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Sporotrichosis

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161. Tacrolimus Increases the Effectiveness of Itraconazole and Fluconazole against Sporothrix spp. Full Text available with Trip Pro

Tacrolimus Increases the Effectiveness of Itraconazole and Fluconazole against Sporothrix spp. Calcineurin inhibitors - such as the clinically used drug tacrolimus - are active against important fungal pathogens, particularly when combined with azoles. However, tacrolimus has not been tested against sporotrichosis, an endemic subcutaneous mycosis with worldwide distribution. Here, we evaluated the activity of tacrolimus and cyclosporine A in vitro - as monotherapy and in combination (...) with itraconazole or fluconazole - against yeasts of Sporothrix brasiliensis and S. schenckii, the main sporotrichosis agents in Brazil. We also analyzed the effect of tacrolimus treatment on intracellular neutral lipid levels, which typically increase after azole treatment. Tacrolimus inhibited the growth of yeasts from S. brasiliensis and S. schenckii reference isolates, with minimum inhibitory concentration (MIC) values (required for ≥50% growth inhibition) of 1 and 2 mg/L, respectively. Importantly

2017 Frontiers in microbiology

162. Genetic variation of Sporothrix globosa isolates from diverse geographic and clinical origins in China Full Text available with Trip Pro

Genetic variation of Sporothrix globosa isolates from diverse geographic and clinical origins in China Sporothrix globosa is the main causative agent of sporotrichosis, a common mycosis that usually affects the skin, in China. Despite increasing efforts in the molecular identification of this fungal pathogen, its modes of transmission and epidemiology remain poorly understood. The goals of this study were to assess the genetic diversity of S. globosa using amplified fragment length polymorphism

2017 Emerging Microbes & Infections

163. Sporotrichoid leishmaniasis: a cross-sectional clinical, epidemiological and laboratory study in Rio de Janeiro State, Brazil Full Text available with Trip Pro

and epidemiological presentation were found between SL patients as compared to CL ones, in a region with a known predominance of Leishmania (Viannia) braziliensis. The results are similar to the features of most of the sporotrichosis patients as described in literature, making the differential diagnosis between ATL and sporotrichosis more important in overlapping areas for both diseases, like in Rio de Janeiro State.

2017 Revista do Instituto de Medicina Tropical de São Paulo

164. Recombinant 60-kDa heat shock protein from Paracoccidioides brasiliensis: is it a good antigen for serological diagnosis of paracoccidioidomycosis? Full Text available with Trip Pro

healthy subjects had 27% positivity to rPbHsp60 and none to rgp43. When rPbHsp60 was used in ELISA, we did not observe significant differences between the reactions with sera from PCM patients and healthy subjects, while the difference was clearly evident when the antigen was rgp43. Furthermore, rPbHsp60 was recognized by sera from patients with histoplasmosis, aspergillosis, sporotrichosis or tuberculosis in an ELISA test. These results show that rPbHsp60 is not a good antigen for PCM diagnosis.

2017 Brazilian Journal of Medical and Biological Research

165. A rare case of disseminated Sporothrix schenckii with bone marrow involvement in a patient with idiopathic CD4 lymphocytopenia Full Text available with Trip Pro

A rare case of disseminated Sporothrix schenckii with bone marrow involvement in a patient with idiopathic CD4 lymphocytopenia Sporothrix schenckii is a pathogen with a predilection for dissemination in immunocompromised individuals, often with HIV. We report a case of disseminated sporotrichosis in an unfortunate 25 year old male (without HIV) who was originally treated for presumed pneumonia. The patient continued to worsen clinically and further work-up eventually revealed Sporothrix

