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Squamous Cell Carcinoma of the Skin

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181. Cutaneous squamous cell carcinoma with subtle perineural invasion detected with cytokeratin and epithelial membrane antigen immunohistochemistry Full Text available with Trip Pro

squamous cell carcinoma immunohistochemistry perineural invasion radiation therapy skin cancer squamous cell carcinoma 2018 10 16 6 0 2018 10 16 6 0 2018 10 16 6 1 epublish 30320199 10.1016/j.jdcr.2018.09.002 S2352-5126(18)30247-9 PMC6180242 J Am Acad Dermatol. 2018 Feb;78(2):237-247 29332704 Australas J Dermatol. 2014 May;55(2):107-10 24372092 Oral Oncol. 2012 Oct;48(10):918-922 22425152 JAAD Case Rep. 2016 Aug 24;2(4):346-9 27617283 Cancer. 2007 Mar 15;109(6):1053-9 17279578 J Cutan Pathol. 2008 Apr (...) Cutaneous squamous cell carcinoma with subtle perineural invasion detected with cytokeratin and epithelial membrane antigen immunohistochemistry 30320199 2019 02 26 2352-5126 4 9 2018 Oct JAAD case reports JAAD Case Rep Cutaneous squamous cell carcinoma with subtle perineural invasion detected with cytokeratin and epithelial membrane antigen immunohistochemistry. 934-937 10.1016/j.jdcr.2018.09.002 Lee Alison K AK Department of Dermatology, Yale School of Medicine, New Haven, Connecticut. Yoo

2018 JAAD Case Reports

182. The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions Full Text available with Trip Pro

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions Background: Human papillomavirus (HPV) has long been proposed as a cofactor in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). More recently, the striking clinico-pathological features of cSCCs that complicate treatment of metastatic melanoma with inhibitors targeting BRAF mutations (BRAFi) has prompted speculation concerning (...) to determine the presence and viral load of HPyVs with affinity for the skin (HPyV6, HPyV7, HPyV9, MCPyV, and TSPyV). These data were correlated with previous genetic mutational analysis of H, K and NRAS, NOTCH1/2, TP53, CDKN2A, CARD11, CREBBP, TGFBR1/2. Chromosomal aberrations were profiled using single nucleotide polymorphism (SNP) arrays. Results: Forty-five skin lesions from seven patients treated with single agent vemurafenib in 2012-2013 were analyzed: 12 cSCC, 19 viral warts (VW), 2 actinic

2018 Frontiers in microbiology

183. Would Marjolin see it coming? Two unusual cases of squamous cell carcinoma Full Text available with Trip Pro

Would Marjolin see it coming? Two unusual cases of squamous cell carcinoma Cutaneous squamous cell carcinoma (SCC) is a common skin cancer, second in incidence only to basal cell carcinoma (BCC). The incidence of SCC increases significantly with age; thus, it is rarely diagnosed in young patients. In this paper, we present two cases of young patients who presented clinically with purulent lesions that were later diagnosed as large primary SCCs.A review of the medical records of two patients who (...) sending tissue samples to pathology. Biopsies of the lesions were performed to obtain a tissue diagnosis due to recurrence approximately one year after the initial treatment. Histological evaluation revealed well differentiated squamous cell carcinomas. Surgical intervention with wide excision with adjuvant chemotherapy was recommended based on biopsy and CT scan results.Aggressive behavior of SCC in young patients is uncommon. The patients in this report were diagnosed only one year after the first

2018 International journal of surgery case reports

184. Aggressive squamous cell carcinoma in a patient on the Janus kinase inhibitor ruxolitinib Full Text available with Trip Pro

