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Squamous Cell Carcinoma of the Skin

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41. GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms Full Text available with Trip Pro

GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms Initial investigations reported GATA3 to be a sensitive and relatively specific marker for mammary and urothelial carcinomas. Recently, GATA3 expression has been described in several other epithelial tumors. However, there has been only limited investigation of GATA3 expression in cutaneous epithelial tumors. The objective of this study was to examine the immunohistochemical expression of GATA3 (...) Merkel cell carcinomas exhibited focal weak staining. Our findings demonstrate that GATA3 is expressed in a wide variety of benign and malignant cutaneous epithelial neoplasms. In addition to carcinomas of breast and urothelial origin and other more recently described GATA3-positive tumors, the differential diagnosis of a metastatic tumor of unknown primary origin that expresses GATA3 should also include a carcinoma of cutaneous epithelial origin.

2015 The American Journal of dermatopathology

42. Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery. (Abstract)

Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery. Koebnerized non-melanoma skin cancer following skin trauma represents a rare and obscure event.To study molecular pathological parameters in koebnerized squamous cell carcinomas (K-SCCs) occurring after complete tumour removal.We assessed two patients with multiple sclerosis who were on treatment with dimethylfumarate (DMF) preceded (...) high Ki-67, p16 and p53 expression which was comparable to the expression observed in primary SCCs as well as K-SCCs. Protein expression of Ki-67, p16 and mutant p53 was barely detected in the specimens of the healthy controls. A decreased protein expression of TET-2 enzyme was seen in all tumours and healthy appearing skin when compared to the skin of healthy controls.We observed two patients with K-SCCs developing under DMF treatment. In healthy appearing skin of patients with K-SCCs, wound

2018 Journal of the European Academy of Dermatology and Venereology

43. Reply to Gambichler T et al.: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery. Full Text available with Trip Pro

Reply to Gambichler T et al.: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery. 29797668 2019 01 18 1468-3083 33 1 2019 Jan Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Reply to Gambichler T et al.: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell (...) carcinomas following skin surgery. e3-e4 10.1111/jdv.15084 Nwabudike L C LC N. Paulescu Institute, Bucharest, Romania. Tatu A L AL Medical and Pharmaceutical Research Unit/Competitive, Interdisciplinary Research Integrated Platform "Dunărea de Jos", ReForm-UDJG, Dermatology, Faculty of Medicine and Pharmacy, Pharmacology Sciences Department, University "Dunarea de Jos", Galati, Romania. eng Letter 2018 06 07 England J Eur Acad Dermatol Venereol 9216037 0926-9959 2018 5 26 6 0 2018 5 26 6 0 2018 5 26 6 0

2018 Journal of the European Academy of Dermatology and Venereology

44. Ingenol mebutate gel (Picato): suspension of the licence due to risk of skin malignancy

with ingenol mebutate gel in 1262 patients (1.0% versus 0.1% of patients); A higher incidence of tumours, including basal cell carcinoma, Bowen’s disease and squamous cell carcinoma, was seen compared with vehicle in four clinical trials with ingenol disoxate (an ester related to ingenol mebutate whose clinical development has been stopped) in 1234 patients (7.7% versus 2.9% of patients). Post-marketing reports of skin tumours in patients treated with ingenol mebutate gel have also been received. Time (...) to January 2020, we have received reports of 10 cases of skin malignancies in the UK associated with ingenol mebutate gel, including cutaneous squamous cell carcinoma (including one metastatic case), atypical fibroxanthoma, neuroendocrine carcinoma of the skin, Bowen’s disease, and basosquamous carcinoma. These reports were received in both clinical trial and post-marketing settings. Article citation: Drug Safety Update volume 13, issue 7: February 2020: 1. Data derived from IQVIA MIDAS Q4 2018 to Q3

2020 MHRA Drug Safety Update

45. Congenital ichthyosis patient with squamous cell carcinoma of the skin who received concurrent chemoradiation: A case report Full Text available with Trip Pro

