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121. The EANM practice guidelines for Bone Scintigraphy

]. Primary tumours of bone are relatively rare in adults, whereasbonemetastasesofothercancerenti- ties (e.g. breast, prostate, lung, renal cancer, etc.) are very frequent. In prostate cancer, the assessment of bonescansisincreasinglystandardizedbycalculation of the bone scan index and reporting of progression according toPCWG-2 criteria[25,26]. 2. Rheumatology & Chronicinflammatoryarthritis,includingrheumatoid arthritis, spondyloarthropathies and related disorders (ankylosingspondylitis

2016 European Association of Nuclear Medicine

122. Epidural steroid injection therapy for low back pain: a meta-analysis

, infection, spondyloarthropathy, pregnancy and pain following back surgery were excluded. Studies with control groups using steroid injection or surgery were excluded. Where reported, epidural injections were performed using caudal, interlaminar or transforaminal approaches. Most studies included patients with subacute or chronic pain; approximately one third of studies focused exclusively on chronic low back pain. Most studies included patients suffered from radicular pain. More than half

2014 DARE.

123. Sciatica (lumbar radiculopathy)

management of low back pain, published by a Canadian guideline group [ ]. [ ; ; ; ; ; ; ; ; ] Differential diagnosis What else might it be? If there are no suggesting a serious underlying cause, consider the following conditions that may present similarly to sciatica: Referred pain from hip osteoarthritis. For more information, see the CKS topic on . Sacroiliitis in ankylosing spondylitis and other spondyloarthropathies. For more information, see the CKS topic on . Intervertebral facet joint pain

2018 NICE Clinical Knowledge Summaries

124. Ectopic Spinal Calcification Associated with Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Quantitative Micro-CT Analysis. (PubMed)

Ectopic Spinal Calcification Associated with Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Quantitative Micro-CT Analysis. Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory spondyloarthropathy identified radiographically by calcification of the ligaments and/or entheses along the anterolateral aspect of the vertebral column. The etiology and pathogenesis of calcifications are unknown, and the diagnosis of DISH is currently based on radiographic criteria associated

2019 Journal of Orthopaedic Research

125. Ankylosing Spondylitis: MRI

(Achilles), uveitis, dactylitis, psoriasis, Crohn colitis, family history of spondyloarthropathy, positive HLA-B27 result, good response to nonsteroidal anti-inflammatory drugs, and positive C reactive protein result. MRI findings in ankylosing spondylitis - Active inflammatory lesions of sacroiliac joints with bone marrow edema. - Chronic inflammatory lesions of sacroiliac joints with subchondral erosions / sclerosis / fat deposition & ankylosis. - Active inflammatory lesions of spine are spondylitis

2019 Sumer's Radiology Blog

126. Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface. (PubMed)

Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface. HLA-B*27:05 is associated with the development of autoimmune spondyloarthropathies, but the precise causal relationship between the MHC haplotype and disease pathogenesis is yet to be elucidated. Studies focusing on the structure and cellular trafficking of HLA-B*27:05 implicate several links between the onset of inflammation and the unusual conformations of the molecule inside

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2018 PLoS ONE

127. Obesity and response to anti-tumor necrosis factor-α agents in patients with select immune-mediated inflammatory diseases: A systematic review and meta-analysis. (PubMed)

inflammatory diseases-inflammatory bowel diseases (IBD), rheumatoid arthritis (RA), spondyloarthropathies (SpA), psoriasis and psoriatic arthritis (PsA)-treated with anti-TNF agents, and reporting outcomes, stratified by body mass index (BMI) categories or weight. Primary outcome was failure to achieve clinical remission or response or treatment modification. We performed random effects meta-analysis and estimated odds ratios (OR) and 95% confidence interval (CI).Based on 54 cohorts including 19,372

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2018 PLoS ONE

128. IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota. (PubMed)

IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota. Certain gut bacterial families, including Bacteroidaceae, Porphyromonadaceae and Prevotellaceae, are increased in people suffering from spondyloarthropathy (SpA), a disease group associated with IL23R signalling variants. To understand the relationship between host interleukin (IL)-23 signalling and gut bacterial dysbiosis in SpA, we inhibited IL-23 in dysbiotic ZAP-70

