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Sporotrichosis

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181. Construction and analysis of the cDNA subtraction library of yeast and mycelial phases of Sporothrix globosa isolated in China: identification of differentially expressed genes Full Text available with Trip Pro

Construction and analysis of the cDNA subtraction library of yeast and mycelial phases of Sporothrix globosa isolated in China: identification of differentially expressed genes Species included in the Sporothrix schenckii complex are temperature-dependent with dimorphic growth and cause sporotrichosis that is characterized by chronic and fatal lymphocutaneous lesions. The putative species included in the Sporothrix complex are S. brasiliensis, S. globosa, S. mexicana, S. pallida, S. schenckii (...) , and S. lurei. S. globosa is the causal agent of sporotrichosis in China, and its pathogenicity appears to be closely related to the dimorphic transition, i.e. from the mycelial to the yeast phase, it adapts to changing environmental conditions. To determine the molecular mechanisms of the switching process that mediates the dimorphic transition of S. globosa, suppression subtractive hybridization (SSH) was used to prepare a complementary DNA (cDNA) subtraction library from the yeast and mycelial

2015 Journal of Zhejiang University. Science. B

182. Subcutaneous mycoses in coastal Karnataka in south India. (Abstract)

Karnataka, India.Between January 2005 and January 2013, a total of 25 patients were diagnosed with subcutaneous mycoses based on a detailed clinical history and presentation, histopathology, and culture of organisms.Chromoblastomycosis was the infection most commonly seen (n = 16 patients, 64%), followed by mycetoma (n = 4, 16%), sporotrichosis (n = 4, 16%), and rhinoentomophthoromycosis (n = 1, 4%). The extremities were the most common site of involvement, with the lower limb being most affected (64

2015 International Journal of Dermatology

183. Invasive Mould Infections in Indian ICUs

microscopy demonstrating septate hyphae invading tissue or aspirate from sterile sites Probable: Host criteria of EORTC Host with COPD satisfying definitions by Bulpa P, et al Eur Resp J 2007 Host in ICU satisfying clinical algorithm by Blot SI, et al Am J Resp Crit Care Med 2012 Exclusion criteria: Endemic mycoses (histoplasmosis, sporotrichosis, penicilliosis) Yeast infections Allergic fungal diseases like allergic bronchopulmonary aspergillosis Infection limited to the skin only Contacts and Locations

2015 Clinical Trials

184. Skin and subcutaneous infections in south-east Asia. (Abstract)

Skin and subcutaneous infections in south-east Asia. We reviewed current literature on four different skin and subcutaneous infections which are often touted as 'emerging diseases' of south-east Asia, namely melioidosis, penicilliosis, sporotrichosis and Mycobacterium marinum infection. Lack of consensus treatment guidelines, high treatment costs and limited investigative capability in certain endemic areas are among the challenges faced by managing physicians. With the increase in borderless (...) travelling, it is hoped that this review will facilitate better understanding and heighten the clinical suspicion of such infections for clinicians in other parts of the world.An increasing number of cases of melioidosis and penicilliosis have been reported within and outside its endemic areas, but epidemiological data on sporotrichosis and M. marinum infections are still sparse. The clinical features of these infections remain historically unchanged and more disseminated infections are seen particularly

2015 Current Opinion in Infectious Diseases

185. Phenotypic Characteristics Associated with Virulence of Clinical Isolates from the Sporothrix Complex Full Text available with Trip Pro

Phenotypic Characteristics Associated with Virulence of Clinical Isolates from the Sporothrix Complex The Sporothrix complex members cause sporotrichosis, a subcutaneous mycosis with a wide spectrum of clinical manifestations. Several specific phenotypic characteristics are associated with virulence in many fungi, but studies in this field involving the Sporothrix complex species are scarce. Melanization, thermotolerance, and production of proteases, catalase, and urease were investigated in 61 (...) S. brasiliensis, one S. globosa, and 10 S. schenckii strains. The S. brasiliensis strains showed a higher expression of melanin and urease compared with S. schenckii. These two species, however, presented similar thermotolerances. Our S. globosa strain had low expression of all studied virulence factors. The relationship between these phenotypes and clinical aspects of sporotrichosis was also evaluated. Strains isolated from patients with spontaneous regression of infection were heavily

