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Immunity and Treatment of Sporotrichosis Species of the Sporothrix complex are the etiological agents of sporotrichosis, an important subcutaneous mycosis with several clinical forms and an increasing incidence around the world that affects humans and other mammals. The immunological mechanisms involved in the prevention and control of this mycosis are not entirely understood. Many reports have suggested that cell-mediated immunity has an essential role in the development of the disease, being
Extracellular Vesicles From Sporothrix brasiliensis Are an Important Virulence Factor That Induce an Increase in Fungal Burden in Experimental SporotrichosisSporotrichosis is a mycosis that affects the skin, lymphatic system and other organs in humans and animals. The disease has a worldwide distribution, with endemic areas in Brazil, and is caused by a complex of species, including Sporothrix brasiliensis. Some fungi release extracellular vesicles (EVs) that can interact with the host cell
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases â€“ a comparative study of leishmaniasis and sporotrichosis The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We (...) used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. LCL-ATL and SCL-ATL had a significantly higher percentage of CD8, FasL and NOS2 than sporotrichosis. In contrast, LC-SP had a substantially higher percentage of CD4, BCl2 and neutrophils than ATL lesions. These results indicated some differences in the profile of the in situ immune response
The Infection Returns: A Case of Pulmonary Sporotrichosis Relapse after Chemotherapy Pulmonary sporotrichosis is a rare disease caused by a dimorphic fungus, Sporothrix schenckii. It is rarely found in association with malignancy. We present a case of pulmonary sporotrichosis recurrence after chemotherapy.A 44-year-old man, treated for pulmonary sporotrichosis in the past, presented with dysphagia and was found to have squamous cell carcinoma of the esophagus. After undergoing chemotherapy
Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area Sporotrichosis is caused by species of the genus Sporothrix. From 1998 to 2015, 4,703 cats were diagnosed at the Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil. Even after the description of the Sporothrix species, the characterisation of feline isolates is not performed routinely.To characterise (...) of the species.In phenotypic tests, 34 isolates were characterised as S. brasiliensis, one as S. schenckii and 12 as Sporothrix spp. PCR identified all isolates as S. brasiliensis.S. brasiliensis is the only etiological agent of feline sporotrichosis in Rio de Janeiro to date. None association was found between the isolates and the clinical and epidemiological data. In addition, we strongly recommend the use of molecular techniques for the identification of isolates of Sporothrix spp.
An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis Sporothrix brasiliensis is the most virulent fungus of the Sporothrix complex and is the main species recovered in the sporotrichosis zoonotic hyperendemic area in Rio de Janeiro. A vaccine against S. brasiliensis could improve the current sporotrichosis situation. Here, we show 3 peptides from S. brasiliensis immunogenic proteins that have a higher (...) likelihood for engaging MHC-class II molecules. We investigated the efficiency of the peptides as vaccines for preventing subcutaneous sporotrichosis. In this study, we observed a decrease in lesion diameters in peptide-immunized mice, showing that the peptides could induce a protective immune response against subcutaneous sporotrichosis. ZR8 peptide is from the GP70 protein, the main antigen of the Sporothrix complex, and was the best potential vaccine candidate by increasing CD4+ T cells and higher
A case of disseminated sporotrichosis caused by Sporothrix brasiliensis This paper presents a case of disseminated sporotrichosis in a 13-year-old female, originating from a rural area in Minas Gerais state, Brazil. The patient was hospitalized in Santa Casa hospital of Belo Horizonte, with hyporexia, prostration, fever and disseminated ulcerative lesions, besides anemia, leucopenia and sepsis of probable cutaneous focus. The patient was admitted without proven immunosuppression. She (...) was diagnosed with cutaneous-disseminated sporotrichosis. The drug therapy chosen was itraconazole during 12 months, leading to important clinical improvement and healing of cutaneous lesions.
Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982-2012). This study discusses a historical patient series and is designed to describe clinical and epidemiological characteristics of human sporotrichosis in the state of Espírito Santo, Brazil. Data were derived from patients treated at the Infectious Diseases service of Cassiano Antônio Moraes University Hospital in Vitória, the state capital, from July 1982 to June (...) 2012. A total of 171 patients were diagnosed with sporotrichosis, mostly men (80.7%) with a median age of 33 years and 5 months. We can presume an approximate average incidence rate of 4.9 cases per 100,000 inhabitants during the studied period. All the patients were involved in occupational or leisure activities with direct contact with soil or plants. Most cases were recorded in the mountainous region of the state during the hot and rainy periods. The average time elapsed from lesion progression
Cryosurgery for the treatment of cutaneous sporotrichosis: Experience with 199 cases. 30560992 2019 02 14 1365-2133 2018 Dec 18 The British journal of dermatology Br. J. Dermatol. Cryosurgery for the treatment of cutaneous sporotrichosis: experience with 199 cases. 10.1111/bjd.17532 Fichman V V https://orcid.org/0000-0003-0348-8008 Infectious Dermatology Clinical Research Laboratory, Rio de Janeiro, Brazil. do Valle A C F ACF Infectious Dermatology Clinical Research Laboratory, Rio de Janeiro
Cutaneous sporotrichosis treated with methylene blue-daylight photodynamic therapy. 28846164 2018 03 14 1468-3083 32 3 2018 Mar Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Cutaneous sporotrichosis treated with methylene blue-daylight photodynamic therapy. e90-e91 10.1111/jdv.14545 García-Malinis A J AJ Unit of Dermatology, San Jorge Hospital, Avenida Martinez de Velasco, 36, Huesca, Spain. Unit of Dermatology, Jaca Hospital, Avenida
Cutaneous disseminated sporotrichosis: Clinical experience of 24 cases. 28833587 2018 02 21 1468-3083 32 2 2018 Feb Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Cutaneous disseminated sporotrichosis: clinical experience of 24 cases. e77-e79 10.1111/jdv.14533 Bonifaz A A Dermatology Service & Mycology Department, Hospital General de México, "Dr. Eduardo Liceaga", Mexico City, Mexico. Tirado-Sánchez A A Dermatology Service & Mycology
Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus). 29080316 2018 03 25 1468-3083 32 4 2018 Apr Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus). e157-e158 10.1111/jdv.14661 Fichman V V http://orcid.org/0000-0003-0348-8008 Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation
Sporotrichosis masquerading as pyoderma gangrenosum. 28627095 2017 12 27 1468-3083 31 12 2017 Dec Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Sporotrichosis masquerading as pyoderma gangrenosum. e539-e541 10.1111/jdv.14421 Lima R B RB Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. Jeunon-Sousa M A J MAJ Laboratório Investigação em Dermatologia, Rio de Janeiro, Brazil. Jeunon T T Laboratório Investigação em
Sporotrichosis among children of a hyperendemic area in Peru: an 8-year retrospective study. The clinical and epidemiologic characteristics of pediatric sporotrichosis are poorly understood.To describe the incidence and clinical characteristics of cases of sporotrichosis in children 14 years of age and younger reported in Abancay from 2004 to 2011, stratified according to age.We performed a retrospective review of pediatric patients 14 years of age and younger who were diagnosed (...) with sporotrichosis in a referral center at Abancay, a poor area located in the south central highlands of Peru, to estimate the incidence rates (per 100,000 person-years) according to age and sporotrichosis type (lymphocutaneous and fixed), and clinical characteristics of these patients.Of the 240 pediatric cases identified, 131 (54.6%) were male. The median age at baseline was 6 years. The mean incidence rate was 81.4 cases per 100,000 person-years for the period from 2004 to 2011, and was highest among
