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Squamous Cell Carcinoma of the Skin

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41. A giant squamous cell carcinoma of the skin of the thoracic wall: a case report and review of the literature (PubMed)

A giant squamous cell carcinoma of the skin of the thoracic wall: a case report and review of the literature We report a case of a 48-year-old white woman who presented with a huge cutaneous protruding tumor of the thoracic wall below her left breast.The lesion was excised with clear margins from the adjacent skin, and subcutaneous tissue was left to heal with second intention. A histological examination of the surgical specimen revealed a well-differentiated infiltrative cutaneous squamous (...) cell carcinoma. Our patient neglected to attend our Oncological Department to receive chemotherapy. Today, 12 months after surgery, she is alive and without evidence of disease recurrence.Cutaneous squamous cell carcinoma can reach a huge size if left untreated. Surgery is the primary mode of treatment, followed by chemotherapy if applicable.

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2017 Journal of medical case reports

42. Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1 (PubMed)

Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1 Antimicrobial peptide LL-37 serves a function in the host defense against microbial invasion, and also regulates cell proliferation, immune activity and angiogenesis. Previous studies have reported that LL-37 participates in the development of numerous tumour types, such as ovarian cancer, lung cancer, melanoma and breast cancer. However, the function of LL-37 in the development (...) of skin squamous cell carcinoma (SCC) has not yet been fully elucidated. The aim of the current study was to investigate how LL-37 promotes the expression of Y-box binding protein 1 (YB-1) in SCC. Short interfering RNA (siRNA) was used to inhibit the expression of YB-1, and in vitro MTT and Transwell migration assays were used to evaluate the effect of reduced YB-1 on the viability and invasion of A431 cells. A431 cells were stimulated with LL-37, and quantitative polymerase chain reaction

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2017 Experimental and therapeutic medicine

43. A case report of Muir-Torre syndrome in a woman with breast cancer and MSI-Low skin squamous cell carcinoma (PubMed)

A case report of Muir-Torre syndrome in a woman with breast cancer and MSI-Low skin squamous cell carcinoma The tumor spectrum in the Lynch syndrome is well defined, comprising an increased risk of developing colonic and extracolonic malignancies. Muir-Torre syndrome is a variant with a higher risk of skin disease. Patients have been described carrying mutations in the mismatch repair genes and presenting tumors with unusual histology or affected organ not part of the Lynch syndrome spectrum (...) . Hence, the real link between Lynch syndrome, or Muir-Torre syndrome, and these tumors remains difficult to assess.We present the case of a 45-year-old-woman, diagnosed with breast cancer at 39 years of age and skin squamous cell carcinoma (SCC) at 41 years of age, without personal history of colorectal cancer. The microsatellite instability analysis performed on the skin SCC showed a low-level of microsatellite instability (MSI-Low). The immunohistochemical expression analysis of the four DNA

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2017 Hereditary cancer in clinical practice

44. Cetuximab Immunoliposomes enhance Delivery of 5-FU to Skin Squamous Carcinoma Cells (PubMed)

Cetuximab Immunoliposomes enhance Delivery of 5-FU to Skin Squamous Carcinoma Cells Topical chemotherapy of skin cancers is a promising strategy for reduction of side effects and for improvement of patient compliance. The combination of the chemotherapeutic 5-fluouracil (5-FU) and the anti- EGFR antibody cetuximab is a strategy to inhibit tumor growth. Their skin penetration, however, is hampered by their high hydrophilicity, which could be improved by encapsulation in delivery systems (...) different methods and drug-to-lipid ratios.Liposomes containing DSPC and Chol at drug-to-lipid ratio 0.1 prepared by the thin lipid hydration method resulted in the best 5-FU encapsulation and were chosen to conjugate with cetuximab. Cetuximab was directly coupled to preformed liposomes using DSPE-mPEG2000-Mal as an anchor. In A431 skin carcinoma cells, at 72 h, 5-FU liposomes showed a 5-fold lower IC50 than 5-FU solution. Additionally, 5-FU immunoliposomes resulted in a 4-fold lower cetuximab IC50 than

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2017 Anti-cancer agents in medicinal chemistry

45. Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population (PubMed)

Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin cancers is as yet unknown.We aimed to investigate whether rice intake contributes to urinary arsenic concentration and risk of squamous cell carcinoma (SCC) of the skin in a U.S. population.Rice consumption was assessed using a food frequency

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2017 Environmental health perspectives

46. Frequency of Squamous Cell Carcinoma In Situ and Squamous Cell Carcinoma in Re-Excisions of Biopsy-Proven Cutaneous Squamous Cell Carcinoma In Situ. (PubMed)

