How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

19 results for

Squaric Acid Wart Therapy

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial. (PubMed)

Treatment of Multiple-Resistant and/or Recurrent Cutaneous Warts With Squaric Acid Dibutylester: A Randomized, Double-blind, Vehicle-controlled Clinical Trial. Contact immunotherapy with squaric acid dibutylester (SADBE) for cutaneous warts has been reported to be effective, although no controlled studies are available so far.The aim of this study was to evaluate the efficacy of SADBE on cutaneous warts by a randomized, double-blind, vehicle-controlled, clinical trial.Thirty-six patients were (...) randomly assigned to SADBE (18 cases) or vehicle (18 cases) group. At 8 weeks, subjects were clinically evaluated for number/size reduction rate and for Investigator Global Assessment. Those who showed improvement extended therapy up to 40 weeks, whereas those who showed unresponsiveness were either switched to SADBE application for up to 48 weeks (if in the vehicle group) or withdrawn from the study (if under SADBE).At 8 weeks, a significant reduction in wart number (P = 0.020) and size (P = 0.010

2018 Dermatitis : contact, atopic, occupational, drug

2. Squaric Acid Wart Therapy

Squaric Acid Wart Therapy Squaric Acid Wart Therapy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Squaric Acid Wart Therapy Squaric (...) Acid Wart Therapy Aka: Squaric Acid Wart Therapy From Related Chapters II. Mechanism Squaric Acid is a universal sensitizer III. Technique Consider applying high dose for sesnitization first Apply Squaric Acid 2% in acetone to unbroken skin Probably not needed Apply Squaric acid 0.2% weekly to wart Cover with bandage Remove after 24 hours and then wash off Reapply on a weekly basis for 6-8 weeks Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2018 FP Notebook

3. A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis

completed by Lee et al of 29 patients with recalcitrant warts demonstrated complete clearance in 69% of patients with application every 2-4 weeks. Silverberg et al showed a complete clearance in 58% of patients (n=61) when SADBE was applied 3 times weekly. A placebo-controlled clinical study completed at Massachusetts General Hospital showed that squaric acid prevented recurrence of herpetic lesions. The effect of SADBE of delaying new herpes labialis outbreaks was highly significant (p<0.01 (...) A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

4. Squaric Acid Wart Therapy

Squaric Acid Wart Therapy Squaric Acid Wart Therapy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Squaric Acid Wart Therapy Squaric (...) Acid Wart Therapy Aka: Squaric Acid Wart Therapy From Related Chapters II. Mechanism Squaric Acid is a universal sensitizer III. Technique Consider applying high dose for sesnitization first Apply Squaric Acid 2% in acetone to unbroken skin Probably not needed Apply Squaric acid 0.2% weekly to wart Cover with bandage Remove after 24 hours and then wash off Reapply on a weekly basis for 6-8 weeks Images: Related links to external sites (from Bing) These images are a random sampling from a Bing

2015 FP Notebook

5. Study of A-101 Topical Solution for the Treatment of Common Warts

used any of the following topical therapies within the specified period prior to Visit 2 on, or in the proximity to any of the common warts identified for treatment, that in the investigator's opinion interferes with the study medication treatment or the study assessments: LASER, light or other energy-based therapy (e.g., intense pulsed light [IPL], photodynamic therapy [PDT]); 180 days Immunotherapy (e.g., imiquimod, squaric acid dibutyl ester[SADBE], etc.) 12 weeks Liquid nitrogen (...) , electrodesiccation, curettage; 60 days Hydrogen peroxide; 90 days Antimetabolite therapy (e.g., 5-fluorouracil); 8 weeks Retinoids; 90 days Over-the-counter (OTC) wart therapies and cantharidin; 28 days Subject currently has or has had any of the following within the specified period prior to Visit 1 on or in the proximity to any of the common warts identified for treatment that, in the investigator's opinion, interferes with the study medication treatment or the study assessments: Cutaneous malignancy; 180 days