Sporotrichosis in the nailâ€”An unusual location and presentation 29387746 2019 02 26 2352-5126 4 1 2018 Jan JAAD case reports JAAD Case Rep Sporotrichosis in the nail-An unusual location and presentation. 47-49 10.1016/j.jdcr.2017.08.003 Larson Krista N KN Department of Dermatology, West Virginia University, Morgantown, West Virginia. Pandey Shaily S Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina. Hoover William W 3rd Department of Dermatology, University (...) of North Carolina, Chapel Hill, North Carolina. Sun Natalie Z NZ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina. eng Case Reports 2017 12 19 United States JAAD Case Rep 101665210 2352-5126 fungus nail disorders sporotrichosis 2018 2 2 6 0 2018 2 2 6 0 2018 2 2 6 1 epublish 29387746 10.1016/j.jdcr.2017.08.003 S2352-5126(17)30184-4 PMC5771738 Ann Dermatol. 2016 Apr;28(2):251-2 27081278 Indian J Dermatol. 2013 Sep;58(5):409 24082217 J Am Acad Dermatol. 2012 May;66(5
Painful linear ulcers: A case of cutaneous sporotrichosis mimicking pyoderma gangrenosum 29264381 2019 02 26 2352-5126 3 6 2017 Nov JAAD case reports JAAD Case Rep Painful linear ulcers: A case of cutaneous sporotrichosis mimicking pyoderma gangrenosum. 519-521 10.1016/j.jdcr.2017.07.014 Charles Kristy K Department of Dermatology, Michigan Medicine, Ann Arbor, Michigan. Lowe Lori L Department of Dermatology, Michigan Medicine, Ann Arbor, Michigan. Department of Pathology, Michigan Medicine, Ann (...) Arbor, Michigan. Shuman Emily E Department of Infectious Disease, Michigan Medicine, Ann Arbor, Michigan. Cha Kelly B KB Department of Dermatology, Michigan Medicine, Ann Arbor, Michigan. eng Case Reports 2017 11 06 United States JAAD Case Rep 101665210 2352-5126 cutaneous sporotrichosis cutaneous ulcer sporotrichoid 2017 12 22 6 0 2017 12 22 6 0 2017 12 22 6 1 epublish 29264381 10.1016/j.jdcr.2017.07.014 S2352-5126(17)30163-7 PMC5729013 Curr Opin Infect Dis. 2008 Apr;21(2):129-33 18317034 Clin
Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease Sporotrichosis is an implantation or inoculation mycosis caused by species of Sporothrix schenckii complex; its main manifestations are limited to skin; however, cutaneous-disseminated, disseminated (visceral) and extracutaneous variants of sporotrichosis can be associated with immunosuppression, including HIV-AIDS, chronic alcoholism or more virulent strains. The most common extracutaneous form (...) of sporotrichosis includes pulmonary, osteoarticular and meningeal. The laboratory diagnosis requires observing yeast forms and isolating the fungus; the two main causative agents are Sporothrix schenckii (ss) and Sporothrix brasiliensis. Antibody levels and species recognition by Polimerase Chain Reaction using biological samples or cultures are also useful. The treatment of choice for most cases is amphotericin B and subsequent itraconazole for maintenance therapy.
Disseminated Sporotrichosis with Osteolytic Bone Involvement 28349410 2018 11 13 1525-1497 32 9 2017 Sep Journal of general internal medicine J Gen Intern Med Disseminated Sporotrichosis with Osteolytic Bone Involvement. 1063 10.1007/s11606-017-4048-4 Aronowitz Paul B PB Department of Internal Medicine, University of California, Davis, School of Medicine, 4150 V Street, Suite 3100, Sacramento, CA, 95817, USA. Paronowitz@ucdavis.edu. Gilroy Meghan M Division of Gastroenterology, Hepatology (...) & Nutrition, University of Utah, Salt Lake City, Utah, USA. Christiansen Katerina N KN Department of Internal Medicine, University of California, Davis, School of Medicine, 4150 V Street, Suite 3100, Sacramento, CA, 95817, USA. eng Journal Article 2017 03 27 United States J Gen Intern Med 8605834 0884-8734 clinical image dermatology diagnosis infectious disease sporotrichosis 2016 12 21 2017 03 09 2017 02 22 2017 3 30 6 0 2017 3 30 6 0 2017 3 29 6 0 ppublish 28349410 10.1007/s11606-017-4048-4 10.1007
Cutaneous Nocardiosis Simulating Cutaneous Lymphatic SporotrichosisSporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by Nocardia brasiliensis. It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed (...) along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis. We present a 61-year-old man who, after an insect bite in the left leg, developed an ulcerated lesion associated with ascending lymphangitis, nonresponsive to previous antibiotic therapies. The patient was admitted for investigation, based on the main diagnostic hypothesis of lymphatic cutaneous sporotrichosis entailed by the highly suggestive morphology, associated with the epidemiologic information that he