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Squamous Cell Carcinoma of the Skin

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41. Cancer cell of origin controls epithelial-to-mesenchymal transition in skin squamous cell carcinoma (Full text)

Cancer cell of origin controls epithelial-to-mesenchymal transition in skin squamous cell carcinoma 28607908 2018 11 13 2306-9759 4 2017 Stem cell investigation Stem Cell Investig Cancer cell of origin controls epithelial-to-mesenchymal transition in skin squamous cell carcinoma. 34 10.21037/sci.2017.04.03 Chandrakesan Parthasarathy P Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Stephenson Cancer Center, University of Oklahoma Health Sciences (...) Center, Oklahoma City, OK, USA. Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. eng Editorial Comment 2017 05 05 China Stem Cell Investig 101672113 2306-9759 Cell Stem Cell. 2017 Feb 2;20(2):191-204.e5 27889319 Conflicts of Interest: The author has no conflicts of interest to declare. 2017 03 16 2017 04 07 2017 6 14 6 0 2017 6 14 6 0 2017 6 14 6 1 epublish 28607908 10.21037/sci.2017.04.03 sci-04-2017.04.03 PMC5460141 Nat Rev Cancer. 2013 Feb;13(2):97-110 23344542 Nat Rev Cancer

2017 Stem Cell Investigation PubMed abstract

42. Having a first-degree relative with melanoma increases lifetime risk of melanoma, squamous cell carcinoma, and basal cell carcinoma. (Abstract)

, and Health Professionals Follow-up Study for more than 20 years. Cox proportional hazards regression controlling for known risk factors for skin cancer was used to estimate association between family history of melanoma and melanoma and KCs.Compared with those without a family history of melanoma, individuals with a family history of melanoma had a 74% increased risk of melanoma (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.45-2.09), a 22% increased risk of squamous cell carcinoma (HR, 1.22 (...) Having a first-degree relative with melanoma increases lifetime risk of melanoma, squamous cell carcinoma, and basal cell carcinoma. Previous studies have found familial aggregation of melanoma and keratinocyte cancers (KCs).We sought to determine the risk of melanoma and KCs in those with a positive family history of melanoma while controlling for pigmentary and environmental risk factors.We prospectively followed 216,115 participants from the Nurses' Health Study, Nurse's Health Study 2

2019 Journal of American Academy of Dermatology

43. Seed and soil? - Pharyngeal Merkel cell carcinoma after radiotherapy for laryngeal squamous cell carcinoma. (Full text)

Seed and soil? - Pharyngeal Merkel cell carcinoma after radiotherapy for laryngeal squamous cell carcinoma. Merkel cell carcinoma (MCC) is a neuroendocrine cutaneous malignancy that may present as metastatic disease without a known primary site but, most commonly originates in the sun-exposed skin of the head, neck, and extremities. We present a 66-year-old male treated with chemo-radiation for T3N2cM0 laryngeal squamous cell carcinoma (SCCa) six years before he was diagnosed with MCC isolated

2019 American Journal of Otolaryngology PubMed abstract

44. 'Eternal sunshine of the spotless islands': how dermoscopy may influence confocal microscopy when dealing with squamous cells carcinoma simulating basal cell carcinoma. (Abstract)

'Eternal sunshine of the spotless islands': how dermoscopy may influence confocal microscopy when dealing with squamous cells carcinoma simulating basal cell carcinoma. Basal cell carcinoma (BCC) represents one of the best indications for the use of in-vivo reflectance confocal microscopy (RCM). High levels of diagnostic accuracy is reached with the combined use of dermoscopy and RCM for BCC diagnosis that is based on a set of distinct confocal features. Furthermore, new handled devices allowed (...) to speed-up the confocal examination at patient's bedside, making easier and faster the systematic use of RCM for atypical skin lesions. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 Journal of the European Academy of Dermatology and Venereology

45. Risk of Aggressive Skin Cancers Following Kidney Retransplantation in Patients With Previous Posttransplant Cutaneous Squamous Cell Carcinomas: A Retrospective Study of 53 Cases. (Abstract)