2018 Clinical Trials

6. A Study of A-101 Topical Solution for the Treatment of Common Warts

and intra-nasal steroids are permitted); 28 days Subject has used any of the following topical therapies within the specified period prior to Visit 2 on, or in the proximity to any of the common warts identified for treatment, that in the investigator's opinion interferes with the study medication treatment or the study assessments: LASER, light or other energy-based therapy (e.g., intense pulsed light [IPL], photodynamic therapy [PDT]); 180 days Immunotherapy (e.g., imiquimod, squaric acid dibutyl (...) ester[SADBE], etc.) 12 weeks Liquid nitrogen, electrodesiccation, curettage; 60 days Hydrogen peroxide; 90 days Antimetabolite therapy (e.g., 5-fluorouracil); 8 weeks Retinoids; 90 days Over-the-counter (OTC) wart therapies and cantharidin; 28 days Subject currently has or has had any of the following within the specified period prior to Visit 1 on or in the proximity to any of the common warts identified for treatment that, in the investigator's opinion, interferes with the study medication

2018 Clinical Trials

7. A Study of A-101 Solution in Subjects With Common Warts.

, might put the subject at undue risk by study participation or interfere with the study conduct or evaluations: - LASER (pulsed-dye laser), light (intense pulsed light, photo-dynamic therapy, other energy based therapy); Immuno-therapy ( imiquimod, squaric acid dibutyl ester, etc.); Anti-metabolite therapy (5-fluorouracil); Retinoids; Liquid nitrogen, electrodesiccation, curettage; Over-the-counter wart therapies Subject has had any of the following within the specified period prior to enrollment (...) on the trunk or extremities Subject is immune compromised (due to chemotherapy, systemic steroids, genetic immunodeficiency, transplant status, etc.) Subject has a history of Human Immunodeficiency Virus (HIV) infection Subject has had any Human Papilloma Virus (HPV) vaccine within 1 year prior to enrollment Subject has used any of the following intralesional therapies within the specified period prior to enrollment to the Target Wart: Immunotherapy (Candida antigen, mumps antigen, Trichophyton antigen

2016 Clinical Trials

8. Childhood skin and soft tissue infections: new discoveries and guidelines regarding the management of bacterial soft tissue infections, molluscum contagiosum, and warts. (PubMed)

virus strains have been detected in cutaneous warts in children.The high-risk human papilloma virus vaccine may play a role in treating pediatric cutaneous warts in the future, and topical squaric acid dibutylester may effectively treat recalcitrant warts. Finally, both molluscum contagiosum and warts have a high rate of resolution after an extended period of time without any intervention. (...) with systemic antibiotics covering Staphylococcus aureus species, especially community acquired methicillin-resistant S. aureus. For the treatment of molluscum contagiosum, topical cantharidin has a high satisfaction rate among patients and providers. Potassium hydroxide solution is a potentially effective and cheap form of molluscum contagiosum treatment. Imiquimod, however, has an unfavorable efficacy and safety profile as a therapy for molluscum contagiosum. Regarding warts, high-risk human papilloma

2016 Current Opinion in Pediatrics

9. Warts and verrucae

acid preparations that may be prescribed on an FP10 see the section on . Cryotherapy with liquid nitrogen (usually carried out every 2 weeks for up to 3–4 months until the wart is gone, or for a maximum of 6 treatments). Note, cryotherapy is only suitable for older children who are likely to tolerate this treatment. For information on who should not receive cryotherapy, see the section on . Combination therapy with salicylic acid and cryotherapy (applying topical salicylic acid preparations between (...) if a superficial nerve is frozen. Normal feeling usually returns within a few months. Tendon or nerve damage with aggressive therapy. Onychodystrophy (malformation of the nails) following treatment of periungual warts. Supporting evidence Supporting evidence Evidence on topical salicylic acid and cryotherapy only are reviewed here as these are the only treatments recommended in primary care. Evidence on topical salicylic acid and cryotherapy Evidence on topical salicylic acid and cryotherapy There is weak

2014 NICE Clinical Knowledge Summaries

10. Warts, Nongenital (Treatment)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) difference between the treatments in clearance of the plantar warts at 12 weeks and again at 6 months. [ ] The lesser cost of the salicylic acid topical treatment made it more cost-effective than the liquid nitrogen treatment. Several topical agents are available that can be applied by trained personnel in a physician's office. Cantharidin is an extract of the blister beetle that causes epidermal necrosis and blistering. Dibutyl squaric acid, also known as squaric acid dibutyl ester (SADBE

