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61. Overview of Seronegative Spondyloarthropathies

Overview of Seronegative Spondyloarthropathies Overview of Seronegative Spondyloarthropathies - Musculoskeletal and Connective Tissue Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / OTHER (...) Clinic Foundation Click here for Patient Education NOTE: This is the Professional Version. CONSUMERS: Seronegative spondyloarthropathies (seronegative spondyloarthritides) share certain clinical characteristics (eg, back pain, uveitis, GI symptoms, rashes). Some are strongly associated with the HLA-B27 allele. Clinical and genetic similarities suggest that they also share similar causes or pathophysiologies. Rheumatoid factor (RF) is usually negative in the spondyloarthropathies (hence, why

2013 Merck Manual (19th Edition)

62. What is the role of HLA-B27 in spondyloarthropathies? (Abstract)

What is the role of HLA-B27 in spondyloarthropathies? HLA-B27 (Human Leukocyte Antigen-B27) accounts approximately for the one third of the overall genetic susceptibility to spondylorthropathies (SpAs). Up to 70 HLA-B27 subtypes have been reported all over the world with a decreasing north-south gradient of its frequency, which is reverse to that of endemic malaria. In an attempt to explain the possible role of HLA-B27 in SpAs pathogenesis, several theories have been suggested [1. Arthritogenic

2011 Autoimmunity reviews

63. Prevalence of Thyroid Autoimmunity in Patients with Spondyloarthropathies. (Abstract)

Prevalence of Thyroid Autoimmunity in Patients with Spondyloarthropathies. To evaluate the prevalence of chronic autoimmune thyroiditis or Hashimoto's thyroiditis (HT) in a group of patients with spondyloarthritis (SpA).We evaluated serum levels of thyroid-stimulating hormone, free triiodothyronine, and free thyroxine, and titers of antithyroglobulin and antithyroid peroxidase (anti-TPO) antibodies in 357 consecutive patients with SpA. We also recruited 318 healthy age-matched controls

2011 Journal of Rheumatology

64. Skeletal fluorosis mimicking seronegative spondyloarthropathy: a deceptive presentation. (Abstract)

Skeletal fluorosis mimicking seronegative spondyloarthropathy: a deceptive presentation. Skeletal fluorosis is rarely recognized early and is a major cause of morbidity. We report on a 40-year-old man with skeletal fluorosis mimicking seronegative spondyloarthropathy.

2011 Tropical Doctor

65. Safety of Etoricoxib (MK-0663) in Patients With Spondyloarthropathy (SpA)/Ankylosing Spondylitis (AS) in Sweden (EP07013.013.11.082)

Safety of Etoricoxib (MK-0663) in Patients With Spondyloarthropathy (SpA)/Ankylosing Spondylitis (AS) in Sweden (EP07013.013.11.082) Safety of Etoricoxib (MK-0663) in Patients With Spondyloarthropathy (SpA)/Ankylosing Spondylitis (AS) in Sweden (EP07013.013.11.082) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You (...) have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Safety of Etoricoxib (MK-0663) in Patients With Spondyloarthropathy (SpA)/Ankylosing Spondylitis (AS) in Sweden (EP07013.013.11.082) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01327638

2011 Clinical Trials

66. The Ankylosing Spondylitis Disease Activity Score is a highly discriminatory measure of disease activity and efficacy following tumour necrosis factor-α inhibitor therapies in ankylosing spondylitis and undifferentiated spondyloarthropathies in China. Full Text available with Trip Pro

The Ankylosing Spondylitis Disease Activity Score is a highly discriminatory measure of disease activity and efficacy following tumour necrosis factor-α inhibitor therapies in ankylosing spondylitis and undifferentiated spondyloarthropathies in China. To validate the clinical value of the new Ankylosing Spondylitis Disease Activity Scores (ASDASs) in assessing the disease activity and efficacy of TNF-α inhibitor in AS and uSpA patients in China.Two hundred and thirty patients were included

