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Squamous Cell Carcinoma of the Skin

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101. Survival Outcomes for Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck. (PubMed)

Survival Outcomes for Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck. Survival outcomes for advanced non-melanoma skin cancers of the head and neck treated with surgical resection are not well described in the literature. We aimed to describe outcomes for T3 and T4 cutaneoous squamous cell carcinoma of the head or neck treated with surgical resection at 1 tertiary academic medical center.We analyzed a retrospective cohort of patients diagnosed with T3 or T4 cutaneous squamous (...) cell carcinoma (SCC) of the head or neck from 2005 to 2016 treated with definitive surgical resection. Survival outcomes were examined using Kaplan-Meier analysis, and multivariate analysis was completed with Cox proportional hazard model.Forty-three patients met inclusion criteria. The mean age at diagnosis was 74.7 years (SD = 10.2), and 34 (79.1%) patients were male. Twelve (27.9%) patients were immunosuppressed. Radical resection, defined as temporal bone resection, orbital exenteration

2019 Rhinology and Laryngology

102. Expression of indolamine-2,3-dioxygenase and cyclooxygenase-2 in different disease stages of cutaneous squamous cell carcinoma. (PubMed)

Expression of indolamine-2,3-dioxygenase and cyclooxygenase-2 in different disease stages of cutaneous squamous cell carcinoma. 31251418 2019 07 09 1468-3083 2019 Jun 28 Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Expression of indolamine-2,3-dioxygenase and cyclooxygenase-2 in different disease stages of cutaneous squamous cell carcinoma. 10.1111/jdv.15763 Gambichler T T https://orcid.org/0000-0001-7862-3695 Department of Dermatology (...) , Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany. Selke L L Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany. Rüddel I I Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany. Dreißigacker M M Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany. Stockfleth E E Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany. Schmitz L L https://orcid.org/0000

2019 Journal of the European Academy of Dermatology and Venereology

103. Immunotherapeutic Strategies for Cutaneous Squamous Cell Carcinoma Prevention in Xeroderma Pigmentosum. (PubMed)

Immunotherapeutic Strategies for Cutaneous Squamous Cell Carcinoma Prevention in Xeroderma Pigmentosum. Xeroderma pigmentosum (XP) is an autosomal recessive disorder of nucleotide excision repair, characterized by hypersensitivity to ultraviolet light (UV) radiation.1-3 In individuals with XP, the incidence of non-melanoma skin cancers prior to the age of 20 years is approximately 10,000 times that seen in the general population.4 The most common cause of death in this patient population (...) is skin cancer, including metastatic melanoma and metastatic cutaneous squamous cell carcinoma (cSCC).4 Sun avoidance is the main mode of skin cancer prevention in XP patients.5 However, the development of invasive skin cancers at an early age and challenges associated with avoiding sun exposure highlight the critical need for additional cancer prevention strategies in this high-risk population. We report cSCC incidence before and after starting immune checkpoint blockade (ICB) therapy in a single

2019 British Journal of Dermatology

104. Human papillomavirus 16 and p16 positive nasal cutaneous squamous cell carcinoma in immunocompetent men in their twenties. (PubMed)

Human papillomavirus 16 and p16 positive nasal cutaneous squamous cell carcinoma in immunocompetent men in their twenties. Cutaneous squamous cell carcinoma is usually associated with long-term ultraviolet light exposure. Human papillomavirus 16 is a high-risk mucosal human papillomavirus type, usually associated with anogenital and oropharyngeal cancer. This paper describes the first two cases of human papillomavirus 16 and p16 related nasal cutaneous squamous cell carcinoma.Prospective case (...) was driving the disease process. Except for superficial burns, neither patient had other risk factors.Changes in sexual practices have led to an increase in human papillomavirus positive oropharyngeal carcinoma and there may be an associated increase in human papillomavirus type 16 positive nasal cutaneous squamous cell carcinoma.

2019 Journal of Laryngology & Otology

105. The detection rate of Human Papillomavirus (HPV) in well differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma? (PubMed)

The detection rate of Human Papillomavirus (HPV) in well differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma? The "keratinocyte skin cancer" term stands as a sort of umbrella covering different stages within the progression of cutaneous squamous cell carcinoma (cSCC). The invasive forms of are further classified on the basis of histopathologic differentiation grade as well differentiated, moderate and poorly

2019 British Journal of Dermatology

106. Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States. (PubMed)

Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States. Retinoids are bioactive forms of vitamin A that are essential in the maintenance of epithelial maturation and differentiation. Synthetic retinoids are used in chemoprevention of skin cancer among high-risk populations with potential adverse effects. Epidemiologic data on vitamin A intake and risk of cutaneous squamous cell carcinoma (SCC) are limited.To examine whether vitamin A intake

