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Sporotrichosis

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21. An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis Full Text available with Trip Pro

An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis Sporothrix brasiliensis is the most virulent fungus of the Sporothrix complex and is the main species recovered in the sporotrichosis zoonotic hyperendemic area in Rio de Janeiro. A vaccine against S. brasiliensis could improve the current sporotrichosis situation. Here, we show 3 peptides from S. brasiliensis immunogenic proteins that have a higher (...) likelihood for engaging MHC-class II molecules. We investigated the efficiency of the peptides as vaccines for preventing subcutaneous sporotrichosis. In this study, we observed a decrease in lesion diameters in peptide-immunized mice, showing that the peptides could induce a protective immune response against subcutaneous sporotrichosis. ZR8 peptide is from the GP70 protein, the main antigen of the Sporothrix complex, and was the best potential vaccine candidate by increasing CD4+ T cells and higher

2018 Scientific reports

22. Sporotrichin Skin Test for the Diagnosis of Sporotrichosis Full Text available with Trip Pro

Sporotrichin Skin Test for the Diagnosis of Sporotrichosis Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichin is an antigenic complex comprised of a peptide-rhamnomannan, which is relevant with respect to pathogenic fungi; it is primarily used (...) for serological and skin testing. We present a study regarding the use of sporotrichin as a diagnostic aid for cutaneous sporotrichosis. Furthermore, 138 cases with suspicion of sporotrichosis were included, 55 of which were proven through cultures. Moreover, out of these 55 cases, 52 (94.5%) tested positive for sporotrichin, while the negative cases corresponded to the disseminated cutaneous forms. We observed a sensitivity of 94.5% and a specificity of 95.2%. We consider that the use of sporotrichin

2018 Journal of Fungi

23. Primary conjunctival sporotrichosis: An atypical presentation of the disease Full Text available with Trip Pro

Primary conjunctival sporotrichosis: An atypical presentation of the disease 29984295 2019 02 26 2352-5126 4 5 2018 Jun JAAD case reports JAAD Case Rep Primary conjunctival sporotrichosis: An atypical presentation of the disease. 497-499 10.1016/j.jdcr.2018.01.022 Ferreira Thiago Amparo TA Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Sodré Celso Tavares CT Sector (...) of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. eng Case Reports 2018 05 07 United States JAAD Case Rep 101665210 2352-5126 Sporothrix complex conjunctiva sporotrichosis subcutaneous mycosis 2018 7 10 6 0 2018 7 10 6 0 2018 7 10 6 1 epublish 29984295 10.1016/j.jdcr.2018.01.022 S2352-5126(18)30034-1 PMC6031559 Cad Saude Publica. 2012 Oct;28(10):1867-80 23090167 Am J Ophthalmol Case Rep. 2017 Sep

2018 JAAD Case Reports

24. Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis Full Text available with Trip Pro

Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Fifty-two cats with skin (...) lesions and a definitive diagnosis of sporotrichosis were treated with itraconazole for a maximum period of 36 weeks. The animals were submitted to clinical examination and two subsequent collections of samples from the same skin lesion for fungal diagnosis and histopathology, as well as serology for feline immunodeficiency (FIV) and leukaemia (FeLV) viruses. Thirty-seven (71%) cats were clinically cured. Nasal mucosa lesions and respiratory signs were associated with treatment failure. Cats

2018 Scientific reports

25. Draft Genome Sequences of Two Sporothrix schenckii Clinical Isolates Associated with Human Sporotrichosis in Colombia Full Text available with Trip Pro

Draft Genome Sequences of Two Sporothrix schenckii Clinical Isolates Associated with Human Sporotrichosis in Colombia Sporothrix schenckii is a thermodimorphic fungal pathogen with a high genetic diversity. In this work, we present the assembly and similarity analysis of the whole-genome sequences of two clinical isolates from Colombia of S. schenckiisensu stricto.Copyright © 2018 Gomez et al.

