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Squamous Cell Carcinoma of the Skin

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13941. Geographic variation and risk of skin cancer in US women. Differences between melanoma, squamous cell carcinoma, and basal cell carcinoma. Full Text available with Trip Pro

Geographic variation and risk of skin cancer in US women. Differences between melanoma, squamous cell carcinoma, and basal cell carcinoma. Occurrences of melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) have been associated with varying geography. Our goal was to evaluate differences in risk of these skin cancers according to residence at varying UV indices at 3 time points.Prospective 1984-2002 study of 84 836 female nurses who lived in different UV index regions

2008 Archives of Internal Medicine

13942. Predictors of skin-related quality of life after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma. Full Text available with Trip Pro

Predictors of skin-related quality of life after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma. To identify predictors of skin-related quality of life (QOL) after treatment of nonmelanoma skin cancer (NMSC).Prospective cohort study of consecutive patients with NMSC diagnosed in 1999 and 2000.University-affiliated private practice and a Veterans Affairs clinic.A total of 633 patients who responded to a questionnaire before treatment.Skin-related QOL, measured (...) with the 16-item version of Skindex-16, a validated measure. Skindex-16 scores vary from 0 (best QOL) to 100 (worst QOL) and are reported in 3 domains: symptoms, emotional effects, and effects on functioning.Controlling for treatment group, the strongest independent predictor of skin-related QOL after treatment of NMSC was pretreatment skin-related QOL. Other patient characteristics that predicted better QOL included less comorbidity and better mental health status. No tumor or care characteristic

2007 Archives of Dermatology

13943. Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin. (Abstract)

Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin. This study evaluates several tumor-related markers to examine the expression pattern of markers according to the invasiveness and histopathologic differentiation of squamous cell carcinoma and basal cell carcinoma.Ninety-four cases of squamous cell carcinoma and 108 cases of basal cell carcinoma using tissue array in order (...) of squamous cell carcinoma was correlated with Ki-67 index. The loss of palisading arrangement in basal cell carcinoma was correlated with the MMP-1 expression of stromal cells (P = 0.045).CD44v6 and MMP-1, expressed in tumor cells and stromal cells respectively, are significant markers associated with the invasiveness of tumors in squamous cell carcinoma and basal cell carcinoma of the skin and that it will be helpful to evaluate the invasiveness by measuring the expression of these markers.

2008 Journal of Surgical Oncology

13944. Relationship of treatment delay with surgical defect size from keratinocyte carcinoma (basal cell carcinoma and squamous cell carcinoma of the skin). Full Text available with Trip Pro

Relationship of treatment delay with surgical defect size from keratinocyte carcinoma (basal cell carcinoma and squamous cell carcinoma of the skin). Larger keratinocyte carcinoma (KC) lesions are associated with higher morbidity. This study examined the association of potentially modifiable characteristics, including treatment delay, with KC defect size after Mohs micrographic surgery (MMS). A stratified random sample of patients treated for KC with MMS were selected for telephone interview

2005 Journal of Investigative Dermatology

13945. Squamous cell carcinoma of skin with a rhabdoid phenotype: a case report Full Text available with Trip Pro

Squamous cell carcinoma of skin with a rhabdoid phenotype: a case report A 67 year old man presented with a polypoid lesion on the temple that had all the light microscopic, immunohistochemical, and ultrastructural features of a rhabdoid tumour. There was an area of intraepidermal carcinoma and invasive squamous carcinoma at the base of the polyp. The tumour progressed aggressively and the patient died five months after primary excision. Cutaneous tumours with a rhabdoid morphology have been (...) described previously and tend to have a very poor prognosis. No previously published report describes a clear squamous histogenesis.

2000 Journal of Clinical Pathology

13946. Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas. Full Text available with Trip Pro

Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas. VLA integrins in human skin were examined by indirect immunofluorescence utilizing antibodies recognizing the beta 1, alpha 2, alpha 3, or alpha 5 subunits. Staining of fetal, newborn, or adult skin with antibodies to beta 1, alpha 2, or alpha 3 subunits gave essentially similar staining patterns: intense staining was associated with the basal layer (...) of previously unrecognized ligands in the intercellular spaces of keratinocytes. Examination of nine nodular basal cell carcinomas revealed a prominent staining reaction with anti-beta 1 and anti-alpha 3 antibodies at the periphery of the tumor islands. In contrast, staining of five squamous cell carcinomas revealed either the absence of integrins or altered and variable expression. Thus, matrix components and their receptors may participate in modulation of growth, development, and organization of human

1989 Journal of Clinical Investigation

13947. Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation. Full Text available with Trip Pro

Interleukin-10 promoter polymorphisms and susceptibility to skin squamous cell carcinoma after renal transplantation. After organ transplantation, susceptibility to cancer is multifactorial, especially for skin carcinomas. Risk factors may include genetic susceptibilities, such as the control of cytokine production. Interleukin-10 is a cytokine that is implicated in tumorigenesis, and it has been shown that polymorphisms in its gene promoter correlate with differential amounts of production (...) . The aim of this study was to investigate a possible association between interleukin-10 gene promoter polymorphisms and the occurrence of skin carcinomas after renal transplantation. Seventy kidney transplant recipients who developed a squamous cell carcinoma or a basal cell carcinoma were examined for polymorphisms in the interleukin-10 gene promoter using polymerase chain reaction based methods. Single base pair mutations were studied at positions -1082, -819, and -592. These patients were compared

