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Squamous Cell Carcinoma of the Skin

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13781. Lymph node metastases from cutaneous squamous cell carcinoma of the head and neck. (Abstract)

Lymph node metastases from cutaneous squamous cell carcinoma of the head and neck. Cutaneous squamous cell carcinoma (CSCC) has been reported to metastasize to parotid and cervical lymph nodes. Few prospective investigations of associated clinical and histopathologic findings and their effect on patient outcomes exist. We seek to identify risk factors for nodal metastases in CSCC and determine the impact of lymphatic spread on survival and recurrence.Subset analysis of a prospective (...) , longitudinal database of patients with CSCC at a comprehensive cancer center.Eligible patients with nonmelanoma skin cancer were consecutively enrolled in a prospective database from July 1996 through June 2001; this cohort was then followed to the key endpoints of recurrence and mortality.Two hundred ten patients were enrolled, and 193 patients with CSCC of the head and neck are included in this analysis. The incidence of nodal metastases in this population was 20.7% at study entry. Median follow-up

2005 Laryngoscope

13782. Molecular basis of posttransplant squamous cell carcinoma: the potential role of cyclosporine a in carcinogenesis. (Abstract)

Molecular basis of posttransplant squamous cell carcinoma: the potential role of cyclosporine a in carcinogenesis. Cyclosporine (CSA) is a widely used immunosuppressive agent, predominantly for transplant patients. It is well recognized that transplant patients are prone to develop squamous carcinoma of the skin and mucosa, and this high incidence of squamous carcinoma in the transplant population cannot be explained by immunosuppression alone. We hypothesize that CSA may play a significant (...) for cell-cycle regulation, apoptosis, and oncogene/tumor-suppressor activation. These functions of CSA on skin and mucosa systems at the molecular level are likely important in the pathogenesis of squamous carcinoma in transplant patients.

2006 Laryngoscope

13783. Evaluation of the American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma and proposal of a new staging system. (Abstract)

Evaluation of the American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma and proposal of a new staging system. To identify and propose corrections for deficiencies in the American Joint Committee on Cancer (AJCC) system for staging cutaneous squamous cell carcinoma (CSCC).Prognostic factors for CSCC were identified by retrospective analysis of the published literature. Limitations and deficiencies in the current AJCC staging system for CSCC were then determined (...) , identification of patients with perineural invasion, and the addition of tumor thickness or depth of invasion. The N classification has been expanded to include the number and size of nodal metastases.The current AJCC staging system for carcinoma of the skin has deficiencies that limit its use for CSCC. The proposed TMN staging system for CSCC more accurately reflects the prognosis and natural history of CSCC.

2005 Dermatologic Surgery

13784. Squamous cell carcinoma of the auricle and Mohs micrographic surgery. (Abstract)

Squamous cell carcinoma of the auricle and Mohs micrographic surgery. Squamous cell carcinoma (SCC) of the ear compared with SCC occurring at other skin sites has an increased incidence of recurrence following treatment.To determine the following variables: patient age and gender, life status, tumor location, and recurrence rate following Mohs micrographic surgery (MMS).The charts of 117 patients with 144 invasive SCCs of the auricle were reviewed. The patients were contacted by telephone

2005 Dermatologic Surgery

13785. Squamous cell carcinoma of the lower lip: exact location match in siblings. (Abstract)

Squamous cell carcinoma of the lower lip: exact location match in siblings. In recent years, genetic contribution to the development of skin cancers is under the magnifying glass of several authors and is now regarded as the main initial etiology in carcinogenesis.Two siblings who had squamous cell carcinoma of the lower lip showing an exact location match are presented.They did not share common environmental factors, and there was no history of tobacco and/or alcohol abuse.It would

2005 Dermatologic Surgery

13786. Management of squamous cell carcinoma in a patient with recessive-type epidermolysis bullosa dystrophica. (Abstract)

Management of squamous cell carcinoma in a patient with recessive-type epidermolysis bullosa dystrophica. Surgical treatment of a recessive dystrophic epidermolysis bullosa patient is very difficult for both the surgeon and the anesthetist because of the fragility of the skin and abnormal nature of the tumor bed.We report a case of 54-year-old Japanese recessive dystrophic epidermolysis bullosa patient with squamous cell carcinoma (SCC) of the lateral malleolus.A tumor measuring 5.0 x 5.5 cm (...) was surgically excised. The defect was then reconstructed by full-thickness skin grafting. To avoid airway complications, general anesthesia was administered using a face mask. Because the regional lymph nodes were swollen before surgery, the patient underwent sentinel lymph node biopsy.The patient remains well with no sign of recurrence or metastasis 7 months after surgery.To preserve activities of daily living, surgery should be performed for squamous cell carcinomas arising in recessive dystrophic

