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Squamous Cell Carcinoma of the Skin

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161. Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence Full Text available with Trip Pro

Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence Esophageal cancer occurs as either squamous cell carcinoma (ESCC) or adenocarcinoma. ESCCs comprise almost 90% of cases worldwide, and recur with a less than 15% five-year survival rate despite available treatments. The identification of new ESCC drivers and therapeutic targets is critical for improving outcomes. Here we report that expression of the human DEK oncogene is strongly upregulated (...) human skin, thus linking high DEK expression in keratinocytes to oncogenic phenotypes. However, the role of DEK over-expression in ESCC development remains unknown in human cells or genetic mouse models. To define the consequences of Dek overexpression in vivo, we generated and validated a tetracycline responsive Dek transgenic mouse model referred to as Bi-L-Dek. Dek overexpression was induced in the basal keratinocytes of stratified squamous epithelium by crossing Bi-L-Dek mice to keratin 5

2018 PLoS genetics

162. Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B Full Text available with Trip Pro

Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs. In contrast with Notch, we show that the transcription factor CSL (also known as RBP-Jκ), a key effector of canonical Notch signaling endowed with intrinsic transcription-repressive functions, plays a tumor-promoting function in SCC development. Expression of this gene (...) decreased in upper epidermal layers and human keratinocytes (HKCs) undergoing differentiation, while it increased in premalignant and malignant SCC lesions from skin, head/neck, and lung. Increased CSL levels enhanced the proliferative potential of HKCs and SCC cells, while silencing of CSL induced growth arrest and apoptosis. In vivo, SCC cells with increased CSL levels gave rise to rapidly expanding tumors, while cells with silenced CSL formed smaller and more differentiated tumors with enhanced

2018 The Journal of clinical investigation

163. A giant cutaneous squamous cell carcinoma of the neck Full Text available with Trip Pro

101517926 IM Aged Carcinoma, Squamous Cell diagnosis pathology Fatal Outcome Head and Neck Neoplasms diagnosis pathology Humans Male Skin Neoplasms diagnosis pathology Squamous Cell Carcinoma of Head and Neck Skin chemotherapy squamous cell carcinoma 2018 01 26 2018 05 01 2018 9 1 6 0 2018 9 1 6 0 2018 10 3 6 0 epublish 30167050 10.11604/pamj.2018.30.22.14984 PAMJ-30-22 PMC6110546 (...) A giant cutaneous squamous cell carcinoma of the neck 30167050 2018 10 01 2019 02 21 1937-8688 30 2018 The Pan African medical journal Pan Afr Med J A giant cutaneous squamous cell carcinoma of the neck. 22 10.11604/pamj.2018.30.22.14984 Bazine Aziz A Medical Oncology Department, Military Hospital Moulay Ismaïl, Meknès, Morocco. Fetohi Mohamed M Medical Oncology Department, Military Hospital Moulay Ismaïl, Meknès, Morocco. eng Case Reports Journal Article 2018 05 15 Uganda Pan Afr Med J

2018 The Pan African medical journal

164. Squamous Cell Carcinoma Arising within Verruca Vulgaris on the Nipple Full Text available with Trip Pro

Squamous Cell Carcinoma Arising within Verruca Vulgaris on the Nipple Cutaneous squamous cell carcinoma (SCC) is a common form of skin cancer and often appears as a hard, scaly lump that occasionally ulcerates. It is usually associated with cumulative exposure to ultraviolet light, although prior scarring, chronic wounds, exposure to radiation, HPV infection, and immunosuppression are also associated risk factors. Primary SCC of the nipple is very rare and only a few cases have been reported

2018 Case reports in dermatological medicine

165. Advanced squamous-cell carcinoma of the lower lip Full Text available with Trip Pro

Beneficência, Ribeirão Preto, São Paulo, Brazil. eng Case Reports Journal Article 2018 06 20 Uganda Pan Afr Med J 101517926 IM Adult Carcinoma, Squamous Cell diagnosis pathology therapy Fatal Outcome Humans Lip Neoplasms diagnosis pathology therapy Male Prognosis Squamous Cell carcinoma neglected diseases skin neoplasms 2017 11 09 2018 05 19 2018 10 31 6 0 2018 10 31 6 0 2018 12 13 6 0 epublish 30374394 10.11604/pamj.2018.30.148.14352 PAMJ-30-148 PMC6201625 (...) Advanced squamous-cell carcinoma of the lower lip 30374394 2018 12 12 2018 12 12 1937-8688 30 2018 The Pan African medical journal Pan Afr Med J Advanced squamous-cell carcinoma of the lower lip. 148 10.11604/pamj.2018.30.148.14352 Filho Fred Bernardes FB Dermatology Division, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. Grupioni Priscila Vinhal PV Department of Oncology, Hospital Imaculada Conceição da Sociedade Portuguesa de