2017 IDCases

166. Safety and Efficacy of Nemolizumab in PN

, psoriasis, acne, folliculitis, habitual picking, lymphomatoid papulosis, chronic actinic dermatitis, dermatitis herpetiformis, sporotrichosis, bullous disease Unilateral lesions of prurigo (e.g only one arm affected) Cutaneous bacterial or viral infection within 1 week before the baseline visit. Infection requiring treatment with oral or parenteral antibiotics, antivirals, antiparasitics or antifungals within 1 week before the screening visit, or during the screening period, unless completely resolved (...) at the screening/ baseline visits respectively, Any uncontrolled or serious disease, or any medical or surgical condition, that may either interfere with the interpretation of the clinical trial results and/or put the subject at Chronic pruritus resulting from another condition than PN such as scabies, insect bite, lichen simplex chronicus, psoriasis, acne, folliculitis, habitual picking, lymphomatoid papulosis, chronic actinic dermatitis, dermatitis herpetiformis, sporotrichosis, bullous disease Contacts

2017 Clinical Trials

167. Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease. (Abstract)

of the published literature in PubMed, LILACS, and SciELO to estimate the burden of subcutaneous mycoses in 25 regions in Peru. The disease burden was determined in terms of prevalence (number of cases per 100,000 inhabitants) and the number of reported cases per year per region.A total of 26 studies were eligible for inclusion. Results showed that sporotrichosis was the most common subcutaneous mycosis (99.7%), whereas lobomycosis, chromoblastomycosis, and subcutaneous phaeohyphomycosis were rare. Cases (...) of eumycetoma and subcutaneous zygomycosis were not found. Of the 25 regions, the burden of sporotrichosis was estimated for four regions classified as endemic; in nine regions, only isolated cases were reported. The highest burden of sporotrichosis was in Apurimac (15 cases/100,000 inhabitants; 57 cases/year), followed by Cajamarca (3/100,000 inhabitants; 30/year), Cusco (0.5/100,000 inhabitants; 4/year), and La Libertad (0.2/100,000 inhabitants; 2/year). In two regions, the mycoses predominantly affected

2017 International Journal of Dermatology

168. Unique case report of a chromomycosis and Listeria in soft tissue and cerebellar abscesses after kidney transplantation. Full Text available with Trip Pro

was reached.A 49-year old male originating from the Caribbean presented a scalp lesion which was surgically removed in his hometown where it was misdiagnosed as a sporotrichosis on histology, 3 years after he received a kidney transplant. He received no additional treatment and the scalp lesion healed. One year later, an abscess of each thigh due to both F. pedrosoi and L. monocytogenes was diagnosed in our institution. A contemporary asymptomatic cerebellar abscess was also found by systematic MRI

2017 BMC Infectious Diseases

169. Origin and distribution of Sporothrix globosa causing sapronoses in Asia. Full Text available with Trip Pro

Origin and distribution of Sporothrix globosa causing sapronoses in Asia. The aim of the study was to evaluate the main sources and epidemiological patterns and speculate on the evolutionary origin of Sporothrix globosa in Asia.Case and case series literature on sporotrichosis in Asia from January 2007 onwards were reviewed using meta-analysis. Phylogenetic analysis of relevant S. globosa was carried out on the basis of concatenated sequences of ITS, TEF3 and CAL. A haplotype network of CAL (...) sequences of 281 Sporothrix isolates was analysed to determine the population structure of S. globosa.Nearly all cases of sporotrichosis caused by S. globosa in Asia were human. In contrast to the remaining pathogenic Sporothrix species, feline transmission was exceptional; nearly all regional cat-associated cases were caused by Sporothrix schenckii. While the latter species was highly variable and showed recombination, S. globosa seemed to be a clonal offshoot, as was Sporothrix brasiliensis