Frequency of Squamous Cell Carcinoma In Situ and Squamous Cell Carcinoma in Re-Excisions of Biopsy-Proven Cutaneous Squamous Cell Carcinoma In Situ. 27943251 2019 03 25 2019 03 25 1365-2133 177 6 2017 12 The British journal of dermatology Br. J. Dermatol. Frequency of squamous cell carcinoma in situ (SCCIS) and SCC in re-excisions of biopsy-proven cutaneous SCCIS. 1747-1748 10.1111/bjd.15230 Chang Y C YC Department of Dermatology, Boston University School of Medicine, 609 Albany St, Boston, MA (...) Keratosis, Actinic pathology Male Neoplasm Recurrence, Local pathology Reoperation Retrospective Studies Skin Neoplasms pathology surgery 2016 12 13 6 0 2019 3 26 6 0 2016 12 13 6 0 ppublish 27943251 10.1111/bjd.15230

2016 British Journal of Dermatology

47. Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. (PubMed)

Immunosuppressive Medications and Squamous Cell Skin Carcinoma: Nested Case-Control Study Within the Skin Cancer after Organ Transplant (SCOT) Cohort. Organ transplant recipients (OTRs) have a substantially elevated risk of squamous cell skin carcinoma (SCSC), largely attributed to immunosuppressive medications used to prevent graft rejection, although data to support the role of newer drugs in SCSC risk are sparse. We investigated the association between immunosuppressive medications and SCSC (...) risk among cardiac and renal transplant recipients in the SCOT cohort study. Incident cases were ascertained through medical record review after self-report of skin biopsy (n = 170). Controls without SCSC (n = 324) were matched to cases on sex, age, race, transplant year, hospital, donor type, organ transplanted, and time between transplantation and interview. Conditional logistic regression was used to evaluate the association between specific medications and SCSC. Users of the antimetabolite

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2016 American Journal of Transplantation

48. Post-hysterectomy rare collision vulva tumor with long-term human papilloma virus infection composed of squamous cell carcinoma of the labia major and adenosquamous carcinoma of bartholin gland: A case report. (PubMed)

with long-term HPV infection composed of squamous cell carcinoma of the labia major and adenosquamous carcinoma of bartholin gland.The extensive excision of the vulva, bilateral inguinal lymph nodes dissection, and local skin flap transposition surgeon was done to this patient. The final certificate diagnosis was: vulvar tumor T1bM0N0 composed of squamous cell carcinoma of the labia major and adenosquamous carcinoma of bartholin gland; HPV infection; post hysterectomy, and bilateral salpingectomy.The (...) Post-hysterectomy rare collision vulva tumor with long-term human papilloma virus infection composed of squamous cell carcinoma of the labia major and adenosquamous carcinoma of bartholin gland: A case report. Post-hysterectomy collision tumors of the vulva has rarely been reported. Though long-term HPV infection may induce vulva tumor, but the relationship between HPV infection and collision vulva tumor is not clear. And there are no clear rules of the post-hysterectomy cancer surveillance

2019 Medicine

49. Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. (PubMed)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. Cutaneous squamous cell carcinomas are a common form of highly mutated keratinocyte skin cancers that are of particular concern in immunocompromised patients. Here we report on the efficacy of topically applied MS-275, a clinically used histone deacetylase inhibitor, for the treatment and management (...) of this disease. At 2 mg/kg, MS-275 significantly decreased tumor burden in an SKH-1 hairless mouse model of UVB radiation-induced skin carcinogenesis. MS-275 was cell permeable as a topical formulation and induced histone acetylation changes in mouse tumor tissue. MS-275 was also effective at inhibiting the proliferation of patient derived cutaneous squamous cell carcinoma lines and was particularly potent toward cells isolated from a regional metastasis on an immunocompromised individual. Our findings

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2019 PLoS ONE

50. Needs and preferences of patients regarding basal cell carcinoma and cutaneous squamous cell carcinoma care: a qualitative focus group study. (PubMed)

Needs and preferences of patients regarding basal cell carcinoma and cutaneous squamous cell carcinoma care: a qualitative focus group study. Despite the high and rising incidence rate of keratinocyte cancer (KC) and the importance of incorporating patient values into evidence-based care, few studies have focused on the perspectives of patients with KC.To identify the needs and preferences of patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) regarding care.A qualitative (...) takes you seriously and communicates well; (iii) a short waiting period and the best treatment with direct results; (iv) to be seen by the same physician; a preference for a dermatologist during (v) treatment and (vi) follow-up; (vii) a general need for structured follow-up care and (viii) a full-body skin examination during follow-up. Patients with BCC additionally expressed the need for openness and transparency and wanting to participate in shared decision making.It is advocated to organize skin

