How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

13,956 results for

Squamous Cell Carcinoma of the Skin

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

21. Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. Full Text available with Trip Pro

Skin cancer precursor immunotherapy for squamous cell carcinoma prevention. Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). However, the long-term effectiveness of calcipotriol plus 5-FU treatment for SCC prevention is unknown.We performed a blinded prospective cohort study on participants of a randomized double-blind clinical trial in which a 4-day course of topical (...) calcipotriol plus 5-FU combination was compared to Vaseline plus 5-FU (control) for AK treatment. SCC and basal cell carcinoma (BCC) incidences were assessed at 1, 2, and 3 years after trial. Tissues were analyzed for calcipotriol plus 5-FU-induced T cell immunity in the skin.Calcipotriol plus 5-FU-induced tissue-resident memory T (Trm) cell formation in face and scalp skin associated with significantly higher erythema scores compared with control (P < 0.01). Importantly, more participants in the test

2019 JCI insight Controlled trial quality: uncertain

22. Total body skin examination increases squamous cell carcinoma detection: a retrospective cohort study. (Abstract)

Total body skin examination increases squamous cell carcinoma detection: a retrospective cohort study. Squamous cell carcinomas (SCCs) have the potential for local tissue destruction and metastasis. The risk of complications increases if the lesion is not diagnosed and excised in a timely manner. Total body skin examination (TBSE) has been reported to increase melanoma detection; the objective of this study was to determine if it also increases SCC detection. Analysis of 469 SCCs diagnosed (...) at a UK tertiary centre showed that 6.8% of these were detected incidentally and not from the index lesion that prompted referral. These incidentally detected SCCs tended to represent early disease, and therefore carried lower risk of complications. Our findings suggest that full skin checks may increase the number of SCCs detected, and at an earlier stage of disease. Therefore, we encourage the use of TBSE in all dermatology outpatient appointments, and make suggestions as to how to incorporate

2019 Clinical & Experimental Dermatology

23. Usefulness of real-time elastography for diagnosing lymph node metastasis of skin cancer; does elastography potentially eliminate the need for sentinel lymph node biopsy in squamous cell carcinoma? (Abstract)

Usefulness of real-time elastography for diagnosing lymph node metastasis of skin cancer; does elastography potentially eliminate the need for sentinel lymph node biopsy in squamous cell carcinoma? The metastatic involvement of regional lymph nodes is the most important prognostic factor for overall survival of skin cancer patients. The sonographic technique of freehand real-time tissue elastography (RTE), which displays tissue rigidity as a color overlay of the tissue image, was developed.Our (...) purpose was to evaluate the benefit of RTE for detecting lymph node metastases of skin cancer noninvasively before operation.We first selected lymph nodes of skin cancer patients which had already been diagnosed by biopsy as being reactive or metastatic, and then retrospectively collected images of RTE and B-mode and color Doppler ultrasound on those lymph nodes performed preoperatively. Twenty-one lymph nodes from 12 patients with squamous cell carcinoma (SCC), 23 lymph nodes from 14 patients

2019 Journal of the European Academy of Dermatology and Venereology

24. Antitumor Effects of DC Vaccine With ALA-PDT-Induced Immunogenic Apoptotic Cells for Skin Squamous Cell Carcinoma in Mice Full Text available with Trip Pro

Antitumor Effects of DC Vaccine With ALA-PDT-Induced Immunogenic Apoptotic Cells for Skin Squamous Cell Carcinoma in Mice Targeted immunotherapy using dendritic cell vaccine has been employed for the treatment of solid tumors. Topical 5-aminolevulinic acid-mediated photodynamic therapy, an established approach for topical cancers, can induce an effective antitumor immune response. We have previously shown that 5-aminolevulinic acid-mediated photodynamic therapy-induced tumor lysates could (...) considerably enhance antigen-presenting capacity of ex vivo-generated dendritic cells. The current study further demonstrates that 5-aminolevulinic acid-mediated photodynamic therapy dendritic cell vaccine can induce immune responses against cancers. Dendritic cells pulsed by photodynamic therapy-treated skin squamous cell carcinoma cells inhibited squamous cell carcinoma to a greater extent than tumor lysates treated by photodynamic therapy alone or dendritic cells pulsed by freeze-thawed treated tumor