2014 eMedicine.com

11. Warts, Nongenital (Follow-up)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) difference between the treatments in clearance of the plantar warts at 12 weeks and again at 6 months. [ ] The lesser cost of the salicylic acid topical treatment made it more cost-effective than the liquid nitrogen treatment. Several topical agents are available that can be applied by trained personnel in a physician's office. Cantharidin is an extract of the blister beetle that causes epidermal necrosis and blistering. Dibutyl squaric acid, also known as squaric acid dibutyl ester (SADBE

2014 eMedicine.com

12. Warts, Plantar (Follow-up)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) difference between the treatments in clearance of the plantar warts at 12 weeks and again at 6 months. [ ] The lesser cost of the salicylic acid topical treatment made it more cost-effective than the liquid nitrogen treatment. Several topical agents are available that can be applied by trained personnel in a physician's office. Cantharidin is an extract of the blister beetle that causes epidermal necrosis and blistering. Dibutyl squaric acid, also known as squaric acid dibutyl ester (SADBE

2014 eMedicine Emergency Medicine

13. Warts, Plantar (Treatment)

, or symptomatic warts or warts that have been present for more than 2 years. Topical agents Salicylic acid is a first-line therapy used to treat warts. [ ] It is available without a prescription and can be applied by the patient at home. Cure rates from 70-80% are reported. A nonblinded, randomized controlled trial compared treatment of plantar warts with 50% salicylic acid topical (Verrugon) applied daily with cryotherapy with liquid nitrogen (up to 4 treatments 2-3 wk apart). The study found no significant (...) difference between the treatments in clearance of the plantar warts at 12 weeks and again at 6 months. [ ] The lesser cost of the salicylic acid topical treatment made it more cost-effective than the liquid nitrogen treatment. Several topical agents are available that can be applied by trained personnel in a physician's office. Cantharidin is an extract of the blister beetle that causes epidermal necrosis and blistering. Dibutyl squaric acid, also known as squaric acid dibutyl ester (SADBE

2014 eMedicine Emergency Medicine

14. Topical treatments for cutaneous warts. (PubMed)

in this update). There was a wide range of different treatments and a variety of trial designs. Many of the studies were judged to be at high risk of bias in one or more areas of trial design.Trials of salicylic acid (SA) versus placebo showed that the former significantly increased the chance of clearance of warts at all sites (RR (risk ratio) 1.56, 95% CI (confidence interval) 1.20 to 2.03). Subgroup analysis for different sites, hands (RR 2.67, 95% CI 1.43 to 5.01) and feet (RR 1.29, 95% CI 1.07 to 1.55 (...) (RR 1.43, 95% CI 0.51 to 4.05).We could not combine data from trials of the following treatments: intralesional 5-fluorouracil, topical zinc, silver nitrate (which demonstrated possible beneficial effects), topical 5-fluorouracil, pulsed dye laser, photodynamic therapy, 80% phenol, 5% imiquimod cream, intralesional antigen, and topical alpha-lactalbumin-oleic acid (which showed no advantage over placebo).We did not identify any RCTs that evaluated surgery (curettage, excision), formaldehyde

2012 Cochrane database of systematic reviews (Online)

15. Warts

an immune response to HPV. Such irritants include salicylic acid (SCA), trichloroacetic acid, 5- fluorouracil , podophyllum resin , tretinoin, and cantharidin . Topical imiquimod 5% cream induces skin cells to locally produce antiviral cytokines. Topical cidofovir and contact immunotherapy (eg, squaric acid dibutyl ester and Candida allergen) have been used to treat warts. Warts can first be soaked in hot water at 113° F for 30 min ≥ 3 times/wk. After soaking, the skin is more permeable to topical drugs (...) in place for several days. The wart is then debrided while damp and soft, followed by destruction by freezing or using caustics (eg, 30 to 70% trichloroacetic acid). Other destructive treatments (eg, CO 2 laser, pulsed-dye laser, various acids) are often effective. Periungual warts Combination therapy with liquid nitrogen and imiquimod 5% cream, tretinoin, or SCA is effective and usually safer than liquid nitrogen alone or cautery. Using liquid nitrogen and cautery to treat periungual and lateral

