoidance, the level of depression and anxiety. The numbers of errors and reaction times were analysed with a three-way ANOVA (Group x target modality x number of stimulations). No between-group significant difference was found for the reaction time performance and the mean number of detection

2000 European psychiatry : the journal of the Association of European Psychiatrists Controlled trial quality: uncertain

30669. Low-field magnetic stimulation in bipolar depression using an MRI-based stimulator. (PubMed)

Low-field magnetic stimulation in bipolar depression using an MRI-based stimulator. Anecdotal reports have suggested mood improvement in patients with bipolar disorder immediately after they underwent an echo-planar magnetic resonance spectroscopic imaging (EP-MRSI) procedure that can be performed within clinical MR system limits. This study evaluated possible mood improvement associated with this procedure.The mood states of subjects in an ongoing EP-MRSI study of bipolar disorder were (...) assessed by using the Brief Affect Scale, a structured mood rating scale, immediately before and after an EP-MRSI session. Sham EP-MRSI was administered to a comparison group of subjects with bipolar disorder, and actual EP-MRSI was administered to a comparison group of healthy subjects. The characteristics of the electric fields generated by the EP-MRSI scan were analyzed.Mood improvement was reported by 23 of 30 bipolar disorder subjects who received the actual EP-MRSI examination, by three of 10

2004 American Journal of Psychiatry

30670. Enhancement of Use-Dependent Plasticity by Somatosensory Stimulation in Chronic Stroke

Enhancement of Use-Dependent Plasticity by Somatosensory Stimulation in Chronic Stroke Enhancement of Use-Dependent Plasticity by Somatosensory Stimulation in Chronic Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Enhancement of Use-Dependent Plasticity by Somatosensory Stimulation in Chronic Stroke The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00028379 Recruitment Status : Completed First Posted : December 28, 2001 Last Update Posted : March 4, 2008 Sponsor: National Institute

2001 Clinical Trials

30671. Use of Transcranial Magnetic Stimulation (TMS) and Magnetic Resonance Imaging (MRI) to Study Visual Attention

or significant closed head injury will be excluded. Subjects with cochlear implants, implanted brain stimulators, aneurysm clips or other metal in the head (except mouth) will be excluded. Subjects taking tricyclic anti-depressants, neuroleptic agents or other drugs that lower the seizure threshold will be excluded. Subjects with a history of illicit drug use or who are abusing or withdrawing from alcohol abuse will be excluded. Subjects with a history of a major psychiatric disorder will be excluded (...) Use of Transcranial Magnetic Stimulation (TMS) and Magnetic Resonance Imaging (MRI) to Study Visual Attention Use of Transcranial Magnetic Stimulation (TMS) and Magnetic Resonance Imaging (MRI) to Study Visual Attention - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2000 Clinical Trials

30672. Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy

Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00001672 Recruitment Status : Completed First Posted : December 10, 2002 Last Update Posted

1999 Clinical Trials

30673. Earlier use of adjunctive vagus nerve stimulation therapy for refractory epilepsy. (PubMed)

Earlier use of adjunctive vagus nerve stimulation therapy for refractory epilepsy. Recent studies suggest that epilepsy that is unresponsive to medical therapy is likely to be refractory from the onset. Identifying such patients early and treating them with nonpharmacologic therapies may improve their outcome. We hypothesized that patients who had adjunctive therapy with vagus nerve stimulation (VNS) earlier in the course of their epilepsy would have a better response compared with patients who (...) had VNS therapy instituted later in the course. Patients in the VNS patient outcome registry who were more than 5 years post onset of their seizure disorder at implantation and had seizure frequency data available at both baseline and 3 months comprised the control group (n = 2785). These data were obtained retrospectively. Patients who were implanted between August 15, 2000 and July 31, 2001 who had epilepsy for 5 years or less at implantation or who had tried four or fewer standard antiepileptic

2002 Neurology

30674. Meta-Analysis of Thirty-Four Independent Samples Studied Using PET Reveals a Significantly Attenuated Central Response to Noxious Stimulation in Clinical Pain Patients. (PubMed)

Meta-Analysis of Thirty-Four Independent Samples Studied Using PET Reveals a Significantly Attenuated Central Response to Noxious Stimulation in Clinical Pain Patients. Chronic pain disorder is widely understood as a "biopsychosocial" phenomenon, meaning that it is influenced by psychology and certain life events. This broad understanding of chronic pain suggests that central responses during pain experience should be altered in patients compared with pain-free volunteers. A total of 34 studies (...) are reviewed, revealing a widespread "neuromatrix" of activated regions. These regions include the brain stem, thalamus, and lentiform nucleus, and the insula, prefrontal, parietal, and anterior cingulate cortices. Meta-analysis of these studies does not reveal any single region or pattern of activity to be of particular influence during chronic pain but does reveal a generally reduced response to noxious stimulation in patients with concomitant clinical pain. The relevance of this finding remains unclear