2018 British Journal of Dermatology

51. A case of combined Merkel cell carcinoma and squamous cell carcinoma: Molecular insights and diagnostic pitfalls (PubMed)

of Michigan, Ann Arbor, Michigan. Department of Dermatology, University of Michigan, Ann Arbor, Michigan. Harms Paul W PW Department of Pathology, University of Michigan, Ann Arbor, Michigan. Department of Dermatology, University of Michigan, Ann Arbor, Michigan. eng Case Reports 2018 11 03 United States JAAD Case Rep 101665210 2352-5126 MCC, Merkel cell carcinoma MCPyV, Merkel cell polyomavirus MMS, Mohs micrographic surgery Merkel cell carcinoma NMSC, nonmelanoma skin cancer SCC, squamous cell carcinoma (...) A case of combined Merkel cell carcinoma and squamous cell carcinoma: Molecular insights and diagnostic pitfalls 30417062 2019 02 26 2352-5126 4 10 2018 Nov JAAD case reports JAAD Case Rep A case of combined Merkel cell carcinoma and squamous cell carcinoma: Molecular insights and diagnostic pitfalls. 996-999 10.1016/j.jdcr.2018.08.004 Falto Aizpurua Leyre A LA Department of Dermatology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico. Wang Min M Department

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2018 JAAD Case Reports

52. Tumor cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma. (PubMed)

Tumor cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma. Incidence of epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is increasing worldwide.To study the role of complement classical pathway components C1q, C1r and C1s in the progression of cSCC.The mRNA levels of C1Q subunits, C1R and C1S in cSCC cell lines, normal human epidermal keratinocytes (NHEKs), cSCC tumors in vivo and normal skin were analyzed with quantitative (...) skin. Abundant expression of C1r and C1s by tumor cells was detected in invasive sporadic cSCCs and recessive dystrophic epidermolysis bullosa-associated cSCCs, whereas the expression of C1r and C1s was lower in cSCC in situ, actinic keratosis, and normal skin. Knockdown of C1r and C1s expression in cSCC cells inhibited activation of ERK1/2 and Akt, promoted apoptosis of cSCC cells and significantly suppressed growth and vascularization of human cSCC xenograft tumors in vivo.These results provide

2019 British Journal of Dermatology

53. Mohs micrographic surgery as treatment option for non-basal cell or squamous cell carcinomas in the United States. (PubMed)

Mohs micrographic surgery as treatment option for non-basal cell or squamous cell carcinomas in the United States. Background: Skin cancer has the highest incidence of all cancers in the United States. Conventional surgical excision (CSE) and Mohs micrographic surgery (MMS) are among the most common surgical treatment options for skin cancer. Objective: The purpose of this study was to examine utilization patterns of MMS compared to CSE in the United States for non-basal cell carcinoma (BCC (...) ) or squamous cell carcinoma (SCC) skin cancers. Methods: Data from the NCI SEER program, collected from 1973 to 2015, were retrospectively analyzed. Cases were separated into MMS and CSE. Patient characteristics were analyzed. Multivariate models were fitted to evaluate significant predictors for MMS. Results: Of the total procedures performed during the years 1988-2015, a total of 12,654 MMS cases and 267,291 CSE were considered for analysis. Females, white, and non-Hispanic patients of increasing age

2019 Journal of Dermatological Treatment

54. Management of primary cutaneous squamous cell carcinoma

) is a malignant tumour of keratinocytes arising within the epidermis or its appendages. It has a variable spectrum of clinical presentation and risk, ranging from the common, usually low-risk, keratotic plaque through to the less common, larger, rapidly growing and usually high-risk, exophytic skin lesion nodule. 1, 2 Squamous cell carcinoma is the second most common skin cancer, after basal cell carcinoma (BCC) and its incidence is increasing throughout the world. 3-5 In the 10-year period from 2001 to 2011 (...) with high-risk factors such as larger tumour diameter (p 0.1 mm was associated with increased risk of metastasis (HR 5.6, 95% CI 1.1 to 27.9) although this was due in part to the association with other high-risk factors such as tumour diameter and depth of invasion. 52 Many skin cancer staging systems use PNI as a high-risk feature. 21, 27 R Perineural invasion should be considered a high-risk feature in patients with primary squamous cell carcinoma. Presence or absence of perineural invasion should

2014 SIGN

55. Nivolumab (squamous cell carcinoma of the head and neck) - Addendum to Commission A17-24

Nivolumab (squamous cell carcinoma of the head and neck) - Addendum to Commission A17-24 1 Translation of addendum A17-54 Nivolumab (Plattenepithelkarzinom des Kopf-Hals-Bereichs) – Addendum zum Auftrag A17-24 (Version 1.0; Status: 25 October 2017). Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Addendum 25 October 2017 1.0 Commission: A17-54 Version: Status (...) : IQWiG Reports – Commission No. A17-54 Nivolumab (squamous cell carcinoma of the head and neck) – Addendum to Commission A17-24 1 Addendum A17-54 Version 1.0 Nivolumab – Addendum to Commission A17-24 25 October 2017 Institute for Quality and Efficiency in Health Care (IQWiG) - i - Publishing details Publisher: Institute for Quality and Efficiency in Health Care Topic: Nivolumab (squamous cell carcinoma of the head and neck) – Addendum to Commission A17-24 Commissioning agency: Federal Joint Committee

