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Sporotrichosis

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121. Ultrastructural study of the mycelial phase of clinical isolates of Sporothrix schenckii obtained from feline, canine and human cases of sporotrichosis Full Text available with Trip Pro

Ultrastructural study of the mycelial phase of clinical isolates of Sporothrix schenckii obtained from feline, canine and human cases of sporotrichosis Using transmission electron microscopy, we studied the presence of melanin and cell wall thickness of clinical isolates of Sporothrix schenckii obtained from cats, dogs and humans as compared to reference strains. We detected differences regarding presence of the melanin among the clinical isolates of S. schenckii and a correlation between

2011 Brazilian Journal of Microbiology

122. Disseminated sporotrichosis Full Text available with Trip Pro

Disseminated sporotrichosis Sporotrichosis is a subacute or chronic infection caused by Sporothrix schenckii. It is a primary cutaneous infection and it has different clinical forms: disseminated by lymphatic vessels (75%), localised cutaneous form (20%), disseminated cutaneous and extracuteus rarely. The systemic disseminated sporotrichosis is considered a severe opportunistic infection. The best diagnostic test is the culture. The authors report a case of a 36-year-old man, originally from (...) Puebla, Mexico, with a diagnosis of disseminated sporotrichosis. Differential diagnosis with other pathologies includes leishmaniasis, chromoblastomycosis, tuberculosis verrucose and lymphangitis. The development of unusual presentations in immunocompromised patients has been reported.

2011 BMJ case reports

123. Comparative study of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis. (Abstract)

Comparative study of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis. Itraconazole is currently used for the treatment of cutaneous sporotrichosis. Terbinafine at a daily dose of 250 mg has been successfully applied to the treatment of cutaneous sporotrichosis.To compare the efficacy of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis.A bidirectional cohort study was conducted on 55 patients (...) for two patients of the itraconazole group.Terbinafine administered at a daily dose of 250 mg is an effective and well-tolerated option for the treatment of cutaneous sporotrichosis.

2011 Mycopathologia Controlled trial quality: uncertain

124. Efficacy and safety of itraconazole pulses vs. continuous regimen in cutaneous sporotrichosis. (Abstract)

Efficacy and safety of itraconazole pulses vs. continuous regimen in cutaneous sporotrichosis. Primary observation of using itraconazole pulse regimen (commonly used for onychomycosis) in five sporotrichosis patients produced satisfactory effect, but there are no randomized controlled trials to assess this regimen and to compare with routine continuous regimen.The aim of this study was to compare the efficacy and safety of itraconazole pulse regimen, as a new treatment option for cutaneous (...) sporotrichosis, with continuous regimen.A prospective, randomized, evaluator-blind, controlled study was performed. A total of 50 cutaneous sporotrichosis patients were divided randomly into two groups: Pulsed Rx (npulse=25), treated with itraconazole 200 mg b.i.d. for 1 week and off for 3 weeks; Daily Rx (ncont=25), treated with itraconazole 100 mg bid continuously. In total, 46 patients (npulse=22, ncont=24) were assessable at the end of the study. Cure rates at weeks 12, 24 and 48 along with the course