2018 The Pan African medical journal

166. Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas Full Text available with Trip Pro

Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas Cutaneous squamous cell carcinoma (SCC) is among the most common cancers in humans, and many patients with SCC will develop multiple tumors within their lifetime. The field cancerization concept, originally proposed over 60 years ago, hypothesized that multiple primary cancers may arise simultaneously and coexist with subclinical precursor lesions within a defined field. Genetic sequencing (...) of SCC and precursor lesions has identified what may be the earliest clonal proliferations in SCC development and confirmed that field cancerization in the skin is mediated by ultraviolet radiation. For patients with multiple SCCs and severe actinic damage, treatment of precursor lesions within a cancerized field can decrease the risk of subsequent cancer development. Sunblock is an effective intervention for field cancerization, even in patients with established disease. There is now direct evidence

2018 F1000Research

167. Squamous Cell Carcinomas in Two Cases of Nail Lichen Planus: Is There a Real Association? Full Text available with Trip Pro

Squamous Cell Carcinomas in Two Cases of Nail Lichen Planus: Is There a Real Association? Lichen planus (LP) is a chronic inflammatory disease that affects the skin and oral mucosa. Although its etiology is unknown, its potential for cancerization has been confirmed. We herein report the cases of a brother and sister, both with a 15-year history of nail lichen planus of the fingers and toes, who developed squamous cell carcinomas of the nail bed and matrix. This article shows the potential

2018 Dermatology and therapy

168. Effective treatment of a platinum-resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition Full Text available with Trip Pro

Effective treatment of a platinum-resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non-melanoma skin cancer. Platinum-based regimens have been an integral part of palliative care for patients with locally advanced or metastatic disease. There is no evidence of efficacy for later lines of chemotherapy and no targeted therapy has been introduced as 'standard of care'. Here we report on the case (...) of an elderly cSCC patient, resistant to conventional therapy, however successfully treated with anti-epidermal growth factor receptor (EGFR) agent (Cetuximab) in addition to a daily dose of Curcumin phospholipid. The patient responded to treatment and experienced no recurrence for 11 months with only minor skin-related toxicity. To our knowledge, this is the first report of clinical evidence that an anti EGFR targeted therapy with a daily oral dose of Curcumin phospholipid is well tolerated and results

2018 Molecular and clinical oncology

169. A Review of the Literature of Surgical and Nonsurgical Treatments of Invasive Squamous Cells Carcinoma Full Text available with Trip Pro

A Review of the Literature of Surgical and Nonsurgical Treatments of Invasive Squamous Cells Carcinoma Cutaneous squamous cell carcinoma (cSCC) is an increasing public health problem. It is a primary malignant skin tumor with Malpighian differentiation and together with basal cell carcinoma is classified among nonmelanoma skin cancers (NMSCs). cSCC usually occurs on photoexposed areas, such as the head, the neck, and the extremities, and its incidence increases with age. Invasive forms (...) of this skin tumor tend to be more aggressive showing a higher metastatic potential, usually regarding regional lymph nodes. Treatment options for invasive cSCCs include both surgical and nonsurgical options. The therapeutic choice depends on several factors, such as anatomic location, risk factors for tumor recurrence, age, and health status of the patient. This review aims to provide an overview of the current evidence on therapeutic surgical and nonsurgical management of invasive cSCC.