, Dallas, Texas. eng Case Reports 2018 04 30 United States JAAD Case Rep 101665210 2352-5126 BCC, basal cell carcinoma JAK, Janus kinase Janus kinase SCC, squamous cell carcinoma myelofibrosis polycythemia vera ruxolitinib skin cancer 2018 7 10 6 0 2018 7 10 6 0 2018 7 10 6 1 epublish 29984281 10.1016/j.jdcr.2018.01.001 S2352-5126(18)30007-9 PMC6031591 Leukemia. 2016 Aug;30(8):1701-7 27211272 J Drugs Dermatol. 2017 May 1;16(5):508-511 28628689 N Engl J Med. 2015 Jan 29;372(5):426-35 25629741 Drugs (...) Aggressive squamous cell carcinoma in a patient on the Janus kinase inhibitor ruxolitinib 29984281 2019 02 26 2352-5126 4 5 2018 Jun JAAD case reports JAAD Case Rep Aggressive squamous cell carcinoma in a patient on the Janus kinase inhibitor ruxolitinib. 455-457 10.1016/j.jdcr.2018.01.001 Aboul-Fettouh Nader N Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas. Nijhawan Rajiv I RI Department of Dermatology, University of Texas Southwestern Medical Center

2018 JAAD Case Reports

185. Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B Full Text available with Trip Pro

Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs. In contrast with Notch, we show that the transcription factor CSL (also known as RBP-Jκ), a key effector of canonical Notch signaling endowed with intrinsic transcription-repressive functions, plays a tumor-promoting function in SCC development. Expression of this gene (...) decreased in upper epidermal layers and human keratinocytes (HKCs) undergoing differentiation, while it increased in premalignant and malignant SCC lesions from skin, head/neck, and lung. Increased CSL levels enhanced the proliferative potential of HKCs and SCC cells, while silencing of CSL induced growth arrest and apoptosis. In vivo, SCC cells with increased CSL levels gave rise to rapidly expanding tumors, while cells with silenced CSL formed smaller and more differentiated tumors with enhanced

2018 The Journal of clinical investigation

186. A giant cutaneous squamous cell carcinoma of the neck Full Text available with Trip Pro

101517926 IM Aged Carcinoma, Squamous Cell diagnosis pathology Fatal Outcome Head and Neck Neoplasms diagnosis pathology Humans Male Skin Neoplasms diagnosis pathology Squamous Cell Carcinoma of Head and Neck Skin chemotherapy squamous cell carcinoma 2018 01 26 2018 05 01 2018 9 1 6 0 2018 9 1 6 0 2018 10 3 6 0 epublish 30167050 10.11604/pamj.2018.30.22.14984 PAMJ-30-22 PMC6110546 (...) A giant cutaneous squamous cell carcinoma of the neck 30167050 2018 10 01 2019 02 21 1937-8688 30 2018 The Pan African medical journal Pan Afr Med J A giant cutaneous squamous cell carcinoma of the neck. 22 10.11604/pamj.2018.30.22.14984 Bazine Aziz A Medical Oncology Department, Military Hospital Moulay Ismaïl, Meknès, Morocco. Fetohi Mohamed M Medical Oncology Department, Military Hospital Moulay Ismaïl, Meknès, Morocco. eng Case Reports Journal Article 2018 05 15 Uganda Pan Afr Med J

2018 The Pan African medical journal

187. Effective treatment of a platinum-resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition Full Text available with Trip Pro

Effective treatment of a platinum-resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non-melanoma skin cancer. Platinum-based regimens have been an integral part of palliative care for patients with locally advanced or metastatic disease. There is no evidence of efficacy for later lines of chemotherapy and no targeted therapy has been introduced as 'standard of care'. Here we report on the case (...) of an elderly cSCC patient, resistant to conventional therapy, however successfully treated with anti-epidermal growth factor receptor (EGFR) agent (Cetuximab) in addition to a daily dose of Curcumin phospholipid. The patient responded to treatment and experienced no recurrence for 11 months with only minor skin-related toxicity. To our knowledge, this is the first report of clinical evidence that an anti EGFR targeted therapy with a daily oral dose of Curcumin phospholipid is well tolerated and results