Risk of Aggressive Skin Cancers Following Kidney Retransplantation in Patients With Previous Posttransplant Cutaneous Squamous Cell Carcinomas: A Retrospective Study of 53 Cases. The course of skin cancer after retransplantation in organ-transplant recipients who have already developed posttransplant skin cancer has not been assessed.This retrospective multicentric study included 53 patients with a history of cutaneous squamous cell carcinoma (SCC) after a first kidney transplantation who (...) %) patients developed SCC in dialysis and 39 (73.6%) after the second transplantation, respectively. Twenty aggressive SCC developed over the study period. They occurred in 14 (26.4%) patients after retransplantation vs 5 (9.4%) after the first transplantation with a median delay of 50 months and were responsible for 5 deaths. Fair skin type, multiple tumors before retransplantation, treatment with azathioprine, T cell-depleting antibodies, and delayed revision of immunosuppression were associated

2017 Transplantation

46. Surgical Treatment of Subungual Squamous Cell Carcinoma by Wide Excision of the Nail Unit and Skin Graft Reconstruction: An Evaluation of Treatment Efficiency and Outcomes. (Full text)

Surgical Treatment of Subungual Squamous Cell Carcinoma by Wide Excision of the Nail Unit and Skin Graft Reconstruction: An Evaluation of Treatment Efficiency and Outcomes. The best surgical treatment modalities for subungual squamous cell carcinoma (SUSCC) without bone invasion need to be determined. The limited available data on Mohs micrographic surgery do not demonstrate its use as a standard procedure. A previous study in a limited series of patients has shown that wide surgical excision (...) of the nail unit was associated with a low rate of recurrence.To confirm the efficiency of wide surgical excision of the nail unit with full-thickness skin graft reconstruction on a series of patients with SUSCC with an extended follow-up and to evaluate short- and long-term postoperative morbidity and patient satisfaction.A consecutive series of 55 patients with biopsy-proven SUSCC without bone invasion treated by wide surgical excision of the nail unit followed by full-thickness skin graft

2017 JAMA dermatology (Chicago, Ill.) PubMed abstract

47. Incidence of skin toxicity in squamous cell carcinoma of the head and neck treated with radiotherapy and cetuximab: A systematic review. (Abstract)

Incidence of skin toxicity in squamous cell carcinoma of the head and neck treated with radiotherapy and cetuximab: A systematic review. Radiotherapy plus cetuximab is an effective combination therapy for locally advanced head and neck squamous cell carcinoma. The aim of our study was to determine the frequency of skin toxicity in patients receiving the combined treatment.Forty-eight studies were included in our analysis, for a total of 2152 patients. The mean rates of G3/G4 radiation (...) dermatitis and acneiform rash were 32.5% (SD: 20.4; 95% CI: 28.5-36.5) and 13.4% (SD: 11.5; 95% CI: 11.2-15.6), respectively. The majority of studies referred to CTCAE scales for reporting both side effects (85.7% and 92.1%, respectively). Data on the management of skin toxicity were available in only 35.4% of the reviewed literature.severe radiation dermatitis is a frequent side effect induced by the combination of radiotherapy and cetuximab in head and neck cancer. The lack of predictive biomarkers

2017 Critical reviews in oncology/hematology

48. Cetuximab Immunoliposomes enhance Delivery of 5-FU to Skin Squamous Carcinoma Cells (Full text)

Cetuximab Immunoliposomes enhance Delivery of 5-FU to Skin Squamous Carcinoma Cells Topical chemotherapy of skin cancers is a promising strategy for reduction of side effects and for improvement of patient compliance. The combination of the chemotherapeutic 5-fluouracil (5-FU) and the anti- EGFR antibody cetuximab is a strategy to inhibit tumor growth. Their skin penetration, however, is hampered by their high hydrophilicity, which could be improved by encapsulation in delivery systems (...) different methods and drug-to-lipid ratios.Liposomes containing DSPC and Chol at drug-to-lipid ratio 0.1 prepared by the thin lipid hydration method resulted in the best 5-FU encapsulation and were chosen to conjugate with cetuximab. Cetuximab was directly coupled to preformed liposomes using DSPE-mPEG2000-Mal as an anchor. In A431 skin carcinoma cells, at 72 h, 5-FU liposomes showed a 5-fold lower IC50 than 5-FU solution. Additionally, 5-FU immunoliposomes resulted in a 4-fold lower cetuximab IC50 than