2011 Rheumatology (Oxford, England) Controlled trial quality: predicted high

67. Validity of enthesis ultrasound assessment in spondyloarthropathy Full Text available with Trip Pro

Validity of enthesis ultrasound assessment in spondyloarthropathy To develop an ultrasound enthesis score and to assess its validity in the diagnostic classification of the spondyloarthropathies (SpAs).Twenty-five patients with SpA and 29 healthy controls participated in a blinded, gender-matched, cross-sectional study involving ultrasound assessment. The following entheses were explored bilaterally: proximal plantar fascia, distal Achilles tendon, distal and proximal patellar ligament, distal

2009 EvidenceUpdates

68. Spondyloarthritis in over 16s: diagnosis and management

. If the test is positive, refer the person to a rheumatologist for a spondyloarthritis assessment. 1.2 Diagnosing spondyloarthritis in specialist care settings Diagnostic criteria for suspected spondyloarthritis Diagnostic criteria for suspected spondyloarthritis 1.2.1 In specialist care settings, consider using validated spondyloarthritis criteria to guide clinical judgement when diagnosing spondyloarthritis. Examples include: general spondyloarthritis criteria: Amor European Spondyloarthropathy Study

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

70. Chronic Foot Pain

such as the seronegative spondyloarthropathies, rheumatoid arthritis, gout, or systemic lupus erythematosus [28]. In athletes, plantar fasciitis is a common cause of foot pain and is attributed to mechanical stresses, presumably due to repetitive trauma, which causes plantar fascia microtearing at its origin as well as fascial and perifascial inflammation. Plantar fasciitis is also common in obese patients and in patients who have flat feet. Though radiography is typically insensitive to fasciitis, it should

2020 American College of Radiology

71. Abdominal and pelvic imaging

18 Perianal fistula/abscess (fistula in ano) 18 Hepatobiliary Indications 18 Biliary tract dilatation or obstruction 18 Cholecystitis 18 Choledocholithiasis 19 Imaging of the Abdomen and Pelvis Copyright © 2020 AIM Specialty Health ® All Rights Reserved. 3 Diffuse liver disease 19 Focal liver lesion 20 Hepatomegaly 22 Jaundice 22 Primary sclerosing cholangitis 22 Osseous Indications 22 Avascular necrosis, bilateral hip 22 Axial spondyloarthropathy 23 Developmental hip dysplasia (Pediatric only

2020 AIM Specialty Health

72. Assessment of back pain

strain/sprain Herniated nucleus pulposus Spinal stenosis Compression fracture Degenerative disc disease or facet arthropathy Sacroiliitis Spondylolysis and/or spondylolisthesis Vertebral discitis/osteomyelitis Malignancy Inflammatory spondyloarthropathy Connective tissue disease Aortic abdominal aneurysm Pancreatitis Pyelonephritis Renal colic Peptic ulcer disease Contributors Authors Associate Professor Department of Orthopedic Surgery William Beaumont Hospital Royal Oak MI Disclosures DKP is a paid

2018 BMJ Best Practice

73. Chikungunya virus infection

by polyarthritis and systemic manifestations that may last for months or years and may resemble rheumatoid arthritis or a seronegative spondyloarthropathy. Has a global distribution, thanks to a genetic change enabling the virus to be transmitted by Aedes albopictus (a more widespread Aedes vector), as well as Aedes aegypti . Locally acquired cases have been reported in the US and Europe. Diagnosis is based on clinical manifestations and epidemiological clues. Confirmation is via serological detection

2018 BMJ Best Practice

74. Assessment of inflamed joint

infections Parvoviral syndrome Lyme disease Juvenile idiopathic arthritis (oligo-articular type) Acute rheumatic fever (ARF) Sarcoidosis Spondyloarthropathy Systemic lupus erythematosus (SLE) Adult-onset Still's disease (AOSD) Reactive arthritis Ankylosing spondylitis (AS) Osteoarthritis Trauma Non-traumatic haemarthrosis Hypertrophic osteoarthropathy Intra-articular metastatic cancer Synovial sarcoma Arbovirus infections (e.g., chikungunya) Inflammatory bowel disease (ulcerative colitis and Crohn's