2015 BioMed research international

186. The difficult management of disseminated Sporothrix brasiliensis in a patient with advanced AIDS Full Text available with Trip Pro

The difficult management of disseminated Sporothrix brasiliensis in a patient with advanced AIDS Sporotrichosis is an infection caused by a dimorphic fungus of the Sporothrix schenckii complex. Host immunity is an important factor in the clinical manifestations of the disease. Deeply immunocompromised individuals, especially those infected with the Human Immunodeficiency Virus (HIV) and T CD4 counts < 350 cells/ul lymphocytes, may present with the systemic form of sporotrichosis. This report (...) describes a case of disseminated sporotrichosis caused by S. brasiliensis in a patient with advanced AIDS. The skin, lungs, bones and central nervous system were affected. Medical treatment involved the administration of amphotericin B, terbinafine, itraconazole and posaconazole. Posaconazole was associated with the best clinical response and clearing of the fungus from the central nervous system.

2015 AIDS research and therapy

187. Higher sensitivity of immunohistochemistry for bona fide diagnosis of dog Leishmania (Viannia) braziliensis - driven American tegumentary leishmaniasis: description of an optimized immunohistochemistry method. (Abstract)

of IHC for the detection of amastigote forms and other Leishmania sp. antigen-positive cells and compares the results of IHC, histopathology and cytopathology for the diagnosis of canine ATL. In addition, possible cross-reactivity with sporotrichosis is analyzed.Forty paraffin-embedded biopsies and 40 smears of cutaneous lesions from dogs with ATL, confirmed by isolation and characterization of Leishmania (Viannia) braziliensis, and 40 paraffin-embedded biopsies of cutaneous lesions from dogs (...) with sporotrichosis, confirmed by isolation of Sporothrix schenckii in culture (control group), were studied.Immunohistochemistry was more sensitive in detecting amastigote forms than cytopathology and histopathology, with a positivity rate of 70% (n=28) versus 37.5% and 22.5% for histopathology and cytopathology, respectively. Cytoplasmic staining of mononuclear and endothelial cells was detected by IHC, which was highly specific since no cytoplasmic staining of these cells or staining of fungal structures

2015 Transactions of the Royal Society of Tropical Medicine & Hygiene

188. Miltefosine is active against Sporothrix brasiliensis isolates with in vitro low susceptibility to amphotericin B or itraconazole. Full Text available with Trip Pro

Miltefosine is active against Sporothrix brasiliensis isolates with in vitro low susceptibility to amphotericin B or itraconazole. Sporotrichosis is a common mycosis caused by dimorphic fungi from the Sporothrix schenckii complex. In recent years, sporotrichosis incidence rates have increased in the Brazilian state of Rio de Janeiro, where Sporothrix brasiliensis is the species more frequently isolated from patients. The standard antifungals itraconazole and amphotericin B are recommended (...) as first-line therapy for cutaneous/lymphocutaneous and disseminated sporotrichosis, respectively, although decreased sensitivity to these drugs in vitro was reported for clinical isolates of S. brasiliensis. Here, we evaluated the activity of the phospholipid analogue miltefosine - already in clinical use against leishmaniasis - towards the pathogenic yeast form of S. brasiliensis isolates with low sensitivity to itraconazole or amphotericin B in vitro. Miltefosine had fungicidal activity

2015 Journal of Medical Microbiology

189. Genome Sequence of the Pathogenic Fungus Sporothrix schenckii (ATCC 58251) Full Text available with Trip Pro

Genome Sequence of the Pathogenic Fungus Sporothrix schenckii (ATCC 58251) Sporothrix schenckii is a pathogenic dimorphic fungus that grows as a yeast and as mycelia. This species is the causative agent of sporotrichosis, typically a skin infection. We report the genome sequence of S. schenckii, which will facilitate the study of this fungus and of the Sporothrix schenckii group. Copyright © 2014 Cuomo et al.