2000 Current review of pain

30675. Transcranial magnetic stimulation: using a law of physics to treat psychopathology. (PubMed)

Transcranial magnetic stimulation: using a law of physics to treat psychopathology. 10212551 1999 05 19 2018 11 13 1180-4882 24 2 1999 Mar Journal of psychiatry & neuroscience : JPN J Psychiatry Neurosci Transcranial magnetic stimulation: using a law of physics to treat psychopathology. 97-101 Hasey G M GM Department of Psychiatry, McMaster University, Hamilton, Ont. eng Journal Article Review Canada J Psychiatry Neurosci 9107859 1180-4882 IM Electromagnetic Fields adverse effects Humans Mental (...) Disorders therapy 28 1999 4 23 1999 4 23 0 1 1999 4 23 0 0 ppublish 10212551 PMC1188989 J Natl Cancer Inst. 1994 Jun 15;86(12):921-5 8196082 Am J Psychiatry. 1998 Nov;155(11):1608-10 9812128 Neuroreport. 1995 Nov 13;6(16):2171-6 8595196 Neurology. 1996 Feb;46(2):499-502 8614521 Brain Res. 1995 Nov 13;699(1):130-2 8616602 Lancet. 1996 Jul 27;348(9022):233-7 8684201 J Neuropsychiatry Clin Neurosci. 1996 Spring;8(2):172-80 9081553 Neuropsychobiology. 1996;34(4):204-7 9121622 Prog Neuropsychopharmacol Biol

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1999 Journal of Psychiatry and Neuroscience

30676. Adolescent stimulant use (PubMed)

Adolescent stimulant use 12137070 2002 08 15 2018 11 13 0820-3946 167 1 2002 Jul 09 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Adolescent stimulant use. 15; author reply 15-6 Safer Daniel D Zito Julie Magno JM eng Comment Letter Canada CMAJ 9711805 0820-3946 0 Anti-Obesity Agents 0 Central Nervous System Stimulants AIM IM CMAJ. 2001 Oct 16;165(8):1039-44 11699699 Adolescent Adult Amphetamine-Related Disorders Anti-Obesity Agents Canada (...) Central Nervous System Stimulants Child Drug Utilization Female Humans Male 2002 7 26 10 0 2002 8 16 10 1 2002 7 26 10 0 ppublish 12137070 PMC116630 CMAJ. 2001 Oct 16;165(8):1039-44 11699699

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2002 CMAJ: Canadian Medical Association Journal

30677. Central motor conduction in degenerative ataxic disorders: a magnetic stimulation study. (PubMed)

Central motor conduction in degenerative ataxic disorders: a magnetic stimulation study. Central motor conduction to small hand muscles was measured using magnetic stimulation of the motor cortex and electrical stimulation of proximal motor roots in 11 patients with Friedreich's ataxia, 10 patients with early onset cerebellar ataxia with retained tendon reflexes (EOCA) and 13 patients with late onset degenerative cerebellar disease (LOCD). Central motor conduction was abnormal in 91 (...) % with Friedreich's ataxia, 70% with EOCA and 38% with LOCD. Central motor conduction abnormalities were not specific to individual disorders but were more severe and were related to disease duration in Friedreich's ataxia and EOCA.

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1988 Journal of neurology, neurosurgery, and psychiatry

30678. Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders

Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood Disorders The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00001545 Recruitment Status : Completed First Posted : November 4, 1999 Last Update Posted : July 13, 2006

1999 Clinical Trials

30679. Effect of stimulant medication on driving performance of young adults with attention-deficit hyperactivity disorder: a preliminary double-blind placebo controlled trial. (PubMed)

Effect of stimulant medication on driving performance of young adults with attention-deficit hyperactivity disorder: a preliminary double-blind placebo controlled trial. Driving performance of adult males with attention-deficit hyperactivity disorder (ADHD) was compared with matched controls in a double-blind (Ritalin vs. placebo) cross-over design, using a high-fidelity driving simulator. Seven ADHD and six non-ADHD drivers (mean age 22) were screened to rule out comorbidity and assess (...) (p < .05), demonstrated significant improvement under the Ritalin condition (p < .05), rated themselves as driving poorer during the placebo condition (p = .05), and tended to perceive their driving to be better during the Ritalin condition (p = .07). This would suggest that individuals with ADHD should have the therapeutic benefit of a stimulant medication when operating a vehicle.

2000 The Journal of nervous and mental disease

30680. The specificity of the effects of stimulant medication on classroom learning-related measures of cognitive processing for attention deficit disorder children. (PubMed)

The specificity of the effects of stimulant medication on classroom learning-related measures of cognitive processing for attention deficit disorder children. There appear to be beneficial effects of stimulant medication on daily classroom measures of cognitive functioning for Attention Deficit Disorder (ADD) children, but the specificity and origin of such effects is unclear. Consistent with previous results, 0.3 mg/kg methylphenidate improved ADD children's performance on a classroom reading (...) comprehension measure. Using the Posner letting-matching task and four additional measures of phonological processing, we attempted to isolate the effects of methylphenidate to parameter estimates of (a) selective attention, (b) the basic cognitive process of retrieving name codes from permanent memory, and (c) a constant term that represented nonspecific aspects of information processing. Responses to the letter-matching stimuli were faster and more accurate with medication compared to placebo

1991 Journal of abnormal child psychology Controlled trial quality: uncertain

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