2013 Merck Manual (19th Edition)

16. Cantharidin and Occlusion in Verruca Epithelium

warts present at baseline in an anatomic location that the subject, parent/guardian or the physician is unwilling to treat or are located in an area that cannot be easily occluded with tape. Have had any previous treatment of common warts including, but not limited to, the use of cantharidin, antivirals, retinoids, salicylic acid, lactic acid, hydrogen peroxide, candida antigen, diphencyprone, dinitrochlorobenzene, sandalwood oil, thuja oil, squaric acid dibutyl ester, povidone iodine, nitric oxide (...) , using the VP-102 applicator. Drug: VP-102-cantharidin topical film forming solution VP-102 cantharidin topical film forming solution. Other Name: Subjects will receive treatment to their warts with VP-102 Device: VP-102 Applicator The applicator is used to apply the Study drug.The product is a combination therapy which includes the drug VP-102 and the applicator which is the device. Outcome Measures Go to Primary Outcome Measures : Cohort 1-Proportion of subjects exhibiting complete clearance of all

2018 Clinical Trials

17. Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)

. Squaric acid dibutyl ester (SADBE) is a topical immunotherapeutic agent used in the treatment of verruca vulgaris and alopecia areata. A study completed by Lee et al of 29 patients with recalcitrant warts demonstrated complete clearance in 69% of patients with application every 2-4 weeks. Silverberg et al showed a complete clearance in 58% of patients (n=61) when SADBE was applied 3 times weekly. SADBE has been reported to cause eczema, lymphadenopathy, blistering, allergic contact dermatitis, skin (...) acid dibutyl ester (SADBE) is a topical immunotherapeutic agent used in the treatment of verruca vulgaris and alopecia areata. During a recent FDA Compounding Advisory Committee Meeting, it was recommended that squaric acid dibutylester be included on the list of bulk drug substances allowed for use in compounding under section 503A of the Federal Food, Drug, and Cosmetic Act. And SADBE has now been so listed under section 503A. A study completed by Lee et al of 29 patients with recalcitrant warts

2018 Clinical Trials

18. The therapeutic use of topical contact sensitizers in benign dermatoses

were conducted using the MeSH terms 'alopecia areata', 'warts', 'topical immunotherapy' and 'contact sensitizers', and the textwords 'alopecia areata', 'warts', 'topical immunotherapy', 'contact sensitizers', 'diphenylcyclopropenone', 'dinitrochlorobenzene' and 'squaric acid dibutyl ester'. The Cochrane Database of Systematic Reviews, DARE and the NHS HTA (UK) Internet sites were also searched. Additional studies were identified by examining citations from reference lists, and letters were sent (...) ), dinitrochlorobenzene (DNCB) and squaric acid dibutyl ester (SADBE) as sole treatment. Studies using these substances as part of combination treatment were excluded, unless at least one treatment arm used a contact sensitizer alone. A variety of dosages and frequencies of treatment were used, which are too numerous to report in this abstract; details of the specific treatment regimens were tabulated;. Participants included in the review Patients with AA or viral warts. The types of AA were totalis or universalis

2001 DARE.

19. Guidelines for management of cutaneous warts

carcinomata. Numerous HPV types have been found in benign and malignant squamous lesions in immunocompromised patients and the precise role they play in initiation and progression of malignancy is yet to be elucidated. Table 2. Summary of treatments for warts Strength of evidence Treatment Suggested method of use A, I Cryotherapy 15±20 s single or double freeze of warts, every 3±4 weeks B, I Photodynamic therapy 3 treatments: 20% topical amino-laesulinic acid 1 irradiation B, II ii Salicylic acid (SA (...) of various ages. The above-mentioned therapies could all be considered alone, sequentially or in combination. Treatment in groups (1) or (2) could be performed by general practitioner but those in group (3) are more specialized.8 J.C.STERLING ET AL. q 2001 British Association of Dermatologists, British Journal of Dermatology , 144,4±11 4 Salicylic acid 50% ointment for use on plantar warts. Before application of wart paints, excess keratin should be pared away or filed with sandpaper or emery board

2001 British Association of Dermatologists

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>