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Squamous Cell Carcinoma of the Skin

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13921. Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas. (Full text)

Intercellular junctions of methylcholanthrene-induced rat skin basocellular and squamous carcinomas. The occurrence of different intercellular junctions in epithelial rat skin tumours induced by methylcholanthrene was investigated using thin sections and freeze-fracture replicas examined by electron microscopy. Tumours which appeared first were basal cell carcinomas. Later, different tumours of hair follicle and of sebaceous gland origin were formed. Finally, in the majority of tumours (...) a squamous component evolved. Metastases developed from the squamous carcinomas exclusively. Desmosomes and gap junctions were detected in basal cell carcinomas whereas, in squamous carcinomas, tight junctions were also seen. While all three types of junction were found in the primary squamous tumours, the tumour metastases in lymph nodes and lungs contained only desmosomes.

1984 British journal of cancer PubMed

13922. Multiple squamous skin carcinomas following excess sunbed use (Full text)

Multiple squamous skin carcinomas following excess sunbed use 11733592 2002 01 14 2018 11 13 0141-0768 94 12 2001 Dec Journal of the Royal Society of Medicine J R Soc Med Multiple squamous skin carcinomas following excess sunbed use. 636-7 Roest M A MA Department of Dermatology, Amersham Hospital, Bucks, UK. mroest@doctors.org.uk Keane F M FM Agnew K K Hawk J L JL Griffiths W A WA eng Case Reports Journal Article England J R Soc Med 7802879 0141-0768 IM Adult Carcinoma, Squamous Cell etiology (...) Female Humans Neoplasms, Radiation-Induced etiology Skin Neoplasms etiology Skin Pigmentation Ultraviolet Rays adverse effects 2001 12 6 10 0 2002 1 15 10 1 2001 12 6 10 0 ppublish 11733592 PMC1282298 Am J Epidemiol. 1990 Feb;131(2):232-43 2296977 BMJ. 1990 Oct 6;301(6755):773-4 2275730 Br J Dermatol. 1998 Sep;139(3):428-38 9767287 Cancer Surv. 1996;26:173-91 8783573 Photodermatol Photoimmunol Photomed. 1998 Apr;14(2):79-87 9638731 N Engl J Med. 1995 May 25;332(21):1450-1 7723815

2001 Journal of the Royal Society of Medicine PubMed

13923. Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. (PubMed)

than 10 actinic keratoses and at most 2 squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) skin cancers. Subjects were randomly assigned to receive oral retinol (25,000 IU) or placebo supplementation daily for up to 5 years. The primary end points for the trial were time to first new SCC or BCC. During a median follow-up time of 3.8 years, we found that 526 subjects had a first new skin cancer. Comparing retinol-supplemented subjects with placebo-supplemented subjects showed a hazard ratio (...) Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. We conducted a randomized, double-blind, controlled trial to examine the efficacy of retinol supplementation on the incidence of first new nonmelanoma skin cancer in moderate-risk subjects. A total of 2297 free-living subjects were enrolled; subjects resided in Arizona (median age, 63 years) and had a history of more

1997 Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

13924. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. (PubMed)

Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. The use of sunscreens on the skin can prevent sunburn but whether long-term use can prevent skin cancer is not known. Also, there is evidence that oral betacarotene supplementation lowers skin-cancer rates in animals, but there is limited evidence of its effect in human beings.In a community-based randomised trial with a 2 by 2 (...) factorial design, individuals were assigned to four treatment groups: daily application of a sun protection factor 15-plus sunscreen to the head, neck, arms, and hands, and betacarotene supplementation (30 mg per day); sunscreen plus placebo tablets; betacarotene only; or placebo only. Participants were 1621 residents of Nambour in southeast Queensland, Australia. The endpoints after 4.5 years of follow-up were the incidence of basal-cell and squamous-cell carcinomas both in terms of people treated

1999 Lancet

13925. Predictors of skin-related quality of life after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma. (Full text)

Predictors of skin-related quality of life after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma. To identify predictors of skin-related quality of life (QOL) after treatment of nonmelanoma skin cancer (NMSC).Prospective cohort study of consecutive patients with NMSC diagnosed in 1999 and 2000.University-affiliated private practice and a Veterans Affairs clinic.A total of 633 patients who responded to a questionnaire before treatment.Skin-related QOL, measured (...) with the 16-item version of Skindex-16, a validated measure. Skindex-16 scores vary from 0 (best QOL) to 100 (worst QOL) and are reported in 3 domains: symptoms, emotional effects, and effects on functioning.Controlling for treatment group, the strongest independent predictor of skin-related QOL after treatment of NMSC was pretreatment skin-related QOL. Other patient characteristics that predicted better QOL included less comorbidity and better mental health status. No tumor or care characteristic

