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121. British Association of Dermatologists' guidelines for the safe and effective prescribing of methotrexate for skin disease

impairment and/or high levels of distress (e.g. severe nail disease or involvement at high-impact sites); (iii) phototherapy has been ineffective, cannot be used or has resulted in rapid relapse (rapid relapse is de?ned as > 50% of baseline disease severity within 3 months). It is crucial to consider the presence of psoriatic arthritis in patients with psoriasis, as MTX can be an important agent for most patterns of psoriatic arthritis, although notably not for spondyloarthropathy. 13 If psoriatic

2016 British Association of Dermatologists

122. Identification of myeloid cells in the human enthesis as the main source of local IL-23 production. Full Text available with Trip Pro

immunohistochemistry (IHC), digested for myeloid cell phenotyping, sorted and stimulated with different adjuvants (lipopolysaccharide and mannan). Stimulated enthesis fractions were analysed for inducible production of spondyloarthropathy disease-relevant mediators (IL-23 full protein, TNF, IL-1β and CCL20). Myeloid populations were also compared with matched blood populations for further mRNA analysis and the effect of PDE4 inhibition was assessed.A myeloid cell population (CD45+ HLADR+ CD14+ CD11c+) phenotype

2019 Annals of the Rheumatic Diseases

123. Surgical treatment of the severely damaged atlantoaxial joint with C1-C2 facet spacers: Three case reports. Full Text available with Trip Pro

and fixation, and posterior decompression with AA or occipitocervical fixation, is often the only treatment available. However, there have only been 2 reports of C1-C2 facet spacer use in treating AAS. Here, we report the case histories of 3 patients with severely damaged and subluxated AA joints and symptomatic basilar invagination (BI), malalignment, or C2 root compression.The cases included 2 women with rheumatoid arthritis and 1 man with spondyloarthropathy secondary to ulcerative colitis.Radiographic

2019 Medicine

124. Radiographic Prevalence of Sacroiliac Joint Abnormalities and Clinical Outcomes in Patients With Femoroacetabular Impingement Syndrome. (Abstract)

primary hip arthroscopy for FAIS from January 2012 to January 2016 were identified. The exclusion criteria included patients undergoing bilateral or revision surgery, those with a history of dysplasia, and those with less than 2 years' follow-up. On radiographs, the SIJs were graded using modified New York criteria for spondyloarthropathy. CT and MRI scans were reviewed for joint surface erosion, subchondral sclerosis, joint space narrowing, pseudo-widening, bone marrow edema, and ankylosis. Patients

2019 Arthroscopy

125. IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota. (Abstract)

IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota. Certain gut bacterial families, including Bacteroidaceae, Porphyromonadaceae and Prevotellaceae, are increased in people suffering from spondyloarthropathy (SpA), a disease group associated with IL23R signalling variants. To understand the relationship between host interleukin (IL)-23 signalling and gut bacterial dysbiosis in SpA, we inhibited IL-23 in dysbiotic ZAP-70

2019 Annals of the rheumatic diseases

126. Ectopic Spinal Calcification Associated with Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Quantitative Micro-CT Analysis. (Abstract)

Ectopic Spinal Calcification Associated with Diffuse Idiopathic Skeletal Hyperostosis (DISH): A Quantitative Micro-CT Analysis. Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory spondyloarthropathy identified radiographically by calcification of the ligaments and/or entheses along the anterolateral aspect of the vertebral column. The etiology and pathogenesis of calcifications are unknown, and the diagnosis of DISH is currently based on radiographic criteria associated

2019 Journal of Orthopaedic Research

129. Temporomandibular joints: Prevalence of degenerative joint disease

was not conducted. Results 32 studies from 16 different countries were included. Sample sizes ranged from 15 – 3435 patients. 13 studies reported on prevalence of DJD in TMJ secondary to rheumatic systemic diseases (juvenile idiopathic arthritis [JIA], rheumatoid arthritis [RA], Marfan’s syndrome, ankylosing spondylitis, spondyloarthropathy, and mixed connective tissue diseases) 19 studies investigated the prevalence of DJD among patients with TMD in different populations Only 6 studies were classified as being

2018 The Dental Elf

130. Sacroiliac joint injections with corticosteroids for treatment of chronic low back pain

-related pain. Localizing the source of low back pain to the SIJ is challenging due to its similar symptoms with other lumbar disorders such as disc herniation and lumbar stenosis. Several diagnostic tests or provocative maneuvers are used during physical examination to help localize the pain to the SIJ. Imaging studies generally do not help to localize pain, but can rule out disorders such as fracture, tumor, or spondyloarthropathy. Pain relief following image-guided injection of local anesthetic

2014 Health Technology Assessment (HTA) Database.

131. Musculoskeletal ultrasonography for diagnosis of low back pain

. 2013 Authors' conclusions It is estimated that 80% of people have low back pain (LBP) at some time in their lives, and 5% to 10% develop chronic symptoms. The differential diagnosis is complex since etiologies include trauma, neurologic and degenerative disc disease, spondyloarthropathies, and other musculoskeletal and inflammatory conditions. LBP may not always be accurately diagnosed by the reference standards, physical examination, and plain x-rays. Other commonly used imaging tests

2014 Health Technology Assessment (HTA) Database.

132. Stelara (ustekinumab Janssen Biotech Inc.) for treatment of psoriatic arthritis

arthritis. Lansdale: HAYES, Inc.. Health Technology Brief Publication. 2013 Authors' conclusions Psoriasis is a chronic inflammatory disorder characterized by red, scaly skin lesions that are typically located on the elbows, knees, lower back, and umbilical area. Some patients with psoriasis develop psoriatic arthritis (PsA), which is a seronegative inflammatory spondyloarthropathy (spondylarthritis, or inflammation of the vertebral column). The incidence of PsA in patients with psoriasis is unclear