2018 Genome Announcements

26. Sporotrichosis: From KOH to Molecular Biology Full Text available with Trip Pro

Sporotrichosis: From KOH to Molecular Biology Sporotrichosis is a cosmopolitan, chronic granulomatous mycosis, acquired by traumatic inoculation and caused by Sporothrix schenckii complex. Several methods of diagnostic are available, from KOH to molecular biology. In this review, we describe from the simplest (clinical diagnosis) to the most advanced diagnostic techniques (molecular biology).

2018 Journal of Fungi

27. A case of disseminated sporotrichosis caused by Sporothrix brasiliensis Full Text available with Trip Pro

A case of disseminated sporotrichosis caused by Sporothrix brasiliensis This paper presents a case of disseminated sporotrichosis in a 13-year-old female, originating from a rural area in Minas Gerais state, Brazil. The patient was hospitalized in Santa Casa hospital of Belo Horizonte, with hyporexia, prostration, fever and disseminated ulcerative lesions, besides anemia, leucopenia and sepsis of probable cutaneous focus. The patient was admitted without proven immunosuppression. She (...) was diagnosed with cutaneous-disseminated sporotrichosis. The drug therapy chosen was itraconazole during 12 months, leading to important clinical improvement and healing of cutaneous lesions.

2018 Medical mycology case reports

28. Zoonotic Sporotrichosis Related to Cat Contact: First Case Report from Panama in Central America Full Text available with Trip Pro

Zoonotic Sporotrichosis Related to Cat Contact: First Case Report from Panama in Central America A previously healthy 34-year-old man presented with a four-week-old upper arm injury that started with a cat scratch and progressed into painless erythematous nodular ascending lesions in the left upper limb. We made the diagnosis of sporotrichosis based on the epidemiological association of the contact with a cat and culture identification. Sporotrichosis is a mycosis implantation caused (...) by the Sporothrix schenckii complex. We present the first Central American case of sporotrichosis associated with contact with a feline.

2018 Cureus

29. A randomized comparison of combined itraconazole and Nd:YAG 1064-nm laser vs itraconazole alone for the treatment of cutaneous sporotrichosis. (Abstract)

A randomized comparison of combined itraconazole and Nd:YAG 1064-nm laser vs itraconazole alone for the treatment of cutaneous sporotrichosis.

2018 European journal of dermatology : EJD Controlled trial quality: uncertain

30. Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis Full Text available with Trip Pro

Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases – a comparative study of leishmaniasis and sporotrichosis The clinical presentations of skin diseases produced by different pathogens, as American tegumentary leishmaniasis (ATL) and sporotrichosis can be similar and possibly influenced by the skin immune system (SIS). The aim of the study was to understand the underlying mechanisms of skin inflammation produced by different pathogens. We (...) used immunohistochemistry to analyze 96 patients: a- localized cutaneous leishmaniasis (LCL-ATL); b- sporotrichoid cutaneous leishmaniasis (SCL-ATL); c-lymphocutaneous (LC-SP); d- fixed (F-SP) sporotrichosis. LCL-ATL and SCL-ATL had a significantly higher percentage of CD8, FasL and NOS2 than sporotrichosis. In contrast, LC-SP had a substantially higher percentage of CD4, BCl2 and neutrophils than ATL lesions. These results indicated some differences in the profile of the in situ immune response

2018 Scientific reports

31. Disseminated Sporotrichosis with Osteolytic Bone Involvement Full Text available with Trip Pro

Disseminated Sporotrichosis with Osteolytic Bone Involvement 28349410 2018 11 13 1525-1497 32 9 2017 Sep Journal of general internal medicine J Gen Intern Med Disseminated Sporotrichosis with Osteolytic Bone Involvement. 1063 10.1007/s11606-017-4048-4 Aronowitz Paul B PB Department of Internal Medicine, University of California, Davis, School of Medicine, 4150 V Street, Suite 3100, Sacramento, CA, 95817, USA. Paronowitz@ucdavis.edu. Gilroy Meghan M Division of Gastroenterology, Hepatology (...) & Nutrition, University of Utah, Salt Lake City, Utah, USA. Christiansen Katerina N KN Department of Internal Medicine, University of California, Davis, School of Medicine, 4150 V Street, Suite 3100, Sacramento, CA, 95817, USA. eng Journal Article 2017 03 27 United States J Gen Intern Med 8605834 0884-8734 clinical image dermatology diagnosis infectious disease sporotrichosis 2016 12 21 2017 03 09 2017 02 22 2017 3 30 6 0 2017 3 30 6 0 2017 3 29 6 0 ppublish 28349410 10.1007/s11606-017-4048-4 10.1007