2017 Anti-cancer agents in medicinal chemistry PubMed abstract

49. A giant squamous cell carcinoma of the skin of the thoracic wall: a case report and review of the literature (Full text)

A giant squamous cell carcinoma of the skin of the thoracic wall: a case report and review of the literature We report a case of a 48-year-old white woman who presented with a huge cutaneous protruding tumor of the thoracic wall below her left breast.The lesion was excised with clear margins from the adjacent skin, and subcutaneous tissue was left to heal with second intention. A histological examination of the surgical specimen revealed a well-differentiated infiltrative cutaneous squamous (...) cell carcinoma. Our patient neglected to attend our Oncological Department to receive chemotherapy. Today, 12 months after surgery, she is alive and without evidence of disease recurrence.Cutaneous squamous cell carcinoma can reach a huge size if left untreated. Surgery is the primary mode of treatment, followed by chemotherapy if applicable.

2017 Journal of medical case reports PubMed abstract

50. A case report of Muir-Torre syndrome in a woman with breast cancer and MSI-Low skin squamous cell carcinoma (Full text)

A case report of Muir-Torre syndrome in a woman with breast cancer and MSI-Low skin squamous cell carcinoma The tumor spectrum in the Lynch syndrome is well defined, comprising an increased risk of developing colonic and extracolonic malignancies. Muir-Torre syndrome is a variant with a higher risk of skin disease. Patients have been described carrying mutations in the mismatch repair genes and presenting tumors with unusual histology or affected organ not part of the Lynch syndrome spectrum (...) . Hence, the real link between Lynch syndrome, or Muir-Torre syndrome, and these tumors remains difficult to assess.We present the case of a 45-year-old-woman, diagnosed with breast cancer at 39 years of age and skin squamous cell carcinoma (SCC) at 41 years of age, without personal history of colorectal cancer. The microsatellite instability analysis performed on the skin SCC showed a low-level of microsatellite instability (MSI-Low). The immunohistochemical expression analysis of the four DNA

2017 Hereditary cancer in clinical practice PubMed abstract

51. Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1 (Full text)

Antimicrobial peptide LL-37 promotes the viability and invasion of skin squamous cell carcinoma by upregulating YB-1 Antimicrobial peptide LL-37 serves a function in the host defense against microbial invasion, and also regulates cell proliferation, immune activity and angiogenesis. Previous studies have reported that LL-37 participates in the development of numerous tumour types, such as ovarian cancer, lung cancer, melanoma and breast cancer. However, the function of LL-37 in the development (...) of skin squamous cell carcinoma (SCC) has not yet been fully elucidated. The aim of the current study was to investigate how LL-37 promotes the expression of Y-box binding protein 1 (YB-1) in SCC. Short interfering RNA (siRNA) was used to inhibit the expression of YB-1, and in vitro MTT and Transwell migration assays were used to evaluate the effect of reduced YB-1 on the viability and invasion of A431 cells. A431 cells were stimulated with LL-37, and quantitative polymerase chain reaction

2017 Experimental and therapeutic medicine PubMed abstract

52. Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population (Full text)

Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population Rice contains arsenic, a known skin carcinogen. Rice intake has been associated with arsenic-related skin lesions in South Asia, but its association with skin cancers is as yet unknown.We aimed to investigate whether rice intake contributes to urinary arsenic concentration and risk of squamous cell carcinoma (SCC) of the skin in a U.S. population.Rice consumption was assessed using a food frequency

