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Spondyloarthropathy

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141. Shifting the Focus: The Primary Role of IL-23 in Psoriasis and other Inflammatory Disorders. (PubMed)

interleukin (IL)-12/23 and IL-17. The most recent evidence suggests that IL-23 might be an even more potent target for the effective treatment of psoriasis and other autoimmune inflammatory disorders. This review will describe recent developments leading to the current understanding of the key role of IL-23 as a 'master regulator' of autoimmune inflammation and the clinical evidence for agents that specifically target this modulator in the context of treating psoriasis, spondyloarthropathy

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2018 Journal of the European Academy of Dermatology and Venereology

142. Hidradenitis suppurativa associated with systemic lupus erythematosus: A case report. (PubMed)

Hidradenitis suppurativa associated with systemic lupus erythematosus: A case report. Hidradenitis suppurativa (HS) is a chronic inflammatory condition characterized by recurrent swollen, deep, and painful abscesses. Several autoimmune conditions have been shown to be associated with HS including inflammatory bowel disease and spondyloarthropathies.40-year-old female with systemic lupus erythematous (SLE) presented with recurrent abscesses and nodules on her extremities.Early considerations

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2018 Medicine

143. Optimization of an in-house PCR method for the detection of HLA-B*27 alleles (PubMed)

Optimization of an in-house PCR method for the detection of HLA-B*27 alleles The association of spondyloarthropathies with different alleles of human leukocyte antigen (HLA) B*27 is well established. Different subtypes of HLA-B*27 may be linked with different ethnic groups, distinct clinical manifestations, specific age of onset and different prognoses. Polymerase chain reaction with sequence specific primers (PCR-SSP) is the most frequently adapted molecular method used for the recognition

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2018 Biomedical reports

144. Enthesitis: Much More Than Focal Insertion Point Inflammation (PubMed)

Enthesitis: Much More Than Focal Insertion Point Inflammation Recognition of the importance of enthesitis as the pivotal pathological process underpinning spondyloarthropathies (SpA) has increased in recent years. Thus, we summarized the current knowledge on the pathogenic role of enthesitis on SpA shown by both animal models and human studies in vivo.Experimental models have shown several SpA-like diseases that commence at entheses and are linked to nail disease as well as dactylitis, two

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2018 Current Rheumatology Reports

145. Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus (PubMed)

patients with rheumatoid arthritis, primary anti-phospholipid syndrome, spondyloarthropathy, psoriatic arthritis, and systemic sclerosis. A positive test result in SNEC ELISA significantly correlated with serological variables and reflected the uptake of opsonized SNEC by neutrophils. This stresses the relevance of SNECs in the pathogenesis of SLE. We conclude that SNEC ELISA allows for the sensitive detection of pathologically relevant AAb, enabling its diagnostic usage. A positive SNEC test reflects

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2018 Frontiers in immunology

146. Quo vadis, biological treatment for psoriasis and psoriatic arthritis? (PubMed)

Quo vadis, biological treatment for psoriasis and psoriatic arthritis? Psoriasis is a chronic autoimmune disease that affects approximately 2-3% of the world's population. Although the cutaneous manifestations of the disease are the most prevalent, psoriasis is also associated with a systemic inflammation and various co-morbidities linked with autoinflammatory processes. One of those processes is psoriatic arthritis, an inflammatory, seronegative spondyloarthropathy that develops in 13.8-30

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2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

147. The Immunogenicity and Safety of Zostavax® in Rheumatoid Arthritis Patients Using Abatacept

, the investigators used the administrative databases of a national U.S. Healthcare organization (Aetna) to conduct an observational study to examining Zostavax use in patients with RA and other rheumatic diseases (e.g. spondyloarthropathies). Among a total of 19,326 RA patients older than age 50, only 206 (1%) received zoster vaccine, suggesting that clinicians may be uncomfortable using the vaccine in RA patients. Additionally, approximately 60 vaccinated patients were using anti-TNF therapies within one month

2018 Clinical Trials

148. Study of Safety and Efficacy of HLX01+MTX in Patients With Rheumatoid Arthritis

. Previously or currently suffering from inflammatory joint diseases other than RA (e.g. gout, reactive arthritis, psoriatic arthritis, seronegative spondyloarthropathies, Lyme disease, etc.), or other systemic autoimmune diseases (e.g., systemic lupus erythematosus, inflammatory bowel disease, pulmonary fibrosis, Felty's syndrome, scleroderma, inflammatory myopathy, mixed connective tissue disease, or any overlap syndromes). Evidence significant unconcomitant diseases, such as, but not limited to, nervous

2018 Clinical Trials

149. Rheumatological Manifestations in Inflammatory Bowel Diseases

Information provided by (Responsible Party): Mustafa badary, Assiut University Study Details Study Description Go to Brief Summary: IBD-related arthropathy is one of a group of inflammatory arthritides considered as seronegative spondyloarthropathies, a group of disorders that also includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and undifferentiated SpA. IBD-related SpA is mainly characterized by axial involvement but may also be associated with peripheral symptoms

2018 Clinical Trials

150. To Assess the Patients' Ability to Self-Administer Fasinumab in an Unsupervised Setting

arthritis, pseudo-gout, gout, spondyloarthropathy, polymyalgia rheumatica, joint infections within the past 5 years), Paget's disease of the spine, pelvis or femur, neuropathic disorders, multiple sclerosis, fibromyalgia, tumors or infections of the spinal cord, or renal osteodystrophy History or presence on imaging of arthropathy (osteonecrosis, subchondral insufficiency fracture, rapidly progressive OA type 1 or type 2), stress fracture, recent stress fracture, neuropathic joint arthropathy, hip