2011 Journal of the European Academy of Dermatology and Venereology : JEADV Controlled trial quality: uncertain

125. Sporotrichosis Caused by Sporothrix mexicana, Portugal. Full Text available with Trip Pro

Sporotrichosis Caused by Sporothrix mexicana, Portugal. 22000393 2012 02 14 2018 11 13 1080-6059 17 10 2011 Oct Emerging infectious diseases Emerging Infect. Dis. Sporotrichosis caused by Sporothrix Mexicana, Portugal. 1975-6 10.3201/eid1710.110737 Dias Nicolina Marques NM Oliveira Manoel Marques Evangelista MM Santos Cledir C Zancope-Oliveira Rosely Maria RM Lima Nelson N eng GENBANK JF970258 Case Reports Letter United States Emerg Infect Dis 9508155 1080-6040 0 Antifungal Agents 0 Calmodulin (...) IM Adult Antifungal Agents pharmacology Calmodulin genetics Genes, Fungal Humans Male Microbial Sensitivity Tests Molecular Sequence Data Portugal Sporothrix drug effects genetics isolation & purification Sporotrichosis microbiology 2011 10 18 6 0 2011 10 18 6 0 2012 2 15 6 0 ppublish 22000393 10.3201/eid1710.110737 PMC3310684 J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):451-9 15761423 Clin Dermatol. 2006 May-Jun;24(3):201-12 16714201 J Clin Microbiol. 2006 Sep;44(9):3251-6 16954256 Mycopathologia

2011 Emerging Infectious Diseases

126. Sporotrichosis Full Text available with Trip Pro

Sporotrichosis Sporotrichosis - Wikipedia Sporotrichosis From Wikipedia, the free encyclopedia Sporotrichosis Other names Rose gardener's disease Cytologic preparation from a case of feline sporotrichosis; phagocytic cells show numerous variably-shaped yeast forms within Sporotrichosis is a disease caused by the infection of the . This fungal disease usually affects the , although other rare forms can affect the , , , and even the . Because can spread the disease, it is one of a few diseases (...) referred to as rose-thorn or rose-gardeners' disease . Because S. schenckii is naturally found in soil, , , and plants, it usually affects , gardeners, and agricultural workers. It enters through small cuts and abrasions in the skin to cause the infection. In case of sporotrichosis affecting the lungs, the fungal spores enter through the respiratory pathways. Sporotrichosis can also be acquired from handling cats with the disease; it is an occupational hazard for veterinarians. Sporotrichosis

2012 Wikipedia

128. CRACKCast E090 – Liver and Biliary Tract

Rocky Mountain spotted fever Sporotrichosis Staphylococcus aureus Streptococcus pyogenes Syphilis Toxoplasmosis Tuberculosis However, we really care about three in the ED: HIV, Hep B, Hep C. Steps: Initiate basic wound care (if not already done). Wash with water and mild soap thoroughly! Have baseline “exposed” labs drawn per protocol If possible get source labs tested The only real actionable lab on the day of exposure is a source with positive rapid HIV test. Figure out if there is any actionable

2017 CandiEM

129. Endemic Mycoses in Children. (Abstract)

Endemic Mycoses in Children. The endemic mycoses are a group of infections caused by fungi with a distinct geographic distribution, defined by climatic and environmental conditions. The systemic endemic mycoses, namely histoplasmosis, blastomycosis, talaromycosis, coccidioidomycosis and paracoccidioidomycosis, occur after the inhalation of fungal spores. The cutaneous endemic mycoses, including sporotrichosis, mycetoma, entomophthoramycosis and chromoblastomycosis, enter the host via traumatic

2019 Pediatric Infectious Dsease Journal

130. Palate ulcer, uvular destruction and nasal septal perforation caused by Sporothrix brasiliensis in an HIV-infected patient Full Text available with Trip Pro

Palate ulcer, uvular destruction and nasal septal perforation caused by Sporothrix brasiliensis in an HIV-infected patient Sporotrichosis is a human and animal disease caused by dimorphic pathogenic species of the genus Sporothrix. We report a dramatic presentation of Sporothrix brasiliensis infection, with destruction of the nasal septum, soft palate, and uvula of an HIV-infected woman. She was successfully treated with amphotericin B deoxycholate followed by itraconazole. Sporotrichosis

2018 Medical mycology case reports

131. Domestic feline contribution in the transmission of Sporothrix in Rio de Janeiro State, Brazil: a comparison between infected and non-infected populations Full Text available with Trip Pro