2017 Environmental health perspectives PubMed abstract

53. A case of combined Merkel cell carcinoma and squamous cell carcinoma: Molecular insights and diagnostic pitfalls (Full text)

of Michigan, Ann Arbor, Michigan. Department of Dermatology, University of Michigan, Ann Arbor, Michigan. Harms Paul W PW Department of Pathology, University of Michigan, Ann Arbor, Michigan. Department of Dermatology, University of Michigan, Ann Arbor, Michigan. eng Case Reports 2018 11 03 United States JAAD Case Rep 101665210 2352-5126 MCC, Merkel cell carcinoma MCPyV, Merkel cell polyomavirus MMS, Mohs micrographic surgery Merkel cell carcinoma NMSC, nonmelanoma skin cancer SCC, squamous cell carcinoma (...) A case of combined Merkel cell carcinoma and squamous cell carcinoma: Molecular insights and diagnostic pitfalls 30417062 2019 02 26 2352-5126 4 10 2018 Nov JAAD case reports JAAD Case Rep A case of combined Merkel cell carcinoma and squamous cell carcinoma: Molecular insights and diagnostic pitfalls. 996-999 10.1016/j.jdcr.2018.08.004 Falto Aizpurua Leyre A LA Department of Dermatology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico. Wang Min M Department

2018 JAAD Case Reports PubMed abstract

54. Needs and preferences of patients regarding basal cell carcinoma and cutaneous squamous cell carcinoma care: a qualitative focus group study. (Abstract)

Needs and preferences of patients regarding basal cell carcinoma and cutaneous squamous cell carcinoma care: a qualitative focus group study. Despite the high and rising incidence rate of keratinocyte cancer (KC) and the importance of incorporating patient values into evidence-based care, few studies have focused on the perspectives of patients with KC.To identify the needs and preferences of patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) regarding care.A qualitative (...) takes you seriously and communicates well; (iii) a short waiting period and the best treatment with direct results; (iv) to be seen by the same physician; a preference for a dermatologist during (v) treatment and (vi) follow-up; (vii) a general need for structured follow-up care and (viii) a full-body skin examination during follow-up. Patients with BCC additionally expressed the need for openness and transparency and wanting to participate in shared decision making.It is advocated to organize skin

2018 British Journal of Dermatology

55. Post-hysterectomy rare collision vulva tumor with long-term human papilloma virus infection composed of squamous cell carcinoma of the labia major and adenosquamous carcinoma of bartholin gland: A case report. (Full text)

with long-term HPV infection composed of squamous cell carcinoma of the labia major and adenosquamous carcinoma of bartholin gland.The extensive excision of the vulva, bilateral inguinal lymph nodes dissection, and local skin flap transposition surgeon was done to this patient. The final certificate diagnosis was: vulvar tumor T1bM0N0 composed of squamous cell carcinoma of the labia major and adenosquamous carcinoma of bartholin gland; HPV infection; post hysterectomy, and bilateral salpingectomy.The (...) Post-hysterectomy rare collision vulva tumor with long-term human papilloma virus infection composed of squamous cell carcinoma of the labia major and adenosquamous carcinoma of bartholin gland: A case report. Post-hysterectomy collision tumors of the vulva has rarely been reported. Though long-term HPV infection may induce vulva tumor, but the relationship between HPV infection and collision vulva tumor is not clear. And there are no clear rules of the post-hysterectomy cancer surveillance

2019 Medicine PubMed abstract

56. Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. (Full text)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. Cutaneous squamous cell carcinomas are a common form of highly mutated keratinocyte skin cancers that are of particular concern in immunocompromised patients. Here we report on the efficacy of topically applied MS-275, a clinically used histone deacetylase inhibitor, for the treatment and management (...) of this disease. At 2 mg/kg, MS-275 significantly decreased tumor burden in an SKH-1 hairless mouse model of UVB radiation-induced skin carcinogenesis. MS-275 was cell permeable as a topical formulation and induced histone acetylation changes in mouse tumor tissue. MS-275 was also effective at inhibiting the proliferation of patient derived cutaneous squamous cell carcinoma lines and was particularly potent toward cells isolated from a regional metastasis on an immunocompromised individual. Our findings

2019 PLoS ONE PubMed abstract

57. Mohs micrographic surgery as treatment option for non-basal cell or squamous cell carcinomas in the United States. (Abstract)