Congenital ichthyosis patient with squamous cell carcinoma of the skin who received concurrent chemoradiation: A case report 29556584 2018 11 14 2452-1094 3 1 2018 Jan-Mar Advances in radiation oncology Adv Radiat Oncol Congenital ichthyosis patient with squamous cell carcinoma of the skin who received concurrent chemoradiation: A case report. 76-80 10.1016/j.adro.2017.09.006 Cerra-Franco Alberto A Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana (...) 7593802 Nat Genet. 2006 Mar;38(3):337-42 16444271 Br J Dermatol. 2011 Aug;165(2):263-8 21517795 Arch Dermatol. 2012 Sep;148(9):1080-1 22986871 Head Neck. 2017 Apr;39(4):679-683 28032670 J Am Acad Dermatol. 2010 Oct;63(4):607-41 20643494 Int J Radiat Oncol Biol Phys. 1995 Mar 30;31(5):1341-6 7713792 Int J Surg Oncol. 2011;2011:464829 22312508 Cancer. 1986 May 15;57(10):2026-9 3955509

2017 Advances in radiation oncology

46. Comparison of P53 Intensity, Frequency and Size in Normal Skin Periphery of Squamous Cell Carcinoma, Basal Cell Carcinoma And Melanocytic Nevus in Persian Skin Type Full Text available with Trip Pro

Comparison of P53 Intensity, Frequency and Size in Normal Skin Periphery of Squamous Cell Carcinoma, Basal Cell Carcinoma And Melanocytic Nevus in Persian Skin Type Non-Melanoma Skin Cancer (NMSC), the most prevalent types being Squamous Cell Carcinoma (SCC) and Basal Cell Carcinoma (BCC), is the most common type of malignancy in human beings. These neoplasms are more frequent in the elderly and fair skinned people and mainly occur on sun-exposed sites of the body. Ultraviolet B (UVB) has (...) a well-known effect in induction and promotion of growth of these cancers. The p53 tumor suppressor gene is believed to be an early target in UV-induced skin carcinogenesis. Aggregates of keratinocytes with p53 protein overexpression are frequently identified in normal human skin and are more prevalent in chronically sun-exposed skin, and have been proposed to play a role in skin cancer pathogenesis. The aim of this study was to clarify the potential role of P53 in the development

2017 Iranian Journal of Pathology

47. The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma Full Text available with Trip Pro

, Carvalho AL, Pinto CA, Kowalski LP. Predictive factors of occult metastasis and prognosis of clinical stages I and II squamous cell carcinoma of the tongue and floor of the mouth. Oral Oncol. 2004;40:780–6. 12. Yamamoto E, Miyakawa A, Kohama G. Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity. Head Neck Surg. 1984;6:938–47. 13. Alkureishi LW, Ross GL, Shoaib T, Soutar DS, Robertson AG, Sorensen JA, et al. Does tumour depth affect nodal staging in squamous cell (...) carcinoma of the head and neck. Laryngoscope. 2008;118:629–34. 14. Goerkem M, Braun J, Stoeckli SJ. Evaluation of clinical and histomorphological parameters as potential predictors of occult metastases in sentinel lymph nodes of early squamous cell carcinomas of the oral cavity. Ann Surg Oncol. 2010;17:527–35. 15. D’Cruz AK, Vaish R, Kapre N, Dandekar M, Gupta S, Hawaldar R, et al. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med. 2015;373:521–9. 16. Inoue H, Nibu K

2019 European Association of Nuclear Medicine

48. Cutaneous Malignant Neoplasms in Hematopoietic Cell Transplant Recipients: A Systematic Review. (Abstract)

neoplasm risk factors were extracted from included articles. The level of evidence for each study was assessed using the Strength of Recommendation Taxonomy scale.Patients who underwent hematopoietic cell transplantation had an increased risk of squamous cell carcinoma, basal cell carcinoma, and melanoma. Factors such as primary disease, chronic graft-vs-host disease, prolonged immunosuppression, radiation exposure, light skin color, sex, and T-cell depletion are risk factors for cutaneous malignant (...) factors for cutaneous malignant neoplasms following hematopoietic cell transplantation.A systematic review was conducted using Medline and Cochrane databases from January 1995 to December 2013. Retrospective and prospective reviews containing at least 100 patients who underwent hematopoietic cell transplantation reporting skin cancer as a primary outcome were included. Information regarding the entire cohort, data for the subset who developed cutaneous malignant neoplasms, and cutaneous malignant

