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Sporotrichosis

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181. Skin and subcutaneous infections in south-east Asia. Full Text available with Trip Pro

Skin and subcutaneous infections in south-east Asia. We reviewed current literature on four different skin and subcutaneous infections which are often touted as 'emerging diseases' of south-east Asia, namely melioidosis, penicilliosis, sporotrichosis and Mycobacterium marinum infection. Lack of consensus treatment guidelines, high treatment costs and limited investigative capability in certain endemic areas are among the challenges faced by managing physicians. With the increase in borderless (...) travelling, it is hoped that this review will facilitate better understanding and heighten the clinical suspicion of such infections for clinicians in other parts of the world.An increasing number of cases of melioidosis and penicilliosis have been reported within and outside its endemic areas, but epidemiological data on sporotrichosis and M. marinum infections are still sparse. The clinical features of these infections remain historically unchanged and more disseminated infections are seen particularly

2015 Current Opinion in Infectious Diseases

182. Phenotypic Characteristics Associated with Virulence of Clinical Isolates from the Sporothrix Complex Full Text available with Trip Pro

Phenotypic Characteristics Associated with Virulence of Clinical Isolates from the Sporothrix Complex The Sporothrix complex members cause sporotrichosis, a subcutaneous mycosis with a wide spectrum of clinical manifestations. Several specific phenotypic characteristics are associated with virulence in many fungi, but studies in this field involving the Sporothrix complex species are scarce. Melanization, thermotolerance, and production of proteases, catalase, and urease were investigated in 61 (...) S. brasiliensis, one S. globosa, and 10 S. schenckii strains. The S. brasiliensis strains showed a higher expression of melanin and urease compared with S. schenckii. These two species, however, presented similar thermotolerances. Our S. globosa strain had low expression of all studied virulence factors. The relationship between these phenotypes and clinical aspects of sporotrichosis was also evaluated. Strains isolated from patients with spontaneous regression of infection were heavily

2015 BioMed research international

183. Construction and analysis of the cDNA subtraction library of yeast and mycelial phases of Sporothrix globosa isolated in China: identification of differentially expressed genes Full Text available with Trip Pro

Construction and analysis of the cDNA subtraction library of yeast and mycelial phases of Sporothrix globosa isolated in China: identification of differentially expressed genes Species included in the Sporothrix schenckii complex are temperature-dependent with dimorphic growth and cause sporotrichosis that is characterized by chronic and fatal lymphocutaneous lesions. The putative species included in the Sporothrix complex are S. brasiliensis, S. globosa, S. mexicana, S. pallida, S. schenckii (...) , and S. lurei. S. globosa is the causal agent of sporotrichosis in China, and its pathogenicity appears to be closely related to the dimorphic transition, i.e. from the mycelial to the yeast phase, it adapts to changing environmental conditions. To determine the molecular mechanisms of the switching process that mediates the dimorphic transition of S. globosa, suppression subtractive hybridization (SSH) was used to prepare a complementary DNA (cDNA) subtraction library from the yeast and mycelial

2015 Journal of Zhejiang University. Science. B

184. Respiratory Failure due to Possible Donor-Derived Sporothrix schenckii Infection in a Lung Transplant Recipient Full Text available with Trip Pro

after transplant in a bilateral single lung transplant recipient. This is the first case report of sporotrichosis in a lung transplant recipient. Our patient responded well to amphotericin induction therapy followed by maintenance therapy with itraconazole. The implications of donor-derived fungal infections and Sporothrix in transplant recipients are reviewed. Early recognition and management of these fungi are essential in improving outcomes.