2017 Journal of General Internal Medicine

32. Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease Full Text available with Trip Pro

Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease Sporotrichosis is an implantation or inoculation mycosis caused by species of Sporothrix schenckii complex; its main manifestations are limited to skin; however, cutaneous-disseminated, disseminated (visceral) and extracutaneous variants of sporotrichosis can be associated with immunosuppression, including HIV-AIDS, chronic alcoholism or more virulent strains. The most common extracutaneous form (...) of sporotrichosis includes pulmonary, osteoarticular and meningeal. The laboratory diagnosis requires observing yeast forms and isolating the fungus; the two main causative agents are Sporothrix schenckii (ss) and Sporothrix brasiliensis. Antibody levels and species recognition by Polimerase Chain Reaction using biological samples or cultures are also useful. The treatment of choice for most cases is amphotericin B and subsequent itraconazole for maintenance therapy.

2017 Journal of Fungi

33. Painful linear ulcers: A case of cutaneous sporotrichosis mimicking pyoderma gangrenosum Full Text available with Trip Pro

Painful linear ulcers: A case of cutaneous sporotrichosis mimicking pyoderma gangrenosum 29264381 2019 02 26 2352-5126 3 6 2017 Nov JAAD case reports JAAD Case Rep Painful linear ulcers: A case of cutaneous sporotrichosis mimicking pyoderma gangrenosum. 519-521 10.1016/j.jdcr.2017.07.014 Charles Kristy K Department of Dermatology, Michigan Medicine, Ann Arbor, Michigan. Lowe Lori L Department of Dermatology, Michigan Medicine, Ann Arbor, Michigan. Department of Pathology, Michigan Medicine, Ann (...) Arbor, Michigan. Shuman Emily E Department of Infectious Disease, Michigan Medicine, Ann Arbor, Michigan. Cha Kelly B KB Department of Dermatology, Michigan Medicine, Ann Arbor, Michigan. eng Case Reports 2017 11 06 United States JAAD Case Rep 101665210 2352-5126 cutaneous sporotrichosis cutaneous ulcer sporotrichoid 2017 12 22 6 0 2017 12 22 6 0 2017 12 22 6 1 epublish 29264381 10.1016/j.jdcr.2017.07.014 S2352-5126(17)30163-7 PMC5729013 Curr Opin Infect Dis. 2008 Apr;21(2):129-33 18317034 Clin

2017 JAAD Case Reports

34. Sporotrichosis in the nail—An unusual location and presentation Full Text available with Trip Pro

Sporotrichosis in the nail—An unusual location and presentation 29387746 2019 02 26 2352-5126 4 1 2018 Jan JAAD case reports JAAD Case Rep Sporotrichosis in the nail-An unusual location and presentation. 47-49 10.1016/j.jdcr.2017.08.003 Larson Krista N KN Department of Dermatology, West Virginia University, Morgantown, West Virginia. Pandey Shaily S Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina. Hoover William W 3rd Department of Dermatology, University (...) of North Carolina, Chapel Hill, North Carolina. Sun Natalie Z NZ Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina. eng Case Reports 2017 12 19 United States JAAD Case Rep 101665210 2352-5126 fungus nail disorders sporotrichosis 2018 2 2 6 0 2018 2 2 6 0 2018 2 2 6 1 epublish 29387746 10.1016/j.jdcr.2017.08.003 S2352-5126(17)30184-4 PMC5771738 Ann Dermatol. 2016 Apr;28(2):251-2 27081278 Indian J Dermatol. 2013 Sep;58(5):409 24082217 J Am Acad Dermatol. 2012 May;66(5