2017 Journal of Medical Microbiology

170. Treatment of Fungal Infections in Adult Pulmonary, Critical Care, and Sleep Medicine: An Official ATS Statement

A. Stevens, on behalf of the American Thoracic Society Fungal Working Group THIS OFFICIAL STATEMENT OF THE AMERICAN THORACIC SOCIETY (ATS) WAS APPROVED BY THE ATS BOARD OF DIRECTORS, MAY 2010 CONTENTS Introduction Methods Antifungal Agents: General Considerations Polyenes Triazoles Echinocandins Treatment of Fungal Infections Histoplasmosis Sporotrichosis Blastomycosis Coccidioidomycosis Paracoccidioidomycosis Cryptococcosis Aspergillosis Candidiasis Pneumocystis Pneumonia Treatment of Other Fungi (...) mycoses, including histoplasmosis, sporotrichosis, blastomycosis, and coccidioidomycosis; fungal infections of special concern for immune-compromised and critically ill patients, including crypto- coccosis, aspergillosis, candidiasis, and Pneumocystis pneumonia; andrareandemergingfungalinfections. Keywords: fungal pneumonia; amphotericin; triazole antifungal; echinocandin The incidence, diagnosis, and clinical severity of pulmonary fungal infections have dramatically increased in recent years

2011 American Thoracic Society

171. Sporothrix Species Causing Outbreaks in Animals and Humans Driven by Animal–Animal Transmission Full Text available with Trip Pro

pathogenicity Sporotrichosis epidemiology transmission Virulence Zoonoses transmission 2016 7 15 6 0 2016 7 16 6 0 2017 11 29 6 0 epublish 27415796 10.1371/journal.ppat.1005638 PPATHOGENS-D-16-00185 PMC4945023 BMC Genomics. 2014 Oct 29;15:943 25351875 Nature. 2011 Oct 26;480(7377):376-8 22031324 J Proteomics. 2015 Feb 6;115:8-22 25434489 Fungal Biol. 2016 Feb;120(2):246-64 26781380 PLoS Negl Trop Dis. 2013 Jun 20;7(6):e2281 23818999 PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3094 25233227 Mycoses. 2015 Nov;58(11

2016 PLoS pathogens

172. Adamantylidene-substituted alkylphosphocholine TCAN26 is more active against Sporothrix schenckii than miltefosine Full Text available with Trip Pro

Adamantylidene-substituted alkylphosphocholine TCAN26 is more active against Sporothrix schenckii than miltefosine Sporotrichosis is the most frequent subcutaneous mycosis in the world and its increasing incidence has led to the search for new therapeutic options for its treatment. In this study, we demonstrated that three structural analogues of miltefosine (TCAN26, TC19, and TC70) showed inhibitory activity against Sporothrix schenckii sensu stricto and that TCAN26 was more active in vitro

2016 Memórias do Instituto Oswaldo Cruz

173. Whole-Genome Sequencing and In Silico Analysis of Two Strains of Sporothrix globosa Full Text available with Trip Pro

Whole-Genome Sequencing and In Silico Analysis of Two Strains of Sporothrix globosa Sporothrix globosa is a thermo-dimorphic fungus belonging to a pathogenic clade that also includes Sporothrix schenckii, which causes human and animal sporotrichosis. Here, we present the first genome assemblies of two S. globosa strains providing data for future comparative genomic studies in pathogenic Sporothrix species.© The Author 2016. Published by Oxford University Press on behalf of the Society

2016 Genome biology and evolution

174. Melanins Protect Sporothrix brasiliensis and Sporothrix schenckii from the Antifungal Effects of Terbinafine Full Text available with Trip Pro

Melanins Protect Sporothrix brasiliensis and Sporothrix schenckii from the Antifungal Effects of Terbinafine Terbinafine is a recommended therapeutic alternative for patients with sporotrichosis who cannot use itraconazole due to drug interactions or side effects. Melanins are involved in resistance to antifungal drugs and Sporothrix species produce three different types of melanin. Therefore, in this study we evaluated whether Sporothrix melanins impact the efficacy of antifungal drugs (...) of the Sporothrix complex from the effects of terbinafine and that the development of new antifungal drugs targeting melanin synthesis may improve sporotrichosis therapies.

