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Squamous Cell Carcinoma of the Skin

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81. Needs and preferences of patients regarding basal cell carcinoma and cutaneous squamous cell carcinoma care: a qualitative focus group study. Full Text available with Trip Pro

Needs and preferences of patients regarding basal cell carcinoma and cutaneous squamous cell carcinoma care: a qualitative focus group study. Despite the high and rising incidence rate of keratinocyte cancer (KC) and the importance of incorporating patient values into evidence-based care, few studies have focused on the perspectives of patients with KC.To identify the needs and preferences of patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) regarding care.A qualitative (...) takes you seriously and communicates well; (iii) a short waiting period and the best treatment with direct results; (iv) to be seen by the same physician; a preference for a dermatologist during (v) treatment and (vi) follow-up; (vii) a general need for structured follow-up care and (viii) a full-body skin examination during follow-up. Patients with BCC additionally expressed the need for openness and transparency and wanting to participate in shared decision making.It is advocated to organize skin

2018 British Journal of Dermatology

82. Collagens xv and XVIII show different expression and localisation in cutaneous squamous cell carcinoma: type XV appears in tumour stroma while XVIII becomes up-regulated in tumour cells and lost from microvessels. (Abstract)

Collagens xv and XVIII show different expression and localisation in cutaneous squamous cell carcinoma: type XV appears in tumour stroma while XVIII becomes up-regulated in tumour cells and lost from microvessels. As the second most common skin malignancy, cutaneous squamous cell carcinoma (cSCC) is an increasing health concern, while its pathogenesis at molecular level remains largely unknown. We studied the expression and localisation of two homologous basement membrane (BM) collagens, types (...) XV and XVIII, at different stages of cSCC. These collagens are involved in angiogenesis and tumorigenesis, but their role in cancer development is incompletely understood. Quantitative RT-PCR analysis revealed upregulation of collagen XVIII, but not collagen XV, in primary cSCC cells in comparison with normal human epidermal keratinocytes. In addition, the Ha-ras-transformed invasive cell line II-4 expressed high levels of collagen XVIII mRNA, indicating upregulation in the course of malignant

2015 Experimental Dermatology

83. The effect of wool hydrolysates on squamous cell carcinoma cells in vitro. Possible implications for cancer treatment. Full Text available with Trip Pro

The effect of wool hydrolysates on squamous cell carcinoma cells in vitro. Possible implications for cancer treatment. Squamous cell carcinoma of the skin is the second most common cutaneous malignancy. Despite various available treatment methods and advances in noninvasive diagnostic techniques, the incidence of metastatic cutaneous squamous cell carcinoma is rising. Deficiency in effective preventive or treatment methods of transformed keratinocytes leads to necessity of searching for new (...) anticancer agents. The present study aims to evaluate the possibility of using wool hydrolysates as such agents. Commercially available compounds such as 5-fluorouracil, ingenol mebutate, diclofenac sodium salt were also used in this study. The process of wool degradation was based on chemical pre-activation and enzymatic digestion of wool. The effect of mentioned compounds on cell viability of squamous carcinoma cell line and healthy keratinocytes was evaluated. The obtained data show a significantly

2017 PLoS ONE

84. Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. Full Text available with Trip Pro

of this disease. At 2 mg/kg, MS-275 significantly decreased tumor burden in an SKH-1 hairless mouse model of UVB radiation-induced skin carcinogenesis. MS-275 was cell permeable as a topical formulation and induced histone acetylation changes in mouse tumor tissue. MS-275 was also effective at inhibiting the proliferation of patient derived cutaneous squamous cell carcinoma lines and was particularly potent toward cells isolated from a regional metastasis on an immunocompromised individual. Our findings (...) Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. Cutaneous squamous cell carcinomas are a common form of highly mutated keratinocyte skin cancers that are of particular concern in immunocompromised patients. Here we report on the efficacy of topically applied MS-275, a clinically used histone deacetylase inhibitor, for the treatment and management

2019 PLoS ONE

85. p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker. Full Text available with Trip Pro

p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker. The p63 gene is often overexpressed in squamous cell carcinomas; however, how its overexpression contributes to tumor formation and expansion is still incompletely understood. Devos et al. report the development of a versatile mouse model demonstrating that p63 facilitates squamous cell carcinoma formation in skin and providing an excellent tool to dissect the relevance of its downstream signaling pathways

2017 Journal of Investigative Dermatology

86. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. Full Text available with Trip Pro

Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. The G-protein-coupled receptors LGR4, LGR5 and LGR6 are Wnt signaling mediators, but their functions in squamous cell carcinoma (SCC) are unclear. Using lineage tracing in Lgr5-EGFP-CreERT2/Rosa26-Tomato and Lgr6-EGFP-CreERT2/Rosa26-Tomato reporter mice, we demonstrate that Lgr6, but not Lgr5, acts as an epithelial stem cell marker in SCCs in vivo. We identify, by single-molecule in situ hybridization and cell sorting, rare cells (...) . These data provide a model for human patients with germline loss-of-function mutations in Wnt pathway genes, including RSPO1 or LGR4, who show increased susceptibility to squamous tumor development.

