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Spondyloarthropathy

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141. The link between COPD and ankylosing spondylitis: A population based study. (PubMed)

The link between COPD and ankylosing spondylitis: A population based study. Ankylosing spondylitis (AS) is one of the most common and severe subtypes of the spondyloarthropathies. Extra-articular involvement among AS patients, including lung disease, has been described widely. Chronic obstructive pulmonary disease (COPD) has been linked to several autoimmune diseases, however, very few studies have investigated the association between AS and COPD.To assess whether an association exists between

2018 European journal of internal medicine

142. Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre. (PubMed)

Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre. Childhood-onset spondyloarthropathies usually start with enthesitis and peripheral arthritis. However, axial disease may develop afterward. Patients are most often classified, following revised (Edmonton 2011) ILAR criteria, as enthesitis-related arthritis, psoriatic arthritis, or unclassified juvenile idiopathic (...) arthritis, particularly in cases of psoriasis in the patient or a first-degree relative. In adults, peripheral spondyloarthritis is classified by ASAS criteria.We retrospectively studied patients with childhood-onset spondyloarthropathies followed for more than one year in our referral centre. We did not exclude patients with a personal or familial history of psoriasis.We included 114 patients followed between January 2008 and December 2015 for a median of 2.5 years (IQR = 2.3). Sixty-nine per-cent

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2018 Pediatric Rheumatology

143. Persistent fever and destructive arthritis caused by dialysis-related amyloidosis: A case report. (PubMed)

Persistent fever and destructive arthritis caused by dialysis-related amyloidosis: A case report. Dialysis-related amyloidosis (DRA) can present rheumatic manifestations in patients on long-term hemodialysis. Typical articular symptoms with DRA involve carpal-tunnel syndrome, effusion in large joints, spondyloarthropathy, or cystic bone lesions, which are usually with non-inflammatory processes.A 64-year-old man on hemodialysis for >30 years was admitted because of intermittent fever

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2018 Medicine

144. Shifting the Focus: The Primary Role of IL-23 in Psoriasis and other Inflammatory Disorders. (PubMed)

interleukin (IL)-12/23 and IL-17. The most recent evidence suggests that IL-23 might be an even more potent target for the effective treatment of psoriasis and other autoimmune inflammatory disorders. This review will describe recent developments leading to the current understanding of the key role of IL-23 as a 'master regulator' of autoimmune inflammation and the clinical evidence for agents that specifically target this modulator in the context of treating psoriasis, spondyloarthropathy

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2018 Journal of the European Academy of Dermatology and Venereology

145. Hidradenitis suppurativa associated with systemic lupus erythematosus: A case report. (PubMed)

Hidradenitis suppurativa associated with systemic lupus erythematosus: A case report. Hidradenitis suppurativa (HS) is a chronic inflammatory condition characterized by recurrent swollen, deep, and painful abscesses. Several autoimmune conditions have been shown to be associated with HS including inflammatory bowel disease and spondyloarthropathies.40-year-old female with systemic lupus erythematous (SLE) presented with recurrent abscesses and nodules on her extremities.Early considerations

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2018 Medicine

146. Optimization of an in-house PCR method for the detection of HLA-B*27 alleles (PubMed)

Optimization of an in-house PCR method for the detection of HLA-B*27 alleles The association of spondyloarthropathies with different alleles of human leukocyte antigen (HLA) B*27 is well established. Different subtypes of HLA-B*27 may be linked with different ethnic groups, distinct clinical manifestations, specific age of onset and different prognoses. Polymerase chain reaction with sequence specific primers (PCR-SSP) is the most frequently adapted molecular method used for the recognition

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2018 Biomedical reports

147. Enthesitis: Much More Than Focal Insertion Point Inflammation (PubMed)

Enthesitis: Much More Than Focal Insertion Point Inflammation Recognition of the importance of enthesitis as the pivotal pathological process underpinning spondyloarthropathies (SpA) has increased in recent years. Thus, we summarized the current knowledge on the pathogenic role of enthesitis on SpA shown by both animal models and human studies in vivo.Experimental models have shown several SpA-like diseases that commence at entheses and are linked to nail disease as well as dactylitis, two

