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Squaric Acid Wart Therapy

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1. Squaric Acid Wart Therapy

search on the term "Squaric Acid Wart Therapy." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pharmacology About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided into a tree of 31 specialty books and 728 chapters. Content is with systematic literature reviews (...) Squaric Acid Wart Therapy Squaric Acid Wart Therapy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Squaric Acid Wart Therapy Squaric

2018 FP Notebook

2. Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial. (Abstract)

Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial. Contact immunotherapy with squaric acid dibutylester (SADBE) for cutaneous warts has been reported to be effective, although no controlled studies are available so far.The aim of this study was to evaluate the efficacy of SADBE on cutaneous warts by a randomized, double-blind, vehicle-controlled, clinical trial.Thirty-six patients were (...) randomly assigned to SADBE (18 cases) or vehicle (18 cases) group. At 8 weeks, subjects were clinically evaluated for number/size reduction rate and for Investigator Global Assessment. Those who showed improvement extended therapy up to 40 weeks, whereas those who showed unresponsiveness were either switched to SADBE application for up to 48 weeks (if in the vehicle group) or withdrawn from the study (if under SADBE).At 8 weeks, a significant reduction in wart number (P = 0.020) and size (P = 0.010

2018 Dermatitis : contact, atopic, occupational, drug Controlled trial quality: uncertain

3. A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis

Acid Dibutyl Ester in Subjects With Herpes Labialis Actual Study Start Date : March 12, 2018 Estimated Primary Completion Date : October 2018 Estimated Study Completion Date : December 2018 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: Group A Treated with 2% Squaric Acid Dibutyl Ester (SADBE) on day 0 and with 2% SADBE on the visits at week 3, week 6, week 9, and month 8. Drug: Squaric Acid Dibutyl (...) : To assess efficacy of repeat topical application of 2% and 0.5% SADBE in the prevention of herpes labialis episodes. Condition or disease Intervention/treatment Phase Herpes Labialis HSV Drug: Squaric Acid Dibutyl Ester Phase 2 Detailed Description: Primary oral infection with the herpes simplex virus (HSV) typically occurs at a young age, is asymptomatic, and is not associated with significant morbidity. After primary oral infection, HSV may persist in a latent state in the trigeminal ganglion

2018 Clinical Trials

4. Squaric Acid Wart Therapy

search on the term "Squaric Acid Wart Therapy." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Pharmacology About FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in 1995, this collection now contains 6656 interlinked topic pages divided into a tree of 31 specialty books and 728 chapters. Content is with systematic literature reviews (...) Squaric Acid Wart Therapy Squaric Acid Wart Therapy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Squaric Acid Wart Therapy Squaric

2015 FP Notebook

5. A Study of A-101 Topical Solution for the Treatment of Common Warts

and intra-nasal steroids are permitted); 28 days Subject has used any of the following topical therapies within the specified period prior to Visit 2 on, or in the proximity to any of the common warts identified for treatment, that in the investigator's opinion interferes with the study medication treatment or the study assessments: LASER, light or other energy-based therapy (e.g., intense pulsed light [IPL], photodynamic therapy [PDT]); 180 days Immunotherapy (e.g., imiquimod, squaric acid dibutyl (...) -Blind, Vehicle-Controlled, Parallel-Group Study of A-101 Topical Solution Applied Twice a Week in Subjects With Common Warts Actual Study Start Date : September 17, 2018 Estimated Primary Completion Date : April 28, 2019 Estimated Study Completion Date : July 10, 2019 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Active Comparator: A-101 Topical solution, hydrogen peroxide 45% Drug: A-101 hydrogen

2018 Clinical Trials

6. Study of A-101 Topical Solution for the Treatment of Common Warts

used any of the following topical therapies within the specified period prior to Visit 2 on, or in the proximity to any of the common warts identified for treatment, that in the investigator's opinion interferes with the study medication treatment or the study assessments: LASER, light or other energy-based therapy (e.g., intense pulsed light [IPL], photodynamic therapy [PDT]); 180 days Immunotherapy (e.g., imiquimod, squaric acid dibutyl ester[SADBE], etc.) 12 weeks Liquid nitrogen (...) , electrodesiccation, curettage; 60 days Hydrogen peroxide; 90 days Antimetabolite therapy (e.g., 5-fluorouracil); 8 weeks Retinoids; 90 days Over-the-counter (OTC) wart therapies and cantharidin; 28 days Subject currently has or has had any of the following within the specified period prior to Visit 1 on or in the proximity to any of the common warts identified for treatment that, in the investigator's opinion, interferes with the study medication treatment or the study assessments: Cutaneous malignancy; 180 days