2014 Genome Announcements

190. Chronic Hand Infections. (Abstract)

, the paronychia or nail plate), subcutaneous (mainly lymphocutaneous sporotrichosis and dermatiaceous infections), and deep fungal infections. Each type of deep fungal infection has a "classic" presentation and this is emphasized. Finally, common chronic viral infections of the hand include warts and orf. Copyright © 2014 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

2014 Journal of Hand Surgery - American

191. Keratoacanthoma (Overview)

treatment of multiple eruptive keratoacanthomas: case report and review of a controversial therapy. Dermatol Surg . 2002 Oct. 28(10):954-8. . Frank TL, Maguire HC Jr, Greenbaum SS. Multiple painful keratoacanthomas. Int J Dermatol . 1996 Sep. 35(9):648-50. . Meffert JJ. Cutaneous sporotrichosis presenting as a keratoacanthoma. Cutis . 1998 Jul. 62(1):37-9. . Patel NP, Cervino AL. Treatment of keratoacanthoma: Is intralesional methotrexate an option?. Can J Plastic Surg . Summer 2011. (19)2:e15-8. Sayama

2014 eMedicine.com

192. Acneiform Eruptions (Overview)

, [ , ] sporotrichosis, [ ] rosacea, and perioral dermatitis. Next: Etiology See . Previous Next: Patient Education For patient education resources, see the ; and , as well as and . Previous References Józwiak S, Schwartz RA, Janniger CK, Michalowicz R, Chmielik J. Skin lesions in children with tuberous sclerosis complex: their prevalence, natural course, and diagnostic significance. Int J Dermatol . 1998 Dec. 37(12):911-7. . Song MG, Park KB, Lee ES. Resurfacing of facial angiofibromas in tuberous sclerosis (...) patients using CO2 laser with flashscanner. Dermatol Surg . 1999 Dec. 25(12):970-3. . Harden D, Keeling JH. Papular and nodular lesions of the scalp, face, and neck. Secondary syphilis. Arch Dermatol . 1997 Aug. 133(8):1027, 1030. . Lambert WC, Bagley MP, Khan Y, Schwartz RA. Pustular acneiform secondary syphilis. Cutis . 1986 Jan. 37(1):69-70. . Kusuhara M, Hachisuka H, Sasai Y. Statistical survey of 150 cases with sporotrichosis. Mycopathologia . 1988 May. 102(2):129-33. . Held JL, Andrew JE, Toback

2014 eMedicine.com

193. Acute Febrile Neutrophilic Dermatosis (Overview)

mycobacteria , Mycobacterium chelonae , and Penicillium species. [ , , ] Notably, Yersinia -associated Sweet syndrome has been noted to improve with antibiotics. [ ] Fungal infections have also been linked in the onset of Sweet syndrome, as it may be a presenting feature of coccidiomycosis and has been associated with sporotrichosis. [ , ] Viral agents such as HIV, cytomegalovirus (CMV), hepatitis A, hepatitis B, and parvovirus B19 have also been implicated. [ , ] Iatrogenic causes of Sweet syndrome (...) ]. Ann Dermatol Venereol . 1990. 117(11):858-60. . DiCaudo DJ, Ortiz KJ, Mengden SJ, Lim KK. Sweet syndrome (acute febrile neutrophilic dermatosis) associated with pulmonary coccidioidomycosis. Arch Dermatol . 2005 Jul. 141(7):881-4. . Freitas DF, Valle AC, Cuzzi T, et al. Sweet syndrome associated with sporotrichosis. Br J Dermatol . 2012 Jan. 166(1):212-3. . Oskay T, Karademir A, Kutluay L. Sweet's syndrome associated with cytomegalovirus infection. Int J Dermatol . 2004 Jan. 43(1):57-9. . Fortna

2014 eMedicine.com

194. Cutaneous Manifestations of HIV Disease (Overview)

the following: Scaling plaques Crusted ulcers Ecthymalike lesions Verrucous ulcers Inflammatory nodules Panniculitis Pustular lesions Draining sinuses Localized skin involvement resembling sporotrichosis is unusual. Primary cutaneous MAC infection manifesting as sporotrichosislike lesions was described in a patient with AIDS. [ ] The possibility of coinfections, which may be multiple, should be kept in mind. Coinfection with B quintana , MAC, and CMV has been reported in an AIDS patient. [ ] In patients