Domestic feline contribution in the transmission of Sporothrix in Rio de Janeiro State, Brazil: a comparison between infected and non-infected populations Sporotrichosis is a neglected zoonosis caused by pathogenic fungi belonging to the Sporothrix schenckii complex. In Rio de Janeiro state, this disease reached an epidemic status with over 4700 domestic felines and around 4000 humans affected since the mid-90s. The present study evaluated clinical and epidemiological aspects and also (...) the frequency of colonization and infection by these fungi in healthy cats and among those with suspicious cutaneous lesions, inhabiting four Rio de Janeiro state distinct areas.Three hundred and seventy-one cats were included in two groups: 175 healthy cats [CRG] and 196 cats showing lesions suggesting sporotrichosis [SSG]. Mycological diagnosis allowed SSG animals to be divided in positive [104 cats; +SG] and negative [92 cats; -SG] groups. Nails, oral mucosa and lesions swabs were submitted to culture

2018 BMC veterinary research

132. Population Structure and Genetic Diversity of Sporothrix globosa in China According to 10 Novel Microsatellite Loci. Full Text available with Trip Pro

Population Structure and Genetic Diversity of Sporothrix globosa in China According to 10 Novel Microsatellite Loci. Sporothrix globosa is the most important agent of sporotrichosis in China. The aim of this study is to investigate the population parameters of S. globosa.In the present study, we developed a set of microsatellite markers that have a cumulative discriminatory power of 1.000. Using these microsatellite loci, 120 strains of S. globosa that had clear sampling information were

2018 Journal of Medical Microbiology

133. Dacryocystitis due to sporothrix inoculated vis an unusual mode: Case report. Full Text available with Trip Pro

Dacryocystitis due to sporothrix inoculated vis an unusual mode: Case report. Sporotrichosis is the most common subcutaneous mycosis. It is caused by the dimorphic fungus Sporothrix schenckii. Ocular sporotrichosis is uncommon and has been rarely reported.We describe a 34-year-old female who presented with a nodule increasing in size near the medial angle of the left eye. Originally, she was misdiagnosed with a dacryocyst space-occupying lesion, and the lesion was removed by surgery.Findings

2018 Medicine

134. Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response Full Text available with Trip Pro

Monitoring Fungal Burden and Viability of Sporothrix spp. in Skin Lesions of Cats for Predicting Antifungal Treatment Response Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide (KI). Treatment-naïve cats with culture-confirmed sporotrichosis (...) when using ITZ alone. After twelve weeks, the median fungal burden decreased to zero in both treatment protocols, suggesting a potential decrease in the risk of transmission of Sporothrix spp. from cats. These findings encourage the early treatment of feline sporotrichosis as a control measure. Moreover, the fungal burden in feline sporotrichosis lesions can be a prognostic indicator and a parameter for choosing appropriate therapeutic regimen.

2018 Journal of Fungi

135. Molecular Identification, Antifungal Susceptibility, and Geographic Origin of Clinical Strains of Sporothrix schenckii Complex in Mexico Full Text available with Trip Pro

Molecular Identification, Antifungal Susceptibility, and Geographic Origin of Clinical Strains of Sporothrix schenckii Complex in Mexico Sporotrichosis is a subcutaneous mycosis caused by Sporothrix schenckii complex. The disease has been reported worldwide. However, the incidence of the etiological agent varies in its geographic distribution. We studied 39 clinical isolates of Sporothrix schenckii from diverse regions in Mexico, collected from 1998 to 2016. Molecular identification (...) (2.5%). Terbinafine exhibited the best in vitro antifungal activity, while fluconazole was ineffective against Sporothrix schenckii complex. Our results showed diverse geographic distribution of clinical isolates in eight states; definitive identification was done by CAL gen PCR-sequencing. In Mexico, S. schenckii is considered to be an etiological agent of human sporotrichosis cases, and lymphocutaneous is the most prevalent form of the disease. This study revealed four clades of S. schenckiisensu

2018 Journal of Fungi

136. Sporotrichoid Keratoacanthomas: Case Report and Review of Neoplasms Presenting in a Sporotrichoid Pattern Full Text available with Trip Pro