2017 Nature Genetics

87. DNA Damage-Inducible Transcript 4 Is an Innate Guardian for Human Squamous Cell Carcinoma and an Molecular Vector for Anti-carcinoma Effect of 1,25(OH)<sub>2</sub> D<sub>3</sub>. (Abstract)

DNA Damage-Inducible Transcript 4 Is an Innate Guardian for Human Squamous Cell Carcinoma and an Molecular Vector for Anti-carcinoma Effect of 1,25(OH)2 D3. Cutaneous squamous cell carcinoma (SCC) is one of the most common non-melanoma skin cancers worldwide. While its exact tumorigenesis mechanisms is far from well-established and less satisfied therapeutic strategy can be clinically used nowadays. In this study, we intended to investigate the role of DNA damage-inducible (...) vitamin D receptor (VDR)-DDIT4 transcription complex was verified by ChIP-qPCR, which showed the molecular mechanism of how 1,25(OH)2 D3 promotes DDIT4 transcription. Thirdly, xenograft tumor-bearing mice model treated by gradient concentrations of 1,25(OH)2 D3 revealed the obvious anti-carcinoma effect of 1,25(OH)2 D3 in vivo and DDIT4 acted the molecular vector of 1,25(OH)2 D3 through mTORC1. Lastly, elevated DDIT4 expression was verified in human actinic keratoses tissue, and chronic long-term

2018 Experimental Dermatology

88. The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study. (Abstract)

The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study. Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs).The aim of our study was to evaluate incidence and survival for cases of CACs and investigate their association with other skin neoplasms.We conducted a population-based study. Data on incident cases of CACs were obtained from the Tuscany Cancer Registry between 1985 and 2010. In order (...) to determine whether the occurrence of squamous cell carcinoma (SCC) among patients with CAC is higher or lower than expected in the general population, the standardized incidence ratio (SIR) was calculated.A total of 242 patients with CAC were observed; the age-standardized incidence rate was 3·8 cases per million person-years. From 1997 to 2010 crude incidence rates increased by 159%. Age-specific incidence was higher in men over 80 years old than in women of the same age and younger individuals

2018 British Journal of Dermatology

89. Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas Full Text available with Trip Pro

Recent advances in field cancerization and management of multiple cutaneous squamous cell carcinomas Cutaneous squamous cell carcinoma (SCC) is among the most common cancers in humans, and many patients with SCC will develop multiple tumors within their lifetime. The field cancerization concept, originally proposed over 60 years ago, hypothesized that multiple primary cancers may arise simultaneously and coexist with subclinical precursor lesions within a defined field. Genetic sequencing (...) of SCC and precursor lesions has identified what may be the earliest clonal proliferations in SCC development and confirmed that field cancerization in the skin is mediated by ultraviolet radiation. For patients with multiple SCCs and severe actinic damage, treatment of precursor lesions within a cancerized field can decrease the risk of subsequent cancer development. Sunblock is an effective intervention for field cancerization, even in patients with established disease. There is now direct evidence

2018 F1000Research

90. Management of Squamous Cell Cancer of the Vulva

cancers of the vulva have a high recurrence rate due to their association with human papillomavirus and skin dysplasia (high). 11 Vulvar squamous cell cancer with nodal recurrence is typically fatal and its treatment should be individualized and guided by the size of disease and previous treatment (low). Recommendations 1 Any worrisome vulvar lesion should be referred to an appropriate clinician for vulvar biopsy. Punch biopsies of adequate size (at least 4 mm wide) and depth (to subcutaneous fat (...) ) are most likely to achieve pathologic diagnosis (strong, high). 2 Once vulvar squamous cell cancer is diagnosed, a referral should be made to a gynaecologic oncologist (strong, high). 3 Clinicians should strongly recommend the human papillomavirus vaccine for all females 9 to 45 years of age to reduce the burden of all human papillomavirus–related diseases (strong, high). 4 Inguinal sentinel lymph node mapping for surgical staging of vulvar cancer is appropriate for unifocal tumours, <4 cm in widest

