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Stimulant Use Disorder

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1. Pharmacotherapy for Stimulant Use Disorders

Pharmacotherapy for Stimulant Use Disorders Management Briefs eBrief-no147 -- Pharmacotherapy for Stimulant Use Disorders Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs eBrief-no147 -- Pharmacotherapy for Stimulant Use Disorders Health Services Research & Development Management eBrief no. 147 » Issue 147 October 2018 The report is a product of the VA/HSR&D Evidence Synthesis Program (...) . Pharmacotherapy for Stimulant Use Disorders: A Systematic Review Stimulant use disorders, specifically cocaine and methamphetamine use disorders, present ongoing public health problems in the United States, with major medical, psychiatric, cognitive, socioeconomic, and legal consequences. There are more emergency department visits associated with cocaine compared with other illicit substances, and several US cities consider methamphetamine as the drug of abuse associated with the "most serious consequences

2018 Veterans Affairs - R&D

2. Diagnoses of Cardiovascular Disease or Substance Addiction/Abuse in US Adults Treated for ADHD with Stimulants or Atomoxetine: Is Use Consistent with Product Labeling? Full Text available with Trip Pro

Diagnoses of Cardiovascular Disease or Substance Addiction/Abuse in US Adults Treated for ADHD with Stimulants or Atomoxetine: Is Use Consistent with Product Labeling? Among US adults, utilization of pharmacotherapy for attention-deficit hyperactivity disorder (ADHD) has increased more than ninefold since 1995-1996. Potential contraindications to ADHD pharmacotherapy include serious cardiovascular disease (CVD) and, for stimulants, addictions and bipolar disorder (BPD).To assess the prevalence (...) of potential contraindications among adults treated with ADHD pharmacotherapy.A retrospective cohort analysis was performed using the Truven Health MarketScan® database. Subjects filled ≥ 1 prescription for atomoxetine or ≥ 1 stimulant in 2014-2015, were aged 18-64 years, commercially insured throughout observation, and diagnosed with ADHD on two or more medical claims. Diagnoses and medical procedures were measured in the 12 months prior to pharmacotherapy initiation. Metrics included serious CVD

2018 Drugs - real world outcomes

3. Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure caused by motor neurone disease

of implementing NICE recommendations wherever possible. This guidance replaces IPG307. © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 1 of 71 1 Recommendations Recommendations 1.1 Current evidence on intramuscular diaphragm stimulation for ventilator- dependent chronic respiratory failure caused by motor neurone disease suggests that there are serious long-term safety concerns. Evidence on efficacy is limited and therefore (...) , this procedure should not be used to treat this condition. 2 2 Indications and current treatments Indications and current treatments 2.1 Motor neurone disease is a neurodegenerative condition affecting the brain and spinal cord. The most common type of the disease is amyotrophic lateral sclerosis. Motor neurone disease is characterised by the degeneration of primarily motor neurones, leading to muscle weakness, limb weakness, problems with speech, swallowing and breathing, which ultimately leads

2017 National Institute for Health and Clinical Excellence - Interventional Procedures

4. Level of Tumor Necrosis Factor Production by Stimulated Blood Mononuclear Cells Can Be Used to Predict Response of Patients With Inflammatory Bowel Diseases to Infliximab. (Abstract)

Level of Tumor Necrosis Factor Production by Stimulated Blood Mononuclear Cells Can Be Used to Predict Response of Patients With Inflammatory Bowel Diseases to Infliximab. A substantial proportion patients with inflammatory bowel disease (IBD) have a primary non-response to infliximab; markers are needed to identify patients most likely to respond to treatment. We investigated whether production of tumor necrosis factor (TNF) by peripheral blood mononuclear cells (PBMCs) can be used as a marker (...) to predict response.We performed a prospective study of 41 adults with IBD (mean age, 38 years; 21 male; 21 with Crohn's disease and 20 with ulcerative colitis) not treated with a biologic agent within the past 6 months; patients were given their first infusion of infliximab at a hospital or clinic in Berlin, Germany. We collected data on clinical scores, levels of C-reactive protein, and ultrasound results (Limberg scores) at baseline (before the first infusion) and after 6 weeks (3rd infliximab