2016 PloS one

175. Δ24-Sterol Methyltransferase Plays an Important Role in the Growth and Development of Sporothrix schenckii and Sporothrix brasiliensis Full Text available with Trip Pro

reaction catalyzed by 24-SMT has a strong antiproliferative effect via disruption of ergosterol homeostasis, suggesting that this enzyme is a promising target for novel antifungal therapies against sporotrichosis, either as sole treatments or in combination with itraconazole.

2016 Frontiers in microbiology

176. The Upside of Bias: A Case of Chronic Meningitis Due to Sporothrix Schenckii in an Immunocompetent Host Full Text available with Trip Pro

infection. We describe an immunocompetent patient with chronic meningitis who partially responded to empiric fluconazole. Prompted by a recent culture-confirmed case of meningeal sporotrichosis, we tested for S schenckii antibodies from the cerebrospinal fluid, which were positive. His clinical and functional status improved, and the S schenckii antibody titer decreased with itraconazole therapy. Clinicians should consider S schenckii in the differential diagnosis for chronic meningitis, even

2016 The Neurohospitalist

177. The divorce of Sporothrix and Ophiostoma: solution to a problematic relationship Full Text available with Trip Pro

The divorce of Sporothrix and Ophiostoma: solution to a problematic relationship One of the causal agents of human sporotrichosis, Sporothrix schenckii, is the type species of the genus Sporothrix. During the course of the last century the asexual morphs of many Ophiostoma spp. have also been treated in Sporothrix. More recently several DNA-based studies have suggested that species of Sporothrix and Ophiostoma converge in what has become known as Ophiostoma s. lat. Were the one fungus one name

2016 Studies in mycology

178. Molecular Diagnosis of Pathogenic Sporothrix Species Full Text available with Trip Pro

Molecular Diagnosis of Pathogenic Sporothrix Species Sporotrichosis is a chronic (sub)cutaneous infection caused by thermodimorphic fungi in the order, Ophiostomatales. These fungi are characterized by major differences in routes of transmission, host predilections, species virulence, and susceptibilities to antifungals. Sporothrix species emerge in the form of outbreaks. Large zoonoses and sapronoses are ongoing in Brazil and China, respectively. Current diagnostic methods based on morphology (...) . brasiliensis, S. schenckii, S. globosa, S. mexicana, S. pallida, and O. stenoceras. We employed a murine model of disseminated sporotrichosis to optimize a PCR assay for detecting Sporothrix in clinical specimens.Primer-BLAST searches revealed candidate sequences that were conserved within a single species. Species-specific primers showed no significant homology with human, mouse, or microorganisms outside the Sporothrix genus. The detection limit was 10-100 fg of DNA in a single round of PCR

2015 PLoS neglected tropical diseases

179. Rapid Identification of Emerging Human-Pathogenic Sporothrix Species with Rolling Circle Amplification Full Text available with Trip Pro

Rapid Identification of Emerging Human-Pathogenic Sporothrix Species with Rolling Circle Amplification Sporothrix infections are emerging as an important human and animal threat among otherwise healthy patients, especially in Brazil and China. Correct identification of sporotrichosis agents is beneficial for epidemiological surveillance, enabling implementation of adequate public-health policies and guiding antifungal therapy. In areas of limited resources where sporotrichosis is endemic, high

2015 Frontiers in microbiology

180. Respiratory Failure due to Possible Donor-Derived Sporothrix schenckii Infection in a Lung Transplant Recipient Full Text available with Trip Pro

after transplant in a bilateral single lung transplant recipient. This is the first case report of sporotrichosis in a lung transplant recipient. Our patient responded well to amphotericin induction therapy followed by maintenance therapy with itraconazole. The implications of donor-derived fungal infections and Sporothrix in transplant recipients are reviewed. Early recognition and management of these fungi are essential in improving outcomes.

2015 Case reports in infectious diseases

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