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Spondyloarthropathy

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141. Class II Invariant Chain HCV Vaccine Study

, lactation or willingness/intention to become pregnant during the study Personal history of autoimmune disease History of major autoimmune disease in first degree relative, e.g. Type 1 diabetes, Graves' Disease, Systemic Lupus Erythematosus (SLE) or Spondyloarthropathy (AS). HLA type B27 positive individuals History of cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) History of serious psychiatric condition Any other serious chronic illness requiring hospital specialist

2018 Clinical Trials

142. Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee

/acetaminophen, or combinations thereof Consent to allow all radiographs and medical/surgical/hospitalization records of care received elsewhere prior to and during the study period to be shared with the investigator Key Exclusion Criteria: History or presence at the screening visit of non-OA inflammatory joint disease (eg, rheumatoid arthritis, lupus erythematosus, psoriatic arthritis, pseudo-gout, gout, spondyloarthropathy, polymyalgia rheumatica, joint infections within the past 5 years), Paget's disease

2018 Clinical Trials

143. Value of Tomosynthesis for the Detection of Sacro-iliitis (TOMOS SI)

See Sponsor: University Hospital, Montpellier Collaborators: DMS Apelem Thales Digisens Medecom BPI France European Regional Development Fund Information provided by (Responsible Party): University Hospital, Montpellier Study Details Study Description Go to Brief Summary: Spondyloarthropathies (SpAs) are chronic inflammatory diseases encompassing ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthropathy, and undifferentiated SpA. In 2001, the estimated prevalence

2018 Clinical Trials

144. Cross-sectional survey of the undergraduate rheumatology curriculum in European medical schools: a EULAR School of Rheumatology initiative Full Text available with Trip Pro

. Similarly, interpretation of investigations undertaken on synovial fluid was taught in only 16 schools. While disease-modifying anti-rheumatic drugs and biological agents, and urate-lowering treatment were included in the curricula of 20 and 21 institutions, respectively, only curricula from 18 schools included core non-pharmacological interventions. Osteoarthritis, gout, rheumatoid arthritis, spondyloarthropathy, polymyalgia rheumatica and lupus were included in the curriculum of all institutions

2018 RMD open

145. Can power Doppler ultrasound of the entheses help in classifying recent axial spondyloarthritis? Data from the DESIR cohort Full Text available with Trip Pro

% European Spondyloarthropathy Study Group criteria and 59% both.In a cohort of patients with recent IBP, the prevalence of PDUS enthesitis was low (14.4%); however, its specificity for classifying patients as axSpA according to ASAS criteria was high (83.5%). PDUS enthesitis might be of additional value for classifying as patients with axSpA IBP who do not fulfil ASAS criteria.

2018 RMD open

146. The Management of Acute Anterior Uveitis Complicating Spondyloarthritis: Present and Future Full Text available with Trip Pro

The Management of Acute Anterior Uveitis Complicating Spondyloarthritis: Present and Future Spondyloarthropathies (SpA) encompass a group of chronic inflammatory diseases sharing common genetic and clinical features, including the association with HLA-B27 antigen, the involvement of both the axial and the peripheral skeleton, the presence of dactylitis, enthesitis, and typical extra-articular manifestations such as psoriasis, inflammatory bowel disease, and acute anterior uveitis (AAU

2018 BioMed research international

147. Feasibility of cardiovascular disease risk assessments in rheumatology outpatient clinics: experiences from the nationwide NOCAR project Full Text available with Trip Pro

referred to their primary care physician for initiation of CVD preventive measures.Data collection (autumn 2015) showed that five of the NOCAR centres had implemented CVD risk assessments. There were 8789 patients eligible for CVD risk evaluation (rheumatoid arthritis (RA), 4483; ankylosing spondylitis (AS), 1663; psoriatic arthritis (PsA), 1928; unspecified and other forms of spondyloarthropathies (SpA), 715) of whom 41.4 % received a CVD risk assessment (RA, 44.7%; AS, 43.4%; PsA, 36.3%; SpA, 30.6

2018 RMD open

148. Quo vadis, biological treatment for psoriasis and psoriatic arthritis? Full Text available with Trip Pro

Quo vadis, biological treatment for psoriasis and psoriatic arthritis? Psoriasis is a chronic autoimmune disease that affects approximately 2-3% of the world's population. Although the cutaneous manifestations of the disease are the most prevalent, psoriasis is also associated with a systemic inflammation and various co-morbidities linked with autoinflammatory processes. One of those processes is psoriatic arthritis, an inflammatory, seronegative spondyloarthropathy that develops in 13.8-30

2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

149. Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus Full Text available with Trip Pro

patients with rheumatoid arthritis, primary anti-phospholipid syndrome, spondyloarthropathy, psoriatic arthritis, and systemic sclerosis. A positive test result in SNEC ELISA significantly correlated with serological variables and reflected the uptake of opsonized SNEC by neutrophils. This stresses the relevance of SNECs in the pathogenesis of SLE. We conclude that SNEC ELISA allows for the sensitive detection of pathologically relevant AAb, enabling its diagnostic usage. A positive SNEC test reflects

2018 Frontiers in immunology

150. Enthesitis: Much More Than Focal Insertion Point Inflammation Full Text available with Trip Pro

Enthesitis: Much More Than Focal Insertion Point Inflammation Recognition of the importance of enthesitis as the pivotal pathological process underpinning spondyloarthropathies (SpA) has increased in recent years. Thus, we summarized the current knowledge on the pathogenic role of enthesitis on SpA shown by both animal models and human studies in vivo.Experimental models have shown several SpA-like diseases that commence at entheses and are linked to nail disease as well as dactylitis, two

2018 Current Rheumatology Reports

151. Hidradenitis suppurativa associated with systemic lupus erythematosus: A case report. Full Text available with Trip Pro

