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2. Sporotrichosis

Sporotrichosis Sporotrichosis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Sporotrichosis Last reviewed: February 2019 Last updated: March 2018 Summary Endemic mycosis with worldwide distribution caused by the dimorphic fungus Sporothrix schenckii . The vast majority of sporotrichosis infections are lymphocutaneous or fixed cutaneous forms, although osteoarticular, pulmonary, meningeal, and disseminated (...) sporotrichosis may occur, especially in patients with diabetes, alcoholism, AIDS, and haematological malignancies, but also in normal hosts. Lymphocutaneous sporotrichosis is caused by traumatic inoculation of the fungus into the skin and results in an initial nodular lesion that usually ulcerates, which is followed by ascending nodular lymphangitis. The definitive test for diagnosis of lymphocutaneous sporotrichosis is culture of the fungus from skin lesions. Because of their non-specific presentation

2018 BMJ Best Practice

3. Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis in epidemic areas (PubMed)

Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis in epidemic areas Sporotrichosis is a subcutaneous mycosis caused by Sporothrix sp., a dimorphic fungus. Although the cutaneous form is the most frequent form, the ocular presentation has been increasingly diagnosed in epidemic areas. We describe three cases of ocular sporotrichosis with the involvement of the ocular adnexa due to autoinoculation without trauma with successful antifungal treatment.Patient 1 (...) evolution. Specimens were obtained from the lesions of the three patients, and the cultures were positive for Sporothrix sp. The three cases were diagnosed as ocular sporotrichosis and were successfully treated with itraconazole (200-400 mg/d). Two of the three patients developed sequelae such as conjunctival fibrosis and symblepharon.We emphasize the importance of the ophthalmologist being familiar with the diagnosis and management of this rare and frequently misdiagnosed form of sporotrichosis.

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2017 American journal of ophthalmology case reports

4. Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis. (PubMed)

Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis. Feline sporotrichosis due to Sporothrix brasiliensis is frequently severe and often correlated to zoonotic transmission. Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV) cause immunodeficiency in cats; no association has been identified with critical cases of sporotrichosis. Moreover, the cytokine profile in Sporothrix-infected cats and a potential impact (...) of retrovirus co-infections on their immunity is unknown. This study assessed immunological parameters in cats with sporotrichosis with and without FIV or FeLV co-infection. FeLV infection was detected by antigen ELISA and by provirus PCR. FIV infection was investigated through ELISA and Western blot. Cytokine transcription (IFN-γ, IL-4, IL-5, IL-6, IL-10, IL-12, TNF-α) was quantified using RT-qPCR and lymphocyte subpopulations (CD4, CD8, CD5 and CD21) were assessed by flow cytometry. Thirty cats

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2018 PLoS ONE

5. Effective treatment using itraconazole combined with terbinafine in the treatment of nasal sporotrichosis: A case report. (PubMed)

Effective treatment using itraconazole combined with terbinafine in the treatment of nasal sporotrichosis: A case report. Sporotrichosis is a subacute or chronic infection caused by sporothrix schenckii complex. The misdiagnosis rate of sporotrichosis is very high. Fungal microscopic examination and timely culture help us make an accurate diagnosis and treatment. We observed that combined treatments are more effective than monotherapy in treatment of sporotrichosis.A 47-year-old female (...) of sporothrix-like species appeared by fungal culture. The diagnosis of sporotrichosis was finally confirmed based on the lesion characteristics and the results of laboratory examination.The lesions did not alleviate with Itraconazole oral administration for 1 month. Then we treated the patient with the combination therapy of itraconazole (ITR) and terbinafine. At the same time, the compound glycyrrhizin tablet was used for liver protection.The patient was free of clinical symptoms of sporotrichosis

2019 Medicine

6. Disseminated sporotrichosis following iatrogenic immunosuppression for suspected pyoderma gangrenosum. (PubMed)

Disseminated sporotrichosis following iatrogenic immunosuppression for suspected pyoderma gangrenosum. Sporotrichosis is an infection caused by the dimorphic fungus Sporothrix schenckii and related species that often arises from traumatic inoculation of inhabited soil and organic debris into skin. The infection is usually limited to the skin in immunocompetent patients, usually as lymphocutaneous sporotrichosis. Accurate diagnosis rests on clinical data and culture, and might be facilitated (...) by biopsy identification of suppurative and granulomatous inflammation with fungal elements. In this Grand Round, we present a dramatic case of cutaneous sporotrichosis initially presented with an atypical large ulcer without associated lymphocutaneous spread, clinically mimicking pyoderma gangrenosum, and subsequently progressed to disseminated sporotrichosis in the setting of iatrogenic immunosuppression. We further review the clinical features, risk factors, and treatment of these disseminated

2019 Lancet infectious diseases

7. Mannose-Binding Lectin and MBL-Associated Serine Protease-2 Genotypes and Serum Levels in Patients with Sporotrichosis. (PubMed)

Mannose-Binding Lectin and MBL-Associated Serine Protease-2 Genotypes and Serum Levels in Patients with Sporotrichosis. Mannose-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are important proteins in the lectin pathway of the immune system. Mannose-binding lectin and MASP-2 deficiencies have been reported to be responsible for various fungal infections. We investigated the association of MBL and MASP-2 variants with sporotrichosis in a Chinese population and revealed one (...) rare heterozygous mutation in a disseminated cutaneous patient without immunosuppressive conditions (p.156_159dupCHNH). We also found that sporotrichosis patients had decreased levels of MBL and MASP-2 in their serum samples compared with controls. Our findings linked, for the first time, MASP-2 deficiencies with susceptibility to Sporothrix sp.