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2018 Current Rheumatology Reports

148. Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus (PubMed)

patients with rheumatoid arthritis, primary anti-phospholipid syndrome, spondyloarthropathy, psoriatic arthritis, and systemic sclerosis. A positive test result in SNEC ELISA significantly correlated with serological variables and reflected the uptake of opsonized SNEC by neutrophils. This stresses the relevance of SNECs in the pathogenesis of SLE. We conclude that SNEC ELISA allows for the sensitive detection of pathologically relevant AAb, enabling its diagnostic usage. A positive SNEC test reflects

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2018 Frontiers in immunology

149. Quo vadis, biological treatment for psoriasis and psoriatic arthritis? (PubMed)

Quo vadis, biological treatment for psoriasis and psoriatic arthritis? Psoriasis is a chronic autoimmune disease that affects approximately 2-3% of the world's population. Although the cutaneous manifestations of the disease are the most prevalent, psoriasis is also associated with a systemic inflammation and various co-morbidities linked with autoinflammatory processes. One of those processes is psoriatic arthritis, an inflammatory, seronegative spondyloarthropathy that develops in 13.8-30

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2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

150. The Immunogenicity and Safety of Zostavax® in Rheumatoid Arthritis Patients Using Abatacept

, the investigators used the administrative databases of a national U.S. Healthcare organization (Aetna) to conduct an observational study to examining Zostavax use in patients with RA and other rheumatic diseases (e.g. spondyloarthropathies). Among a total of 19,326 RA patients older than age 50, only 206 (1%) received zoster vaccine, suggesting that clinicians may be uncomfortable using the vaccine in RA patients. Additionally, approximately 60 vaccinated patients were using anti-TNF therapies within one month

2018 Clinical Trials

151. Study of Safety and Efficacy of HLX01+MTX in Patients With Rheumatoid Arthritis

. Previously or currently suffering from inflammatory joint diseases other than RA (e.g. gout, reactive arthritis, psoriatic arthritis, seronegative spondyloarthropathies, Lyme disease, etc.), or other systemic autoimmune diseases (e.g., systemic lupus erythematosus, inflammatory bowel disease, pulmonary fibrosis, Felty's syndrome, scleroderma, inflammatory myopathy, mixed connective tissue disease, or any overlap syndromes). Evidence significant unconcomitant diseases, such as, but not limited to, nervous

2018 Clinical Trials

152. Rheumatological Manifestations in Inflammatory Bowel Diseases

Information provided by (Responsible Party): Mustafa badary, Assiut University Study Details Study Description Go to Brief Summary: IBD-related arthropathy is one of a group of inflammatory arthritides considered as seronegative spondyloarthropathies, a group of disorders that also includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and undifferentiated SpA. IBD-related SpA is mainly characterized by axial involvement but may also be associated with peripheral symptoms

2018 Clinical Trials

153. To Assess the Patients' Ability to Self-Administer Fasinumab in an Unsupervised Setting

arthritis, pseudo-gout, gout, spondyloarthropathy, polymyalgia rheumatica, joint infections within the past 5 years), Paget's disease of the spine, pelvis or femur, neuropathic disorders, multiple sclerosis, fibromyalgia, tumors or infections of the spinal cord, or renal osteodystrophy History or presence on imaging of arthropathy (osteonecrosis, subchondral insufficiency fracture, rapidly progressive OA type 1 or type 2), stress fracture, recent stress fracture, neuropathic joint arthropathy, hip