2017 JAAD Case Reports

35. Sporotrichosis in a liver transplant patient: A case report and literature review Full Text available with Trip Pro

Sporotrichosis in a liver transplant patient: A case report and literature review The liver transplant patient was admitted to the hospital with hyperemic, granulomatous, ulcerated lesion in the anterior compartment of the right lower limb with report of local trauma. The agent Sporothrix schenckii was isolated from biopsy of the lesion and lymph nodes of the right lower limb. In this case, the treatment was difficult because the patient has severe pulmonary hypertension and took the following

2017 Medical mycology case reports

36. Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis Full Text available with Trip Pro

Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis Sporotrichosis is the subcutaneous mycosis caused by several species of the Sporothrix genus. With worldwide occurrence, the State of Rio de Janeiro is presently undergoing a zoonotic sporotrichosis epidemic. The form of lymphocutaneous nocardiosis is rare, being caused especially by Nocardia brasiliensis. It appears as a nodular or ulcerated lesion, with multiple painful erythematous nodules or satellite pustules distributed (...) along the lymphatic tract, similar to the lymphocutaneous variant of sporotrichosis. We present a 61-year-old man who, after an insect bite in the left leg, developed an ulcerated lesion associated with ascending lymphangitis, nonresponsive to previous antibiotic therapies. The patient was admitted for investigation, based on the main diagnostic hypothesis of lymphatic cutaneous sporotrichosis entailed by the highly suggestive morphology, associated with the epidemiologic information that he

2017 Case reports in dermatology

37. Rapidly Progressive Disseminated Sporotrichosis as the First Presentation of HIV Infection in a Patient with a Very Low CD4 Cell Count Full Text available with Trip Pro

Rapidly Progressive Disseminated Sporotrichosis as the First Presentation of HIV Infection in a Patient with a Very Low CD4 Cell Count Sporotrichosis is a human and animal disease caused by species of the Sporothrix schenckii complex. It is classically acquired through traumatic inoculation of fungal elements. Most frequently, sporotrichosis presents as a fixed cutaneous or as a lymphocutaneous form. A much smaller number of cases occur as cutaneous disseminated and disseminated forms (...) . These cases require immediate diagnosis and management to reduce morbidity and mortality. We present the case of a 34-year-old male patient in whom the first presentation of HIV infection was a rapidly progressive sporotrichosis with multiple cutaneous lesions, a high fungal burden in tissues, and pulmonary involvement. He had an extremely low CD4 cell count (06/mm3). Treatment with amphotericin B deoxycholate led to complete clinical resolution. Sporotrichosis remains a neglected opportunistic infection

2017 Case reports in infectious diseases

38. Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report Full Text available with Trip Pro

Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals

2017 Medical mycology case reports

39. Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission Full Text available with Trip Pro

Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission 28103311 2018 01 02 2019 02 02 1553-7374 13 1 2017 01 PLoS pathogens PLoS Pathog. Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission. e1006077 10.1371/journal.ppat.1006077 Gremião Isabella Dib Ferreira ID Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil. Miranda Luisa (...) Cats Epidemics Humans Sporotrichosis epidemiology transmission Zoonoses epidemiology transmission The authors have declared that no competing interests exist. 2017 1 20 6 0 2017 1 20 6 0 2018 1 3 6 0 epublish 28103311 10.1371/journal.ppat.1006077 PPATHOGENS-D-16-01061 PMC5245785 Cad Saude Publica. 2012 Oct;28(10):1867-80 23090167 Clin Infect Dis. 1993 Mar;16(3):384-7 8095815 Med Mycol. 2008 Feb;46(1):53-6 17885948 Int J Dermatol. 2009 Nov;48(11):1198-200 20064175 Biomed Res Int. 2015;2015:212308

2017 PLoS pathogens

40. Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus). (Abstract)

Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus). 29080316 2018 03 25 1468-3083 32 4 2018 Apr Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus). e157-e158 10.1111/jdv.14661 Fichman V V http://orcid.org/0000-0003-0348-8008 Laboratory of Clinical Research on Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation

2017 Journal of the European Academy of Dermatology and Venereology

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