2018 Molecular and clinical oncology

188. A case report of squamous cell carcinoma in a suprapubic urinary catheter tract: surgical excision and simultaneous colostomy formation Full Text available with Trip Pro

A case report of squamous cell carcinoma in a suprapubic urinary catheter tract: surgical excision and simultaneous colostomy formation Squamous cell carcinoma (SCC) arising from a suprapubic cystostomy tract is a rare complication of long-term suprapubic catheterization (SPC). A 53-year-old man with paraplegia secondary to spina bifida presented with a painful granulomatous lesion around his SPC site that was being treated with silver nitrate cauterization in the community. Consequently, he (...) developed a sacral pressure sore due to reduced mobility from the pain. He also had increasing difficulties with defaecation secondary to his spina bifida. His sacral pressure sore was secondary to a cryptoglandular fistula with coccygeal osteomylelitis. Post-operative pathology revealed infiltrative SCC involving full thickness of the specimen from skin to the bladder wall with clear surgical margins. We describe the first case requiring a simultaneous suprapubic tract SCC excision and colostomy

2018 Journal of surgical case reports

189. Adenoid Squamous Cell Carcinoma of Oral Cavity: a Case Report Full Text available with Trip Pro

Adenoid Squamous Cell Carcinoma of Oral Cavity: a Case Report Adenoid squamous cell carcinoma is a rare variant of squamous cell carcinoma with features of adenoid pattern. It has been reported to originate in the sun- exposed skin of the head and neck region. Although rare, there are cases documented within the oral cavity and nasopharynx. The clinical behaviour and the prognosis are variable. We report a case of adenoid squamous cell carcinoma in a 63-year-old female patient presented (...) with a large mass in the left mandibular alveolar ridge. Histologically, the lesion showed areas of conventional squamous cell carcinoma along with atypical epithelial cells forming a glandular pattern. However, there is no evidence of glandular differentiation, secretory activity or its products. Adenoid squamous cell carcinoma must be differentiated from adenosquamous carcinoma in which adenocarcinoma elements are positive for mucins. There are few cases reported to establish biological behaviour

2018 Journal of dentistry

190. Peri - and Intraocular Mutilating Advanced Squamous Cell Carcinoma: “Monsters Inside Your Body”? Full Text available with Trip Pro

Peri - and Intraocular Mutilating Advanced Squamous Cell Carcinoma: “Monsters Inside Your Body”? Periocular malignancies represent between 5% and 10% of all types of skin cancers. The incidence of eyelid (but also the periocular located) malignancies seems to differ in distribution across the continents. The incidence of eyelid tumours (but also the periocular located tumours) in a predominantly white population determined that BCC is the most common malignant periocular eyelid tumour (...) in whites. This finding has been replicated consistently throughout the literature, with BCC representing 85-95% of all eyelid malignancies, SCC representing 3.4 - 12.6%, Seb Ca representing 0.6 - 10.2%, and both melanoma and Merkel cell carcinoma representing less than 1%. Most periocular skin cancers are associated with ultraviolet radiation (UVR) exposure. Ultraviolet radiation causes local immune suppression, which, coupled with DNA abnormalities in tumour suppressor genes and oncogenes, leads

2018 Open access Macedonian journal of medical sciences

191. Clinical Remission of Cutaneous Squamous Cell Carcinoma of the Auricle with Cetuximab and Nivolumab Full Text available with Trip Pro

Clinical Remission of Cutaneous Squamous Cell Carcinoma of the Auricle with Cetuximab and Nivolumab Cutaneous squamous cell carcinomas (SCC) affecting the regions of the head and neck can be challenging to resect surgically and refractory to chemotherapy or radiation therapy. Consequently; the treatment of squamous cell carcinomas of the skin is a focus of current research. One such advancement is immunotherapy. Herein we describe clinical remission of invasive, poorly differentiated squamous (...) cell carcinoma of the pre-auricular region with external auditory canal involvement using cetuximab, an epidermal growth factor receptor (EGFR) antibody; and nivolumab, a programmed death receptor-1 (PD-1) antibody. Such durable and comprehensive disease resolution demonstrates the therapeutic potential of cetuximab and nivolumab in surgically challenging, treatment-resistant cutaneous squamous cell carcinoma.