2020 Clinical Gastroenterology and Hepatology

5. Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents. Full Text available with Trip Pro

Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents. Disorders of compulsivity such as stimulant use disorder (SUD) and obsessive-compulsive disorder (OCD) are characterised by deficits in behavioural flexibility, some of which have been captured using probabilistic reversal learning (PRL) paradigms.This study used (...) -controlled, randomised design. We compared seven models using a bridge sampling estimate of the marginal likelihood.Stimulus-bound perseveration, a measure of the degree to which participants responded to the same stimulus as before irrespective of outcome, was significantly increased in SUD, but decreased in OCD, compared to controls (on placebo). Individuals with SUD also exhibited reduced reward-driven learning, whilst both the SUD and OCD groups showed increased learning from punishment (nonreward

2019 Psychopharmacology Controlled trial quality: uncertain

6. Stimulant treatment profiles predicting co-occurring substance use disorders in individuals with attention-deficit/hyperactivity disorder. Full Text available with Trip Pro

Stimulant treatment profiles predicting co-occurring substance use disorders in individuals with attention-deficit/hyperactivity disorder. Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of developing substance use disorders (SUDs) and nicotine dependence (ND). It remains unclear whether and how stimulant treatment may affect this risk. We aimed to investigate how stimulant use profiles influence the risk of SUDs and ND, using a novel data-driven community (...) detection analysis to construct different stimulant use profiles. Comprehensive lifetime stimulant prescription data and data on SUDs and ND were available for 303 subjects with ADHD and 219 controls, with a mean age 16.3 years. Community detection was used to define subgroups based on multiple indicators of treatment history, start age, treatment duration, total dose, maximum dose, variability, stop age. In stimulant-treated participants, three subgroups with distinct medication trajectories were

2019 European child & adolescent psychiatry

7. Deep Brain Stimulation for Parkinson’s Disease: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

-Effectiveness, and Guidelines Last updated: December 14, 2018 Project Number: RC1049-000 Product Line: Research Type: Devices and Systems Report Type: Summary with Critical Appraisal Result type: Report Question What is the comparative clinical effectiveness of deep brain stimulation versus standard care for treatment of Parkinson’s disease? What is the cost-effectiveness of deep brain stimulation versus standard care for treatment of Parkinson’s disease? What are evidence-based guidelines informing the use (...) of deep brain stimulation for treatment of Parkinson’s disease? Key Message The clinical evidence on the effectiveness of deep brain stimulation for Parkinson’s disease compared to standard of care (i.e., best medical therapy) was mixed. Several unique outcomes were used to quantify clinical effectiveness, making it challenging to compile the clinical evidence. Furthermore, the methodological quality of the evidence was moderate resulting in some uncertainty in the findings. Evidence from three

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Changes in opiate and stimulant use through 10 years: The role of contextual factors, mental health disorders and psychosocial factors in a prospective SUD treatment cohort study. Full Text available with Trip Pro

Changes in opiate and stimulant use through 10 years: The role of contextual factors, mental health disorders and psychosocial factors in a prospective SUD treatment cohort study. To examine temporal changes in opiate and stimulant use among patients in substance abuse treatment over a ten-year observation period and to explore the role of contextual factors, mental health disorders and psychosocial factors on these changes.A cohort of 481 patients was prospectively interviewed at admission (...) to treatment and after 1, 2, 7 and 10 years. The sample was recruited from 20 facilities in the Greater Oslo region, Norway.The majority of patients were poly-drug users and 80% had used both opiates and stimulants the last 30 days prior to treatment admission. Last-month use of heroin, other opiates, cocaine and amphetamines declined from 80% to 34% at the end of the observation period. The most substantial reduction was observed between baseline and one-year follow-up. Use of heroin decreased the most