Mohs micrographic surgery as treatment option for non-basal cell or squamous cell carcinomas in the United States. Background: Skin cancer has the highest incidence of all cancers in the United States. Conventional surgical excision (CSE) and Mohs micrographic surgery (MMS) are among the most common surgical treatment options for skin cancer. Objective: The purpose of this study was to examine utilization patterns of MMS compared to CSE in the United States for non-basal cell carcinoma (BCC (...) ) or squamous cell carcinoma (SCC) skin cancers. Methods: Data from the NCI SEER program, collected from 1973 to 2015, were retrospectively analyzed. Cases were separated into MMS and CSE. Patient characteristics were analyzed. Multivariate models were fitted to evaluate significant predictors for MMS. Results: Of the total procedures performed during the years 1988-2015, a total of 12,654 MMS cases and 267,291 CSE were considered for analysis. Females, white, and non-Hispanic patients of increasing age

2019 Journal of Dermatological Treatment

58. Tumor cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma. (Full text)

Tumor cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma. Incidence of epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is increasing worldwide.To study the role of complement classical pathway components C1q, C1r and C1s in the progression of cSCC.The mRNA levels of C1Q subunits, C1R and C1S in cSCC cell lines, normal human epidermal keratinocytes (NHEKs), cSCC tumors in vivo and normal skin were analyzed with quantitative (...) skin. Abundant expression of C1r and C1s by tumor cells was detected in invasive sporadic cSCCs and recessive dystrophic epidermolysis bullosa-associated cSCCs, whereas the expression of C1r and C1s was lower in cSCC in situ, actinic keratosis, and normal skin. Knockdown of C1r and C1s expression in cSCC cells inhibited activation of ERK1/2 and Akt, promoted apoptosis of cSCC cells and significantly suppressed growth and vascularization of human cSCC xenograft tumors in vivo.These results provide

2019 British Journal of Dermatology PubMed abstract

59. Association of BRCA2 K3326* With Small Cell Lung Cancer and Squamous Cell Cancer of the Skin. (Full text)

* are fundamentally different from those associated with 999del5. We report for the first time an association between K3326* and small cell lung cancer (odds ratio [OR] = 2.06, 95% confidence interval [CI] = 1.35 to 3.16) and squamous cell carcinoma of the skin (OR = 1.69, 95% CI = 1.26 to 2.26). Individuals homozygous for K3326* reach old age and have children. Unlike BRCA2 999del5, the K3326* allele does not affect the level of BRCA2 transcripts, and the allele is expressed to the same extent as the wild-type (...) Association of BRCA2 K3326* With Small Cell Lung Cancer and Squamous Cell Cancer of the Skin. Most pathogenic mutations in the BRCA2 gene carry a high risk of hereditary breast and ovarian cancer (HBOC). However, a stop-gain mutation, K3326* (rs11571833), confers risk of lung cancer and cancers of the upper-aero-digestive tract but only a modest risk of breast or ovarian cancer. The Icelandic population provides an opportunity for comprehensive characterization of the cancer risk profiles

2018 Journal of the National Cancer Institute PubMed abstract

60. Management of primary cutaneous squamous cell carcinoma

) is a malignant tumour of keratinocytes arising within the epidermis or its appendages. It has a variable spectrum of clinical presentation and risk, ranging from the common, usually low-risk, keratotic plaque through to the less common, larger, rapidly growing and usually high-risk, exophytic skin lesion nodule. 1, 2 Squamous cell carcinoma is the second most common skin cancer, after basal cell carcinoma (BCC) and its incidence is increasing throughout the world. 3-5 In the 10-year period from 2001 to 2011 (...) with high-risk factors such as larger tumour diameter (p 0.1 mm was associated with increased risk of metastasis (HR 5.6, 95% CI 1.1 to 27.9) although this was due in part to the association with other high-risk factors such as tumour diameter and depth of invasion. 52 Many skin cancer staging systems use PNI as a high-risk feature. 21, 27 R Perineural invasion should be considered a high-risk feature in patients with primary squamous cell carcinoma. Presence or absence of perineural invasion should

2014 SIGN

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