2018 Clinical Trials

154. Alloimmune Response to Citrullinated Shared Epitope Sequence in Patients With Rheumatoid Arthritis

Patients with psoriatic arthritis, peripheric spondyloarthropathies and connective tissue diseases. Diagnostic Test: Research new biomarker for RA Analyze T and B cell response against new citrullinated peptides Healthy controls From health blood donors Diagnostic Test: Research new biomarker for RA Analyze T and B cell response against new citrullinated peptides Outcome Measures Go to Primary Outcome Measures : T cell response [ Time Frame: 2 years ] Proliferation against new citrullinated peptides B

2018 Clinical Trials

155. Risk of Tuberculous and Other Infections in Patients of Spondyloarthritis Treated With Tofacitinib in Bangladesh

Identifier: NCT03504072 Recruitment Status : Recruiting First Posted : April 20, 2018 Last Update Posted : April 23, 2018 See Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Information provided by (Responsible Party): Md. Nazrul Islam, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Study Details Study Description Go to Brief Summary: Treatment failure of Spondyloarthropathies (SpA) leads to marked functional disability, higher rates of morbidity, mortality (...) Phase 4 Detailed Description: Spondyloarthropathies (SpA) are non curable, diseases of young subjects, treatment failure leads to marked functional disability, higher rates of morbidity, mortality and poor quality of life. Effective drugs may not be safe in different geographic backgrounds. Bangladesh is a TB endemic country so patients are at risk of TB and other infections at background. The aim of this study will be to evaluation the risk of tuberculosis and other infections in refractory SpA

2018 Clinical Trials

156. Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis

(Anti-CCP antibodies & Rheumatoid Factor checked ), psoriatic arthritis or spondyloarthropathy Symptomatic knee pain On usual care for arthritis including disease-modifying anti-rheumatic drugs (DMARDs), paracetamol and/or NSAIDs Exclusion Criteria: Other rheumatological diagnosis e.g. systemic lupus erythematosus, fibromyalgia, Polymyalgia Rheumatica, Gout, Giant Cell Arteritis, Sjogren's syndrome History of uncontrolled depression Recent surgery Uncontrolled ischaemic heart disease Uncontrolled

2018 Clinical Trials

157. Value of Tomosynthesis for the Detection of Sacro-iliitis (TOMOS SI)

See Sponsor: University Hospital, Montpellier Collaborators: DMS Apelem Thales Digisens Medecom BPI France European Regional Development Fund Information provided by (Responsible Party): University Hospital, Montpellier Study Details Study Description Go to Brief Summary: Spondyloarthropathies (SpAs) are chronic inflammatory diseases encompassing ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthropathy, and undifferentiated SpA. In 2001, the estimated prevalence

2018 Clinical Trials

158. LIBRE (Ligamys, Internal Bracing, REconstruction) Study: Comparing Three Surgery Techniques After an Acute ACL Rupture.

Arthritis (RA), Spondyloarthropathy (SpA), active malignancy Patient not suited for intervention due to lack of mobility, meaning not achieving 90° of flexion before surgery. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03441295 Contacts Layout table

2018 Clinical Trials

159. EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2)

haemophila, ulcerative colitis, rheumatoid arthritis and spondyloarthropathy, autoimmune hepatitis, others) and secondary malignancy (EBV lymphoproliferative disorders, AML, MDS, skin cancers, and any others Immune reconstitution [ Time Frame: 2 years post-transplant ] Results of routine analysis performed by centres will be investigated in correlation to clinical outcomes parameters and will allow to follow post-transplant immune reconstitution according to ADWP GCP. Eligibility Criteria Go

2018 Clinical Trials

160. Class II Invariant Chain HCV Vaccine Study

, lactation or willingness/intention to become pregnant during the study Personal history of autoimmune disease History of major autoimmune disease in first degree relative, e.g. Type 1 diabetes, Graves' Disease, Systemic Lupus Erythematosus (SLE) or Spondyloarthropathy (AS). HLA type B27 positive individuals History of cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) History of serious psychiatric condition Any other serious chronic illness requiring hospital specialist

2018 Clinical Trials

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