Hidradenitis suppurativa associated with systemic lupus erythematosus: A case report. Hidradenitis suppurativa (HS) is a chronic inflammatory condition characterized by recurrent swollen, deep, and painful abscesses. Several autoimmune conditions have been shown to be associated with HS including inflammatory bowel disease and spondyloarthropathies.40-year-old female with systemic lupus erythematous (SLE) presented with recurrent abscesses and nodules on her extremities.Early considerations

2018 Medicine

152. Shifting the Focus: The Primary Role of IL-23 in Psoriasis and other Inflammatory Disorders. Full Text available with Trip Pro

interleukin (IL)-12/23 and IL-17. The most recent evidence suggests that IL-23 might be an even more potent target for the effective treatment of psoriasis and other autoimmune inflammatory disorders. This review will describe recent developments leading to the current understanding of the key role of IL-23 as a 'master regulator' of autoimmune inflammation and the clinical evidence for agents that specifically target this modulator in the context of treating psoriasis, spondyloarthropathy

2018 Journal of the European Academy of Dermatology and Venereology

153. The link between COPD and ankylosing spondylitis: A population based study. (Abstract)

The link between COPD and ankylosing spondylitis: A population based study. Ankylosing spondylitis (AS) is one of the most common and severe subtypes of the spondyloarthropathies. Extra-articular involvement among AS patients, including lung disease, has been described widely. Chronic obstructive pulmonary disease (COPD) has been linked to several autoimmune diseases, however, very few studies have investigated the association between AS and COPD.To assess whether an association exists between

2018 European journal of internal medicine

154. Safety and Efficacy of Tofacitinib vs Methotrexate in the Treatment of Psoriatic Arthritis

to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway which ultimately decreases the production of pro-inflammatory cytokines, and prevents both inflammatory response and the inflammation-induced damage. It has shown better efficacy in many diseases like Rheumatoid Arthritis, Axial spondyloarthropathies, Psoriasis, Psoriatic Arthritis, Alopecia areata, dry eye disease. This prospective, open label, randomized study will be conducted

2018 Clinical Trials

155. Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre. Full Text available with Trip Pro

Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre. Childhood-onset spondyloarthropathies usually start with enthesitis and peripheral arthritis. However, axial disease may develop afterward. Patients are most often classified, following revised (Edmonton 2011) ILAR criteria, as enthesitis-related arthritis, psoriatic arthritis, or unclassified juvenile idiopathic (...) arthritis, particularly in cases of psoriasis in the patient or a first-degree relative. In adults, peripheral spondyloarthritis is classified by ASAS criteria.We retrospectively studied patients with childhood-onset spondyloarthropathies followed for more than one year in our referral centre. We did not exclude patients with a personal or familial history of psoriasis.We included 114 patients followed between January 2008 and December 2015 for a median of 2.5 years (IQR = 2.3). Sixty-nine per-cent

2018 Pediatric Rheumatology

156. Persistent fever and destructive arthritis caused by dialysis-related amyloidosis: A case report. Full Text available with Trip Pro

Persistent fever and destructive arthritis caused by dialysis-related amyloidosis: A case report. Dialysis-related amyloidosis (DRA) can present rheumatic manifestations in patients on long-term hemodialysis. Typical articular symptoms with DRA involve carpal-tunnel syndrome, effusion in large joints, spondyloarthropathy, or cystic bone lesions, which are usually with non-inflammatory processes.A 64-year-old man on hemodialysis for >30 years was admitted because of intermittent fever

2018 Medicine

157. Current evidence for spinal X-ray use in the chiropractic profession: a narrative review Full Text available with Trip Pro

, with consideration of the related risks and benefits. Current evidence supports the use of spinal X-rays only in the diagnosis of trauma and spondyloarthropathy, and in the assessment of progressive spinal structural deformities such as adolescent idiopathic scoliosis. MRI is indicated to diagnose serious pathology such as cancer or infection, and to assess the need for surgical management in radiculopathy and spinal stenosis. Strong evidence demonstrates risks of imaging such as excessive radiation exposure

2018 Chiropractic & manual therapies

158. Rheumatological Manifestations in Inflammatory Bowel Diseases

Information provided by (Responsible Party): Mustafa badary, Assiut University Study Details Study Description Go to Brief Summary: IBD-related arthropathy is one of a group of inflammatory arthritides considered as seronegative spondyloarthropathies, a group of disorders that also includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and undifferentiated SpA. IBD-related SpA is mainly characterized by axial involvement but may also be associated with peripheral symptoms

2018 Clinical Trials

159. The Immunogenicity and Safety of Zostavax® in Rheumatoid Arthritis Patients Using Abatacept

, the investigators used the administrative databases of a national U.S. Healthcare organization (Aetna) to conduct an observational study to examining Zostavax use in patients with RA and other rheumatic diseases (e.g. spondyloarthropathies). Among a total of 19,326 RA patients older than age 50, only 206 (1%) received zoster vaccine, suggesting that clinicians may be uncomfortable using the vaccine in RA patients. Additionally, approximately 60 vaccinated patients were using anti-TNF therapies within one month

2018 Clinical Trials

160. Optimization of an in-house PCR method for the detection of HLA-B*27 alleles Full Text available with Trip Pro

Optimization of an in-house PCR method for the detection of HLA-B*27 alleles The association of spondyloarthropathies with different alleles of human leukocyte antigen (HLA) B*27 is well established. Different subtypes of HLA-B*27 may be linked with different ethnic groups, distinct clinical manifestations, specific age of onset and different prognoses. Polymerase chain reaction with sequence specific primers (PCR-SSP) is the most frequently adapted molecular method used for the recognition

2018 Biomedical reports

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