2003 Journal of Investigative Dermatology

13948. ZD1839 (Iressa) for Recurrent or Metastatic Squamous Cell Carcinoma of the Skin

ZD1839 (Iressa) for Recurrent or Metastatic Squamous Cell Carcinoma of the Skin ZD1839 (Iressa) for Recurrent or Metastatic Squamous Cell Carcinoma of the Skin - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . ZD1839 (Iressa) for Recurrent or Metastatic Squamous Cell Carcinoma of the Skin The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00054691 Recruitment Status : Completed First Posted : February 7, 2003 Results First Posted : February 12, 2015 Last Update Posted : March 13, 2015 Sponsor: M.D. Anderson

2003 Clinical Trials

13949. Disseminated squamous cell carcinoma of the skin. (Abstract)

Disseminated squamous cell carcinoma of the skin. Squamous cell carcinoma (SCC) accounts for a large proportion of nonmelanoma skin cancers. It may appear mainly on the skin and the mucous membranes; however, it may also appear on any part of the body. The tumor originates from atypical keratinocytes. This tumor, which can be locally destructive, has a metastasis rate of 5% to 10%.To present a patient with disseminated primary SCC of the skin.In this report, we present a unique case (...) original case of disseminated SCC of the skin is presented.

2003 Dermatologic Surgery

13950. Mutational analysis of CDKN2A genes in patients with squamous cell carcinoma of the skin. (Abstract)

Mutational analysis of CDKN2A genes in patients with squamous cell carcinoma of the skin. Nonmelanoma skin cancers [squamous cell carcinomas (SCC) and basal cell carcinomas (BCC)] are the most common neoplasias of the Caucasian population.The purpose of our study was to determine the involvement of CDKN2A genes in the development of sporadic nonmelanoma skin cancer in Greek patients.Allelic imbalance analysis was performed in 22 SCC and five Bowen's disease specimens. Mutational analysis (...) frequency of 3.72%. No mutation was found in any of the five Bowen's disease specimens, or in exon 1beta of CDKN2A, also the gene for p14ARF.Mutations and the high incidence of 9p LOH detected in our SCC samples imply that inactivation of CDKN2A genes, via allelic loss and/or mutation (probably UV-induced) may play a significant role in nonmelanoma skin cancer development, particularly in the more aggressive SCC type.

2003 British Journal of Dermatology

13951. Time trends and familial risks in squamous cell carcinoma of the skin. Full Text available with Trip Pro

Time trends and familial risks in squamous cell carcinoma of the skin. To study time trends and familial clustering of invasive and in situ squamous cell skin cancers (SCC), with particular reference to sun-exposed and covered sites of the body.Epidemiologic follow-up study of the whole population.The Swedish Family-Cancer Database from the year 2000, to cover individuals born after 1931 with their biological parents, totaling 10.2 million persons.Cancer data were obtained from the Swedish

2003 Archives of Dermatology

13952. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Full Text available with Trip Pro

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Sunlight is a carcinogen to which everyone is exposed. Its UV component is the major epidemiologic risk factor for squamous cell carcinoma of the skin. Of the multiple steps in tumor progression, those that are sunlight-related would be revealed if they contained mutations specific to UV. In a series of New England and Swedish patients, we find that 14/24 (58%) of invasive squamous cell carcinomas (...) of the skin contain mutations in the p53 tumor suppressor gene, each altering the amino acid sequence. Involvement of UV light in these p53 mutations is indicated by the presence in three of the tumors of a CC----TT double-base change, which is only known to be induced by UV. UV is also implicated by a UV-like occurrence of mutations exclusively at dipyrimidine sites, including a high frequency of C----T substitutions. p53 mutations in internal malignancies do not show these UV-specific mutations

1991 Proceedings of the National Academy of Sciences of the United States of America

13953. Angiogenic switch occurs late in squamous cell carcinomas of human skin Full Text available with Trip Pro

Angiogenic switch occurs late in squamous cell carcinomas of human skin Angiogenesis is a crucial event in carcinogenesis and its onset has been associated with premalignant tumour stages. In order to elucidate the significance of angiogenesis in different stages of epithelial skin tumours, we analysed the vessel density in ten normal skin samples, 14 actinic keratosis (AK), 12 hypertrophic AKs, and in nine early- and 16 late-stage squamous cell carcinomas (SCCs). Mean vascular density (...) of tumour localization, degree of proliferation and inflammatory cell infiltration. Furthermore, tumour vascularization was not correlated with the expression of vascular endothelial growth factor, a major angiogenic factor, as revealed by in situ hybridization and immunohistochemistry. The restriction of enhanced vascularization to increased tumour thickness may be a major reason for the rather low metastatic spread of cutaneous SCCs.