2018 PLoS ONE

9. Randomized Controlled Trial Comparing Exercise to Health Education for Stimulant Use Disorder: Results From the CTN-0037 STimulant Reduction Intervention Using Dosed Exercise (STRIDE) Study. Full Text available with Trip Pro

Randomized Controlled Trial Comparing Exercise to Health Education for Stimulant Use Disorder: Results From the CTN-0037 STimulant Reduction Intervention Using Dosed Exercise (STRIDE) Study. To evaluate exercise as a treatment for stimulant use disorders.The STimulant Reduction Intervention using Dosed Exercise (STRIDE) study was a randomized clinical trial conducted in 9 residential addiction treatment programs across the United States from July 2010 to February 2013. Of 497 adults referred (...) to the study, 302 met all eligibility criteria, including DSM-IV criteria for stimulant abuse and/or dependence, and were randomized to either a dosed exercise intervention (Exercise) or a health education intervention (Health Education) control, both augmenting treatment as usual and conducted thrice weekly for 12 weeks. The primary outcome of percent stimulant abstinent days during study weeks 4 to 12 was estimated using a novel algorithm adjustment incorporating self-reported Timeline Followback (TLFB

2017 Journal of Clinical Psychiatry Controlled trial quality: uncertain

10. Use of Transcranial Magnetic Stimulation to Reduce Craving for Individuals With Opioid Use Disorder Taking Buprenorphine

. In this study, individuals will receive 10 sessions of TMS. The investigators will assess craving, substance use, and mood throughout the study and one-month post-treatment. Condition or disease Intervention/treatment Phase Opioid-use Disorder Device: Transcranial Magnetic Stimulation Not Applicable Detailed Description: The aim of this study is to investigate the effects of transcranial magnetic stimulation (TMS) on craving in individuals treated with buprenorphine for opioid use disorder. Investigators (...) ) History of complicated withdrawal from alcohol (i.e. delirium tremens, seizure) Substance use disorder in the past year (other than opioid or nicotine), as assessed by drug screens, Neurologic disease including stroke, seizure, migraine, or severe head injury Major medical conditions that are not well-controlled or under the care of a physician Device (i.e. pacemaker, cochlear prosthesis, neurostimulator, intraocular metallic fragments) or ferromagnetic implant above the neck (within 30 cm of coil

2018 Clinical Trials

11. Multiple Sessions of Transcranial Direct Current Stimulation (tDCS) Reduced Craving and Relapses for Alcohol Use: A Randomized Placebo-Controlled Trial in Alcohol Use Disorder Full Text available with Trip Pro

Multiple Sessions of Transcranial Direct Current Stimulation (tDCS) Reduced Craving and Relapses for Alcohol Use: A Randomized Placebo-Controlled Trial in Alcohol Use Disorder Background: Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, has been studied as an adjunctive therapeutic agent for alcohol dependence. In a previous study, we showed that five consecutive sessions of tDCS applied bilaterally over the dorsolateral prefrontal cortex (dlPFC (...) ) reduced relapse to the use of alcohol in alcohol use disorder (AUD) outpatients. However, no changes on craving scores were observed. In the present study, we investigated if an extended number of sessions of the same intervention would reduce craving and relapses for alcohol use in AUD inpatients. Methods: Thus, a randomized, double-blind, sham-controlled, clinical trial with parallel arms was conducted (https://clinicaltrials.gov/ct2/show/NCT02091284). AUD patients from two private and one public

2018 Frontiers in pharmacology Controlled trial quality: predicted high

12. Prevalence and Correlates of Prescription Stimulant Use, Misuse, Use Disorders, and Motivations for Misuse Among Adults in the United States. Full Text available with Trip Pro