2018 Technology in cancer research & treatment

25. Sun protection for preventing basal cell and squamous cell skin cancers. Full Text available with Trip Pro

Sun protection for preventing basal cell and squamous cell skin cancers. 'Keratinocyte cancer' is now the preferred term for the most commonly identified skin cancers basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), which were previously commonly categorised as non-melanoma skin cancers (NMSC). Keratinocyte cancer (KC) represents about 95% of malignant skin tumours. Lifestyle changes have led to increased exposure to the sun, which has, in turn, led to a significant (...) and barrier methods) for preventing keratinocyte cancer (that is, basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) of the skin) in the general population.We searched the following databases up to May 2016: the Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE, Embase, and LILACS. We also searched five trial registries and the bibliographies of included studies for further references to relevant trials.We included randomised controlled clinical trials (RCTs) of preventive

2016 Cochrane

26. Guidelines of care for the management of cutaneous squamous cell carcinoma Full Text available with Trip Pro

Subject Headings) terms used in various combinations in the literature search included carcinoma , basal cell carcinoma , squamous cell carcinoma , skin neoplasms , stage ( ing ), grade ( ing ), score ( ing ), biopsy , pathology , prognosis , signs and symptoms , risk factors , curettage , electrodesiccation , excision , incomplete , cryosurgery , Mohs ( micrographic ) surgery , topical , fluorouracil , imiquimod , laser , radiotherapy , radiation , photochemotherapy , phototherapy , metastasis (...) carcinomas in solid organ transplant recipients: emerging strategies for surveillance, staging, and treatment. Semin Oncol . 2016 ; 43 : 390–394 | | | | has emerged as an increasingly important contributor to tumorigenesis. cSCC can develop on any skin surface. In fair-skinned individuals, who are at highest risk, sun exposed areas, including the head and neck and the backs of the arms and hands, are common anatomic sites. x 12 Alam, M. and Ratner, D. Cutaneous squamous-cell carcinoma. N Engl J Med

2018 American Academy of Dermatology

27. The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma Full Text available with Trip Pro

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma | SpringerLink This service is more advanced with JavaScript available, learn more at Advertisement Hide Search SpringerLink March 2019 , Volume 46, , pp 623–637 | The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma Authors Francesco (...) Giammarile Clare Schilling Gopinanth Gnanasegaran Chandrasckhar Bal Wim J. G. Oyen Domenico Rubello Thomas Schwarz Girolamo Tartaglione Rodolfo Nuñez Miller Diana Paez Fijis W. B. van Leeuwen Renato A. Valdés Olmos Mark McGurk Roberto C. Delgado Bolton Open Access Guidelines First Online: 18 December 2018 2k Downloads Abstract Purpose Sentinel lymph node biopsy is an essential staging tool in patients with clinically localized oral cavity squamous cell carcinoma. The harvesting of a sentinel lymph node

2019 European Association of Nuclear Medicine

28. Risks of different skin tumor combinations after a first melanoma, squamous cell carcinoma and basal cell carcinoma in Dutch population based cohorts: 1989 - 2009. Full Text available with Trip Pro

Risks of different skin tumor combinations after a first melanoma, squamous cell carcinoma and basal cell carcinoma in Dutch population based cohorts: 1989 - 2009. Skin cancer patients are primarily at increased risk of developing subsequent skin cancers of the same type. Shared risk factors might also increase the occurrence of a different type of subsequent skin cancer.To investigate risks of different skin tumour combinations after a first melanoma, squamous cell carcinoma (SCC) and basal (...) cell carcinoma (BCC).All melanoma and SCC patients included in the national Netherlands Cancer Registry (NCR) and all BCC patients included in the regional Eindhoven Cancer Registry (ECR) between 1989 and 2009 were followed until diagnosis of a subsequent different skin cancer (melanoma, SCC or BCC), date of death or end of study. Cumulative risks, standardized incidence ratios (SIR) and absolute excess risks (AER) of subsequent skin cancers were calculated.A total of 50 510 melanoma patients

2017 Journal of the European Academy of Dermatology and Venereology

29. Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway Full Text available with Trip Pro

Preventive effect of Dioscorea japonica on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E2 synthetic pathway Hyperproduced prostaglandin E2 by cyclooxygenase-2 and microsomal prostaglandin E synthase-1 evokes several pathophysiological responses such as inflammation and carcinogenesis. Our recent study demonstrated that Dioscorea japonica extract suppressed the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 and induced apoptosis (...) in lung carcinoma A549 cells. In the present study, we investigated the effects of Dioscorea japonica on squamous cell carcinoma of mouse skin. Dioscorea japonica feeding and Dioscorea japonica extract topical application suppressed the expression of cyclooxygenase-2, microsomal prostaglandin E synthase-1, interleukin-1β and interleukin-6 and inhibited tumor formation, hyperplasia and inflammatory cell infiltration. Immunohistochemical analyses showed the immunoreactivities of cyclooxygenase-2