2015 JAMA dermatology

49. Ingenol mebutate gel (Picato): increased incidence of skin tumours seen in some clinical studies

the incidence for all tumour types together, including basal cell carcinoma, Bowen’s disease, and squamous cell carcinoma. Other studies have not shown an increased incidence of skin tumours with ingenol mebutate. The will consider all relevant data for the risk of skin cancer, including from ongoing studies, and the implications for the balance of benefits and risks of ingenol mebutate. UK reports of skin cancers during use of ingenol mebutate gel In the past year, approximately 32,450 packs of ingenol (...) in the product information. Following a separate recent review of safety data, the product information is being updated to include a warning about reports of basal cell carcinoma, Bowen’s disease, and squamous cell carcinoma, and to advise that ingenol mebutate gel should be used with caution in patients with a history of skin cancer. A letter has also been sent from the manufacturer of Picato to UK prescribers and dispensers to inform them of this risk. Patients should be made aware of this risk

2019 MHRA Drug Safety Update

50. A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors

Escalation - DE), the intention is to include patients with any of the four solid tumor types: Non-Small Cell Lung Cancer (NSCLC), Pancreatic Ductal Adenocarcinoma (PDAC), Triple Negative Breast Cancer (TNBC) or Colorectal Cancer (CRC). In this part of the study safety and tolerability will be documented and the MTD/ RP2D will be determined. Patients will stay on CAN04 treatment until disease progression, unacceptable toxicity, or discontinuation for any other reason. [Completed December 2018] In Part II (...) Immunoglobulin Clinical Trial Infusion Antineoplastic Anticancer Additional relevant MeSH terms: Layout table for MeSH terms Carcinoma, Non-Small-Cell Lung Colorectal Neoplasms Adenocarcinoma Triple Negative Breast Neoplasms Neoplasms Carcinoma, Bronchogenic Bronchial Neoplasms Lung Neoplasms Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Lung Diseases Respiratory Tract Diseases Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms Digestive System Diseases

2017 Clinical Trials

51. Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies

that may significantly alter the absorption of the study drugs (e.g., ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection) Presence of a psychiatric illness or social situation that would limit compliance with study requirements Women who are pregnant or breastfeeding The subject must not have had diagnosis, detection, or treatment of another type of cancer ≤2 years prior to randomization (except basal or squamous cell carcinoma of the skin (...) criteria. Condition or disease Intervention/treatment Phase Solid Tumor, Adult Homologous Recombination Deficiency Drug: Niraparib Drug: Carboplatin Phase 1 Detailed Description: This is a multi-institutional Phase I dose-escalation and dose-expansion trial for patients with advanced, solid tumor malignancies who have pre-identified deleterious germline or somatic mutations in the homologous recombination deoxyribonucleic acid (DNA) repair pathway (HR deficient). The trial is designed to assess

2017 Clinical Trials

52. Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. Full Text available with Trip Pro

Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. Most human papillomavirus (HPV)-associated vulvar squamous cell carcinomas (VSCCs) originate from high-grade squamous intraepithelial lesions, also named usual type vulvar intraepithelial neoplasia. However, growing evidence suggests that morphologic studies have limitations in predicting HPV status in vulvar lesions. We aimed to evaluate adjacent (...) or both in addition to the HPV DNA, whereas cases negative for both markers were classified as nonconclusively associated with HPV. One hundred twenty-one tumors (37.1%) had normal adjacent skin, 191 (58.6%) had only high-grade squamous intraepithelial lesions, also named usual type vulvar intraepithelial neoplasia, and unusual intraepithelial lesions were identified in 14 (4.3%) tumors. Seven cases showed dVIN-like features, 5 showed adjacent LS-like lesion, and in 2 cases dVIN-like and LS-like