). Measurements included prescription stimulant use, use without misuse, misuse without use disorders, and misuse with use disorders, as well as sociodemographic characteristics, health conditions, and mental health factors.Among U.S. adults, 6.6% (annual average) used prescription stimulants overall; 4.5% used without misuse, 1.9% misused without use disorders, and 0.2% had use disorders. Adults with past-year prescription stimulant use disorders did not differ from those with misuse without use disorders (...) Prevalence and Correlates of Prescription Stimulant Use, Misuse, Use Disorders, and Motivations for Misuse Among Adults in the United States. The authors sought to simultaneously examine the prevalence and correlates of prescription stimulant use, misuse, use disorders, and motivations for misuse in the U.S. adult population.This was a nationally representative household population study of adults age 18 or older from the 2015 and 2016 National Surveys on Drug Use and Health (N=102,000

2018 American Journal of Psychiatry

13. Non-medical Prescription Stimulant Use among Post-secondary Students

stimulants, for example Ritalin® (methylphenidate) or Adderall® (amphetamine), are often used to treat attention deficit hyperactivity disorder (ADHD) (Canadian Centre on Substance Abuse, 2016a). Prescription stimulants used as prescribed can be of significant benefit to those who need them. However, the inappropriate use of these drugs can lead to significant harm, and is of particular concern with respect to emerging adults, aged 18–25 (Lakhan & Kirchgessner, 2012; McCabe, Knight, Teter, & Wechsler (...) disorders among young adult women. A study of female university students screened them for an eating disorder, determining those who were at low risk, at high risk or who already had a clinical diagnosis. Ten percent of this group reported inappropriate stimulant use and those who so reported had a greater clinical severity of eating disorder (i.e., those at high risk or those with a subclinical or clinical eating disorder)(Gibbs et al, 2016). It has been suggested that healthcare practitioners who

2018 Canadian Centre on Substance Abuse

14. Aided Language Stimulation Leading to Functional Communication Gains in Children Using Augmentative and Alternative Communication

Aided Language Stimulation Leading to Functional Communication Gains in Children Using Augmentative and Alternative Communication Best Evidence Statement (BESt 211) Copyright © 2018 Cincinnati Children's Hospital Medical Center; all rights reserved Page 1 of 15 October 1, 2018 Aided Language Stimulation Leading to Functional Communication Gains in Children Using Augmentative and Alternative Communication INTRODUCTION / BACKGROUND Limited consistent research exists on forms of intervention (...) for children using AAC as well as to demonstrate to parents how to stimulate both receptive and expressive language in children. Additionally, Cincinnati Children’s Hospital is a research hospital that encourages all disciplines to provide evidence for their treatment models. The current BESt is targeted for a specialized speech-language pathologist who can train parents to implement and use the model of teaching at home. One of the strengths of the treatment technique is the similarity to language

2018 Cincinnati Children's Hospital Medical Center

15. Complex Regional Pain Syndrome Management: An Evaluation of the Risks and Benefits of Spinal Cord Stimulator Use in Pregnancy. (Abstract)

Complex Regional Pain Syndrome Management: An Evaluation of the Risks and Benefits of Spinal Cord Stimulator Use in Pregnancy. We present a case of a young woman diagnosed with complex regional pain syndrome (CRPS) who underwent spinal cord stimulator (SCS) implantation. She had 2 successful pregnancies following implantation.We evaluated the electronic medical records of the patient following SCS implantation and while pregnant with her second and third children. A phone interview (...) was conducted after her third pregnancy to discuss her experience with SCS use during and after pregnancy.Physical medicine and rehabilitation pain management clinic and obstetrician clinic, affiliated with the Medical College of Wisconsin in Milwaukee, Wisconsin.A 26-year-old woman with history of CRPS type I.This 26-year-old woman was diagnosed with CRPS type I after left knee surgery. All conservative treatments had failed prior to her undergoing SCS implantation after the birth of her first child. SCS

2019 Pain Practice

16. Impaired Motor Skill Acquisition Using Mirror Visual Feedback Improved by Transcranial Direct Current Stimulation (tDCS) in Patients With Parkinson's Disease. Full Text available with Trip Pro