2019 Annals of the rheumatic diseases

129. Identification of myeloid cells in the human enthesis as the main source of local IL-23 production. (PubMed)

immunohistochemistry (IHC), digested for myeloid cell phenotyping, sorted and stimulated with different adjuvants (lipopolysaccharide and mannan). Stimulated enthesis fractions were analysed for inducible production of spondyloarthropathy disease-relevant mediators (IL-23 full protein, TNF, IL-1β and CCL20). Myeloid populations were also compared with matched blood populations for further mRNA analysis and the effect of PDE4 inhibition was assessed.A myeloid cell population (CD45+ HLADR+ CD14+ CD11c+) phenotype

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2019 Annals of the Rheumatic Diseases

130. Surgical treatment of the severely damaged atlantoaxial joint with C1-C2 facet spacers: Three case reports. (PubMed)

and fixation, and posterior decompression with AA or occipitocervical fixation, is often the only treatment available. However, there have only been 2 reports of C1-C2 facet spacer use in treating AAS. Here, we report the case histories of 3 patients with severely damaged and subluxated AA joints and symptomatic basilar invagination (BI), malalignment, or C2 root compression.The cases included 2 women with rheumatoid arthritis and 1 man with spondyloarthropathy secondary to ulcerative colitis.Radiographic

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2019 Medicine

131. Radiographic Prevalence of Sacroiliac Joint Abnormalities and Clinical Outcomes in Patients With Femoroacetabular Impingement Syndrome. (PubMed)

primary hip arthroscopy for FAIS from January 2012 to January 2016 were identified. The exclusion criteria included patients undergoing bilateral or revision surgery, those with a history of dysplasia, and those with less than 2 years' follow-up. On radiographs, the SIJs were graded using modified New York criteria for spondyloarthropathy. CT and MRI scans were reviewed for joint surface erosion, subchondral sclerosis, joint space narrowing, pseudo-widening, bone marrow edema, and ankylosis. Patients

2019 Arthroscopy

132. Stelara (ustekinumab Janssen Biotech Inc.) for treatment of psoriatic arthritis

arthritis. Lansdale: HAYES, Inc.. Health Technology Brief Publication. 2013 Authors' conclusions Psoriasis is a chronic inflammatory disorder characterized by red, scaly skin lesions that are typically located on the elbows, knees, lower back, and umbilical area. Some patients with psoriasis develop psoriatic arthritis (PsA), which is a seronegative inflammatory spondyloarthropathy (spondylarthritis, or inflammation of the vertebral column). The incidence of PsA in patients with psoriasis is unclear

2014 Health Technology Assessment (HTA) Database.

133. Musculoskeletal ultrasonography for diagnosis of low back pain

. 2013 Authors' conclusions It is estimated that 80% of people have low back pain (LBP) at some time in their lives, and 5% to 10% develop chronic symptoms. The differential diagnosis is complex since etiologies include trauma, neurologic and degenerative disc disease, spondyloarthropathies, and other musculoskeletal and inflammatory conditions. LBP may not always be accurately diagnosed by the reference standards, physical examination, and plain x-rays. Other commonly used imaging tests

2014 Health Technology Assessment (HTA) Database.

134. Sacroiliac joint injections with corticosteroids for treatment of chronic low back pain

-related pain. Localizing the source of low back pain to the SIJ is challenging due to its similar symptoms with other lumbar disorders such as disc herniation and lumbar stenosis. Several diagnostic tests or provocative maneuvers are used during physical examination to help localize the pain to the SIJ. Imaging studies generally do not help to localize pain, but can rule out disorders such as fracture, tumor, or spondyloarthropathy. Pain relief following image-guided injection of local anesthetic

2014 Health Technology Assessment (HTA) Database.

135. Insight on Bone Morphogenetic Protein 7 in Ankylosing Spondylitis and its association with disease activity and radiographic damage (PubMed)