2015 Case reports in infectious diseases

185. Molecular Diagnosis of Pathogenic Sporothrix Species Full Text available with Trip Pro

Molecular Diagnosis of Pathogenic Sporothrix Species Sporotrichosis is a chronic (sub)cutaneous infection caused by thermodimorphic fungi in the order, Ophiostomatales. These fungi are characterized by major differences in routes of transmission, host predilections, species virulence, and susceptibilities to antifungals. Sporothrix species emerge in the form of outbreaks. Large zoonoses and sapronoses are ongoing in Brazil and China, respectively. Current diagnostic methods based on morphology (...) . brasiliensis, S. schenckii, S. globosa, S. mexicana, S. pallida, and O. stenoceras. We employed a murine model of disseminated sporotrichosis to optimize a PCR assay for detecting Sporothrix in clinical specimens.Primer-BLAST searches revealed candidate sequences that were conserved within a single species. Species-specific primers showed no significant homology with human, mouse, or microorganisms outside the Sporothrix genus. The detection limit was 10-100 fg of DNA in a single round of PCR

2015 PLoS neglected tropical diseases

186. Rapid Identification of Emerging Human-Pathogenic Sporothrix Species with Rolling Circle Amplification Full Text available with Trip Pro

Rapid Identification of Emerging Human-Pathogenic Sporothrix Species with Rolling Circle Amplification Sporothrix infections are emerging as an important human and animal threat among otherwise healthy patients, especially in Brazil and China. Correct identification of sporotrichosis agents is beneficial for epidemiological surveillance, enabling implementation of adequate public-health policies and guiding antifungal therapy. In areas of limited resources where sporotrichosis is endemic, high

2015 Frontiers in microbiology

187. Invasive Mould Infections in Indian ICUs

microscopy demonstrating septate hyphae invading tissue or aspirate from sterile sites Probable: Host criteria of EORTC Host with COPD satisfying definitions by Bulpa P, et al Eur Resp J 2007 Host in ICU satisfying clinical algorithm by Blot SI, et al Am J Resp Crit Care Med 2012 Exclusion criteria: Endemic mycoses (histoplasmosis, sporotrichosis, penicilliosis) Yeast infections Allergic fungal diseases like allergic bronchopulmonary aspergillosis Infection limited to the skin only Contacts and Locations

2015 Clinical Trials

188. Miltefosine is active against Sporothrix brasiliensis isolates with in vitro low susceptibility to amphotericin B or itraconazole. Full Text available with Trip Pro

Miltefosine is active against Sporothrix brasiliensis isolates with in vitro low susceptibility to amphotericin B or itraconazole. Sporotrichosis is a common mycosis caused by dimorphic fungi from the Sporothrix schenckii complex. In recent years, sporotrichosis incidence rates have increased in the Brazilian state of Rio de Janeiro, where Sporothrix brasiliensis is the species more frequently isolated from patients. The standard antifungals itraconazole and amphotericin B are recommended (...) as first-line therapy for cutaneous/lymphocutaneous and disseminated sporotrichosis, respectively, although decreased sensitivity to these drugs in vitro was reported for clinical isolates of S. brasiliensis. Here, we evaluated the activity of the phospholipid analogue miltefosine - already in clinical use against leishmaniasis - towards the pathogenic yeast form of S. brasiliensis isolates with low sensitivity to itraconazole or amphotericin B in vitro. Miltefosine had fungicidal activity

2015 Journal of Medical Microbiology

189. Chronic Hand Infections. (Abstract)

, the paronychia or nail plate), subcutaneous (mainly lymphocutaneous sporotrichosis and dermatiaceous infections), and deep fungal infections. Each type of deep fungal infection has a "classic" presentation and this is emphasized. Finally, common chronic viral infections of the hand include warts and orf. Copyright © 2014 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

2014 Journal of Hand Surgery - American

190. Genome Sequence of the Pathogenic Fungus Sporothrix schenckii (ATCC 58251) Full Text available with Trip Pro

Genome Sequence of the Pathogenic Fungus Sporothrix schenckii (ATCC 58251) Sporothrix schenckii is a pathogenic dimorphic fungus that grows as a yeast and as mycelia. This species is the causative agent of sporotrichosis, typically a skin infection. We report the genome sequence of S. schenckii, which will facilitate the study of this fungus and of the Sporothrix schenckii group. Copyright © 2014 Cuomo et al.

