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Spondyloarthropathy

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21. Intestinal metabolites are profoundly altered in the context of HLA-B27 expression and functionally modulate disease in a rat model of spondyloarthropathy (PubMed)

Intestinal metabolites are profoundly altered in the context of HLA-B27 expression and functionally modulate disease in a rat model of spondyloarthropathy HLA-B27-associated spondyloarthritides are associated with an altered intestinal microbiota and bowel inflammation. We undertook this study to identify HLA-B27-dependent changes in both host and microbial metabolites in the HLA-B27/β2 -microglobulin (β2 m)-transgenic rat and to determine whether microbiota-derived metabolites could impact

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2017 Arthritis & rheumatology (Hoboken, N.J.)

22. Uveitis and spondyloarthropathies. (PubMed)

Uveitis and spondyloarthropathies. Uveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6-9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2-5% in IBD), the presence of HLA-B27 and with increasing (...) in spondyloarthropathy include cytokines within the IL23/IL17 axis, of which the IL17A inhibitor secukinumab has not been shown to be effective in uveitis. Future therapeutic approaches may include small molecules such as selective and non-selective janus kinase and tyrosine kinase inhibitors.Copyright © 2018. Published by Elsevier Ltd.

2017 Best practice & research. Clinical rheumatology

23. Case 234: Neuropathic Spondyloarthropathy. (PubMed)

Case 234: Neuropathic Spondyloarthropathy. History A 70-year-old woman presented to a peripheral hospital with signs and symptoms of acute chronic obstructive pulmonary disease (COPD) exacerbation. The patient also reported acute on chronic onset of thoracolumbar back pain over a period of 24 hours. She denied any history of recent trauma or intravenous drug use. She did not have any long-term indwelling catheters. The patient's medical history was also complicated by stage 4 renal failure from

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2016 Radiology

24. The role of Dickkopf-1 in joint remodeling and fibrosis: A link connecting spondyloarthropathies and scleroderma? (PubMed)

The role of Dickkopf-1 in joint remodeling and fibrosis: A link connecting spondyloarthropathies and scleroderma? Dickkopf-1 (Dkk-1) is a soluble inhibitor of the canonical Wnt pathway, which plays critical roles in embryonic development. Evidence suggests that this molecule regulates several aspects of both bone biology and fibrosis.To provide an overview of our current knowledge of the role of Dkk-1 in joint remodeling and fibrosis.We performed an electronic search (Medline) using

2016 Seminars in arthritis and rheumatism

25. High Prevalence of Back Pain and Axial Spondyloarthropathy in Patients with Hidradenitis Suppurativa. (PubMed)

High Prevalence of Back Pain and Axial Spondyloarthropathy in Patients with Hidradenitis Suppurativa. Hidradenitis suppurativa (HS) is a chronic inflammatory disease, causing fistulating sinuses in the intertriginous skin of axillary, genitofemoral and perianal sites.As other chronic inflammatory diseases, e.g. psoriasis, are frequently associated with spondyloarthropathies (SpA), the goal of this study was to quantify the prevalence of back pain and SpA in HS patients.A prospective

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2016 Dermatology

26. The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies. (PubMed)

The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies. The intestinal microbiome is increasingly implicated in the pathogenesis of ankylosing spondylitis, reactive arthritis, and other diseases collectively known as the spondyloarthropathies (SpAs). In common with other complex inflammatory diseases, SpAs have both a strong genetic and environmental component. Recent genetic studies have highlighted host pathways that may intersect the host

2016 Current Opinion in Rheumatology

27. Biologic agents in juvenile spondyloarthropathies. (PubMed)

Biologic agents in juvenile spondyloarthropathies. The juvenile spondyloarthropathies (JSpA) are a group of related rheumatic diseases characterized by involvement of peripheral large joints, axial joints, and entheses (enthesitis) that begin in the early years of life (prior to 16(th) birthday).The nomenclature and concept of spondyloarthropathies has changed during the last few decades. Although there is not any specific classification of JSpA, diseases under the spondyloarthropathy