2019 American Journal of Tropical Medicine & Hygiene

8. Sporotrichosis in the Highlands of Madagascar, 2013-2017<sup>1</sup>. (PubMed)

Sporotrichosis in the Highlands of Madagascar, 2013-20171. Sporotrichosis is a saprozoonotic fungal infection found mostly in tropical and subtropical areas. Few case reports in Madagascar have been published. To document sporotrichosis epidemiology in Madagascar, we conducted a cross-sectional study. During March 2013-June 2017, we recruited from select hospitals in Madagascar patients with chronic cutaneous lesions suggestive of dermatomycosis. Sporotrichosis was diagnosed for 63 (...) (42.5%) of 148 patients. All but 1 patient came from the central highlands, where the prevalence was 0.21 cases/100,000 inhabitants. Frequency was high (64.7%) among patients <18 years of age. Sporotrichosis was diagnosed for 73.8% of patients with arm lesions, 32.3% with leg lesions, and 15.4% with lesions at other sites. Molecular identification identified 53 Sporothrix schenckii isolates. Among the 32 patients who were followed up, response to itraconazole was complete or major for 15 and minor

2019 Emerging Infectious Diseases

9. A randomized comparison of combined itraconazole and Nd:YAG 1064-nm laser vs itraconazole alone for the treatment of cutaneous sporotrichosis. (PubMed)

A randomized comparison of combined itraconazole and Nd:YAG 1064-nm laser vs itraconazole alone for the treatment of cutaneous sporotrichosis.

2018 European journal of dermatology : EJD

10. Zoonotic Sporotrichosis Related to Cat Contact: First Case Report from Panama in Central America (PubMed)

Zoonotic Sporotrichosis Related to Cat Contact: First Case Report from Panama in Central America A previously healthy 34-year-old man presented with a four-week-old upper arm injury that started with a cat scratch and progressed into painless erythematous nodular ascending lesions in the left upper limb. We made the diagnosis of sporotrichosis based on the epidemiological association of the contact with a cat and culture identification. Sporotrichosis is a mycosis implantation caused (...) by the Sporothrix schenckii complex. We present the first Central American case of sporotrichosis associated with contact with a feline.

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2018 Cureus

11. Immunopathogenesis of Human Sporotrichosis: What We Already Know (PubMed)

Immunopathogenesis of Human Sporotrichosis: What We Already Know Sporotrichosis is a subacute/chronic mycosis caused by dimorphic fungus of the genus Sporothrix. This mycosis may affect both human and domestic animals and in the last few years, the geographic dispersion and increase of sporotrichosis worldwide has been observed. The occurrence of cases related to scratching/bites of domestic felines have increased, characterizing the disease as predominantly a zoonosis. In humans (...) , sporotrichosis mainly involves the cutaneous tegument of infected patients, but other tissues may also present the infection. The main forms of clinical presentation are lymphocutanous sporotrichosis (LC) and fixed sporotrichosis (F). Although less common, mucosal, cutaneous disseminated, and extracutaneous forms have also been described. Multiple factors from the fungus and host can play a role in driving the clinical evolution of sporotrichosis to benign or severe disease. In this review, we discuss

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2018 Journal of Fungi

12. The role of dermoscopy in the diagnosis of deep mycoses and systemic mycoses with cutaneous involvement Comment on "Dermoscopy in disseminated sporotrichosis". (PubMed)

The role of dermoscopy in the diagnosis of deep mycoses and systemic mycoses with cutaneous involvement Comment on "Dermoscopy in disseminated sporotrichosis". 29953679 2019 01 18 1468-3083 33 1 2019 Jan Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol The role of dermoscopy in the diagnosis of deep mycoses and systemic mycoses with cutaneous involvement: Comment on 'Dermoscopy in disseminated sporotrichosis'. e35-e36 10.1111/jdv.15155

2018 Journal of the European Academy of Dermatology and Venereology

13. Dermoscopy in disseminated sporotrichosis. (PubMed)

Dermoscopy in disseminated sporotrichosis. 29953691 2019 01 18 1468-3083 33 1 2019 Jan Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Dermoscopy in disseminated sporotrichosis. e33-e35 10.1111/jdv.15152 Dabas G G http://orcid.org/0000-0001-8675-2825 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Kaur H H Department of Medical Microbiology

2018 Journal of the European Academy of Dermatology and Venereology

14. Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women (PubMed)

Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women Pregnant women with sporotrichosis should not receive systemic antifungal therapy except in severe cases when amphotericin B is recommended. Thermotherapy is the most reported treatment described in this group of patients. It entails weeks of daily self-application of heat to the lesions, requires that the patient faithfully apply it, and it could cause skin burns. Cryosurgery is a useful therapeutic tool for many (...) cutaneous infectious diseases, safe for pregnant women, but not well evaluated for sporotrichosis treatment in this group.The authors conducted a retrospective study describing epidemiological, clinical, and therapeutic data related to four pregnant patients with sporotrichosis treated with cryosurgery. The authors reviewed the clinical records of four pregnant patients diagnosed with cutaneous sporotrichosis and treated with cryosurgery. The sessions were carried out monthly up to clinical cure

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2018 PLoS neglected tropical diseases

15. Sporotrichosis: From KOH to Molecular Biology (PubMed)

Sporotrichosis: From KOH to Molecular Biology Sporotrichosis is a cosmopolitan, chronic granulomatous mycosis, acquired by traumatic inoculation and caused by Sporothrix schenckii complex. Several methods of diagnostic are available, from KOH to molecular biology. In this review, we describe from the simplest (clinical diagnosis) to the most advanced diagnostic techniques (molecular biology).

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2018 Journal of Fungi

16. Primary conjunctival sporotrichosis: An atypical presentation of the disease (PubMed)

Primary conjunctival sporotrichosis: An atypical presentation of the disease 29984295 2019 02 26 2352-5126 4 5 2018 Jun JAAD case reports JAAD Case Rep Primary conjunctival sporotrichosis: An atypical presentation of the disease. 497-499 10.1016/j.jdcr.2018.01.022 Ferreira Thiago Amparo TA Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Sodré Celso Tavares CT Sector (...) of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. eng Case Reports 2018 05 07 United States JAAD Case Rep 101665210 2352-5126 Sporothrix complex conjunctiva sporotrichosis subcutaneous mycosis 2018 7 10 6 0 2018 7 10 6 0 2018 7 10 6 1 epublish 29984295 10.1016/j.jdcr.2018.01.022 S2352-5126(18)30034-1 PMC6031559 Cad Saude Publica. 2012 Oct;28(10):1867-80 23090167 Am J Ophthalmol Case Rep. 2017 Sep

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2018 JAAD Case Reports

17. Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis (PubMed)

Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Fifty-two cats with skin (...) lesions and a definitive diagnosis of sporotrichosis were treated with itraconazole for a maximum period of 36 weeks. The animals were submitted to clinical examination and two subsequent collections of samples from the same skin lesion for fungal diagnosis and histopathology, as well as serology for feline immunodeficiency (FIV) and leukaemia (FeLV) viruses. Thirty-seven (71%) cats were clinically cured. Nasal mucosa lesions and respiratory signs were associated with treatment failure. Cats

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2018 Scientific reports

18. Sporotrichin Skin Test for the Diagnosis of Sporotrichosis (PubMed)

Sporotrichin Skin Test for the Diagnosis of Sporotrichosis Sporotrichosis is the most common implantation mycosis caused by several species of the Sporothrix schenckii complex. The gold standard for diagnosis is concerned with the isolation of the fungus; although, fresh examinations, staining, and biopsies are also helpful for this purpose. The sporotrichin is an antigenic complex comprised of a peptide-rhamnomannan, which is relevant with respect to pathogenic fungi; it is primarily used (...) for serological and skin testing. We present a study regarding the use of sporotrichin as a diagnostic aid for cutaneous sporotrichosis. Furthermore, 138 cases with suspicion of sporotrichosis were included, 55 of which were proven through cultures. Moreover, out of these 55 cases, 52 (94.5%) tested positive for sporotrichin, while the negative cases corresponded to the disseminated cutaneous forms. We observed a sensitivity of 94.5% and a specificity of 95.2%. We consider that the use of sporotrichin

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2018 Journal of Fungi

19. Draft Genome Sequences of Two Sporothrix schenckii Clinical Isolates Associated with Human Sporotrichosis in Colombia (PubMed)

Draft Genome Sequences of Two Sporothrix schenckii Clinical Isolates Associated with Human Sporotrichosis in Colombia Sporothrix schenckii is a thermodimorphic fungal pathogen with a high genetic diversity. In this work, we present the assembly and similarity analysis of the whole-genome sequences of two clinical isolates from Colombia of S. schenckiisensu stricto.Copyright © 2018 Gomez et al.

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2018 Genome Announcements

20. Ecological Determinants of Sporotrichosis Etiological Agents (PubMed)

Ecological Determinants of Sporotrichosis Etiological Agents Ecological determinants of sporotrichosis etiological agents remain poorly understood. For this reason, we performed explorations using local climate estimates to determine the temperature and humidity ranges of the environment where clinically relevant Sporothrix species occur and to identify what plant species are associated with them, using data collected from the published literature. We performed a literature search to identify (...) indicate that sporotrichosis etiological agents grow in soil in ecological niches from soil with wide ranges of temperature and humidity, but they are also associated with a variety of plants, flowers, woody debris, reed leaves, corn stalks, leaves, and wood crumbs, potentially facilitating its establishment and proliferation in the environment.

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2018 Journal of Fungi

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