2018 Clinical Trials

7. Childhood skin and soft tissue infections: new discoveries and guidelines regarding the management of bacterial soft tissue infections, molluscum contagiosum, and warts. (Abstract)

virus strains have been detected in cutaneous warts in children.The high-risk human papilloma virus vaccine may play a role in treating pediatric cutaneous warts in the future, and topical squaric acid dibutylester may effectively treat recalcitrant warts. Finally, both molluscum contagiosum and warts have a high rate of resolution after an extended period of time without any intervention. (...) with systemic antibiotics covering Staphylococcus aureus species, especially community acquired methicillin-resistant S. aureus. For the treatment of molluscum contagiosum, topical cantharidin has a high satisfaction rate among patients and providers. Potassium hydroxide solution is a potentially effective and cheap form of molluscum contagiosum treatment. Imiquimod, however, has an unfavorable efficacy and safety profile as a therapy for molluscum contagiosum. Regarding warts, high-risk human papilloma

2016 Current Opinion in Pediatrics

8. A Study of A-101 Solution in Subjects With Common Warts.

, might put the subject at undue risk by study participation or interfere with the study conduct or evaluations: - LASER (pulsed-dye laser), light (intense pulsed light, photo-dynamic therapy, other energy based therapy); Immuno-therapy ( imiquimod, squaric acid dibutyl ester, etc.); Anti-metabolite therapy (5-fluorouracil); Retinoids; Liquid nitrogen, electrodesiccation, curettage; Over-the-counter wart therapies Subject has had any of the following within the specified period prior to enrollment (...) in Subjects With Common Warts. Study Start Date : December 21, 2015 Actual Primary Completion Date : September 16, 2016 Actual Study Completion Date : September 16, 2016 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: A-101 Solution 40 A-101 Solution 40% administered once per week Drug: A-101 Solution 40 Experimental: A-101 Solution 45 A-101 Solution 45% administered once per week Drug: A-101 Solution 45

2016 Clinical Trials

9. Warts and verrucae

see the section on . Cryotherapy with liquid nitrogen (usually carried out every 2 weeks for up to 3–4 months until the wart is gone, or for a maximum of 6 treatments). Note, cryotherapy is only suitable for older children who are likely to tolerate this treatment. For information on who should not receive cryotherapy, see the section on . Combination therapy with salicylic acid and cryotherapy (applying topical salicylic acid preparations between cryotherapy sessions once the scabbing from (...) %) — licensed for common and plantar warts. Salactol ® (salicylic acid 16.7% plus lactic acid 16.7%) — licensed for warts, plantar warts, and verrucas. Scholl Verruca Removal System 40% Medicated Plasters (40% salicylic acid ) — licensed for common warts on the feet and hands. Verrugon ® (salicylic acid 50%) — licensed for plantar warts only. [ ; ; ; ] Contraindications Who should not receive topical salicylic acid? Topical salicylic acid can cause irritant burning and should not be used

2014 NICE Clinical Knowledge Summaries

10. Warts, Nongenital (Follow-up)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) difference between the treatments in clearance of the plantar warts at 12 weeks and again at 6 months. [ ] The lesser cost of the salicylic acid topical treatment made it more cost-effective than the liquid nitrogen treatment. Several topical agents are available that can be applied by trained personnel in a physician's office. Cantharidin is an extract of the blister beetle that causes epidermal necrosis and blistering. Dibutyl squaric acid, also known as squaric acid dibutyl ester (SADBE

2014 eMedicine.com

11. Warts, Nongenital (Treatment)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) difference between the treatments in clearance of the plantar warts at 12 weeks and again at 6 months. [ ] The lesser cost of the salicylic acid topical treatment made it more cost-effective than the liquid nitrogen treatment. Several topical agents are available that can be applied by trained personnel in a physician's office. Cantharidin is an extract of the blister beetle that causes epidermal necrosis and blistering. Dibutyl squaric acid, also known as squaric acid dibutyl ester (SADBE

2014 eMedicine.com

12. Warts, Plantar (Treatment)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) difference between the treatments in clearance of the plantar warts at 12 weeks and again at 6 months. [ ] The lesser cost of the salicylic acid topical treatment made it more cost-effective than the liquid nitrogen treatment. Several topical agents are available that can be applied by trained personnel in a physician's office. Cantharidin is an extract of the blister beetle that causes epidermal necrosis and blistering. Dibutyl squaric acid, also known as squaric acid dibutyl ester (SADBE

2014 eMedicine Emergency Medicine

13. Warts, Plantar (Follow-up)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) difference between the treatments in clearance of the plantar warts at 12 weeks and again at 6 months. [ ] The lesser cost of the salicylic acid topical treatment made it more cost-effective than the liquid nitrogen treatment. Several topical agents are available that can be applied by trained personnel in a physician's office. Cantharidin is an extract of the blister beetle that causes epidermal necrosis and blistering. Dibutyl squaric acid, also known as squaric acid dibutyl ester (SADBE

