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Squamous Cell Carcinoma of the Skin

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21. Skin microtopography as a measure of photoaging and risk of squamous cell carcinoma of the skin in a US population (PubMed)

Skin microtopography as a measure of photoaging and risk of squamous cell carcinoma of the skin in a US population Skin microtopography as a measure of photoaging is a noninvasive approach to measuring chronic ultraviolet radiation exposure and reflects the degree of dermal elastosis in populations of European descent in the subtropics. Less is known about the utility of this approach in populations at different latitudes, and whether it relates to skin cancer risk.A population-based case (...) -control study of 342 squamous cell carcinoma (SCC) cases and 331 age- and gender-matched controls were evaluated for histologic evidence of solar damage and severity of photoaging based on microtopography on a six-grade scale. Odds ratios (OR) for SCC associated with degree of photoaging were estimated using logistic regression analysis adjusted for potentially confounding factors.After adjustment for known risk factors, SCC was associated with increasing photoaging grade (OR = 1.7, 95% CI = 0.9-3.0

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2017 Photodermatology, photoimmunology & photomedicine

22. The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma | SpringerLink This service is more advanced with JavaScript available, learn more at Advertisement Hide Search SpringerLink March 2019 , Volume 46, , pp 623–637 | The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma Authors Francesco (...) Giammarile Clare Schilling Gopinanth Gnanasegaran Chandrasckhar Bal Wim J. G. Oyen Domenico Rubello Thomas Schwarz Girolamo Tartaglione Rodolfo Nuñez Miller Diana Paez Fijis W. B. van Leeuwen Renato A. Valdés Olmos Mark McGurk Roberto C. Delgado Bolton Open Access Guidelines First Online: 18 December 2018 2k Downloads Abstract Purpose Sentinel lymph node biopsy is an essential staging tool in patients with clinically localized oral cavity squamous cell carcinoma. The harvesting of a sentinel lymph node

2019 European Association of Nuclear Medicine

23. Guidelines of care for the management of cutaneous squamous cell carcinoma

Subject Headings) terms used in various combinations in the literature search included carcinoma , basal cell carcinoma , squamous cell carcinoma , skin neoplasms , stage ( ing ), grade ( ing ), score ( ing ), biopsy , pathology , prognosis , signs and symptoms , risk factors , curettage , electrodesiccation , excision , incomplete , cryosurgery , Mohs ( micrographic ) surgery , topical , fluorouracil , imiquimod , laser , radiotherapy , radiation , photochemotherapy , phototherapy , metastasis (...) carcinomas in solid organ transplant recipients: emerging strategies for surveillance, staging, and treatment. Semin Oncol . 2016 ; 43 : 390–394 | | | | has emerged as an increasingly important contributor to tumorigenesis. cSCC can develop on any skin surface. In fair-skinned individuals, who are at highest risk, sun exposed areas, including the head and neck and the backs of the arms and hands, are common anatomic sites. x 12 Alam, M. and Ratner, D. Cutaneous squamous-cell carcinoma. N Engl J Med

2018 American Academy of Dermatology

24. Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies

Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies Lansbury L, Bath-Hextall F, Perkins W, Stanton W, Leonardi-Bee J CRD summary The authors concluded (...) that evidence on squamous cell carcinoma of the skin was extremely limited. Accurate comparisons of treatment effects was not possible, and the significance of apparent differences between treatments should be interpreted cautiously. The authors acknowledged the poor quality of the evidence and their recommendation for cautious interpretation of the treatment comparisons seems appropriate. Authors' objectives To assess the effectiveness of treatments for non-metastatic squamous cell carcinoma of the skin

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2013 DARE.

25. Heterogeneous relationships of squamous and basal cell carcinomas of the skin with smoking: the UK Million Women Study and meta-analysis of prospective studies. (PubMed)

Heterogeneous relationships of squamous and basal cell carcinomas of the skin with smoking: the UK Million Women Study and meta-analysis of prospective studies. Published findings on the associations between smoking and the incidence of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are inconsistent. We aimed to generate prospective evidence on these relationships overall and by anatomical site.We followed 1,223,626 women without prior cancer by electronic linkage

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2018 British Journal of Cancer

26. Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases (PubMed)

Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases Squamous cell carcinoma antigens 1 and 2 (SCCA1 and 2, SERPIN B3 and B4), members of the ovalbumin serpin (ov-serpin)/clade B serpin family, were originally discovered as tumor-specific antigens and are used as tumor markers for various kinds of squamous cell carcinomas. Recently, our understanding of the underlying mechanisms of how SCCA1/2 enhance tumor growth has greatly increased (...) . Moreover, it has been shown that SCCA1/2 are involved in the pathogenesis of several inflammatory diseases: asthma, psoriasis, and atopic dermatitis (AD). IL-22 and IL-17, signature cytokines of type 17 inflammation, as well as IL-4 and IL-13, signature cytokines of type 2 inflammation, both of which are positively correlated with the pathogenesis of psoriasis and allergic diseases, respectively, can induce expression of SCCA1/2 in airway epithelial cells and/or keratinocytes, leading to high

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2018 International journal of molecular sciences

27. Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway (PubMed)

Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway Hyperproduced prostaglandin E2 by cyclooxygenase-2 and microsomal prostaglandin E synthase-1 evokes several pathophysiological responses such as inflammation and carcinogenesis. Our recent study demonstrated that Dioscorea japonica extract suppressed the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 and induced apoptosis (...) in lung carcinoma A549 cells. In the present study, we investigated the effects of Dioscorea japonica on squamous cell carcinoma of mouse skin. Dioscorea japonica feeding and Dioscorea japonica extract topical application suppressed the expression of cyclooxygenase-2, microsomal prostaglandin E synthase-1, interleukin-1β and interleukin-6 and inhibited tumor formation, hyperplasia and inflammatory cell infiltration. Immunohistochemical analyses showed the immunoreactivities of cyclooxygenase-2

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2018 Journal of clinical biochemistry and nutrition

28. Metastatic squamous cell carcinoma of the skin with clinical response to lapatinib (PubMed)

Metastatic squamous cell carcinoma of the skin with clinical response to lapatinib Lapatinib is a tyrosine kinase inhibitor that blocks the HER2 receptor and is typically used in the setting of metastatic breast cancer. Both ERBB2 (HER2) and ERBB3 (HER3) belong to the same family of receptor tyrosine kinases. Dimerization of these receptors leads to activation of cell proliferation and survival pathways, granting oncogenic potential to dysregulated ERBB/HER receptors. Next generation sequencing (...) (NGS) of tumors has ushered in a new era of personalized oncology therapy and has the ability to detect mutations in ERBB receptors.We present a patient with metastatic cutaneous squamous cell carcinoma who failed surgery, radiation, and anti-PD1 therapy, but showed clinical response to a drug targeting an ERBB3 mutation identified with NGS. Following initiation of the drug lapatinib, this patient exhibited dramatic tumor regression in the skin, soft tissue, bone and nerves.Cutaneous squamous cell

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2018 Experimental hematology & oncology

29. Correlation between tripartite motif-containing protein 44 protein expression and the prognosis of postoperative patients exhibiting skin squamous cell carcinoma. (PubMed)

Correlation between tripartite motif-containing protein 44 protein expression and the prognosis of postoperative patients exhibiting skin squamous cell carcinoma. Tripartite motif-containing protein 44 (TRIM44) plays an important role in the development and progression of some human cancers; however, its role in skin squamous cell carcinoma (SCC) remains unknown. The aim of the present study was to investigate TRIM44 expression and clinicopathological significance of TRIM44 (...) in SCC.Immunohistochemistry (IHC) technique, reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot were performed to evaluate differences in TRIM44 protein expression in SCC and normal skin tissues.IHC showed that the positive rate of TRIM44 staining in SCC tissues 26.00% (9/30), while the positive rate of normal control group was 83.33% (25/30). The positive rate of TRIM44 staining in SCC tissues is significantly lower than normal skin tissue (P <.01). RT-PCR showed that the positive rates of TRIM44

2018 Medicine

30. Case report: Penile squamous cell carcinoma associated with severe hypercalcemia and high levels of Parathyroid Hormone related Peptide (PTHrP) expressed in metastatic skin tissue. (PubMed)

Case report: Penile squamous cell carcinoma associated with severe hypercalcemia and high levels of Parathyroid Hormone related Peptide (PTHrP) expressed in metastatic skin tissue. It is known that high levels of parathyroid hormone-related protein (PTHrP) correlate with a bad prognostic in malignancies. Here we present a patient with advanced penile cancer (PC) without antecedents of human papillomavirus infections and bone metastases but with severe hypercalcemia. By quantitative polymerase

2018 Urology

31. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. (PubMed)

Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. The G-protein-coupled receptors LGR4, LGR5 and LGR6 are Wnt signaling mediators, but their functions in squamous cell carcinoma (SCC) are unclear. Using lineage tracing in Lgr5-EGFP-CreERT2/Rosa26-Tomato and Lgr6-EGFP-CreERT2/Rosa26-Tomato reporter mice, we demonstrate that Lgr6, but not Lgr5, acts as an epithelial stem cell marker in SCCs in vivo. We identify, by single-molecule in situ hybridization and cell sorting, rare cells (...) positive for Lgr6 expression in immortalized keratinocytes and show that their frequency increases in advanced SCCs. Lgr6 expression is enriched in cells with stem cell characteristics, and Lgr6 downregulation in vivo causes increased epidermal proliferation with expanded lineage tracing from epidermal stem cells positive for Lgr6 expression. Surprisingly, mice with germline knockout of Lgr6 are predisposed to SCC development, through a mechanism that includes compensatory upregulation of Lgr5

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2017 Nature Genetics

32. p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker. (PubMed)

p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker. The p63 gene is often overexpressed in squamous cell carcinomas; however, how its overexpression contributes to tumor formation and expansion is still incompletely understood. Devos et al. report the development of a versatile mouse model demonstrating that p63 facilitates squamous cell carcinoma formation in skin and providing an excellent tool to dissect the relevance of its downstream signaling pathways

2017 Journal of Investigative Dermatology

33. Cancer cell of origin controls epithelial-to-mesenchymal transition in skin squamous cell carcinoma (PubMed)

Cancer cell of origin controls epithelial-to-mesenchymal transition in skin squamous cell carcinoma 28607908 2018 11 13 2306-9759 4 2017 Stem cell investigation Stem Cell Investig Cancer cell of origin controls epithelial-to-mesenchymal transition in skin squamous cell carcinoma. 34 10.21037/sci.2017.04.03 Chandrakesan Parthasarathy P Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Stephenson Cancer Center, University of Oklahoma Health Sciences (...) Center, Oklahoma City, OK, USA. Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. eng Editorial Comment 2017 05 05 China Stem Cell Investig 101672113 2306-9759 Cell Stem Cell. 2017 Feb 2;20(2):191-204.e5 27889319 Conflicts of Interest: The author has no conflicts of interest to declare. 2017 03 16 2017 04 07 2017 6 14 6 0 2017 6 14 6 0 2017 6 14 6 1 epublish 28607908 10.21037/sci.2017.04.03 sci-04-2017.04.03 PMC5460141 Nat Rev Cancer. 2013 Feb;13(2):97-110 23344542 Nat Rev Cancer

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2017 Stem Cell Investigation

34. Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma

> 500 msec Active infection requiring systemic therapy Clinically significant hemoptysis or tumor bleeding within 2 weeks prior to first dose of lenvatinib Other active malignancy except for basal cell or squamous cell carcinoma of the skin, or carcinoma in situ of the cervix or bladder Women who are breast feeding or pregnant ° Men or women of reproductive potential who are not willing to employ effective birth control from screening to 30 days after the last dose of study drugs; the definition (...) Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning

2018 Clinical Trials

35. 'Eternal sunshine of the spotless islands': how dermoscopy may influence confocal microscopy when dealing with squamous cells carcinoma simulating basal cell carcinoma. (PubMed)

'Eternal sunshine of the spotless islands': how dermoscopy may influence confocal microscopy when dealing with squamous cells carcinoma simulating basal cell carcinoma. Basal cell carcinoma (BCC) represents one of the best indications for the use of in-vivo reflectance confocal microscopy (RCM). High levels of diagnostic accuracy is reached with the combined use of dermoscopy and RCM for BCC diagnosis that is based on a set of distinct confocal features. Furthermore, new handled devices allowed (...) to speed-up the confocal examination at patient's bedside, making easier and faster the systematic use of RCM for atypical skin lesions. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 Journal of the European Academy of Dermatology and Venereology

36. Having a first-degree relative with melanoma increases lifetime risk of melanoma, squamous cell carcinoma, and basal cell carcinoma. (PubMed)

, and Health Professionals Follow-up Study for more than 20 years. Cox proportional hazards regression controlling for known risk factors for skin cancer was used to estimate association between family history of melanoma and melanoma and KCs.Compared with those without a family history of melanoma, individuals with a family history of melanoma had a 74% increased risk of melanoma (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.45-2.09), a 22% increased risk of squamous cell carcinoma (HR, 1.22 (...) Having a first-degree relative with melanoma increases lifetime risk of melanoma, squamous cell carcinoma, and basal cell carcinoma. Previous studies have found familial aggregation of melanoma and keratinocyte cancers (KCs).We sought to determine the risk of melanoma and KCs in those with a positive family history of melanoma while controlling for pigmentary and environmental risk factors.We prospectively followed 216,115 participants from the Nurses' Health Study, Nurse's Health Study 2