2000 British journal of cancer

13954. The multicentre south European study 'Helios'. II: Different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin. Full Text available with Trip Pro

The multicentre south European study 'Helios'. II: Different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin. The role of sun exposure in development of basal cell and squamous cell carcinomas among different populations from south Europe was investigated. Between 1989 and 1993 we interviewed incident cases and a random population sample of controls from five centres where a cancer registry was operating, whereas we selected a sample of hospital (...) -based cases and controls from the other three centres. We gathered information on life-long exposure to sunlight during different activities. Results are analysed for 1549 basal cell carcinoma (BCC) cases and 228 squamous cell carcinoma (SCC) cases compared with 1795 controls. We observed a statistically significant increase of risk of SCC with increasing sun exposure beyond a threshold of 70,000 cumulated hours of exposure in a lifetime. Sun exposures during work and holidays were, however

1996 British journal of cancer

13955. Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group. (Abstract)

Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group. The primary aims of this study were to assess risk of subsequent basal and squamous cell skin cancer among patients with a prior history of these tumors and to examine these risks in relation to patient characteristics and life-style factors.Follow-up of participants in a randomized trial of betacarotene as a possible skin cancer preventive (...) agent.Clinical centers in Los Angeles, Calif, San Francisco, Calif, Minneapolis, Minn, and Hanover, NH.Patients (n = 1805) who were diagnosed as having a basal or squamous cell skin cancer between January 1980 and February 1986 and were free of skin cancer at study entry.Time from study entry to first new occurrence of basal and squamous cell skin cancer.The estimated risk of developing one or more new skin cancers was 35% at 3 years and 50% at 5 years. New skin cancers tended to be of the same cell type

1992 JAMA Controlled trial quality: uncertain

13956. Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. (Abstract)

Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. In general, the expression of A-type lamins (lamins A and C) has been correlated with a non-proliferating, differentiated state of cells and tissues.To establish and compare (...) the expression patterns of lamins in normal human skin, actinic keratosis (AK), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).Expression patterns of the individual lamin subtypes were studied immunohistochemically. The proliferation capacity of the tumour cells was detected using a specific antibody to Ki-67, and was related to the A-type lamin expression patterns.In normal skin, lamin A was expressed in the suprabasal cell compartment of the epidermis, whereas the basal cells were mostly

2003 British Journal of Dermatology

13957. Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin: analysis of the Singapore Cancer Registry data 1968-97. (Abstract)

Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin: analysis of the Singapore Cancer Registry data 1968-97. There has been an alarming recent increase in skin cancer incidence among fair-skinned populations. Information from Asian populations is less readily available.This study examines time trends and ethnic differences of skin cancers among Asians in Singapore.Data from 1968 to 1997 was obtained from the Singapore Cancer Registry, a population-based registry. Age (...) -standardized incidence rates (ASRs) and age-adjusted average annual percentage change, using the Poisson regression model, were calculated.A total of 2650 basal cell carcinomas (BCCs), 1407 squamous cell carcinomas (SCCs) and 281 melanomas were reported. There was an overall increase of skin cancer from 6.0 per 100000 person years (1968-72) to 8.9 per 100000 person years (1993-97). BCC incidence increased 3% annually, melanoma remained constant, and SCC decreased 0.9% annually. BCC ASRs were highest among

2003 British Journal of Dermatology

13958. The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event Full Text available with Trip Pro

The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event Squamous carcinomas of both human and rodent origin can undergo a transition to a more invasive, metastatic phenotype involving reorganization of the cytoskeleton, loss of cell adhesion molecules such as E-cadherin and acquisition of a fibroblastoid or spindle cell morphology. We have developed a series of cell lines from mouse skin tumors which represent different stages of carcinogenesis (...) . At the genetic level, it is not known whether such changes involve activation of dominantly acting oncogenes or loss of a suppressor function which controls epithelial differentiation. To examine this question, we have carried out a series of fusion experiments between a highly malignant mouse skin spindle cell carcinoma and cell lines derived from premalignant or malignant mouse skin tumors, including both squamous and spindle carcinoma variants. The results show that the spindle cell phenotype

1993 The Journal of cell biology

13959. Basal cell carcinoma of the skin with areas of squamous cell carcinoma: a basosquamous cell carcinoma? Full Text available with Trip Pro

Basal cell carcinoma of the skin with areas of squamous cell carcinoma: a basosquamous cell carcinoma? The diagnosis of basosquamous cell carcinoma is controversial. A review of cases of basal cell carcinoma showed 23 cases that had conspicuous areas of squamous cell carcinoma. This was distinguished from squamous differentiation and keratotic basal cell carcinoma by a comparative study of 40 cases of compact lobular and 40 cases of keratotic basal cell carcinoma. Areas of intermediate tumour (...) differentiation between basal cell and squamous cell carcinoma were found. Basal cell carcinomas with areas of squamous cell carcinoma may be called basosquamous carcinoma.

1985 Journal of Clinical Pathology

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