2018 BioMed research international

170. Rapid onset of multiple concurrent squamous cell carcinomas associated with the use of an arsenic-containing traditional medicine for chronic plaque psoriasis Full Text available with Trip Pro

Rapid onset of multiple concurrent squamous cell carcinomas associated with the use of an arsenic-containing traditional medicine for chronic plaque psoriasis We report a case of a 46-year-old Vietnamese man who developed widespread, numerous and concurrent cutaneous squamous cell carcinomas (SCCs) in non-sun exposed skin areas after taking a traditional medicine (TM) formulation for chronic plaque psoriasis. The SCC lesions began to develop within 12-15 months after beginning the arsenic

2018 BMJ case reports

171. The volatilome – investigation of volatile organic metabolites (VOM) as potential tumor markers in patients with head and neck squamous cell carcinoma (HNSCC) Full Text available with Trip Pro

factors, nutritional and disease status. As a result of pathological processes the individual body odor can be influenced by newly produced or altered compositions of the VOM. Until now, human VOM have been detected in various body media, such as on the skin, in the exhaled air as well as in body fluids such as saliva, mother's milk, sweat, blood and urine.In this retrospective case-control study urinary VOM of 53 therapy-naive patients with head and neck squamous cell carcinoma (HNSCC) and 82 healthy (...) The volatilome – investigation of volatile organic metabolites (VOM) as potential tumor markers in patients with head and neck squamous cell carcinoma (HNSCC) Different organisms such as bacteria, molds and humans produce and release a relative unknown class of metabolites which are responsible for the individual olfactory pattern. These volatile organic metabolites (VOM) represent a kind of biosignature that reflects the sum of all multifactorial influences, including genetics, environmental

2018 Journal of Otolaryngology - Head & Neck Surgery

172. A Case Report of Scrotal Squamous Cell Carcinoma Secondary to Chronic Urinary Irritation Full Text available with Trip Pro

A Case Report of Scrotal Squamous Cell Carcinoma Secondary to Chronic Urinary Irritation Most scrotum cancers are associated with occupational exposure. We report a case of a squamous cell carcinoma of the scrotum in a patient with a proximal meatus, secondary to mistreated urethral stricture. Based on our observations in this case, we think that chronic urinary inflammation of the scrotal skin may also be considered as a risk factor of scrotal cancer.

2018 Cureus

173. Squamous cell carcinoma arising in a chronic perineal wound in a patient with long-standing cutaneous Crohn's disease Full Text available with Trip Pro

hidradenitis suppurativa inflammatory bowel disease medical dermatology skin manifestations of internal diseases squamous cell carcinoma 2018 4 26 6 0 2018 4 26 6 0 2018 4 26 6 1 epublish 29693066 10.1016/j.jdcr.2017.11.007 S2352-5126(17)30282-5 PMC5911976 Am J Gastroenterol. 1991 Dec;86(12):1829-32 1962632 Surg Oncol. 2013 Dec;22(4):230-7 24050823 Cutis. 2013 Jul;92(1):35-9 23961524 J Crohns Colitis. 2013 Jul;7(6):e232-5 23069004 J Am Col Certif Wound Spec. 2011 Sep;3(3):60-4 24525526 J Crohns Colitis (...) Squamous cell carcinoma arising in a chronic perineal wound in a patient with long-standing cutaneous Crohn's disease 29693066 2019 02 26 2352-5126 4 4 2018 May JAAD case reports JAAD Case Rep Squamous cell carcinoma arising in a chronic perineal wound in a patient with long-standing cutaneous Crohn's disease. 346-348 10.1016/j.jdcr.2017.11.007 Powell Helen B HB University of North Carolina School of Medicine, Chapel Hill, North Carolina. Googe Paul B PB Department of Dermatology, University

2018 JAAD Case Reports

174. Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip Full Text available with Trip Pro

Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip An early diagnosis is of overwhelming importance for the management and prognosis of mucocutaneous cancer. Actinic cheilitis (AC), defined by the clonal expansion of genomically unstable keratinocytes, is the most common potentially malignant lesion affecting the lips. Squamous cell carcinoma (SCC) is the most frequent oral malignancy, and there is strong evidence that the majority of the SCCs of the lip originate (...) from AC. There is considerable difficulty in discerning between dysplasia and invasive carcinomas solely on a clinical basis. Although dermoscopy has become an essential tool for skin tumor evaluation, reflectance confocal microscopy (RCM) is a non-invasive imaging technology that has proved itself extremely useful in the diagnosis and monitoring of several skin diseases, including AC and SCC. The present study aimed to re-emphasize the usefulness of RCM in the early detection of malignant

2018 Molecular and clinical oncology

175. WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway Full Text available with Trip Pro

WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway Objectives WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) has been implicated in tumor progression. We aimed to investigate the role of WWP1 in cutaneous squamous cell carcinoma (CSCC). Methods WWP1 gene and protein levels were detected using semi-quantitative reverse transcription (...) -polymerase chain reaction, immunohistochemistry and western blotting. The effects of WWP1 on cell cycle, apoptosis, cell migration and invasion were examined by flow cytometry, wound healing and Transwell assays, respectively. The antitumor efficacy of WWP1 small interfering RNA was determined in CSCC tumor xenografts in mice. Results WWP1 expression was significantly higher in CSCC tissues and cells than in normal skin and cells, respectively. WWP1 expression was significantly associated