Insight on Bone Morphogenetic Protein 7 in Ankylosing Spondylitis and its association with disease activity and radiographic damage Fusion of joints as well as intervertebral spaces by the formation of bony spurs appearing as syndesmophytes and osteophytes are the hallmark of spondyloarthropathies which accounts for disability. The aim of this study was to assess the serum level of bone morphogenetic protein (BMP)-7 in ankylosing spondylitis and its relationship with disease activity (...) and the radiographic damage.This longitudinal case control study was conducted in Ain Shams University Hospitals (Egypt). A total of 55 subjects were included in two case groups and one control group. Group I included 20 patients with Ankylosing Spondylitis (AS) assessed at baseline (defined as Ia and after 18 months defined as Ib). Group II included 20 patients with Rheumatoid Arthritis (RA) and Group III included 15 healthy subjects as controls. Patients with other forms of seronegative spondyloarthropathies

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2016 Electronic physician

136. Temporomandibular joints: Prevalence of degenerative joint disease

was not conducted. Results 32 studies from 16 different countries were included. Sample sizes ranged from 15 – 3435 patients. 13 studies reported on prevalence of DJD in TMJ secondary to rheumatic systemic diseases (juvenile idiopathic arthritis [JIA], rheumatoid arthritis [RA], Marfan’s syndrome, ankylosing spondylitis, spondyloarthropathy, and mixed connective tissue diseases) 19 studies investigated the prevalence of DJD among patients with TMD in different populations Only 6 studies were classified as being

2018 The Dental Elf

137. Feasibility of an Immersive Virtual Reality Based Biofeedback Intervention for Outpatients in Rheumatology

. The objective is to know the usefulness of VR/biofeedback-based therapy in the clinic. Condition or disease Intervention/treatment Rheumatoid Arthritis Systemic Lupus Erythematosus Spondyloarthropathy Vasculitis Device: VR-Biofeedback Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 20 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Feasibility of an Immersive Virtual Reality Based Biofeedback Intervention (...) more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Sampling Method: Non-Probability Sample Study Population Adult patients with Rheumatoid arthritis, SLE, Seronegative Spondyloarthropathy, Myositis, Psoriatic Arthritis, vasculitis or other

2018 Clinical Trials

138. Discriminative Validity of Strain Elastography of the Supraspinatus Tendon

Criteria: Body mass index < 30 Symptomatic: Positive on 3/5 clinical tests (full can, empty can, resisted external rotation, neers, hawkins. Asymptomatic: No shoulder pain in the last year, negative on 5/5 clinical tests (full can, empty can, resisted external rotation, neers, hawkins). Exclusion Criteria: Shoulder-fracture, operation and luxation, known-neuromuscular disease, rheumatoid arthritis, cancer, fibromyalgia, spondyloarthropathy and psychiatric disorders, pregnancy and inability to read

2018 Clinical Trials

139. Safety and Efficacy of Tofacitinib vs Methotrexate in the Treatment of Psoriatic Arthritis

to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway which ultimately decreases the production of pro-inflammatory cytokines, and prevents both inflammatory response and the inflammation-induced damage. It has shown better efficacy in many diseases like Rheumatoid Arthritis, Axial spondyloarthropathies, Psoriasis, Psoriatic Arthritis, Alopecia areata, dry eye disease. This prospective, open label, randomized study will be conducted

2018 Clinical Trials

140. 'As Black as Ink"-A Case of Alkaptonuria-Associated Myelopathy and a Review of the Literature. (PubMed)

of homogentisic acid, with subsequent deposition in ligaments, cartilage, and menisci. Involvement of the spine is termed "ochronotic spondyloarthropathy," of which myelopathy is an uncommon presentation.We present the case of a 57-year-old man with alkaptonuria-associated myelopathy, who underwent surgical decompression. Ten additional cases were identified in the literature by a systematic search of PubMed and Google Scholar.In a patient presenting with myelopathy, alkaptonuria may be suspected because

2018 Spine

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