2004 Dermatologic Surgery

13787. Fluorodeoxyglucose positron emission tomography in cutaneous squamous cell carcinoma: retrospective analysis of 12 patients. (Abstract)

Fluorodeoxyglucose positron emission tomography in cutaneous squamous cell carcinoma: retrospective analysis of 12 patients. Whole-body 18F-fluorodeoxyglucose positron emission tomography (FDG PET) has been used for whole-body imaging modality in detecting malignancy in clinical oncology. However, only a few reports of FDG PET in skin cancers have been described, except for melanoma and lymphoma.To report on the usefulness of FDG PET as a baseline workup study for patients with cutaneous (...) squamous cell carcinoma (SCC).There were 12 cases of SCC (9 cases with high-risk SCC). Of the 12, FDG PET was performed for staging in 11 patients and for restaging in 1 patient 1 year after wide excision.Primary lesions were detected in nine cases (83.3%), lymph node involvement in three cases (25.0%), and distant. organ (lung) involvement in one case (8.3%). In one patient whose primary lesion was positive, stomach cancer with involvement of adrenal glands, omentum, and lymph nodes was incidentally

2005 Dermatologic Surgery

13788. Perineural spread of squamous cell carcinoma involving the spinal accessory nerve in an immunocompromised organ transplant recipient. (Abstract)

Perineural spread of squamous cell carcinoma involving the spinal accessory nerve in an immunocompromised organ transplant recipient. Squamous cell carcinoma is the second most common cutaneous malignancy in humans, affecting approximately 200,000 people in the United States each year. In immunocompromised patients, squamous cell carcinoma is the most common skin cancer, and it also tends to behave more aggressively than in immunocompetent patients.We describe an immunocompromised patient (...) , previously treated for a squamous cell carcinoma of the left posterior shoulder, who subsequently developed a cord-like, intraneural metastasis of the spinal accessory nerve.The patient presented with a 3-month history of lancinating pain of the left neck and shoulder. He had been treated previously for a squamous cell carcinoma of the left posterior shoulder, which subsequently recurred twice. On examination, a cord-like mass was palpable along the path of the spinal accessory nerve. Given

2005 Dermatologic Surgery

13789. Late inguinal metastasis of a well-differentiated subungual squamous cell carcinoma after radical toe amputation. (Abstract)

Late inguinal metastasis of a well-differentiated subungual squamous cell carcinoma after radical toe amputation. Although squamous cell carcinoma (SCC) is commonly found on sun-exposed skin, this malignancy in nail beds is rare. There is a very low rate of metastases, especially for well-differentiated lesions without bony involvement.To present a case of late inguinal metastasis after radical toe amputation 3 years previously for subungual SCC.Case report.The patient received modified

2005 Dermatologic Surgery

13790. Oral squamous cell carcinoma during long-term treatment with hydroxyurea. (Abstract)

Oral squamous cell carcinoma during long-term treatment with hydroxyurea. Hydroxyurea (HU) is commonly used for the treatment of chronic myelogenous leukaemia, polycythemia vera and essential thrombocythaemia. Patients receiving HU present a number of side-effects including skin/mucosa changes and tumours. Mucocutaneous abnormalities include xerosis, ichthyosiform lesions, dark brown pigmentation of skin folds and nails, malleolar ulcers, oral mucositis and oral ulcers. Cutaneous squamous/basal (...) cell carcinomas have also often been reported following long-term administration of HU. HU-induced carcinogenesis is due to both the mutagenic potential of this agent and to an impairment of DNA repair mechanisms after damage by external factors such as ultraviolet radiation. Oral cancer following long-term treatment with HU has been reported only once, in a patient with concomitant multiple skin tumours. We present the unique case of a patient with polycythemia vera who developed oral cancer after

2004 Clinical & Experimental Dermatology

13791. Squamous cell carcinoma of the nail unit with evidence of bony involvement: a multidisciplinary approach to resection and reconstruction. (Abstract)