2018 The Journal of international medical research

176. Case Report: Squamous Cell Carcinoma Referred for Mohs Surgery Found to be Cutaneous Leishmaniasis. Full Text available with Trip Pro

Case Report: Squamous Cell Carcinoma Referred for Mohs Surgery Found to be Cutaneous Leishmaniasis. Chronic skin lesions constitute a clinical diagnostic challenge. We report the case of a patient whose facial lesion was histopathologically compatible with squamous cell carcinoma and hence programmed for Mohs surgery. However, review of the clinical and epidemiological history led to laboratory diagnosis of cutaneous leishmaniasis, treatment with miltefosine, and complete resolution

2018 American Journal of Tropical Medicine & Hygiene

177. Use of dermatoscopy in the detection of squamous cell carcinoma in a patient with recessive dystrophic epidermolysis bullosa Full Text available with Trip Pro

Article 2018 07 31 United States Dermatol Pract Concept 101585990 2160-9381 dermoscopy nonmelanoma skin cancer severe generalized recessive dystrophic bullous epidermolysis squamous cell carcinoma Competing interests: The authors have no conflicts of interest to disclose. 2017 12 05 2018 03 06 2018 8 18 6 0 2018 8 18 6 0 2018 8 18 6 1 epublish 30116669 10.5826/dpc.0803a15 dp0803a15 PMC6092081 Eur J Dermatol. 2015 Apr;25 Suppl 1:30-2 26083672 Br J Dermatol. 2016 Jan;174(1):56-67 26302137 Clin Exp (...) Use of dermatoscopy in the detection of squamous cell carcinoma in a patient with recessive dystrophic epidermolysis bullosa 30116669 2018 11 14 2160-9381 8 3 2018 Jul Dermatology practical & conceptual Dermatol Pract Concept Use of dermatoscopy in the detection of squamous cell carcinoma in a patient with recessive dystrophic epidermolysis bullosa. 227-230 10.5826/dpc.0803a15 Toncic Ruzica Jurakic RJ Department of Dermatology and Venereology, University Hospital Centre Zagreb, University

2018 Dermatology practical & conceptual

178. Perineal squamous cell carcinoma arising from an epidermal cyst: a case report Full Text available with Trip Pro

Perineal squamous cell carcinoma arising from an epidermal cyst: a case report Epidermal cysts and squamous cell carcinomas (SCCs) are common skin lesions. However, a malignant change in an epidermal cyst is very rare. The incidence of a malignant change from an epidermal cyst to cutaneous SCC is 0.011-0.045%. In particular, malignant transformation of an epidermal cyst in the perineum is extremely rare. To date, three cases have been reported in the English literature.We report a case of 51

2018 World journal of surgical oncology

179. Would Marjolin see it coming? Two unusual cases of squamous cell carcinoma Full Text available with Trip Pro

Would Marjolin see it coming? Two unusual cases of squamous cell carcinoma Cutaneous squamous cell carcinoma (SCC) is a common skin cancer, second in incidence only to basal cell carcinoma (BCC). The incidence of SCC increases significantly with age; thus, it is rarely diagnosed in young patients. In this paper, we present two cases of young patients who presented clinically with purulent lesions that were later diagnosed as large primary SCCs.A review of the medical records of two patients who (...) sending tissue samples to pathology. Biopsies of the lesions were performed to obtain a tissue diagnosis due to recurrence approximately one year after the initial treatment. Histological evaluation revealed well differentiated squamous cell carcinomas. Surgical intervention with wide excision with adjuvant chemotherapy was recommended based on biopsy and CT scan results.Aggressive behavior of SCC in young patients is uncommon. The patients in this report were diagnosed only one year after the first

2018 International journal of surgery case reports

180. Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma Full Text available with Trip Pro

Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer with genetic susceptibility loci identified in recent genome-wide association studies (GWAS). Transcriptome-wide association studies (TWAS) using imputed gene expression levels can identify additional gene-level associations. Here we impute gene expression levels in 6891 cSCC cases and 54,566 controls

2018 Nature communications

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