2007 Archives of Dermatology PubMed

13926. Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin: analysis of the Singapore Cancer Registry data 1968-97. (PubMed)

Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin: analysis of the Singapore Cancer Registry data 1968-97. There has been an alarming recent increase in skin cancer incidence among fair-skinned populations. Information from Asian populations is less readily available.This study examines time trends and ethnic differences of skin cancers among Asians in Singapore.Data from 1968 to 1997 was obtained from the Singapore Cancer Registry, a population-based registry. Age (...) -standardized incidence rates (ASRs) and age-adjusted average annual percentage change, using the Poisson regression model, were calculated.A total of 2650 basal cell carcinomas (BCCs), 1407 squamous cell carcinomas (SCCs) and 281 melanomas were reported. There was an overall increase of skin cancer from 6.0 per 100000 person years (1968-72) to 8.9 per 100000 person years (1993-97). BCC incidence increased 3% annually, melanoma remained constant, and SCC decreased 0.9% annually. BCC ASRs were highest among

2003 British Journal of Dermatology

13927. Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. (PubMed)

Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. In general, the expression of A-type lamins (lamins A and C) has been correlated with a non-proliferating, differentiated state of cells and tissues.To establish and compare (...) the expression patterns of lamins in normal human skin, actinic keratosis (AK), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).Expression patterns of the individual lamin subtypes were studied immunohistochemically. The proliferation capacity of the tumour cells was detected using a specific antibody to Ki-67, and was related to the A-type lamin expression patterns.In normal skin, lamin A was expressed in the suprabasal cell compartment of the epidermis, whereas the basal cells were mostly

2003 British Journal of Dermatology

13928. Relationship of treatment delay with surgical defect size from keratinocyte carcinoma (basal cell carcinoma and squamous cell carcinoma of the skin). (Full text)

Relationship of treatment delay with surgical defect size from keratinocyte carcinoma (basal cell carcinoma and squamous cell carcinoma of the skin). Larger keratinocyte carcinoma (KC) lesions are associated with higher morbidity. This study examined the association of potentially modifiable characteristics, including treatment delay, with KC defect size after Mohs micrographic surgery (MMS). A stratified random sample of patients treated for KC with MMS were selected for telephone interview

2005 Journal of Investigative Dermatology PubMed

13929. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. (Full text)

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Sunlight is a carcinogen to which everyone is exposed. Its UV component is the major epidemiologic risk factor for squamous cell carcinoma of the skin. Of the multiple steps in tumor progression, those that are sunlight-related would be revealed if they contained mutations specific to UV. In a series of New England and Swedish patients, we find that 14/24 (58%) of invasive squamous cell carcinomas (...) of the skin contain mutations in the p53 tumor suppressor gene, each altering the amino acid sequence. Involvement of UV light in these p53 mutations is indicated by the presence in three of the tumors of a CC----TT double-base change, which is only known to be induced by UV. UV is also implicated by a UV-like occurrence of mutations exclusively at dipyrimidine sites, including a high frequency of C----T substitutions. p53 mutations in internal malignancies do not show these UV-specific mutations

1991 Proceedings of the National Academy of Sciences of the United States of America PubMed

13930. Angiogenic switch occurs late in squamous cell carcinomas of human skin (Full text)

Angiogenic switch occurs late in squamous cell carcinomas of human skin Angiogenesis is a crucial event in carcinogenesis and its onset has been associated with premalignant tumour stages. In order to elucidate the significance of angiogenesis in different stages of epithelial skin tumours, we analysed the vessel density in ten normal skin samples, 14 actinic keratosis (AK), 12 hypertrophic AKs, and in nine early- and 16 late-stage squamous cell carcinomas (SCCs). Mean vascular density (...) of tumour localization, degree of proliferation and inflammatory cell infiltration. Furthermore, tumour vascularization was not correlated with the expression of vascular endothelial growth factor, a major angiogenic factor, as revealed by in situ hybridization and immunohistochemistry. The restriction of enhanced vascularization to increased tumour thickness may be a major reason for the rather low metastatic spread of cutaneous SCCs.

2000 British journal of cancer PubMed

13931. Squamous cell carcinoma of skin with a rhabdoid phenotype: a case report (Full text)

Squamous cell carcinoma of skin with a rhabdoid phenotype: a case report A 67 year old man presented with a polypoid lesion on the temple that had all the light microscopic, immunohistochemical, and ultrastructural features of a rhabdoid tumour. There was an area of intraepidermal carcinoma and invasive squamous carcinoma at the base of the polyp. The tumour progressed aggressively and the patient died five months after primary excision. Cutaneous tumours with a rhabdoid morphology have been (...) described previously and tend to have a very poor prognosis. No previously published report describes a clear squamous histogenesis.