2018 Journal of clinical medicine

192. Giant Pendulous Carcinosarcoma – Squamous Cell Carcinoma-Type - of the Leg – A Case Report and Review of the Literature Full Text available with Trip Pro

Giant Pendulous Carcinosarcoma – Squamous Cell Carcinoma-Type - of the Leg – A Case Report and Review of the Literature Cutaneous carcinosarcoma (CCS) is a rare non-melanoma skin cancer with a biphasic growth pattern. A tumour is composed of epithelial and mesenchymal cells that show clonality. In most cases, CCS develops in the head-and-neck region on the chronic sun-exposed skin of males. Here, we describe an 80-year-old female patient who developed a giant, pendulous CCS on the leg (...) . A tumour was surgically removed. We found no evidence of metastatic spread.

2018 Open access Macedonian journal of medical sciences

193. Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence Full Text available with Trip Pro

Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence Esophageal cancer occurs as either squamous cell carcinoma (ESCC) or adenocarcinoma. ESCCs comprise almost 90% of cases worldwide, and recur with a less than 15% five-year survival rate despite available treatments. The identification of new ESCC drivers and therapeutic targets is critical for improving outcomes. Here we report that expression of the human DEK oncogene is strongly upregulated (...) human skin, thus linking high DEK expression in keratinocytes to oncogenic phenotypes. However, the role of DEK over-expression in ESCC development remains unknown in human cells or genetic mouse models. To define the consequences of Dek overexpression in vivo, we generated and validated a tetracycline responsive Dek transgenic mouse model referred to as Bi-L-Dek. Dek overexpression was induced in the basal keratinocytes of stratified squamous epithelium by crossing Bi-L-Dek mice to keratin 5

2018 PLoS genetics

194. WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway Full Text available with Trip Pro

WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway Objectives WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) has been implicated in tumor progression. We aimed to investigate the role of WWP1 in cutaneous squamous cell carcinoma (CSCC). Methods WWP1 gene and protein levels were detected using semi-quantitative reverse transcription (...) -polymerase chain reaction, immunohistochemistry and western blotting. The effects of WWP1 on cell cycle, apoptosis, cell migration and invasion were examined by flow cytometry, wound healing and Transwell assays, respectively. The antitumor efficacy of WWP1 small interfering RNA was determined in CSCC tumor xenografts in mice. Results WWP1 expression was significantly higher in CSCC tissues and cells than in normal skin and cells, respectively. WWP1 expression was significantly associated

2018 The Journal of international medical research

195. Squamous Cell Carcinomas in Two Cases of Nail Lichen Planus: Is There a Real Association? Full Text available with Trip Pro

Squamous Cell Carcinomas in Two Cases of Nail Lichen Planus: Is There a Real Association? Lichen planus (LP) is a chronic inflammatory disease that affects the skin and oral mucosa. Although its etiology is unknown, its potential for cancerization has been confirmed. We herein report the cases of a brother and sister, both with a 15-year history of nail lichen planus of the fingers and toes, who developed squamous cell carcinomas of the nail bed and matrix. This article shows the potential (...) for malignant transformation in lichen planus disease and highlights the importance of periodic clinical follow-up.