2014 Genome Announcements

191. Keratoacanthoma (Overview)

treatment of multiple eruptive keratoacanthomas: case report and review of a controversial therapy. Dermatol Surg . 2002 Oct. 28(10):954-8. . Frank TL, Maguire HC Jr, Greenbaum SS. Multiple painful keratoacanthomas. Int J Dermatol . 1996 Sep. 35(9):648-50. . Meffert JJ. Cutaneous sporotrichosis presenting as a keratoacanthoma. Cutis . 1998 Jul. 62(1):37-9. . Patel NP, Cervino AL. Treatment of keratoacanthoma: Is intralesional methotrexate an option?. Can J Plastic Surg . Summer 2011. (19)2:e15-8. Sayama

2014 eMedicine.com

192. Acneiform Eruptions (Overview)

, [ , ] sporotrichosis, [ ] rosacea, and perioral dermatitis. Next: Etiology See . Previous Next: Patient Education For patient education resources, see the ; and , as well as and . Previous References Józwiak S, Schwartz RA, Janniger CK, Michalowicz R, Chmielik J. Skin lesions in children with tuberous sclerosis complex: their prevalence, natural course, and diagnostic significance. Int J Dermatol . 1998 Dec. 37(12):911-7. . Song MG, Park KB, Lee ES. Resurfacing of facial angiofibromas in tuberous sclerosis (...) patients using CO2 laser with flashscanner. Dermatol Surg . 1999 Dec. 25(12):970-3. . Harden D, Keeling JH. Papular and nodular lesions of the scalp, face, and neck. Secondary syphilis. Arch Dermatol . 1997 Aug. 133(8):1027, 1030. . Lambert WC, Bagley MP, Khan Y, Schwartz RA. Pustular acneiform secondary syphilis. Cutis . 1986 Jan. 37(1):69-70. . Kusuhara M, Hachisuka H, Sasai Y. Statistical survey of 150 cases with sporotrichosis. Mycopathologia . 1988 May. 102(2):129-33. . Held JL, Andrew JE, Toback

2014 eMedicine.com

193. Acute Febrile Neutrophilic Dermatosis (Overview)

mycobacteria , Mycobacterium chelonae , and Penicillium species. [ , , ] Notably, Yersinia -associated Sweet syndrome has been noted to improve with antibiotics. [ ] Fungal infections have also been linked in the onset of Sweet syndrome, as it may be a presenting feature of coccidiomycosis and has been associated with sporotrichosis. [ , ] Viral agents such as HIV, cytomegalovirus (CMV), hepatitis A, hepatitis B, and parvovirus B19 have also been implicated. [ , ] Iatrogenic causes of Sweet syndrome (...) ]. Ann Dermatol Venereol . 1990. 117(11):858-60. . DiCaudo DJ, Ortiz KJ, Mengden SJ, Lim KK. Sweet syndrome (acute febrile neutrophilic dermatosis) associated with pulmonary coccidioidomycosis. Arch Dermatol . 2005 Jul. 141(7):881-4. . Freitas DF, Valle AC, Cuzzi T, et al. Sweet syndrome associated with sporotrichosis. Br J Dermatol . 2012 Jan. 166(1):212-3. . Oskay T, Karademir A, Kutluay L. Sweet's syndrome associated with cytomegalovirus infection. Int J Dermatol . 2004 Jan. 43(1):57-9. . Fortna

2014 eMedicine.com

194. Cutaneous Manifestations of HIV Disease (Overview)

the following: Scaling plaques Crusted ulcers Ecthymalike lesions Verrucous ulcers Inflammatory nodules Panniculitis Pustular lesions Draining sinuses Localized skin involvement resembling sporotrichosis is unusual. Primary cutaneous MAC infection manifesting as sporotrichosislike lesions was described in a patient with AIDS. [ ] The possibility of coinfections, which may be multiple, should be kept in mind. Coinfection with B quintana , MAC, and CMV has been reported in an AIDS patient. [ ] In patients