2019 Journal of American Academy of Dermatology

37. Recommendations for Solid Organ Transplantation for Transplant Candidates With a Pretransplant Diagnosis of Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma and Melanoma: A Consensus Opinion From the International Transplant Skin Cancer Collaborat (PubMed)

Recommendations for Solid Organ Transplantation for Transplant Candidates With a Pretransplant Diagnosis of Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma and Melanoma: A Consensus Opinion From the International Transplant Skin Cancer Collaborat Advancements in solid organ transplantation successfully extend the lives of thousands of patients annually. The tenet of organ stewardship aims to prevent the futile expenditure of scarce donor organs in patient populations with high (...) for transplant candidates with a history of either cutaneous squamous cell carcinoma, malignant melanoma, or Merkel cell carcinoma. © Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.

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2016 American Journal of Transplantation

38. Risk of Aggressive Skin Cancers Following Kidney Retransplantation in Patients With Previous Posttransplant Cutaneous Squamous Cell Carcinomas: A Retrospective Study of 53 Cases. (PubMed)

Risk of Aggressive Skin Cancers Following Kidney Retransplantation in Patients With Previous Posttransplant Cutaneous Squamous Cell Carcinomas: A Retrospective Study of 53 Cases. The course of skin cancer after retransplantation in organ-transplant recipients who have already developed posttransplant skin cancer has not been assessed.This retrospective multicentric study included 53 patients with a history of cutaneous squamous cell carcinoma (SCC) after a first kidney transplantation who (...) %) patients developed SCC in dialysis and 39 (73.6%) after the second transplantation, respectively. Twenty aggressive SCC developed over the study period. They occurred in 14 (26.4%) patients after retransplantation vs 5 (9.4%) after the first transplantation with a median delay of 50 months and were responsible for 5 deaths. Fair skin type, multiple tumors before retransplantation, treatment with azathioprine, T cell-depleting antibodies, and delayed revision of immunosuppression were associated

2017 Transplantation

39. Incidence of skin toxicity in squamous cell carcinoma of the head and neck treated with radiotherapy and cetuximab: A systematic review. (PubMed)

Incidence of skin toxicity in squamous cell carcinoma of the head and neck treated with radiotherapy and cetuximab: A systematic review. Radiotherapy plus cetuximab is an effective combination therapy for locally advanced head and neck squamous cell carcinoma. The aim of our study was to determine the frequency of skin toxicity in patients receiving the combined treatment.Forty-eight studies were included in our analysis, for a total of 2152 patients. The mean rates of G3/G4 radiation (...) dermatitis and acneiform rash were 32.5% (SD: 20.4; 95% CI: 28.5-36.5) and 13.4% (SD: 11.5; 95% CI: 11.2-15.6), respectively. The majority of studies referred to CTCAE scales for reporting both side effects (85.7% and 92.1%, respectively). Data on the management of skin toxicity were available in only 35.4% of the reviewed literature.severe radiation dermatitis is a frequent side effect induced by the combination of radiotherapy and cetuximab in head and neck cancer. The lack of predictive biomarkers

2017 Critical reviews in oncology/hematology

40. Surgical Treatment of Subungual Squamous Cell Carcinoma by Wide Excision of the Nail Unit and Skin Graft Reconstruction: An Evaluation of Treatment Efficiency and Outcomes. (PubMed)

Surgical Treatment of Subungual Squamous Cell Carcinoma by Wide Excision of the Nail Unit and Skin Graft Reconstruction: An Evaluation of Treatment Efficiency and Outcomes. The best surgical treatment modalities for subungual squamous cell carcinoma (SUSCC) without bone invasion need to be determined. The limited available data on Mohs micrographic surgery do not demonstrate its use as a standard procedure. A previous study in a limited series of patients has shown that wide surgical excision (...) of the nail unit was associated with a low rate of recurrence.To confirm the efficiency of wide surgical excision of the nail unit with full-thickness skin graft reconstruction on a series of patients with SUSCC with an extended follow-up and to evaluate short- and long-term postoperative morbidity and patient satisfaction.A consecutive series of 55 patients with biopsy-proven SUSCC without bone invasion treated by wide surgical excision of the nail unit followed by full-thickness skin graft

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2017 JAMA dermatology (Chicago, Ill.)

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