2018 American Journal of Surgical Pathology

53. Total body skin examination increases squamous cell carcinoma detection: a retrospective cohort study. (Abstract)

Total body skin examination increases squamous cell carcinoma detection: a retrospective cohort study. Squamous cell carcinomas (SCCs) have the potential for local tissue destruction and metastasis. The risk of complications increases if the lesion is not diagnosed and excised in a timely manner. Total body skin examination (TBSE) has been reported to increase melanoma detection; the objective of this study was to determine if it also increases SCC detection. Analysis of 469 SCCs diagnosed (...) at a UK tertiary centre showed that 6.8% of these were detected incidentally and not from the index lesion that prompted referral. These incidentally detected SCCs tended to represent early disease, and therefore carried lower risk of complications. Our findings suggest that full skin checks may increase the number of SCCs detected, and at an earlier stage of disease. Therefore, we encourage the use of TBSE in all dermatology outpatient appointments, and make suggestions as to how to incorporate

2019 Clinical & Experimental Dermatology

54. Fluorouracil enhances photodynamic therapy of squamous cell carcinoma via a p53 -independent mechanism that increases protoporphyrin IX levels and tumor cell death Full Text available with Trip Pro

Fluorouracil enhances photodynamic therapy of squamous cell carcinoma via a p53 -independent mechanism that increases protoporphyrin IX levels and tumor cell death Photodynamic therapy (PDT), using 5-aminolevulinic acid (ALA) to drive synthesis of protoporphryin IX (PpIX) is a promising, scar-free alternative to surgery for skin cancers, including squamous cell carcinoma (SCC) and SCC precursors called actinic keratoses. In the United States, PDT is only FDA approved for treatment of actinic (...) ), still led to significant beneficial inductions, that is, 2.5-fold for both PpIX and PDT-induced cell death. Thus, neoadjuvantal 5-FU combined with PDT represents a new therapeutic approach that appears useful even for p53-mutant and p53-null tumors. Mol Cancer Ther; 16(6); 1092-101. ©2017 AACR.©2017 American Association for Cancer Research.

2017 Molecular cancer therapeutics

55. Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma Full Text available with Trip Pro

Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. Inflammation is a typical feature in cSCC progression. Analysis of the expression of inflammasome components in cSCC cell lines and normal human epidermal keratinocytes revealed upregulation of the expression of AIM2 mRNA and protein in cSCC cells. Elevated levels of AIM2 mRNA were noted in cSCCs in vivo compared (...) with normal skin. Strong and moderate tumor cell specific expression of AIM2 was detected with immunohistochemistry (IHC) in sporadic human cSCCs in vivo, whereas expression of AIM2 was moderate in cSCC in situ (cSCCIS) and low or absent in actinic keratosis (AK) and normal skin. IHC of cSCCs, cSCCIS and AKs from organ transplant recipients also revealed strong and moderate tumor cell specific expression of AIM2 in cSCCs. Knockdown of AIM2 resulted in reduction in viability of cSCC cells and onset

2017 Oncotarget

56. Finger Pad Squamous Cell Carcinoma: Report of Squamous Cell Carcinoma of the Distal Palmar Digit and Review of Associated Risk Factors, Mimickers, and Treatment of Squamous Cell Carcinoma of Ventral Hand Digits Full Text available with Trip Pro

of the hand. the authors also summarize the clinical differential diagnoses and treatment of squamous cell carcinoma at this location. METHODS: the authors retrospectively reviewed the literature using PubMed and searched for the following terms: squamous cell carcinoma, squamous cell carcinoma in situ, finger, thumb, palmar, and ventral. Papers were critically evaluated and their cited references reviewed. RESULTS: Skin biopsy established the patient's diagnosis. His tumor was excised using Mohs (...) and keratoderma, epidermoid cyst, infection, melanoma, and verrucae. Successful treatment involves removal of the tumor; this is usually accomplished by surgical excision of the tumor, which may include some or all of the affected digit. CONCLUSIONS: The diagnosis of squamous cell carcinoma of the ventral hand digits is often not initially suspected by the patient and/or the clinician. However, despite the occasional delay in diagnosis or subsequent large tumor size, the prognosis for these patients