2014 eMedicine Emergency Medicine

14. Warts

an immune response to HPV. Such irritants include salicylic acid (SCA), trichloroacetic acid, 5- fluorouracil , podophyllum resin , tretinoin, and cantharidin . Topical imiquimod 5% cream induces skin cells to locally produce antiviral cytokines. Topical cidofovir and contact immunotherapy (eg, squaric acid dibutyl ester and Candida allergen) have been used to treat warts. Warts can first be soaked in hot water at 113° F for 30 min ≥ 3 times/wk. After soaking, the skin is more permeable to topical drugs (...) (destructive) methods less desirable. Usual first-line treatment is daily tretinoin (retinoic acid 0.05% cream). If peeling is not sufficient for wart removal, another irritant (eg, 5% benzoyl peroxide ) or 5% SCA cream can be applied sequentially with tretinoin. Imiquimod 5% cream can be used alone or in combination with topical drugs or destructive measures. Topical 5- fluorouracil (1% or 5% cream) can also be used. Plantar warts Treatment of plantar warts is vigorous maceration with 40% SCA plaster kept

2013 Merck Manual (19th Edition)

15. Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)

acid dibutyl ester (SADBE) is a topical immunotherapeutic agent used in the treatment of verruca vulgaris and alopecia areata. During a recent FDA Compounding Advisory Committee Meeting, it was recommended that squaric acid dibutylester be included on the list of bulk drug substances allowed for use in compounding under section 503A of the Federal Food, Drug, and Cosmetic Act. And SADBE has now been so listed under section 503A. A study completed by Lee et al of 29 patients with recalcitrant warts (...) . Squaric acid dibutyl ester (SADBE) is a topical immunotherapeutic agent used in the treatment of verruca vulgaris and alopecia areata. A study completed by Lee et al of 29 patients with recalcitrant warts demonstrated complete clearance in 69% of patients with application every 2-4 weeks. Silverberg et al showed a complete clearance in 58% of patients (n=61) when SADBE was applied 3 times weekly. SADBE has been reported to cause eczema, lymphadenopathy, blistering, allergic contact dermatitis, skin

2018 Clinical Trials

16. Cantharidin and Occlusion in Verruca Epithelium

, using the VP-102 applicator. Drug: VP-102-cantharidin topical film forming solution VP-102 cantharidin topical film forming solution. Other Name: Subjects will receive treatment to their warts with VP-102 Device: VP-102 Applicator The applicator is used to apply the Study drug.The product is a combination therapy which includes the drug VP-102 and the applicator which is the device. Outcome Measures Go to Primary Outcome Measures : Cohort 1-Proportion of subjects exhibiting complete clearance of all (...) warts present at baseline in an anatomic location that the subject, parent/guardian or the physician is unwilling to treat or are located in an area that cannot be easily occluded with tape. Have had any previous treatment of common warts including, but not limited to, the use of cantharidin, antivirals, retinoids, salicylic acid, lactic acid, hydrogen peroxide, candida antigen, diphencyprone, dinitrochlorobenzene, sandalwood oil, thuja oil, squaric acid dibutyl ester, povidone iodine, nitric oxide

2018 Clinical Trials

17. The therapeutic use of topical contact sensitizers in benign dermatoses

were conducted using the MeSH terms 'alopecia areata', 'warts', 'topical immunotherapy' and 'contact sensitizers', and the textwords 'alopecia areata', 'warts', 'topical immunotherapy', 'contact sensitizers', 'diphenylcyclopropenone', 'dinitrochlorobenzene' and 'squaric acid dibutyl ester'. The Cochrane Database of Systematic Reviews, DARE and the NHS HTA (UK) Internet sites were also searched. Additional studies were identified by examining citations from reference lists, and letters were sent (...) ), dinitrochlorobenzene (DNCB) and squaric acid dibutyl ester (SADBE) as sole treatment. Studies using these substances as part of combination treatment were excluded, unless at least one treatment arm used a contact sensitizer alone. A variety of dosages and frequencies of treatment were used, which are too numerous to report in this abstract; details of the specific treatment regimens were tabulated;. Participants included in the review Patients with AA or viral warts. The types of AA were totalis or universalis

2001 DARE.

18. Guidelines for management of cutaneous warts

carcinomata. Numerous HPV types have been found in benign and malignant squamous lesions in immunocompromised patients and the precise role they play in initiation and progression of malignancy is yet to be elucidated. Table 2. Summary of treatments for warts Strength of evidence Treatment Suggested method of use A, I Cryotherapy 15±20 s single or double freeze of warts, every 3±4 weeks B, I Photodynamic therapy 3 treatments: 20% topical amino-laesulinic acid 1 irradiation B, II ii Salicylic acid (SA (...) of various ages. The above-mentioned therapies could all be considered alone, sequentially or in combination. Treatment in groups (1) or (2) could be performed by general practitioner but those in group (3) are more specialized.8 J.C.STERLING ET AL. q 2001 British Association of Dermatologists, British Journal of Dermatology , 144,4±11 4 Salicylic acid 50% ointment for use on plantar warts. Before application of wart paints, excess keratin should be pared away or filed with sandpaper or emery board

2001 British Association of Dermatologists

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