Squamous cell carcinoma of the nail unit with evidence of bony involvement: a multidisciplinary approach to resection and reconstruction. Squamous cell carcinoma (SCC) of the nail bed is a rare disorder that is often misdiagnosed for years before definitive diagnosis with biopsy. Proper evaluation of this carcinoma includes radiographic evaluation for bony involvement of the phalanges of the affected digit. If bony involvement is evident by x-ray, amputation of the distal phalanx (...) cases and a review of the pertinent medical literature.Three SCCs of the nail bed were excised with Mohs micrographic surgery, preserving the volar pulp and skin of the distal finger. The patients were then referred for distal phalanx amputation and reconstruction by a hand surgeon. All patients remained disease free with acceptable function of the reconstructed digits at 15, 17, and 38 months of follow-up.Although uncommon, SCC of the nail bed must be considered in all nails with chronic disease

2004 Dermatologic Surgery

13792. Dermatitis-like squamous cell carcinoma. (Abstract)

Dermatitis-like squamous cell carcinoma. A 78-year-old man with a 2-year history of a large dermatitis-like plaque of his thigh is described. It had a raised elevated border, resembling persistent fungal dermatitis (tinea corporis). However, it proved to be a squamous cell carcinoma, prompting this description and a reminder that skin cancer may mimic dermatitis.

2004 Dermatologic Surgery

13793. Keratoacanthoma-like squamous cell carcinoma within the fibroepithelial polyp. (Abstract)

Keratoacanthoma-like squamous cell carcinoma within the fibroepithelial polyp. Acrochordons (skin tags) are often considered clinically insignificant cutaneous redundancies that should be removed and destroyed with no histopathologic analysis performed. One rarely finds another neoplasm within an acrochordon. We describe a patient with an acrochordon that contained a squamous cell carcinoma that had features resembling a keratoacanthoma. This is the first time to our knowledge that an invasive (...) squamous cell carcinoma has been described within an acrochordon.

2004 Dermatologic Surgery

13794. Squamous cell carcinoma of the scalp after radiotherapy for tinea capitis. (Abstract)

Squamous cell carcinoma of the scalp after radiotherapy for tinea capitis. Radiotherapy for tinea capitis was widely used in the 1930s and 1940s. There is a fourfold increase in the risk for developing nonmelanoma skin cancer in the scalp. Excision of lesions is challenging, as tissue around the wound is atrophic and susceptible to ischemia.To discuss the risk of skin cancer in the older patient who received scalp radiotherapy in childhood and options for scalp reconstruction after excision.A (...) woman developed squamous cell carcinoma on the scalp 67 years after radiotherapy for tinea capitis.The large excision defect was successfully grafted, avoiding the need for complex scalp reconstruction.Patients who received scalp radiotherapy in childhood are at increased risk of developing nonmelanoma skin cancer. The unique anatomy of scalp tissue makes it difficult to close excisional defects. Skin grafting often fails, and complex flaps or the importation of vascularized tissue may be required.

2004 Dermatologic Surgery

13795. Metastatic cutaneous squamous cell carcinoma: an update. (Abstract)

Metastatic cutaneous squamous cell carcinoma: an update. Squamous cell carcinoma (SCC) is the second most common type of skin cancer in the United States. Cutaneous SCC has the potential to metastasize and cause morbidity and mortality.Our purpose was to review and summarize the literature on metastatic cutaneous SCC, including risk factors for metastasis, data from clinical studies, and current management.Multiple studies confirm that even well-differentiated and small tumors (<2 cm) may

2007 Dermatologic Surgery

13796. Diffuse epidermal and periadnexal squamous cell carcinoma in situ: a report of 13 patients. (Abstract)

Diffuse epidermal and periadnexal squamous cell carcinoma in situ: a report of 13 patients. Diffuse epidermal and periadnexal squamous cell carcinoma in situ (DEPS) is a condition in which large areas of skin are affected by atypical keratinocytes that grow beneath the epidermis and encase adnexal epithelia. Normal differentiation of the overlying epidermis and adnexal epithelium is seen.Our aim was to describe the clinical features of DEPS.We undertook a retrospective case series of 13 (...) patients with DEPS.All 13 patients were fair-skinned men older than 50 years with a history of significant sun exposure. The lesions were present on the scalp, face, and neck. Histologic examination showed a growth of atypical keratinocytes in the lower epidermis with encasement of adnexal structures by atypical neoplastic keratinocytes. In the 52 cumulative patient-years of follow-up, we treated 80 invasive squamous cell and 48 basal cell carcinomas in these patients. Despite improvement of DEPS