2000 Journal of Clinical Pathology PubMed

13932. Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas. (Full text)

Localization of integrin receptors for fibronectin, collagen, and laminin in human skin. Variable expression in basal and squamous cell carcinomas. VLA integrins in human skin were examined by indirect immunofluorescence utilizing antibodies recognizing the beta 1, alpha 2, alpha 3, or alpha 5 subunits. Staining of fetal, newborn, or adult skin with antibodies to beta 1, alpha 2, or alpha 3 subunits gave essentially similar staining patterns: intense staining was associated with the basal layer (...) of previously unrecognized ligands in the intercellular spaces of keratinocytes. Examination of nine nodular basal cell carcinomas revealed a prominent staining reaction with anti-beta 1 and anti-alpha 3 antibodies at the periphery of the tumor islands. In contrast, staining of five squamous cell carcinomas revealed either the absence of integrins or altered and variable expression. Thus, matrix components and their receptors may participate in modulation of growth, development, and organization of human

1989 Journal of Clinical Investigation PubMed

13933. The multicentre south European study 'Helios'. II: Different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin. (Full text)

The multicentre south European study 'Helios'. II: Different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin. The role of sun exposure in development of basal cell and squamous cell carcinomas among different populations from south Europe was investigated. Between 1989 and 1993 we interviewed incident cases and a random population sample of controls from five centres where a cancer registry was operating, whereas we selected a sample of hospital (...) -based cases and controls from the other three centres. We gathered information on life-long exposure to sunlight during different activities. Results are analysed for 1549 basal cell carcinoma (BCC) cases and 228 squamous cell carcinoma (SCC) cases compared with 1795 controls. We observed a statistically significant increase of risk of SCC with increasing sun exposure beyond a threshold of 70,000 cumulated hours of exposure in a lifetime. Sun exposures during work and holidays were, however

1996 British journal of cancer PubMed

13934. Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group. (PubMed)

Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group. The primary aims of this study were to assess risk of subsequent basal and squamous cell skin cancer among patients with a prior history of these tumors and to examine these risks in relation to patient characteristics and life-style factors.Follow-up of participants in a randomized trial of betacarotene as a possible skin cancer preventive (...) agent.Clinical centers in Los Angeles, Calif, San Francisco, Calif, Minneapolis, Minn, and Hanover, NH.Patients (n = 1805) who were diagnosed as having a basal or squamous cell skin cancer between January 1980 and February 1986 and were free of skin cancer at study entry.Time from study entry to first new occurrence of basal and squamous cell skin cancer.The estimated risk of developing one or more new skin cancers was 35% at 3 years and 50% at 5 years. New skin cancers tended to be of the same cell type

1992 JAMA

13935. The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event (Full text)

The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event Squamous carcinomas of both human and rodent origin can undergo a transition to a more invasive, metastatic phenotype involving reorganization of the cytoskeleton, loss of cell adhesion molecules such as E-cadherin and acquisition of a fibroblastoid or spindle cell morphology. We have developed a series of cell lines from mouse skin tumors which represent different stages of carcinogenesis (...) . At the genetic level, it is not known whether such changes involve activation of dominantly acting oncogenes or loss of a suppressor function which controls epithelial differentiation. To examine this question, we have carried out a series of fusion experiments between a highly malignant mouse skin spindle cell carcinoma and cell lines derived from premalignant or malignant mouse skin tumors, including both squamous and spindle carcinoma variants. The results show that the spindle cell phenotype

1993 The Journal of cell biology PubMed

13936. Basal cell carcinoma of the skin with areas of squamous cell carcinoma: a basosquamous cell carcinoma? (Full text)

Basal cell carcinoma of the skin with areas of squamous cell carcinoma: a basosquamous cell carcinoma? The diagnosis of basosquamous cell carcinoma is controversial. A review of cases of basal cell carcinoma showed 23 cases that had conspicuous areas of squamous cell carcinoma. This was distinguished from squamous differentiation and keratotic basal cell carcinoma by a comparative study of 40 cases of compact lobular and 40 cases of keratotic basal cell carcinoma. Areas of intermediate tumour (...) differentiation between basal cell and squamous cell carcinoma were found. Basal cell carcinomas with areas of squamous cell carcinoma may be called basosquamous carcinoma.

1985 Journal of Clinical Pathology PubMed

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