2018 Dermatology and therapy

196. Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip Full Text available with Trip Pro

Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip An early diagnosis is of overwhelming importance for the management and prognosis of mucocutaneous cancer. Actinic cheilitis (AC), defined by the clonal expansion of genomically unstable keratinocytes, is the most common potentially malignant lesion affecting the lips. Squamous cell carcinoma (SCC) is the most frequent oral malignancy, and there is strong evidence that the majority of the SCCs of the lip originate (...) from AC. There is considerable difficulty in discerning between dysplasia and invasive carcinomas solely on a clinical basis. Although dermoscopy has become an essential tool for skin tumor evaluation, reflectance confocal microscopy (RCM) is a non-invasive imaging technology that has proved itself extremely useful in the diagnosis and monitoring of several skin diseases, including AC and SCC. The present study aimed to re-emphasize the usefulness of RCM in the early detection of malignant

2018 Molecular and clinical oncology

197. Rapid onset of multiple concurrent squamous cell carcinomas associated with the use of an arsenic-containing traditional medicine for chronic plaque psoriasis Full Text available with Trip Pro

Rapid onset of multiple concurrent squamous cell carcinomas associated with the use of an arsenic-containing traditional medicine for chronic plaque psoriasis We report a case of a 46-year-old Vietnamese man who developed widespread, numerous and concurrent cutaneous squamous cell carcinomas (SCCs) in non-sun exposed skin areas after taking a traditional medicine (TM) formulation for chronic plaque psoriasis. The SCC lesions began to develop within 12-15 months after beginning the arsenic

2018 BMJ case reports

198. miR-181a decelerates proliferation in cutaneous squamous cell carcinoma by targeting the proto-oncogene KRAS. Full Text available with Trip Pro

miR-181a decelerates proliferation in cutaneous squamous cell carcinoma by targeting the proto-oncogene KRAS. Cutaneous squamous cell carcinoma (SCC) is the second most common human skin cancer with a rapidly increasing incidence among the Caucasian population. Among the many regulators, responsible for cancer progression and growth, microRNAs (miRNA) are generally accepted as key players by now. In our current study we found that microRNA-181a (miR-181a) shows low abundance in SCC compared (...) to normal epidermal skin. In vitro, miRNA downregulation in normal primary keratinocytes induced increased proliferation, while in vivo miR-181a downregulation in HaCaT normal keratinocytes showed tumor-like growth increase up to 50%. Inversely, upregulation of these miRNAs in cancer cells lead to reduced cellular proliferation and induction of apoptosis in vitro. An in vivo therapeutic model with induced miR-181a expression in SCC13 cancer cells reduced tumor formation in mice by 80%. Modulation of miR

2017 PLoS ONE

199. Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report. Full Text available with Trip Pro

lymphangitic carcinomatosis and multiple metastases in the lungs and lymph nodes. Skin lesions suggesting malignant tumors were absent. The metastatic lesions consisted largely of acantholytic tumor cells, and the lungs showed usual interstitial pneumonia pattern; vasculitis was absent.This is the first reported case of pulmonary ASQCC resulting in an aggressive clinical course, with marked lymphogenous metastases and PTHrP-associated hypercalcemia. The high serum MPO-ANCA titers were clinicopathologically (...) Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report. Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data

2018 BMC Cancer

200. Intravenous 5-Fluorouracil in Patients With Advanced Squamous Cell Carcinoma: A Retrospective Study. (Abstract)

Intravenous 5-Fluorouracil in Patients With Advanced Squamous Cell Carcinoma: A Retrospective Study. In the EXTREME trial, a combination of cisplatin or carboplatin plus 5-fluorouracil (5-FU) and cetuximab was superior to cisplatin/carboplatin plus 5-FU for first-line treatment of recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). With the aim of improving fluoropyrimidine-related tolerance without decreasing its efficacy, the safety and efficacy of carboplatin plus the oral (...) therapy.Treatment was well tolerated with a high level of compliance (relative dose intensity: 96%, 88%, and 81% for carboplatin, tegafur, and cetuximab, respectively). Grade 3-4 adverse events (AEs) were observed in 38% of patients (skin reactions in 17% of patients, anemia 4%, and neutropenia 3%). Grade 1-2 AEs included skin reactions (52% of patients), hypomagnesemia (20%), asthenia (19%), and anemia (13%). No venous thrombosis related to chemotherapy perfusion was observed. Over a median follow-up of 21

2018 Rhinology and Laryngology

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