2019 JAMA dermatology (Chicago, Ill.)

107. Squamous cell carcinoma of the renal pelvis presenting as an integumentary neoplasm of the flank: A case report. (PubMed)

Squamous cell carcinoma of the renal pelvis presenting as an integumentary neoplasm of the flank: A case report. Although chronic pyelonephritis and urolithiasis are established risk factors for squamous cell carcinoma (SCC), only a minority of patients with chronic urolithiasis eventually develop SCC. It is believed that the chronic irritation leads to squamous cell metaplasia that may subsequently develop into SCC. Although studies show that SSC generally spreads locally with associated (...) symptoms of lymphadenopathy, metastasis to the lungs and liver have also been reported. However, cases spreading to the flank have yet to be reported. Therefore, the use of reconstructive techniques for the repair of extensive soft tissue defects in the flank region after extended retroperitoneal resection, is unknown.We report a 54-year-old man who presented with a 1-month history of an enlarged skin mass on the right flank.The patient was subsequently diagnosed with metastatic SCC involving

2019 Medicine

108. Validation of the English Basal and Squamous Cell Carcinoma Quality of Life (BaSQoL) Questionnaire. (PubMed)

was a prospective, observational study. Patients with basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) were asked to fill out BaSQoL, Skin Cancer Index (SCI), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Descriptive statistics and classical test theory were used to assess validity.One hundred eighty-seven subjects enrolled in this study: 122 with BCC and 65 with SCC. One hundred seventy-one subjects (91.4%) completed questionnaires at all 3 time points; 16 patients (8.6%) were (...) Validation of the English Basal and Squamous Cell Carcinoma Quality of Life (BaSQoL) Questionnaire. Keratinocyte carcinomas (KC) impact patient quality of life (QoL). There is a need for validated QoL instruments specific to KC. The Basal and Squamous Cell Carcinoma QoL (BaSQoL) questionnaire was developed to comprehensively measure issues of importance to patients with KC.To validate and characterize the BaSQoL questionnaire for QoL measurement after diagnosis and treatment of KC.This

2019 Dermatologic Surgery

109. Characteristics of Patients Hospitalized for Cutaneous Squamous Cell Carcinoma. (PubMed)

Characteristics of Patients Hospitalized for Cutaneous Squamous Cell Carcinoma. Knowledge regarding the inpatient burden of cutaneous squamous cell carcinoma (cSCC) is limited.To provide nationally representative estimates for hospitalization characteristics due to cSCC and determine predictors for increased length of stay (LOS) and cost of care.A retrospective cohort study of the 2009 to 2015 National Inpatient Sample. Weighted multivariate logistic/linear regression models were created (...) to evaluate sociodemographic factors associated with cSCC hospitalization and to assess characteristics associated with cost of care and LOS.This study included 15,784 cSCC and 255,244,626 non-SCC inpatients (prevalence = 6.2/100,000 inpatients). On average, cSCC hospitalizations lasted 5.8 days and cost $66,841.00. Cutaneous squamous cell carcinoma most often occurred on the scalp (30.57%), face (21.08%), and lower limb (11.93%). Controlling for all other factors, cSCC inpatients presented to larger

2019 Dermatologic Surgery

110. The role of reflectance confocal microscopy in the diagnosis and management of squamous cell carcinoma in situ treated with photodynamic therapy. (PubMed)

The role of reflectance confocal microscopy in the diagnosis and management of squamous cell carcinoma in situ treated with photodynamic therapy. Reflectance confocal microscopy (RCM) is increasingly used for noninvasive in vivo diagnosis of skin cancers. We seek to determine if RCM is useful for the diagnosis and follow-up of squamous cell carcinoma in situ (SCCIS) posttreatment to document clearance.A pilot prospective study enrolled 10 patients with a total of 11 SCCIS lesions. Clinical (...) cases (25%) showed numerous epidermal dendritic cells, while small bright refractive cells were present in the epidermis in two lesions (25%). Round blood vessels in the superficial dermis were seen in four lesions (50%), while three lesions (37.5%) showed dermal inflammatory cells.There was good correlation between histological and confocal features in patients who underwent RCM imaging prior to biopsy. RCM may be a complementary tool in diagnosing SCCIS and to monitor response to nonsurgical

2019 International Journal of Dermatology

111. Unusual Bone Lesions with Osteonecrosis Mimicking Bone Metastasis of Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa. (PubMed)

Unusual Bone Lesions with Osteonecrosis Mimicking Bone Metastasis of Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa. Some bone lesions are reported to mimic bone metastasis on imaging tests. Herein, we report a case of a 55-year-old Japanese man who presented with a skin tumor on the left lower extremity. He also had a history of recurrent generalized cutaneous blister and erosion formation since childhood. His skin lesions were diagnosed as cutaneous squamous cell (...) carcinoma complicated by recessive dystrophic epidermolysis bullosa. Magnetic resonance imaging of the left lower extremity detected multiple focal bone lesions mimicking bone metastases in the left femur and tibia. However, bone biopsy revealed that the bone lesions were osteonecrosis without tumor cells. We suggest that cancer-induced osteonecrosis should be included in the differential diagnosis of bone lesions suspected of being metastases on magnetic resonance imaging.