2018 Journal of clinical biochemistry and nutrition

30. Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases Full Text available with Trip Pro

Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases Squamous cell carcinoma antigens 1 and 2 (SCCA1 and 2, SERPIN B3 and B4), members of the ovalbumin serpin (ov-serpin)/clade B serpin family, were originally discovered as tumor-specific antigens and are used as tumor markers for various kinds of squamous cell carcinomas. Recently, our understanding of the underlying mechanisms of how SCCA1/2 enhance tumor growth has greatly increased (...) . Moreover, it has been shown that SCCA1/2 are involved in the pathogenesis of several inflammatory diseases: asthma, psoriasis, and atopic dermatitis (AD). IL-22 and IL-17, signature cytokines of type 17 inflammation, as well as IL-4 and IL-13, signature cytokines of type 2 inflammation, both of which are positively correlated with the pathogenesis of psoriasis and allergic diseases, respectively, can induce expression of SCCA1/2 in airway epithelial cells and/or keratinocytes, leading to high

2018 International journal of molecular sciences

31. Correlation between tripartite motif-containing protein 44 protein expression and the prognosis of postoperative patients exhibiting skin squamous cell carcinoma. Full Text available with Trip Pro

Correlation between tripartite motif-containing protein 44 protein expression and the prognosis of postoperative patients exhibiting skin squamous cell carcinoma. Tripartite motif-containing protein 44 (TRIM44) plays an important role in the development and progression of some human cancers; however, its role in skin squamous cell carcinoma (SCC) remains unknown. The aim of the present study was to investigate TRIM44 expression and clinicopathological significance of TRIM44 (...) in SCC.Immunohistochemistry (IHC) technique, reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot were performed to evaluate differences in TRIM44 protein expression in SCC and normal skin tissues.IHC showed that the positive rate of TRIM44 staining in SCC tissues 26.00% (9/30), while the positive rate of normal control group was 83.33% (25/30). The positive rate of TRIM44 staining in SCC tissues is significantly lower than normal skin tissue (P <.01). RT-PCR showed that the positive rates of TRIM44

2018 Medicine

32. Case report: Penile squamous cell carcinoma associated with severe hypercalcemia and high levels of Parathyroid Hormone related Peptide (PTHrP) expressed in metastatic skin tissue. Full Text available with Trip Pro

Case report: Penile squamous cell carcinoma associated with severe hypercalcemia and high levels of Parathyroid Hormone related Peptide (PTHrP) expressed in metastatic skin tissue. It is known that high levels of parathyroid hormone-related protein (PTHrP) correlate with a bad prognostic in malignancies. Here we present a patient with advanced penile cancer (PC) without antecedents of human papillomavirus infections and bone metastases but with severe hypercalcemia. By quantitative polymerase

2018 Urology

33. Heterogeneous relationships of squamous and basal cell carcinomas of the skin with smoking: the UK Million Women Study and meta-analysis of prospective studies. Full Text available with Trip Pro

Heterogeneous relationships of squamous and basal cell carcinomas of the skin with smoking: the UK Million Women Study and meta-analysis of prospective studies. Published findings on the associations between smoking and the incidence of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are inconsistent. We aimed to generate prospective evidence on these relationships overall and by anatomical site.We followed 1,223,626 women without prior cancer by electronic linkage

2018 British Journal of Cancer

34. Metastatic squamous cell carcinoma of the skin with clinical response to lapatinib Full Text available with Trip Pro

Metastatic squamous cell carcinoma of the skin with clinical response to lapatinib Lapatinib is a tyrosine kinase inhibitor that blocks the HER2 receptor and is typically used in the setting of metastatic breast cancer. Both ERBB2 (HER2) and ERBB3 (HER3) belong to the same family of receptor tyrosine kinases. Dimerization of these receptors leads to activation of cell proliferation and survival pathways, granting oncogenic potential to dysregulated ERBB/HER receptors. Next generation sequencing (...) (NGS) of tumors has ushered in a new era of personalized oncology therapy and has the ability to detect mutations in ERBB receptors.We present a patient with metastatic cutaneous squamous cell carcinoma who failed surgery, radiation, and anti-PD1 therapy, but showed clinical response to a drug targeting an ERBB3 mutation identified with NGS. Following initiation of the drug lapatinib, this patient exhibited dramatic tumor regression in the skin, soft tissue, bone and nerves.Cutaneous squamous cell