2014 eMedicine.com

195. Chromoblastomycosis (Overview)

to elephantiasis and involvement of the entire lower limb. Plaque lesion on the foot. The verrucous aspect of the lesion differentiates it from other infectious dermatoses that may present as a verrucous lesion, namely, cutaneous leishmaniasis, sporotrichosis, cutaneous tuberculosis, and cutaneous mycobacteriosis. Culture of Fonsecaea pedrosoi on Sabouraud agar. The black velvety colony has the same macroscopic appearance as the colonies of other chromoblastomycosis-causing agents (eg, Cladosporium carrionii

2014 eMedicine.com

196. Lobomycosis (Overview)

A, Restrepo A, Builes M, Robledo M. Lobomycosis. Report of the eighth Colombian case and review of the literature. J Cutan Pathol . 1976. 3(4):180-9. . Rodríguez G, Sarmiento L. The asteroid bodies of sporotrichosis. Am J Dermatopathol . 1998 Jun. 20(3):246-9. . Rodriguez G, Barrera GP. The asteroid body of lobomycosis. Mycopathologia . 1996-1997. 136(2):71-4. . Fischer M, Chrusciak Talhari A, Reinel D, Talhari S. [Sucessful treatment with clofazimine and itraconazole in a 46 year old patient after 32

2014 eMedicine.com

197. Sarcoidosis (Follow-up)

, and trypanosomiasis Fungal infections - Actinomycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, mucormycosis, nocardiosis, and sporotrichosis Helminth infestations - Ascaris, cysticercosis, taeniasis, Diptera larvae, and nematode infestations (onchocerciasis and Toxocara, Ancylostoma, and Necator species) Viral uveitis - Herpes simplex, herpes zoster, vaccinia, and cytomegalovirus Differential diagnosis of posterior uveitis that may clinically mimic

2014 eMedicine.com

198. Rhinosporidiosis (Follow-up)

Med J . 1996 Jan. 89(1):65-7. . Hospenthal DR. Uncommon Fungi and Prototheca. Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases . 7th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2010. 3365-3376. Hospenthal DR. Entomophthoramycosis, Lobomycosis, Rhinosporidiosis, and Sporotrichosis. Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases. Principles, Pathogens, & Practice . 3rd. Philadelphia, Pa: Saunders

2014 eMedicine.com

199. Chromoblastomycosis (Follow-up)

of Cladosporium carrionii (left) and Fonsecaea pedrosoi (right), the 2 most commonly isolated agents in chromoblastomycosis. Chromoblastomycosis, tumoral form. Chronic disease led to elephantiasis and involvement of the entire lower limb. Plaque lesion on the foot. The verrucous aspect of the lesion differentiates it from other infectious dermatoses that may present as a verrucous lesion, namely, cutaneous leishmaniasis, sporotrichosis, cutaneous tuberculosis, and cutaneous mycobacteriosis. Culture

2014 eMedicine.com

200. Pneumonia, Fungal (Diagnosis)

is soil enriched by nitrogen contained in birds' and bats' droppings, [ ] whereas B dermatitidis is found in the soil and decaying wood, especially in waterways. [ ] Coccidioides species is found in alkaline, highly salinic, sandy soils and extreme temperatures. Sporotrichosis has been described worldwide; prevalence is higher in tropical and temperate zones. Infection generally occurs following traumatic inoculation with soil, plants, and organic matter contaminated with the fungus. However (...) . [ ] Among the Candida species, C albicans and C glabrata rank as the two most frequently isolated organisms. [ ] Despite the frequent isolation of Candida species from respiratory samples in nonneutropenic patients, the organisms are not considered causes of pneumonia regardless of the species isolated. [ ] Pneumonia from Candida species is exceptional in nonneutropenic patients. [ ] Sporothrix schenckii is the etiological agent of sporotrichosis, a chronic fungal infection that most frequently affects

2014 eMedicine.com

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