2018 BMJ Best Practice

75. Assessment of inflamed joint

infections Parvoviral syndrome Lyme disease Juvenile idiopathic arthritis (oligo-articular type) Acute rheumatic fever (ARF) Sarcoidosis Spondyloarthropathy Systemic lupus erythematosus (SLE) Adult-onset Still's disease (AOSD) Reactive arthritis Ankylosing spondylitis (AS) Osteoarthritis Trauma Non-traumatic haemarthrosis Hypertrophic osteoarthropathy Intra-articular metastatic cancer Synovial sarcoma Arbovirus infections (e.g., chikungunya) Inflammatory bowel disease (ulcerative colitis and Crohn's

2018 BMJ Best Practice

76. Chikungunya virus infection

by polyarthritis and systemic manifestations that may last for months or years and may resemble rheumatoid arthritis or a seronegative spondyloarthropathy. Has a global distribution, thanks to a genetic change enabling the virus to be transmitted by Aedes albopictus (a more widespread Aedes vector), as well as Aedes aegypti . Locally acquired cases have been reported in the US and Europe. Diagnosis is based on clinical manifestations and epidemiological clues. Confirmation is via serological detection

2018 BMJ Best Practice

77. Assessment of seronegative arthritis

physical examination should enable the diagnosis to be elucidated in most patients. Supporting or confirmatory data are obtained from laboratory and imaging studies. Spondyloarthropathies, crystalline and viral arthropathies, and rheumatoid arthritis are the most common diagnoses in these patients. Savolainen E, Kaipiainen-Seppanen O, Kroger L, et al. Total incidence and distribution of inflammatory joint diseases in a defined population: results from the Kuopio 2000 arthritis survey. J Rheumatol (...) Undifferentiated spondyloarthropathy Calcium pyrophosphate deposition disease (CPPD) Gout Polymyalgia rheumatica Osteoarthritis Rheumatoid arthritis Systemic lupus erythematosus Septic arthritis Bacterial endocarditis Viral arthritis Enteropathic arthritis Remitting seronegative symmetric synovitis with pitting oedema syndrome Sarcoidosis Juvenile-onset or adult-onset idiopathic arthritis Overlap syndrome Sjogren's syndrome Scleroderma Polymyositis Dermatomyositis Systemic vasculitis Gonococcal arthritis

2018 BMJ Best Practice

78. Ankylosing spondylitis

Ankylosing spondylitis Ankylosing spondylitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Ankylosing spondylitis Last reviewed: February 2019 Last updated: November 2018 Summary Classified as a seronegative spondyloarthropathy. The seronegative spondyloarthropathies (including psoriatic arthritis, enteropathic arthritis, and reactive arthritis) are a heterogenous group of conditions with overlapping clinical

2018 BMJ Best Practice

79. Reactive arthritis

syndrome' has fallen out of favour because of his ties to the Nazi Party and medical experiments on concentration camp prisoners. Lu DW, Katz KA. Declining use of the eponym "Reiter's syndrome" in the medical literature, 1998-2003. J Am Acad Dermatol. 2005;53:720-723. http://www.ncbi.nlm.nih.gov/pubmed/16198806?tool=bestpractice.com ReA belongs to the family of spondyloarthropathies, which share similar clinical, radiographic, and laboratory features that include spinal inflammation and an association (...) with HLA-B27. They include psoriatic arthritis, ankylosing spondylitis, arthritis related to inflammatory bowel disease, and undifferentiated spondyloarthropathy. History and exam presence of risk factors peripheral arthritis axial arthritis constitutional symptoms enthesitis mucous membrane involvement skin rash circinate balanitis ocular manifestations cardiac manifestations male sex HLA-B27 genotype preceding chlamydial or GI infection Diagnostic investigations ESR C-reactive protein (CRP) ANA

2018 BMJ Best Practice

80. Assessment of dysuria

or catheterisation Sexual abuse Athletics Interstitial cystitis Atrophic vaginitis Spondyloarthropathies Non-infectious prostatitis Ketamine bladder Urinary fistula Prostate cancer Bladder cancer Renal cancer Cervical cancer Urethral cancer Penile cancer Drugs or herbs Depression Somatisation disorder (urethral hypersensitivity) Contributors Authors Consultant Urologist Cambridge University Hospitals NHS Foundation Trust Cambridge UK Honorary Lecturer Anglia Ruskin University Cambridge UK Disclosures KS-P

2018 BMJ Best Practice

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