Impaired Motor Skill Acquisition Using Mirror Visual Feedback Improved by Transcranial Direct Current Stimulation (tDCS) in Patients With Parkinson's Disease. Recent non-invasive brain stimulation techniques in combination with motor training can enhance neuroplasticity and learning. It is reasonable to assume that such neuroplasticity-based interventions constitute a useful rehabilitative tool for patients with Parkinson's Disease (PD). Regarding motor skill training, many kinds of tasks (...) that do not involve real motor movements have been applied to PD patients. The purpose of this study is to elucidate whether motor skill training using mirror visual feedback (MVF) is useful to patients with PD in order to improve untrained hand performance dependent on the time course of training; and whether MVF combined with anodal transcranial direct current stimulation (tDCS) over primary motor cortex (M1) causes an additional effect based on increased motor cortical excitability. Eighteen right

2019 Frontiers in neuroscience Controlled trial quality: uncertain

17. Efficacy of repetitive transcranial magnetic stimulation using a figure-8-coil or an H1-Coil in treatment of major depressive disorder; A randomized clinical trial. (Abstract)

Efficacy of repetitive transcranial magnetic stimulation using a figure-8-coil or an H1-Coil in treatment of major depressive disorder; A randomized clinical trial. Repetitive transcranial magnetic stimulation (rTMS) is an evidence-based treatment option for major depressive disorder (MDD). However, comparisons of efficacy between the two FDA-approved protocols of rTMS modalities are lacking. The aim of this industry-independent, randomized-controlled, single-blind trial was to evaluate

2019 Journal of psychiatric research Controlled trial quality: predicted high

18. Measuring change in anhedonia using the "Happy Faces" task pre- to post-repetitive transcranial magnetic stimulation (rTMS) treatment to left dorsolateral prefrontal cortex in Major Depressive Disorder (MDD): relation to empathic happiness. Full Text available with Trip Pro

Measuring change in anhedonia using the "Happy Faces" task pre- to post-repetitive transcranial magnetic stimulation (rTMS) treatment to left dorsolateral prefrontal cortex in Major Depressive Disorder (MDD): relation to empathic happiness. We investigated whether repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) would reduce anhedonia in a sample of 19 depressed adults (Mage = 45.21, SD = 11.21, 63% women) randomized to either active or sham

2019 Translational psychiatry Controlled trial quality: uncertain

19. The interindividual variability of transcranial magnetic stimulation effects: Implications for diagnostic use in movement disorders. (Abstract)

a search of the PubMed database for research and review articles on transcranial magnetic stimulation and its diagnostic utility in movement disorders (specifically Parkinson's disease and atypical parkinsonism, dystonia, Tourette syndrome and other chronic tic disorders, Huntington's disease, and essential tremor). We highlighted contradictions in the literature and common misconceptions with the aim of providing a clearer picture of the reliability of these measures in differential diagnosis (...) The interindividual variability of transcranial magnetic stimulation effects: Implications for diagnostic use in movement disorders. A large number of methods have been described that use transcranial magnetic stimulation to probe the physiology of the human motor cortex. Since the 1990s, hundreds of papers have used them to investigate neurophysiological signatures of different types of movement disorders. However, in recent years there has been increasing recognition of the interindividual

2019 Movement Disorders

20. Resection of tumors within the primary motor cortex using high-frequency stimulation: oncological and functional efficiency of this versatile approach based on clinical conditions. Full Text available with Trip Pro

Resection of tumors within the primary motor cortex using high-frequency stimulation: oncological and functional efficiency of this versatile approach based on clinical conditions. Brain mapping techniques allow one to effectively approach tumors involving the primary motor cortex (M1). Tumor resectability and maintenance of patient integrity depend on the ability to successfully identify motor tracts during resection by choosing the most appropriate neurophysiological paradigm for motor (...) mapping. Mapping with a high-frequency (HF) stimulation technique has emerged as the most efficient tool to identify motor tracts because of its versatility in different clinical settings. At present, few data are available on the use of HF for removal of tumors predominantly involving M1.The authors retrospectively analyzed a series of 102 patients with brain tumors within M1, by reviewing the use of HF as a guide. The neurophysiological protocols adopted during resections were described

2019 Journal of Neurosurgery

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