2019 Society of Obstetricians and Gynaecologists of Canada

91. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters. Full Text available with Trip Pro

The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters. 27193637 2018 02 22 2018 12 02 1600-0625 25 11 2016 11 Experimental dermatology Exp. Dermatol. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters. 863-864 10.1111/exd.13075 Missero Caterina C Department of Biology, University of Naples Federico II and CEINGE Biotecnologie Avanzate, Naples, Italy. caterina.missero@unina.it. eng Journal Article Comment Denmark Exp (...) Dermatol 9301549 0906-6705 0 Tumor Suppressor Protein p53 EC 3.1.3.67 PTEN Phosphohydrolase IM Exp Dermatol. 2016 Sep;25(9):733-5 27095696 Carcinoma, Squamous Cell genetics Evolution, Molecular Humans Mutation PTEN Phosphohydrolase genetics Tumor Suppressor Protein p53 genetics Pten Ras Rb1 Squamous Cell Carcinoma Tp53 2016 05 06 2016 10 30 6 0 2018 2 23 6 0 2016 5 20 6 0 ppublish 27193637 10.1111/exd.13075

2016 Experimental Dermatology

92. Management of primary cutaneous squamous cell carcinoma

) is a malignant tumour of keratinocytes arising within the epidermis or its appendages. It has a variable spectrum of clinical presentation and risk, ranging from the common, usually low-risk, keratotic plaque through to the less common, larger, rapidly growing and usually high-risk, exophytic skin lesion nodule. 1, 2 Squamous cell carcinoma is the second most common skin cancer, after basal cell carcinoma (BCC) and its incidence is increasing throughout the world. 3-5 In the 10-year period from 2001 to 2011 (...) with high-risk factors such as larger tumour diameter (p 0.1 mm was associated with increased risk of metastasis (HR 5.6, 95% CI 1.1 to 27.9) although this was due in part to the association with other high-risk factors such as tumour diameter and depth of invasion. 52 Many skin cancer staging systems use PNI as a high-risk feature. 21, 27 R Perineural invasion should be considered a high-risk feature in patients with primary squamous cell carcinoma. Presence or absence of perineural invasion should

2014 SIGN

93. Incidence of skin toxicity in squamous cell carcinoma of the head and neck treated with radiotherapy and cetuximab: A systematic review. (Abstract)

Incidence of skin toxicity in squamous cell carcinoma of the head and neck treated with radiotherapy and cetuximab: A systematic review. Radiotherapy plus cetuximab is an effective combination therapy for locally advanced head and neck squamous cell carcinoma. The aim of our study was to determine the frequency of skin toxicity in patients receiving the combined treatment.Forty-eight studies were included in our analysis, for a total of 2152 patients. The mean rates of G3/G4 radiation (...) dermatitis and acneiform rash were 32.5% (SD: 20.4; 95% CI: 28.5-36.5) and 13.4% (SD: 11.5; 95% CI: 11.2-15.6), respectively. The majority of studies referred to CTCAE scales for reporting both side effects (85.7% and 92.1%, respectively). Data on the management of skin toxicity were available in only 35.4% of the reviewed literature.severe radiation dermatitis is a frequent side effect induced by the combination of radiotherapy and cetuximab in head and neck cancer. The lack of predictive biomarkers

2017 Critical reviews in oncology/hematology

94. A giant squamous cell carcinoma of the skin of the thoracic wall: a case report and review of the literature Full Text available with Trip Pro

A giant squamous cell carcinoma of the skin of the thoracic wall: a case report and review of the literature We report a case of a 48-year-old white woman who presented with a huge cutaneous protruding tumor of the thoracic wall below her left breast.The lesion was excised with clear margins from the adjacent skin, and subcutaneous tissue was left to heal with second intention. A histological examination of the surgical specimen revealed a well-differentiated infiltrative cutaneous squamous (...) cell carcinoma. Our patient neglected to attend our Oncological Department to receive chemotherapy. Today, 12 months after surgery, she is alive and without evidence of disease recurrence.Cutaneous squamous cell carcinoma can reach a huge size if left untreated. Surgery is the primary mode of treatment, followed by chemotherapy if applicable.