2018 Institute for Quality and Efficiency in Healthcare (IQWiG)

56. A case of multiple squamous cell carcinomas arising from red tattoo pigment (PubMed)

A case of multiple squamous cell carcinomas arising from red tattoo pigment Ornamental tattooing involves the administration of exogenous pigments into the skin to create a permanent design. Our case focuses on a 62-year-old woman who presented with an inflamed enlarging nodule on her right proximal calf, which arose within the red pigment of an ornamental tattoo. The nodule was diagnosed as squamous cell carcinoma (SCC) and subsequently excised. Over the course of the following year (...) , the patient was diagnosed with a total of five additional SCCs that also arose within the red pigment of the tattoo. The increased popularity of tattooing and the lack of industry safety standards for tattoo ink production, especially metal-laden red pigments, may lead to more cases of skin cancer arising within tattoos among patients of all ages.

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2017 International journal of women's dermatology

57. Antimicrobial peptide LL-37 promotes the proliferation and invasion of skin squamous cell carcinoma by upregulating DNA-binding protein A (PubMed)

Antimicrobial peptide LL-37 promotes the proliferation and invasion of skin squamous cell carcinoma by upregulating DNA-binding protein A The antimicrobial peptide LL-37 not only contributes to the host defence against microbial invasion but also regulates immune activity, angiogenesis and cell proliferation. Studies have shown that LL-37 participates in the development of a variety of tumours, such as lung cancer, ovarian cancer, breast cancer and melanoma. However, the role of LL-37 (...) in the development of skin squamous cell carcinoma (SCC) is not clear. The present study used immunohistochemistry to confirm that the expression of human DNA-binding protein A (dbpA) was increased in SCC tissues. After stimulating SCC A341 cells, LL-37 was shown promote the proliferation, migration and invasion of these malignant cells. LL-37 also promoted the upregulation of dbpA mRNA and protein expression. In addition, after using small interfering RNA to silence the normal dbpA expression in these malignant

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2016 Oncology letters

58. From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers (PubMed)

From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers Squamous cells carcinoma (SCC) is the second most frequent of the keratinocyte-derived malignancies after basal cell carcinoma and is associated with a significant psychosocial and economic burden for both the patient himself and society. Reported risk factors for the malignant transformation of keratinocytes and development of SCC include ultraviolet light exposure, followed by chronic scarring and inflammation, exposure

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2016 Disease markers

59. An unusual acneiform presentation representing secondary squamous cell carcinoma of the skin (PubMed)

An unusual acneiform presentation representing secondary squamous cell carcinoma of the skin 27222879 2016 05 25 2019 02 26 2352-5126 2 2 2016 Mar JAAD case reports JAAD Case Rep An unusual acneiform presentation representing secondary squamous cell carcinoma of the skin. 168-70 10.1016/j.jdcr.2016.02.004 Graham Paul M PM Department of Dermatology, St Joesph Mercy Dermatology, Ann Arbor, Michigan. Kolb Logan J LJ Des Moines University, Des Moines, Iowa. Mortazie Michael M Department (...) of Dermatology, St Joesph Mercy Dermatology, Ann Arbor, Michigan. Ramirez James J Department of Dermatopathology, St Joesph Mercy Dermatology, Ann Arbor, Michigan. Fivenson David D Department of Dermatology, St Joesph Mercy Dermatology, Ann Arbor, Michigan. eng Case Reports 2016 04 19 United States JAAD Case Rep 101665210 2352-5126 HNSCC, head and neck SCC SCC, squamous cell carcinoma SSS, secondary SCC of the skin acneiform head and neck squamous cell carcinoma metastatic squamous cell carcinoma oral

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2016 JAAD Case Reports

60. Alcohol intake is associated with increased risk of squamous cell carcinoma of the skin: three US prospective cohort studies (PubMed)

Alcohol intake is associated with increased risk of squamous cell carcinoma of the skin: three US prospective cohort studies The association between alcohol intake and cutaneous squamous cell carcinoma (cSCC) is unclear. We studied the association between alcohol intake and incident invasive cSCC in three cohorts of women and men with repeated assessments of alcohol intake in the US. Information on alcohol intake was collected repeatedly during follow-up. Cumulative average of alcohol intakes

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2016 Nutrition and cancer

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