2017 The Journal of clinical and aesthetic dermatology

57. Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma

of squamous cell cancer Clinical diagnosis of squamous cell cancer of the head and neck (non-nasopharynx primary tumors: oral cavity, oropharynx, hypopharynx, larynx and sinonasal) or skin HNSCC and cSCC cannot be curable by surgery and/or radiation therapy Measureable disease as per RECIST v1.1, which includes locoregional lesions (not amenable to curative surgery and/or radiation) and distant metastatic lesions Blood pressure < 150/90 at screening with or without antihypertensive medications (...) > 500 msec Active infection requiring systemic therapy Clinically significant hemoptysis or tumor bleeding within 2 weeks prior to first dose of lenvatinib Other active malignancy except for basal cell or squamous cell carcinoma of the skin, or carcinoma in situ of the cervix or bladder Women who are breast feeding or pregnant ° Men or women of reproductive potential who are not willing to employ effective birth control from screening to 30 days after the last dose of study drugs; the definition

2018 Clinical Trials

58. Antitumor Effects of DC Vaccine With ALA-PDT-Induced Immunogenic Apoptotic Cells for Skin Squamous Cell Carcinoma in Mice Full Text available with Trip Pro

Antitumor Effects of DC Vaccine With ALA-PDT-Induced Immunogenic Apoptotic Cells for Skin Squamous Cell Carcinoma in Mice Targeted immunotherapy using dendritic cell vaccine has been employed for the treatment of solid tumors. Topical 5-aminolevulinic acid-mediated photodynamic therapy, an established approach for topical cancers, can induce an effective antitumor immune response. We have previously shown that 5-aminolevulinic acid-mediated photodynamic therapy-induced tumor lysates could (...) considerably enhance antigen-presenting capacity of ex vivo-generated dendritic cells. The current study further demonstrates that 5-aminolevulinic acid-mediated photodynamic therapy dendritic cell vaccine can induce immune responses against cancers. Dendritic cells pulsed by photodynamic therapy-treated skin squamous cell carcinoma cells inhibited squamous cell carcinoma to a greater extent than tumor lysates treated by photodynamic therapy alone or dendritic cells pulsed by freeze-thawed treated tumor

2018 Technology in cancer research & treatment

59. Atezolizumab (Tecentriq) - Non-Small-Cell Lung Carcinoma or Transitional Cell Carcinoma

-free survival PK pharmacokinetic Assessment report EMA/153102/2018 Page 6/205 PS performance status PR partial response q3w every 3 weeks QA quality attribute QbD Quality by Design RECIST Response Evaluation Criteria in Solid Tumors SAE serious adverse event SAT severe acute toxicity SD stable disease SOC system organ class TCC transitional cell carcinoma TIR time in response TTOR time to onset of response UC urothelial carcinoma Vss volume of distribution at steady state Assessment report EMA (...) for approximately 85% of all cases (Howlader et al. 2014; Molina et al. 2008). UC Urothelial carcinoma presents the highest recurrence rate among solid tumors and is the second leading cause of death in genitourinary cancers. Despite recent advances in the understanding of the pathophysiology of the disease, the management of UC patients remains a clinically challenging problem (Siegel et al. 2014). Approximately 10%-15% of patients present with metastatic UC at the time of diagnosis. Despite the low frequency

2017 European Medicines Agency - EPARs

60. Cancer cell of origin controls epithelial-to-mesenchymal transition in skin squamous cell carcinoma Full Text available with Trip Pro

Cancer cell of origin controls epithelial-to-mesenchymal transition in skin squamous cell carcinoma 28607908 2018 11 13 2306-9759 4 2017 Stem cell investigation Stem Cell Investig Cancer cell of origin controls epithelial-to-mesenchymal transition in skin squamous cell carcinoma. 34 10.21037/sci.2017.04.03 Chandrakesan Parthasarathy P Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Stephenson Cancer Center, University of Oklahoma Health Sciences (...) Center, Oklahoma City, OK, USA. Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. eng Editorial Comment 2017 05 05 China Stem Cell Investig 101672113 2306-9759 Cell Stem Cell. 2017 Feb 2;20(2):191-204.e5 27889319 Conflicts of Interest: The author has no conflicts of interest to declare. 2017 03 16 2017 04 07 2017 6 14 6 0 2017 6 14 6 0 2017 6 14 6 1 epublish 28607908 10.21037/sci.2017.04.03 sci-04-2017.04.03 PMC5460141 Nat Rev Cancer. 2013 Feb;13(2):97-110 23344542 Nat Rev Cancer

2017 Stem Cell Investigation

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