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Squamous Cell Carcinoma of the Skin

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61. Squamous Cell Carcinoma of the Skin

Squamous Cell Carcinoma of the Skin Squamous Cell Carcinoma of the Skin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Squamous Cell (...) Carcinoma of the Skin Squamous Cell Carcinoma of the Skin Aka: Squamous Cell Carcinoma of the Skin , Squamous Cell Skin Cancer , Squamous Cell Carcinoma , Cutaneous Squamous Cell Carcinoma From Related Chapters II. Epidemiology Age-adjusted : 100-150 per 100,000 persons/year Gender: Twice as common in males in Ethnicities with SCC as most common skin cancer Native Americans Black patients (Peak at ages 40-49) Ethnicities with SCC as second most common skin cancer Chinese and Japanese (peaks after age 60

2018 FP Notebook

62. DNA Damage-Inducible Transcript 4 Is an Innate Guardian for Human Squamous Cell Carcinoma and an Molecular Vector for Anti-carcinoma Effect of 1,25(OH)<sub>2</sub> D<sub>3</sub>. (Full text)

DNA Damage-Inducible Transcript 4 Is an Innate Guardian for Human Squamous Cell Carcinoma and an Molecular Vector for Anti-carcinoma Effect of 1,25(OH)2 D3. Cutaneous squamous cell carcinoma (SCC) is one of the most common non-melanoma skin cancers worldwide. While its exact tumorigenesis mechanisms is far from well-established and less satisfied therapeutic strategy can be clinically used nowadays. In this study, we intended to investigate the role of DNA damage-inducible (...) transcript 4 (DDIT4) in human SCC. Firstly, we identified DDIT4 is significantly suppressed in human SCC tissue and cultured A431 cell line, and reduced DDIT4 accelerates keratinocytes proliferation but impedes the autophagy flux through mTORC1 pathway by affecting the downstream S6 Kinase1, 4E-BP1, Beclin1 and LC3 II/I. While 1,25(OH)2 D3 enhanced DDIT4 expression and activated autophagy and inhibit mTORC1 to take the effect of anti-proliferation and activating autophagy. Further, formation of direct

2018 Experimental Dermatology PubMed abstract

63. The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study. (Abstract)

The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study. Recent studies have shown an increasing incidence of cutaneous adnexal carcinomas (CACs).The aim of our study was to evaluate incidence and survival for cases of CACs and investigate their association with other skin neoplasms.We conducted a population-based study. Data on incident cases of CACs were obtained from the Tuscany Cancer Registry between 1985 and 2010. In order (...) to determine whether the occurrence of squamous cell carcinoma (SCC) among patients with CAC is higher or lower than expected in the general population, the standardized incidence ratio (SIR) was calculated.A total of 242 patients with CAC were observed; the age-standardized incidence rate was 3·8 cases per million person-years. From 1997 to 2010 crude incidence rates increased by 159%. Age-specific incidence was higher in men over 80 years old than in women of the same age and younger individuals

2018 British Journal of Dermatology

64. ST2/IL-33 signaling promotes malignant development of experimental squamous cell carcinoma by decreasing NK cells cytotoxicity and modulating the intratumoral cell infiltrate (Full text)

ST2/IL-33 signaling promotes malignant development of experimental squamous cell carcinoma by decreasing NK cells cytotoxicity and modulating the intratumoral cell infiltrate Squamous cell carcinoma (SCC) is the second most common form of skin cancer and the mechanism(s) involved in the progression of this tumor are unknown. Increases in the expression of IL-33/ST2 axis components have been demonstrated to contribute to neoplastic transformation in several tumor models and interleukin-33 (...) is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue. Based on these observations, we sought to determine the role of the IL-33/ST2 pathway during the development of SCC. Our findings show that ST2-deficiency led to a marked decrease in the severity of skin lesions, suggesting that ST2 signaling contributed to tumor development. An analysis of tumor lesions in wild-type and ST2KO mice revealed that a lack of ST2 was associated with specific and significant reductions

2018 Oncotarget PubMed abstract

65. A case of multiple squamous cell carcinomas arising from red tattoo pigment (Full text)

A case of multiple squamous cell carcinomas arising from red tattoo pigment Ornamental tattooing involves the administration of exogenous pigments into the skin to create a permanent design. Our case focuses on a 62-year-old woman who presented with an inflamed enlarging nodule on her right proximal calf, which arose within the red pigment of an ornamental tattoo. The nodule was diagnosed as squamous cell carcinoma (SCC) and subsequently excised. Over the course of the following year (...) , the patient was diagnosed with a total of five additional SCCs that also arose within the red pigment of the tattoo. The increased popularity of tattooing and the lack of industry safety standards for tattoo ink production, especially metal-laden red pigments, may lead to more cases of skin cancer arising within tattoos among patients of all ages.