2005 Journal of American Academy of Dermatology

13797. Increased metastasis and mortality from cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia. (Abstract)

Increased metastasis and mortality from cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia. In patients with chronic lymphocytic leukemia, squamous cell carcinoma behaves aggressively. Our purpose was to compare squamous cell carcinoma metastasis and mortality between patients with chronic lymphocytic leukemia and control subjects. Medical records were assessed retrospectively for 28 patients with chronic lymphocytic leukemia who underwent surgical excision (...) of cutaneous squamous cell carcinoma and for 56 matched control subjects. The rate of metastasis and mortality from cutaneous squamous cell carcinoma were determined on a per-patient basis. Three of 28 patients with chronic lymphocytic leukemia had metastasis and died of metastatic disease. No metastases or deaths occurred among the 56 control subjects. Compared with control subjects, chronic lymphocytic leukemia patients with cutaneous squamous cell carcinoma were more likely to have metastasis (P = .0031

2005 Journal of American Academy of Dermatology

13798. The expression of p63 in actinic keratoses, seborrheic keratosis, and cutaneous squamous cell carcinomas. (Abstract)

The expression of p63 in actinic keratoses, seborrheic keratosis, and cutaneous squamous cell carcinomas. p63 is a tumor suppressor that likely plays a role in the development of squamous cell carcinomas (SCCs) and possibly premalignant and benign skin tumors. Little data is available on its expression in these tumors.To study the keratinocyte expression profile of p63 in 17 SCCs, 7 actinic keratoses, 2 Bowens tumors, and 7 seborrheic keratoses.Skin tumors specimens were stained (...) in SCCs when compared with normal skin, actinic keratoses, and seborrheic keratoses. Interestingly seborrheic keratoses and Bowens lesions showed expression that was mostly restricted to the basal layer, however significant diffuse staining was also noted. Our results support the notion that p63 plays a role in cell differentiation and tumorigenesis of skin tumors.

2004 Dermatologic Surgery

13799. Histologic features in primary cutaneous squamous cell carcinomas in immunocompromised patients focusing on organ transplant patients. (Abstract)

Histologic features in primary cutaneous squamous cell carcinomas in immunocompromised patients focusing on organ transplant patients. In organ transplant recipients (OTR) there is an increased incidence of cutaneous squamous cell carcinomas (CSCC), and they may be aggressive.We wanted to determine whether any histologic features were characteristic or more common in CSCC of OTR.A total of 518 immunocompetent individuals with 601 primary CSCC were examined. Seventy-nine OTR with 231 primary (...) CSCC, 53 renal OTR, 25 heart/heart lung OTR, and 1 liver OTR were examined.In all patient populations, CSCC occurred dominantly in chronically sun-exposed skin. In OTR, however, a greater percentage occurred on the extremity, particularly the upper extremity, and they occurred at an earlier age. Features that were significantly more common in OTR were acantholytic changes, early dermal invasion, an infiltrative growth pattern with or without desmoplasia, and Bowen's disease with carcinoma. In OTR

2004 Dermatologic Surgery

13800. Guidelines for the management of squamous cell carcinoma in organ transplant recipients. Full Text available with Trip Pro

Guidelines for the management of squamous cell carcinoma in organ transplant recipients. Solid-organ transplant recipients have a high incidence of cutaneous squamous cell carcinoma (SCC) and often develop multiple and aggressive tumors. There are few published studies or reviews, which provide guidance to the clinician in the treatment of these patients.The objective was to develop useful clinical guidelines for the treatment of skin cancer in organ transplant recipients (OTRs).The members (...) of the Guidelines Committee of the International Transplant-Skin Cancer Collaborative (ITSCC) carried out a computerized search utilizing the databases of the National Library of Medicine for reports in the literature on SCC in OTRs. These reports were collectively examined by the group and combined with experiences from the members' clinical practices in the development of the guidelines.More than 300 articles relating to SCC in OTRs were reviewed. In general, reports concerning the prevention and treatment

2004 Dermatologic Surgery

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