2014 eMedicine.com

195. Chromoblastomycosis (Overview)

to elephantiasis and involvement of the entire lower limb. Plaque lesion on the foot. The verrucous aspect of the lesion differentiates it from other infectious dermatoses that may present as a verrucous lesion, namely, cutaneous leishmaniasis, sporotrichosis, cutaneous tuberculosis, and cutaneous mycobacteriosis. Culture of Fonsecaea pedrosoi on Sabouraud agar. The black velvety colony has the same macroscopic appearance as the colonies of other chromoblastomycosis-causing agents (eg, Cladosporium carrionii

2014 eMedicine.com

196. Lobomycosis (Overview)

A, Restrepo A, Builes M, Robledo M. Lobomycosis. Report of the eighth Colombian case and review of the literature. J Cutan Pathol . 1976. 3(4):180-9. . Rodríguez G, Sarmiento L. The asteroid bodies of sporotrichosis. Am J Dermatopathol . 1998 Jun. 20(3):246-9. . Rodriguez G, Barrera GP. The asteroid body of lobomycosis. Mycopathologia . 1996-1997. 136(2):71-4. . Fischer M, Chrusciak Talhari A, Reinel D, Talhari S. [Sucessful treatment with clofazimine and itraconazole in a 46 year old patient after 32

2014 eMedicine.com

197. Sarcoidosis (Follow-up)

, and trypanosomiasis Fungal infections - Actinomycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mucormycosis, nocardiosis, and sporotrichosis Helminth infestations - Ascaris, cysticercosis, taeniasis, Diptera larvae, and nematode infestations (onchocerciasis and Toxocara, Ancylostoma, and Necator species) Viral uveitis - Herpes simplex, herpes zoster, vaccinia, and cytomegalovirus Differential diagnosis of posterior uveitis that may clinically mimic

2014 eMedicine.com

198. Rhinosporidiosis (Follow-up)

Med J . 1996 Jan. 89(1):65-7. . Hospenthal DR. Uncommon Fungi and Prototheca. Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases . 7th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2010. 3365-3376. Hospenthal DR. Entomophthoramycosis, Lobomycosis, Rhinosporidiosis, and Sporotrichosis. Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases. Principles, Pathogens, & Practice . 3rd. Philadelphia, Pa: Saunders

2014 eMedicine.com

199. Chromoblastomycosis (Follow-up)

of Cladosporium carrionii (left) and Fonsecaea pedrosoi (right), the 2 most commonly isolated agents in chromoblastomycosis. Chromoblastomycosis, tumoral form. Chronic disease led to elephantiasis and involvement of the entire lower limb. Plaque lesion on the foot. The verrucous aspect of the lesion differentiates it from other infectious dermatoses that may present as a verrucous lesion, namely, cutaneous leishmaniasis, sporotrichosis, cutaneous tuberculosis, and cutaneous mycobacteriosis. Culture

2014 eMedicine.com

200. Pneumonia, Fungal (Diagnosis)

is soil enriched by nitrogen contained in birds' and bats' droppings, [ ] whereas B dermatitidis is found in the soil and decaying wood, especially in waterways. [ ] Coccidioides species is found in alkaline, highly salinic, sandy soils and extreme temperatures. Sporotrichosis has been described worldwide; prevalence is higher in tropical and temperate zones. Infection generally occurs following traumatic inoculation with soil, plants, and organic matter contaminated with the fungus. However (...) . [ ] Among the Candida species, C albicans and C glabrata rank as the two most frequently isolated organisms. [ ] Despite the frequent isolation of Candida species from respiratory samples in nonneutropenic patients, the organisms are not considered causes of pneumonia regardless of the species isolated. [ ] Pneumonia from Candida species is exceptional in nonneutropenic patients. [ ] Sporothrix schenckii is the etiological agent of sporotrichosis, a chronic fungal infection that most frequently affects

2014 eMedicine.com

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