2017 International journal of women's dermatology PubMed abstract

66. Atezolizumab (Tecentriq) - Non-Small-Cell Lung Carcinoma or Transitional Cell Carcinoma

Atezolizumab (Tecentriq) - Non-Small-Cell Lung Carcinoma or Transitional Cell Carcinoma 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5555 Send a question via our website www.ema.europa.eu/contact © European Medicines Agency, 2018. Reproduction is authorised provided the source is acknowledged. 20 July 2017 EMA/153102/2018 Committee for Medicinal Products for Human Use (CHMP) Assessment (...) -free survival PK pharmacokinetic Assessment report EMA/153102/2018 Page 6/205 PS performance status PR partial response q3w every 3 weeks QA quality attribute QbD Quality by Design RECIST Response Evaluation Criteria in Solid Tumors SAE serious adverse event SAT severe acute toxicity SD stable disease SOC system organ class TCC transitional cell carcinoma TIR time in response TTOR time to onset of response UC urothelial carcinoma Vss volume of distribution at steady state Assessment report EMA

2017 European Medicines Agency - EPARs

67. Thermal photodynamic therapy increases apoptosis and reactive oxygen species generation in cutaneous and mucosal squamous cell carcinoma cells (Full text)

Thermal photodynamic therapy increases apoptosis and reactive oxygen species generation in cutaneous and mucosal squamous cell carcinoma cells Thermal photodynamic therapy (PDT) is an emerging modality to optimize treatment of pre-cancerous squamous cell carcinoma (SCC) lesions, known as actinic keratoses. Thermal PDT involves heating the tissue, skin, or mucosa above normal skin temperature during 5-aminolevulinic (5-ALA) incubation and irradiating with blue light, which leads to cell (...) apoptosis and reactive oxygen species (ROS) generation. To our knowledge, thermal PDT has not been studied for the treatment of cutaneous or mucosal SCC. We incubated two SCC cell lines with 5-ALA for 30 minutes at temperatures between 21 °C and 42 °C and then irradiated cells with 1000 seconds of blue light. We measured changes in apoptosis, necrosis, and ROS. At 36 °C, there was a dose-dependent increase in apoptosis and ROS generation. Thermal incubation of 5-ALA at 39° and 42 °C followed by blue

2018 Scientific reports PubMed abstract

68. Effects of insulin-like growth factor binding protein 3 on apoptosis of cutaneous squamous cell carcinoma cells (Full text)

differentially upregulated genes expressed in human cutaneous squamous cell carcinoma cell lines. Among these 10 genes, IGFBP3 was ranked number 1. By using immunohistochemistry, we found that the expression level of IGFBP3 was significantly elevated in CSCC tissue compared with that in normal human skin tissue. Knockdown of IGFBP3 in A431 cells by transfection with IGFBP3-specific siRNA markedly altered the expression of proteins that contribute to apoptosis via mitochondrial pathways, significantly (...) Effects of insulin-like growth factor binding protein 3 on apoptosis of cutaneous squamous cell carcinoma cells Cutaneous squamous cell carcinoma (CSCC) is the second most common carcinoma worldwide. Clinical treatment for patients with CSCC remains non-ideal. Insulin-like growth factor binding protein 3 (IGFBP3), a member of the insulin-like growth (IGF) system, participates in several biological processes, including cellular proliferation and apoptosis. Here, we explored the functional role

2018 OncoTargets and therapy PubMed abstract

69. Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin (Full text)

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic keratosis (AK). Despite various efforts to characterize these lesions molecularly, the etiology of AK and its progression to cSCC remain partially understood. Here, we use Infinium MethylationEPIC BeadChips to interrogate the DNA (...) methylation status in healthy, AK and cSCC epidermis samples. Importantly, we show that AK methylation patterns already display classical features of cancer methylomes and are highly similar to cSCC profiles. Further analysis identifies typical features of stem cell methylomes, such as reduced DNA methylation age, non-CpG methylation, and stem cell-related keratin and enhancer methylation patterns. Interestingly, this signature is detected only in half of the samples, while the other half shows patterns

2018 Nature communications PubMed abstract

70. Altered density, composition and microanatomical distribution of infiltrating immune cells in cutaneous squamous cell carcinoma of organ transplant recipients. (Abstract)

Altered density, composition and microanatomical distribution of infiltrating immune cells in cutaneous squamous cell carcinoma of organ transplant recipients. The inflammatory tumour microenvironment is crucial for effective tumour control, and long-term immunosuppression has been identified as a major risk factor for skin carcinogenesis. In solid organ transplant recipients (OTRs) undergoing long-term pharmacological immunosuppression, an increased incidence of cutaneous squamous cell (...) carcinoma (SCC) and more aggressive tumour growth compared with immunocompetent patients has been reported.To determine the density and phenotype of immune cells infiltrating SCC and surrounding skin in OTRs, and to characterize the microanatomical distribution patterns in comparison with immunocompetent patients.We analysed immune cell infiltrates within SCC and at defined regions of interest (ROIs) of tumour-surrounding skin in formalin-fixed paraffin-embedded tissue of 20 renal transplant patients