2019 Acta Dermato-Venereologica

112. Interventions for non-metastatic squamous cell carcinoma of the skin. (PubMed)

Interventions for non-metastatic squamous cell carcinoma of the skin. Squamous cell carcinoma (SCC) is the second most common skin cancer, and is becoming increasingly common around the world. Left untreated, it may spread to other parts of the body, and, although the risk is low, it may ultimately lead to death. Surgical excision is the first line of treatment for most skin SCCs, although other forms of treatment are also used depending upon the nature and site of the tumour and individual (...) participant factors. A multi-professional approach is therefore required for the management of people with this condition.To assess the effects of treatments for primary non-metastatic squamous cell carcinoma of the skin.In February 2010 we searched for relevant trials in The Cochrane Skin Group Specialised Register, The Cochrane Library (Issue 1, 2010), MEDLINE, EMBASE, PsycINFO, AMED, LILACS, and the ongoing trials registries.We only included randomised controlled trials (RCTs) of interventions

2010 Cochrane

113. Nivolumab (squamous cell carcinoma of the head and neck) - Benefit assessment according to §35a Social Code Book V

Nivolumab (squamous cell carcinoma of the head and neck) - Benefit assessment according to §35a Social Code Book V Extract 1 Translation of Sections 2.1 to 2.6 of the dossier assessment Nivolumab (Plattenepithelkarzinom des Kopf-Hals- Bereichs) – Nutzenbewertung gemäß § 35a SGB V (Version 1.0; Status: 30 August 2017). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally (...) binding. IQWiG Reports – Commission No. A17-24 Nivolumab (squamous cell carcinoma of the head and neck) – Benefit assessment according to §35a Social Code Book V 1 Extract of dossier assessment A17-24 Version 1.0 Nivolumab (squamous cell carcinoma of the head and neck) 30 August 2017 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Nivolumab (squamous cell carcinoma of the head and neck) – Benefit

2017 Institute for Quality and Efficiency in Healthcare (IQWiG)

114. Altered density, composition and microanatomical distribution of infiltrating immune cells in cutaneous squamous cell carcinoma of organ transplant recipients. (PubMed)

Altered density, composition and microanatomical distribution of infiltrating immune cells in cutaneous squamous cell carcinoma of organ transplant recipients. The inflammatory tumour microenvironment is crucial for effective tumour control, and long-term immunosuppression has been identified as a major risk factor for skin carcinogenesis. In solid organ transplant recipients (OTRs) undergoing long-term pharmacological immunosuppression, an increased incidence of cutaneous squamous cell (...) carcinoma (SCC) and more aggressive tumour growth compared with immunocompetent patients has been reported.To determine the density and phenotype of immune cells infiltrating SCC and surrounding skin in OTRs, and to characterize the microanatomical distribution patterns in comparison with immunocompetent patients.We analysed immune cell infiltrates within SCC and at defined regions of interest (ROIs) of tumour-surrounding skin in formalin-fixed paraffin-embedded tissue of 20 renal transplant patients

2018 British Journal of Dermatology

115. Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin (Full text)

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic keratosis (AK). Despite various efforts to characterize these lesions molecularly, the etiology of AK and its progression to cSCC remain partially understood. Here, we use Infinium MethylationEPIC BeadChips to interrogate the DNA (...) methylation status in healthy, AK and cSCC epidermis samples. Importantly, we show that AK methylation patterns already display classical features of cancer methylomes and are highly similar to cSCC profiles. Further analysis identifies typical features of stem cell methylomes, such as reduced DNA methylation age, non-CpG methylation, and stem cell-related keratin and enhancer methylation patterns. Interestingly, this signature is detected only in half of the samples, while the other half shows patterns

2018 Nature communications PubMed

116. Thermal photodynamic therapy increases apoptosis and reactive oxygen species generation in cutaneous and mucosal squamous cell carcinoma cells (Full text)