2014 Health Technology Assessment (HTA) Database.

133. A systematic evaluation of the therapeutic effectiveness of sacroiliac joint interventions

to be at least one month. Eligible patients were adults (at least 18 years old) with chronic low back and/or lower extremity pain which had lasted for at least three months and for whom other therapies had not worked. The primary outcome of interest was pain relief. Secondary outcomes were functional improvement, change in psychological status, return to work, reduction or elimination of opioid use/other interventions, and complications. Studies of spondyloarthropathy were excluded. Further inclusion

2012 DARE.

134. Feasibility of an Immersive Virtual Reality Based Biofeedback Intervention for Outpatients in Rheumatology

. The objective is to know the usefulness of VR/biofeedback-based therapy in the clinic. Condition or disease Intervention/treatment Rheumatoid Arthritis Systemic Lupus Erythematosus Spondyloarthropathy Vasculitis Device: VR-Biofeedback Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 20 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Feasibility of an Immersive Virtual Reality Based Biofeedback Intervention (...) more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Sampling Method: Non-Probability Sample Study Population Adult patients with Rheumatoid arthritis, SLE, Seronegative Spondyloarthropathy, Myositis, Psoriatic Arthritis, vasculitis or other

2018 Clinical Trials

135. Risk of Tuberculous and Other Infections in Patients of Spondyloarthritis Treated With Tofacitinib in Bangladesh

Identifier: NCT03504072 Recruitment Status : Recruiting First Posted : April 20, 2018 Last Update Posted : April 23, 2018 See Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Information provided by (Responsible Party): Md. Nazrul Islam, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Study Details Study Description Go to Brief Summary: Treatment failure of Spondyloarthropathies (SpA) leads to marked functional disability, higher rates of morbidity, mortality (...) Phase 4 Detailed Description: Spondyloarthropathies (SpA) are non curable, diseases of young subjects, treatment failure leads to marked functional disability, higher rates of morbidity, mortality and poor quality of life. Effective drugs may not be safe in different geographic backgrounds. Bangladesh is a TB endemic country so patients are at risk of TB and other infections at background. The aim of this study will be to evaluation the risk of tuberculosis and other infections in refractory SpA

2018 Clinical Trials

136. Alloimmune Response to Citrullinated Shared Epitope Sequence in Patients With Rheumatoid Arthritis

Patients with psoriatic arthritis, peripheric spondyloarthropathies and connective tissue diseases. Diagnostic Test: Research new biomarker for RA Analyze T and B cell response against new citrullinated peptides Healthy controls From health blood donors Diagnostic Test: Research new biomarker for RA Analyze T and B cell response against new citrullinated peptides Outcome Measures Go to Primary Outcome Measures : T cell response [ Time Frame: 2 years ] Proliferation against new citrullinated peptides B

2018 Clinical Trials

137. Study of Safety and Efficacy of HLX01+MTX in Patients With Rheumatoid Arthritis

. Previously or currently suffering from inflammatory joint diseases other than RA (e.g. gout, reactive arthritis, psoriatic arthritis, seronegative spondyloarthropathies, Lyme disease, etc.), or other systemic autoimmune diseases (e.g., systemic lupus erythematosus, inflammatory bowel disease, pulmonary fibrosis, Felty's syndrome, scleroderma, inflammatory myopathy, mixed connective tissue disease, or any overlap syndromes). Evidence significant unconcomitant diseases, such as, but not limited to, nervous

2018 Clinical Trials

138. Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis

(Anti-CCP antibodies & Rheumatoid Factor checked ), psoriatic arthritis or spondyloarthropathy Symptomatic knee pain On usual care for arthritis including disease-modifying anti-rheumatic drugs (DMARDs), paracetamol and/or NSAIDs Exclusion Criteria: Other rheumatological diagnosis e.g. systemic lupus erythematosus, fibromyalgia, Polymyalgia Rheumatica, Gout, Giant Cell Arteritis, Sjogren's syndrome History of uncontrolled depression Recent surgery Uncontrolled ischaemic heart disease Uncontrolled

2018 Clinical Trials

139. To Assess the Patients' Ability to Self-Administer Fasinumab in an Unsupervised Setting

arthritis, pseudo-gout, gout, spondyloarthropathy, polymyalgia rheumatica, joint infections within the past 5 years), Paget's disease of the spine, pelvis or femur, neuropathic disorders, multiple sclerosis, fibromyalgia, tumors or infections of the spinal cord, or renal osteodystrophy History or presence on imaging of arthropathy (osteonecrosis, subchondral insufficiency fracture, rapidly progressive OA type 1 or type 2), stress fracture, recent stress fracture, neuropathic joint arthropathy, hip

2018 Clinical Trials

140. Viable Allograft Supplemented Disc Regeneration in the Treatment of Patients With Low Back Pain

No chronic use (>7 consecutive days) of anticoagulants (such as aspirin) or NSAIDs prior to treatment Exclusion Criteria: Seropositive or seronegative spondyloarthropathy Type III Modic changes Prior surgeries of segments between L1 and S1 Chemonucleolysis or percutaneous laserectomy of the affected disc prior to the study Chronic facet syndrome Stenosis of the spinal canal that is moderate to severe or more in degree Spondylodiscitis Spondylolisthesis (lysis and degenerative) Severe motor deficit

2018 Clinical Trials

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