Sporotrichoid Keratoacanthomas: Case Report and Review of Neoplasms Presenting in a Sporotrichoid Pattern Sporotrichosis is a fungal infection known for its distinct pattern of infectious skin nodules. Several conditions can present with lesions that appear in a sporotrichoid pattern. An 82-year-old man that presented with three cutaneous nodules on his right leg in a sporotrichoid manner is described; biopsy of each lesion revealed a keratoacanthoma. In addition to keratoacanthomas, other

2018 Cureus

137. Sporothrix schenckii Cell Wall Proteins-Stimulated BMDCs Are Able to Induce a Th1-Prone Cytokine Profile In Vitro Full Text available with Trip Pro

Sporothrix schenckii Cell Wall Proteins-Stimulated BMDCs Are Able to Induce a Th1-Prone Cytokine Profile In Vitro Sporotrichosis is a subcutaneous mycosis affecting humans and other animals. The disease can be acquired by accidental inoculation of the fungus through the skin or through the respiratory system. Sporotrichosis can also be transmitted through bites or scratches by infected cats and more rarely by other animals (zoonotic transmission). Conventional antifungal therapy is especially (...) inefficient in immunocompromised patients, who tend to develop the most severe forms of the disease, thus prompting the search for alternative therapies. Given their antigen-presenting properties, dendritic cells (DCs) have been used in both prophylactic and therapeutic vaccination strategies. Hence, this study aims to assess the use of DCs as a prophylactic tool in sporotrichosis by evaluating the immune profile induced by Sporothrix schenckii cell wall proteins (SsCWP)-stimulated, bone-marrow-derived

2018 Journal of Fungi

138. Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers Full Text available with Trip Pro

Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers Sporotrichosis is a subcutaneous mycosis caused by pathogenic species of the Sporothrix genus. A new emerging species, Sporothrix brasiliensis, is related to cat-transmitted sporotrichosis and has severe clinical manifestations. The cell wall of pathogenic fungi is a unique structure and impacts directly on the host immune

2018 PLoS neglected tropical diseases

139. Nodular Lymphangitis (Sporotrichoid Lymphocutaneous Infections). Clues to Differential Diagnosis Full Text available with Trip Pro

Nodular Lymphangitis (Sporotrichoid Lymphocutaneous Infections). Clues to Differential Diagnosis Nodular lymphangitis, also known as sporotrichoid lymphocutaneous infections, is characterized by suppurative inflammatory nodules along the lymphatic vessels. This manifestation is classic of sporotrichosis, however, other infections such as nocardiosis, atypical mycobacteriosis, leishmaniasis, among others, can also express this clinical pattern. Sporotrichosis, which often occurs in gardeners

2018 Journal of Fungi

140. Proteins Potentially Involved in Immune Evasion Strategies in Sporothrix brasiliensis Elucidated by Ultra-High-Resolution Mass Spectrometry Full Text available with Trip Pro

Proteins Potentially Involved in Immune Evasion Strategies in Sporothrix brasiliensis Elucidated by Ultra-High-Resolution Mass Spectrometry Sporothrix brasiliensis is the prevalent agent of a large zoonotic outbreak in Brazil. With the involvement of several thousands of cases, this is the largest cohort of human and animal sporotrichosis on record in the world. Infections are characterized by local cutaneous dissemination in humans without underlying disease. S. brasiliensis has shown a high (...) to be involved in virulence and immune evasion in other species, several of which had not yet been reported for the Sporothrix species analyzed.IMPORTANCE Sporotrichosis is an important disease in Brazil that is caused by fungi of the genus Sporothrix and affects cats and humans. Our work investigated the proteins differentially expressed by S. brasiliensis in order to find out why this species is more virulent and pathogenic than S. schenckii We verified a set of proteins that may be related to immune

2018 mSphere

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