2018 British Journal of Dermatology

71. The effect of wool hydrolysates on squamous cell carcinoma cells in vitro. Possible implications for cancer treatment. (Full text)

The effect of wool hydrolysates on squamous cell carcinoma cells in vitro. Possible implications for cancer treatment. Squamous cell carcinoma of the skin is the second most common cutaneous malignancy. Despite various available treatment methods and advances in noninvasive diagnostic techniques, the incidence of metastatic cutaneous squamous cell carcinoma is rising. Deficiency in effective preventive or treatment methods of transformed keratinocytes leads to necessity of searching for new (...) anticancer agents. The present study aims to evaluate the possibility of using wool hydrolysates as such agents. Commercially available compounds such as 5-fluorouracil, ingenol mebutate, diclofenac sodium salt were also used in this study. The process of wool degradation was based on chemical pre-activation and enzymatic digestion of wool. The effect of mentioned compounds on cell viability of squamous carcinoma cell line and healthy keratinocytes was evaluated. The obtained data show a significantly

2017 PLoS ONE PubMed abstract

72. Current Basal and Squamous Cell Skin Cancer Management. (Abstract)

Current Basal and Squamous Cell Skin Cancer Management. After studying this article, the participant should be able to: 1. Characterize basal and squamous cell carcinomas as low or high risk based on size, location, histology, and clinical features. 2. Understand appropriate surgical margins in low- and high-risk lesions, and other management options, including Mohs micrographic surgery, electrodissection and curettage, topical agents, cryotherapy, photodynamic therapy, and radiation therapy. 3 (...) . Discuss adjuvant therapies for locally advanced and metastatic disease, including radiation therapy, chemotherapy, and targeted therapies such as hedgehog pathway inhibitors. 4. Educate patients on preventive measures such as skin examinations, sun protection, oral retinoids, and oral nicotinamide (vitamin B3). 5. Devise a reconstructive plan once clear oncologic margins are obtained.With the growing incidence of basal and squamous cell carcinoma, there is an increasing demand for appropriate

2018 Plastic and reconstructive surgery

73. Survival Outcomes for Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck. (Abstract)

Survival Outcomes for Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck. Survival outcomes for advanced non-melanoma skin cancers of the head and neck treated with surgical resection are not well described in the literature. We aimed to describe outcomes for T3 and T4 cutaneoous squamous cell carcinoma of the head or neck treated with surgical resection at 1 tertiary academic medical center.We analyzed a retrospective cohort of patients diagnosed with T3 or T4 cutaneous squamous (...) cell carcinoma (SCC) of the head or neck from 2005 to 2016 treated with definitive surgical resection. Survival outcomes were examined using Kaplan-Meier analysis, and multivariate analysis was completed with Cox proportional hazard model.Forty-three patients met inclusion criteria. The mean age at diagnosis was 74.7 years (SD = 10.2), and 34 (79.1%) patients were male. Twelve (27.9%) patients were immunosuppressed. Radical resection, defined as temporal bone resection, orbital exenteration

2019 Rhinology and Laryngology

74. The detection rate of Human Papillomavirus (HPV) in well differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma? (Abstract)

The detection rate of Human Papillomavirus (HPV) in well differentiated squamous cell carcinoma and keratoacanthoma: is there new evidence for a viral pathogenesis of keratoacanthoma? The "keratinocyte skin cancer" term stands as a sort of umbrella covering different stages within the progression of cutaneous squamous cell carcinoma (cSCC). The invasive forms of are further classified on the basis of histopathologic differentiation grade as well differentiated, moderate and poorly

2019 British Journal of Dermatology

75. Immunotherapeutic Strategies for Cutaneous Squamous Cell Carcinoma Prevention in Xeroderma Pigmentosum. (Abstract)

Immunotherapeutic Strategies for Cutaneous Squamous Cell Carcinoma Prevention in Xeroderma Pigmentosum. Xeroderma pigmentosum (XP) is an autosomal recessive disorder of nucleotide excision repair, characterized by hypersensitivity to ultraviolet light (UV) radiation.1-3 In individuals with XP, the incidence of non-melanoma skin cancers prior to the age of 20 years is approximately 10,000 times that seen in the general population.4 The most common cause of death in this patient population (...) is skin cancer, including metastatic melanoma and metastatic cutaneous squamous cell carcinoma (cSCC).4 Sun avoidance is the main mode of skin cancer prevention in XP patients.5 However, the development of invasive skin cancers at an early age and challenges associated with avoiding sun exposure highlight the critical need for additional cancer prevention strategies in this high-risk population. We report cSCC incidence before and after starting immune checkpoint blockade (ICB) therapy in a single