2018 Clinical Trials

151. Alloimmune Response to Citrullinated Shared Epitope Sequence in Patients With Rheumatoid Arthritis

Patients with psoriatic arthritis, peripheric spondyloarthropathies and connective tissue diseases. Diagnostic Test: Research new biomarker for RA Analyze T and B cell response against new citrullinated peptides Healthy controls From health blood donors Diagnostic Test: Research new biomarker for RA Analyze T and B cell response against new citrullinated peptides Outcome Measures Go to Primary Outcome Measures : T cell response [ Time Frame: 2 years ] Proliferation against new citrullinated peptides B

2018 Clinical Trials

152. Risk of Tuberculous and Other Infections in Patients of Spondyloarthritis Treated With Tofacitinib in Bangladesh

Identifier: NCT03504072 Recruitment Status : Recruiting First Posted : April 20, 2018 Last Update Posted : April 23, 2018 See Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Information provided by (Responsible Party): Md. Nazrul Islam, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Study Details Study Description Go to Brief Summary: Treatment failure of Spondyloarthropathies (SpA) leads to marked functional disability, higher rates of morbidity, mortality (...) Phase 4 Detailed Description: Spondyloarthropathies (SpA) are non curable, diseases of young subjects, treatment failure leads to marked functional disability, higher rates of morbidity, mortality and poor quality of life. Effective drugs may not be safe in different geographic backgrounds. Bangladesh is a TB endemic country so patients are at risk of TB and other infections at background. The aim of this study will be to evaluation the risk of tuberculosis and other infections in refractory SpA

2018 Clinical Trials

153. Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis

(Anti-CCP antibodies & Rheumatoid Factor checked ), psoriatic arthritis or spondyloarthropathy Symptomatic knee pain On usual care for arthritis including disease-modifying anti-rheumatic drugs (DMARDs), paracetamol and/or NSAIDs Exclusion Criteria: Other rheumatological diagnosis e.g. systemic lupus erythematosus, fibromyalgia, Polymyalgia Rheumatica, Gout, Giant Cell Arteritis, Sjogren's syndrome History of uncontrolled depression Recent surgery Uncontrolled ischaemic heart disease Uncontrolled

2018 Clinical Trials

154. Value of Tomosynthesis for the Detection of Sacro-iliitis (TOMOS SI)

See Sponsor: University Hospital, Montpellier Collaborators: DMS Apelem Thales Digisens Medecom BPI France European Regional Development Fund Information provided by (Responsible Party): University Hospital, Montpellier Study Details Study Description Go to Brief Summary: Spondyloarthropathies (SpAs) are chronic inflammatory diseases encompassing ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthropathy, and undifferentiated SpA. In 2001, the estimated prevalence

2018 Clinical Trials

155. LIBRE (Ligamys, Internal Bracing, REconstruction) Study: Comparing Three Surgery Techniques After an Acute ACL Rupture.

Arthritis (RA), Spondyloarthropathy (SpA), active malignancy Patient not suited for intervention due to lack of mobility, meaning not achieving 90° of flexion before surgery. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03441295 Contacts Layout table

2018 Clinical Trials

156. EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2)

haemophila, ulcerative colitis, rheumatoid arthritis and spondyloarthropathy, autoimmune hepatitis, others) and secondary malignancy (EBV lymphoproliferative disorders, AML, MDS, skin cancers, and any others Immune reconstitution [ Time Frame: 2 years post-transplant ] Results of routine analysis performed by centres will be investigated in correlation to clinical outcomes parameters and will allow to follow post-transplant immune reconstitution according to ADWP GCP. Eligibility Criteria Go

2018 Clinical Trials

157. Class II Invariant Chain HCV Vaccine Study

, lactation or willingness/intention to become pregnant during the study Personal history of autoimmune disease History of major autoimmune disease in first degree relative, e.g. Type 1 diabetes, Graves' Disease, Systemic Lupus Erythematosus (SLE) or Spondyloarthropathy (AS). HLA type B27 positive individuals History of cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) History of serious psychiatric condition Any other serious chronic illness requiring hospital specialist

2018 Clinical Trials

158. Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee

/acetaminophen, or combinations thereof Consent to allow all radiographs and medical/surgical/hospitalization records of care received elsewhere prior to and during the study period to be shared with the investigator Key Exclusion Criteria: History or presence at the screening visit of non-OA inflammatory joint disease (eg, rheumatoid arthritis, lupus erythematosus, psoriatic arthritis, pseudo-gout, gout, spondyloarthropathy, polymyalgia rheumatica, joint infections within the past 5 years), Paget's disease

2018 Clinical Trials

159. Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain

No chronic use (>7 consecutive days) of anticoagulants (such as aspirin) or NSAIDs prior to treatment Exclusion Criteria: Seropositive or seronegative spondyloarthropathy Type III Modic changes Prior surgeries of segments between L1 and S1 Chemonucleolysis or percutaneous laserectomy of the affected disc prior to the study Chronic facet syndrome Stenosis of the spinal canal that is moderate to severe or more in degree Spondylodiscitis Spondylolisthesis (lysis and degenerative) Severe motor deficit

2018 Clinical Trials

160. Trial of Ginsenoside Compound K (GCK) Tablet in Patients With Rheumatoid Arthritis

and comply with the requirements of the study protocol. Exclusion Criteria: Patients have prior exposure to any csDMARDs or bDMARDs. Patients have received corticosteroids, or Chinese medicine preparations such as tripterygium wilfordii, total glucosides of paeony for RA treatment. Patients with fibromyalgia Patients diagnosed with any systemic inflammatory disease other than RA, including but not limited to juvenile chronic arthritis, spondyloarthropathy, Crohn's disease, ulcerative colitis, psoriatic

2018 Clinical Trials

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