2017 Journal of medical case reports

95. Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population Full Text available with Trip Pro

Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin cancers is as yet unknown.We aimed to investigate whether rice intake contributes to urinary arsenic concentration and risk of squamous cell carcinoma (SCC) of the skin in a U.S. population.Rice consumption was assessed using a food frequency

2017 Environmental health perspectives

96. Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1 Full Text available with Trip Pro

Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1 Antimicrobial peptide LL-37 serves a function in the host defense against microbial invasion, and also regulates cell proliferation, immune activity and angiogenesis. Previous studies have reported that LL-37 participates in the development of numerous tumour types, such as ovarian cancer, lung cancer, melanoma and breast cancer. However, the function of LL-37 in the development (...) of skin squamous cell carcinoma (SCC) has not yet been fully elucidated. The aim of the current study was to investigate how LL-37 promotes the expression of Y-box binding protein 1 (YB-1) in SCC. Short interfering RNA (siRNA) was used to inhibit the expression of YB-1, and in vitro MTT and Transwell migration assays were used to evaluate the effect of reduced YB-1 on the viability and invasion of A431 cells. A431 cells were stimulated with LL-37, and quantitative polymerase chain reaction

2017 Experimental and therapeutic medicine

97. Cetuximab Immunoliposomes enhance Delivery of 5-FU to Skin Squamous Carcinoma Cells Full Text available with Trip Pro

Cetuximab Immunoliposomes enhance Delivery of 5-FU to Skin Squamous Carcinoma Cells Topical chemotherapy of skin cancers is a promising strategy for reduction of side effects and for improvement of patient compliance. The combination of the chemotherapeutic 5-fluouracil (5-FU) and the anti- EGFR antibody cetuximab is a strategy to inhibit tumor growth. Their skin penetration, however, is hampered by their high hydrophilicity, which could be improved by encapsulation in delivery systems (...) different methods and drug-to-lipid ratios.Liposomes containing DSPC and Chol at drug-to-lipid ratio 0.1 prepared by the thin lipid hydration method resulted in the best 5-FU encapsulation and were chosen to conjugate with cetuximab. Cetuximab was directly coupled to preformed liposomes using DSPE-mPEG2000-Mal as an anchor. In A431 skin carcinoma cells, at 72 h, 5-FU liposomes showed a 5-fold lower IC50 than 5-FU solution. Additionally, 5-FU immunoliposomes resulted in a 4-fold lower cetuximab IC50 than

2017 Anti-cancer agents in medicinal chemistry

98. Evaluation of beta human papillomavirus in skin squamous cell carcinomas in immunosuppressed subjects: a systematic review

Evaluation of beta human papillomavirus in skin squamous cell carcinomas in immunosuppressed subjects: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) cell dose (linear); blinding of outcome assessment reported (stratified yes vs no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease models, the decision to pool certain units of measurement for an outcome

2019 PROSPERO

99. Surgical Treatment of Subungual Squamous Cell Carcinoma by Wide Excision of the Nail Unit and Skin Graft Reconstruction: An Evaluation of Treatment Efficiency and Outcomes. Full Text available with Trip Pro

Surgical Treatment of Subungual Squamous Cell Carcinoma by Wide Excision of the Nail Unit and Skin Graft Reconstruction: An Evaluation of Treatment Efficiency and Outcomes. The best surgical treatment modalities for subungual squamous cell carcinoma (SUSCC) without bone invasion need to be determined. The limited available data on Mohs micrographic surgery do not demonstrate its use as a standard procedure. A previous study in a limited series of patients has shown that wide surgical excision (...) of the nail unit was associated with a low rate of recurrence.To confirm the efficiency of wide surgical excision of the nail unit with full-thickness skin graft reconstruction on a series of patients with SUSCC with an extended follow-up and to evaluate short- and long-term postoperative morbidity and patient satisfaction.A consecutive series of 55 patients with biopsy-proven SUSCC without bone invasion treated by wide surgical excision of the nail unit followed by full-thickness skin graft

2017 JAMA dermatology (Chicago, Ill.)

100. Mohs micrographic surgery as treatment option for non-basal cell or squamous cell carcinomas in the United States. (Abstract)

Mohs micrographic surgery as treatment option for non-basal cell or squamous cell carcinomas in the United States. Background: Skin cancer has the highest incidence of all cancers in the United States. Conventional surgical excision (CSE) and Mohs micrographic surgery (MMS) are among the most common surgical treatment options for skin cancer. Objective: The purpose of this study was to examine utilization patterns of MMS compared to CSE in the United States for non-basal cell carcinoma (BCC (...) ) or squamous cell carcinoma (SCC) skin cancers. Methods: Data from the NCI SEER program, collected from 1973 to 2015, were retrospectively analyzed. Cases were separated into MMS and CSE. Patient characteristics were analyzed. Multivariate models were fitted to evaluate significant predictors for MMS. Results: Of the total procedures performed during the years 1988-2015, a total of 12,654 MMS cases and 267,291 CSE were considered for analysis. Females, white, and non-Hispanic patients of increasing age

2019 Journal of Dermatological Treatment

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