2019 British Journal of Dermatology

76. Characteristics of Patients Hospitalized for Cutaneous Squamous Cell Carcinoma. (Abstract)

Characteristics of Patients Hospitalized for Cutaneous Squamous Cell Carcinoma. Knowledge regarding the inpatient burden of cutaneous squamous cell carcinoma (cSCC) is limited.To provide nationally representative estimates for hospitalization characteristics due to cSCC and determine predictors for increased length of stay (LOS) and cost of care.A retrospective cohort study of the 2009 to 2015 National Inpatient Sample. Weighted multivariate logistic/linear regression models were created (...) to evaluate sociodemographic factors associated with cSCC hospitalization and to assess characteristics associated with cost of care and LOS.This study included 15,784 cSCC and 255,244,626 non-SCC inpatients (prevalence = 6.2/100,000 inpatients). On average, cSCC hospitalizations lasted 5.8 days and cost $66,841.00. Cutaneous squamous cell carcinoma most often occurred on the scalp (30.57%), face (21.08%), and lower limb (11.93%). Controlling for all other factors, cSCC inpatients presented to larger

2019 Dermatologic Surgery

77. Validation of the English Basal and Squamous Cell Carcinoma Quality of Life (BaSQoL) Questionnaire. (Abstract)

was a prospective, observational study. Patients with basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) were asked to fill out BaSQoL, Skin Cancer Index (SCI), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Descriptive statistics and classical test theory were used to assess validity.One hundred eighty-seven subjects enrolled in this study: 122 with BCC and 65 with SCC. One hundred seventy-one subjects (91.4%) completed questionnaires at all 3 time points; 16 patients (8.6%) were (...) Validation of the English Basal and Squamous Cell Carcinoma Quality of Life (BaSQoL) Questionnaire. Keratinocyte carcinomas (KC) impact patient quality of life (QoL). There is a need for validated QoL instruments specific to KC. The Basal and Squamous Cell Carcinoma QoL (BaSQoL) questionnaire was developed to comprehensively measure issues of importance to patients with KC.To validate and characterize the BaSQoL questionnaire for QoL measurement after diagnosis and treatment of KC.This

2019 Dermatologic Surgery

78. Unusual Bone Lesions with Osteonecrosis Mimicking Bone Metastasis of Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa. (Full text)

Unusual Bone Lesions with Osteonecrosis Mimicking Bone Metastasis of Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa. Some bone lesions are reported to mimic bone metastasis on imaging tests. Herein, we report a case of a 55-year-old Japanese man who presented with a skin tumor on the left lower extremity. He also had a history of recurrent generalized cutaneous blister and erosion formation since childhood. His skin lesions were diagnosed as cutaneous squamous cell (...) carcinoma complicated by recessive dystrophic epidermolysis bullosa. Magnetic resonance imaging of the left lower extremity detected multiple focal bone lesions mimicking bone metastases in the left femur and tibia. However, bone biopsy revealed that the bone lesions were osteonecrosis without tumor cells. We suggest that cancer-induced osteonecrosis should be included in the differential diagnosis of bone lesions suspected of being metastases on magnetic resonance imaging.

2019 Acta Dermato-Venereologica PubMed abstract

79. The role of reflectance confocal microscopy in the diagnosis and management of squamous cell carcinoma in situ treated with photodynamic therapy. (Abstract)

The role of reflectance confocal microscopy in the diagnosis and management of squamous cell carcinoma in situ treated with photodynamic therapy. Reflectance confocal microscopy (RCM) is increasingly used for noninvasive in vivo diagnosis of skin cancers. We seek to determine if RCM is useful for the diagnosis and follow-up of squamous cell carcinoma in situ (SCCIS) posttreatment to document clearance.A pilot prospective study enrolled 10 patients with a total of 11 SCCIS lesions. Clinical (...) cases (25%) showed numerous epidermal dendritic cells, while small bright refractive cells were present in the epidermis in two lesions (25%). Round blood vessels in the superficial dermis were seen in four lesions (50%), while three lesions (37.5%) showed dermal inflammatory cells.There was good correlation between histological and confocal features in patients who underwent RCM imaging prior to biopsy. RCM may be a complementary tool in diagnosing SCCIS and to monitor response to nonsurgical

2019 International Journal of Dermatology

80. Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States. (Full text)

Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States. Retinoids are bioactive forms of vitamin A that are essential in the maintenance of epithelial maturation and differentiation. Synthetic retinoids are used in chemoprevention of skin cancer among high-risk populations with potential adverse effects. Epidemiologic data on vitamin A intake and risk of cutaneous squamous cell carcinoma (SCC) are limited.To examine whether vitamin A intake

2019 JAMA dermatology (Chicago, Ill.) PubMed abstract

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