Thermal photodynamic therapy increases apoptosis and reactive oxygen species generation in cutaneous and mucosal squamous cell carcinoma cells Thermal photodynamic therapy (PDT) is an emerging modality to optimize treatment of pre-cancerous squamous cell carcinoma (SCC) lesions, known as actinic keratoses. Thermal PDT involves heating the tissue, skin, or mucosa above normal skin temperature during 5-aminolevulinic (5-ALA) incubation and irradiating with blue light, which leads to cell (...) apoptosis and reactive oxygen species (ROS) generation. To our knowledge, thermal PDT has not been studied for the treatment of cutaneous or mucosal SCC. We incubated two SCC cell lines with 5-ALA for 30 minutes at temperatures between 21 °C and 42 °C and then irradiated cells with 1000 seconds of blue light. We measured changes in apoptosis, necrosis, and ROS. At 36 °C, there was a dose-dependent increase in apoptosis and ROS generation. Thermal incubation of 5-ALA at 39° and 42 °C followed by blue

2018 Scientific reports PubMed

117. Effects of insulin-like growth factor binding protein 3 on apoptosis of cutaneous squamous cell carcinoma cells (Full text)

differentially upregulated genes expressed in human cutaneous squamous cell carcinoma cell lines. Among these 10 genes, IGFBP3 was ranked number 1. By using immunohistochemistry, we found that the expression level of IGFBP3 was significantly elevated in CSCC tissue compared with that in normal human skin tissue. Knockdown of IGFBP3 in A431 cells by transfection with IGFBP3-specific siRNA markedly altered the expression of proteins that contribute to apoptosis via mitochondrial pathways, significantly (...) Effects of insulin-like growth factor binding protein 3 on apoptosis of cutaneous squamous cell carcinoma cells Cutaneous squamous cell carcinoma (CSCC) is the second most common carcinoma worldwide. Clinical treatment for patients with CSCC remains non-ideal. Insulin-like growth factor binding protein 3 (IGFBP3), a member of the insulin-like growth (IGF) system, participates in several biological processes, including cellular proliferation and apoptosis. Here, we explored the functional role

2018 OncoTargets and therapy PubMed

118. Current Basal and Squamous Cell Skin Cancer Management. (PubMed)

Current Basal and Squamous Cell Skin Cancer Management. After studying this article, the participant should be able to: 1. Characterize basal and squamous cell carcinomas as low or high risk based on size, location, histology, and clinical features. 2. Understand appropriate surgical margins in low- and high-risk lesions, and other management options, including Mohs micrographic surgery, electrodissection and curettage, topical agents, cryotherapy, photodynamic therapy, and radiation therapy. 3 (...) . Discuss adjuvant therapies for locally advanced and metastatic disease, including radiation therapy, chemotherapy, and targeted therapies such as hedgehog pathway inhibitors. 4. Educate patients on preventive measures such as skin examinations, sun protection, oral retinoids, and oral nicotinamide (vitamin B3). 5. Devise a reconstructive plan once clear oncologic margins are obtained.With the growing incidence of basal and squamous cell carcinoma, there is an increasing demand for appropriate

2018 Plastic and reconstructive surgery

119. Electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinoma (IPG478)

if it is not treated. Squamous cell carcinoma (SCC) is the second most common type of skin cancer in the UK. It may spread into local lymph nodes and metastasise to other parts of the body. Current treatments for BCC and SCC include surgical excision and radiotherapy, and less commonly curettage, cryotherapy and chemotherapy. The OPCS-4 codes for Electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinoma are: The relevant procurement/delivery codes in categories X70-X72 (depending (...) Electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinoma (IPG478) Overview | Electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinoma | Guidance | NICE Electrochemotherapy for primary basal cell carcinoma and primary squamous cell carcinoma Interventional procedures guidance [IPG478] Published date: February 2014 Share Save Guidance The National Institute for Health and Care Excellence (NICE) issued full guidance to the NHS

2014 National Institute for Health and Clinical Excellence - Interventional Procedures

120. Clinical comparison of actinic changes preceding squamous cell carcinoma vs. intraepidermal carcinoma in renal transplant recipients. (PubMed)

Clinical comparison of actinic changes preceding squamous cell carcinoma vs. intraepidermal carcinoma in renal transplant recipients. Intraepidermal carcinoma (IEC) is a type of in situ squamous cell carcinoma (SCC), although progression of IEC is rare. We sought to investigate differences between the actinic skin changes preceding the development of both SCC and IEC. Photographs of 63 skin sites at which either SCC or IEC subsequently developed in 37 renal transplant recipients (RTRs) were (...) examined for features of actinic change. We found that areas of skin with an actinic keratosis (AK) > 1 cm2 in size were four times more likely to develop SCC as opposed to IEC (OR = 4.42; 95% CI 1.25-15.60). Skin sites with ≥ 25% of the area affected by AK were again four times more likely to develop SCC than IEC. These results highlight the scale of visible actinic damage required for development of SCC compared with IEC, emphasizing the importance of treating areas of skin with marked visible

2017 Clinical & Experimental Dermatology

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