2018 Experimental hematology & oncology

35. Finger Pad Squamous Cell Carcinoma: Report of Squamous Cell Carcinoma of the Distal Palmar Digit and Review of Associated Risk Factors, Mimickers, and Treatment of Squamous Cell Carcinoma of Ventral Hand Digits Full Text available with Trip Pro

of the hand. the authors also summarize the clinical differential diagnoses and treatment of squamous cell carcinoma at this location. METHODS: the authors retrospectively reviewed the literature using PubMed and searched for the following terms: squamous cell carcinoma, squamous cell carcinoma in situ, finger, thumb, palmar, and ventral. Papers were critically evaluated and their cited references reviewed. RESULTS: Skin biopsy established the patient's diagnosis. His tumor was excised using Mohs (...) Finger Pad Squamous Cell Carcinoma: Report of Squamous Cell Carcinoma of the Distal Palmar Digit and Review of Associated Risk Factors, Mimickers, and Treatment of Squamous Cell Carcinoma of Ventral Hand Digits BACKGROUND: Squamous cell carcinoma of the palmar digits is rare. PURPOSE: The authors describe a man with squamous cell carcinoma of the pulp of his left fourth finger, and review the risk factors that may be associated with squamous cell carcinoma development on the ventral digits

2017 The Journal of clinical and aesthetic dermatology

36. Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma

> 500 msec Active infection requiring systemic therapy Clinically significant hemoptysis or tumor bleeding within 2 weeks prior to first dose of lenvatinib Other active malignancy except for basal cell or squamous cell carcinoma of the skin, or carcinoma in situ of the cervix or bladder Women who are breast feeding or pregnant ° Men or women of reproductive potential who are not willing to employ effective birth control from screening to 30 days after the last dose of study drugs; the definition (...) Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning

2018 Clinical Trials

37. Recurrence in Buccinator Muscle Excision With the Skin Versus Without the Skin in Buccal Squamous Cell Carcinoma

Recurrence in Buccinator Muscle Excision With the Skin Versus Without the Skin in Buccal Squamous Cell Carcinoma Recurrence in Buccinator Muscle Excision With the Skin Versus Without the Skin in Buccal Squamous Cell Carcinoma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Recurrence in Buccinator Muscle Excision With the Skin Versus Without the Skin in Buccal Squamous Cell Carcinoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov

2017 Clinical Trials

38. Skin microtopography as a measure of photoaging and risk of squamous cell carcinoma of the skin in a US population Full Text available with Trip Pro

Skin microtopography as a measure of photoaging and risk of squamous cell carcinoma of the skin in a US population Skin microtopography as a measure of photoaging is a noninvasive approach to measuring chronic ultraviolet radiation exposure and reflects the degree of dermal elastosis in populations of European descent in the subtropics. Less is known about the utility of this approach in populations at different latitudes, and whether it relates to skin cancer risk.A population-based case (...) -control study of 342 squamous cell carcinoma (SCC) cases and 331 age- and gender-matched controls were evaluated for histologic evidence of solar damage and severity of photoaging based on microtopography on a six-grade scale. Odds ratios (OR) for SCC associated with degree of photoaging were estimated using logistic regression analysis adjusted for potentially confounding factors.After adjustment for known risk factors, SCC was associated with increasing photoaging grade (OR = 1.7, 95% CI = 0.9-3.0

2017 Photodermatology, photoimmunology & photomedicine

39. p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker. Full Text available with Trip Pro

p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker. The p63 gene is often overexpressed in squamous cell carcinomas; however, how its overexpression contributes to tumor formation and expansion is still incompletely understood. Devos et al. report the development of a versatile mouse model demonstrating that p63 facilitates squamous cell carcinoma formation in skin and providing an excellent tool to dissect the relevance of its downstream signaling pathways

2017 Journal of Investigative Dermatology

40. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. Full Text available with Trip Pro

Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. The G-protein-coupled receptors LGR4, LGR5 and LGR6 are Wnt signaling mediators, but their functions in squamous cell carcinoma (SCC) are unclear. Using lineage tracing in Lgr5-EGFP-CreERT2/Rosa26-Tomato and Lgr6-EGFP-CreERT2/Rosa26-Tomato reporter mice, we demonstrate that Lgr6, but not Lgr5, acts as an epithelial stem cell marker in SCCs in vivo. We identify, by single-molecule in situ hybridization and cell sorting, rare cells (...) positive for Lgr6 expression in immortalized keratinocytes and show that their frequency increases in advanced SCCs. Lgr6 expression is enriched in cells with stem cell characteristics, and Lgr6 downregulation in vivo causes increased epidermal proliferation with expanded lineage tracing from epidermal stem cells positive for Lgr6 expression. Surprisingly, mice with germline knockout of Lgr6 are predisposed to SCC development, through a mechanism that includes compensatory upregulation of Lgr5

2017 Nature Genetics

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>