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2016 Pediatric Rheumatology

28. Spondyloarthropathy due to Inflammatory Bowel Disease

Spondyloarthropathy due to Inflammatory Bowel Disease Spondyloarthropathy due to Inflammatory Bowel Disease Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse (...) Cancer Administration 4 Spondyloarthropathy due to Inflammatory Bowel Disease Spondyloarthropathy due to Inflammatory Bowel Disease Aka: Spondyloarthropathy due to Inflammatory Bowel Disease , Crohn's Disease Associated Arthritis , Ulcerative Colitis Associated Arthritis , Colitic Arthritis , Arthritis associated with Ulcerative Colitis , Inflammatory Bowel Disease with Spondyloarthropathy , Arthropathy of Inflammatory Bowel Disease , Enteropathic Arthritis II. Pathophysiology Associated with Greater

2018 FP Notebook

29. Spondyloarthropathy

Spondyloarthropathy Spondyloarthropathy Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Spondyloarthropathy Spondyloarthropathy Aka (...) : Spondyloarthropathy From Related Chapters II. Clinical Features: Common to every Spondyloarthropathy Inflammatory back pain Dactylitis Inflammation of entire digit Enthesitis Inflammation of tendon and ligament bony attachments Common areas of involvement Achilles tendon insertion ( ) Platar fascia insertion ( ) r tendon insertion (tibial tubercle) margin (superior and inferior) heads Spinal ligament insertion ( l body) III. Causes (e.g. ) IV. Differential Diagnosis V. Labs (RF) negative (ESR) elevated (CRP

2018 FP Notebook

30. Risk of tuberculosis during infliximab therapy for inflammatory bowel disease, rheumatoid arthritis, and spondyloarthropathy: A meta-analysis. (PubMed)

Risk of tuberculosis during infliximab therapy for inflammatory bowel disease, rheumatoid arthritis, and spondyloarthropathy: A meta-analysis. Infliximab is a promising drug with good outcomes demonstrated for diseases such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA) and spondyloarthropathy (SpA). However, treatment with this drug may increase the risk of tuberculosis infection. The aim of the present study was to investigate infliximab-associated tuberculosis infection

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2016 Experimental and therapeutic medicine

31. Prevalence of axial spondyloarthropathy among patients suffering from Fibromyalgia - an MRI study with application of the ASAS classification criteria. (PubMed)

Prevalence of axial spondyloarthropathy among patients suffering from Fibromyalgia - an MRI study with application of the ASAS classification criteria. To evaluate the prevalence of sacroiliitis, the radiographic hallmark of inflammatory spondyloarthropathy, among patients diagnosed with fibromyalgia syndrome (FMS), using the current Assessment of SpondyloArthritis International Society (ASAS) criteria and magnetic resonance imaging.Patients experiencing FMS (American College of Rheumatology

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2016 Arthritis care & research

32. Evaluation of treatments for sacroiliitis in spondyloarthropathy using the Spondyloarthritis Research Consortium Canada scoring system (PubMed)

Evaluation of treatments for sacroiliitis in spondyloarthropathy using the Spondyloarthritis Research Consortium Canada scoring system In this study, the Spondyloarthritis Research Consortium Canada (SPARCC) scoring method was used to compare treatment methods in patients with axial spondyloarthritis (SpA), a form of sacroiliitis. MRI abnormalities in bone marrow edema (BME) were compared before and after treatment in order to compare the efficacy of anti-TNF-α and DMARD, alone

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2016 Arthritis research & therapy

33. Early detection of spondyloarthropathy in patients with psoriasis by using the ultrasonography and magnetic resonance image (PubMed)

Early detection of spondyloarthropathy in patients with psoriasis by using the ultrasonography and magnetic resonance image To assess the validity of ultrasound (US) in the early detection of arthritis and enthesitis, with assessment of the validity of magnetic resonance imaging (MRI) in the early detection of sacroiliitis and spondylitis in patients with psoriasis and to compare the findings of clinical examination and conventional radiography.The study included 50 patients with psoriasis

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2015 European journal of rheumatology

34. Associations between functional FCGR2A R131H and FCGR3A F158V polymorphisms and responsiveness to TNF blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis. (PubMed)

Associations between functional FCGR2A R131H and FCGR3A F158V polymorphisms and responsiveness to TNF blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis. The aim of the current study was to investigate whether FCGR polymorphisms are associated with responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease.We conducted a meta-analysis to evaluate the association between the functional FCGR3A F158V and FCGR2A R131H

2016 Pharmacogenomics

35. Incidence of Spondyloarthropathy in Patients with Crohn`s Disease: A Population-based Study (PubMed)

Incidence of Spondyloarthropathy in Patients with Crohn`s Disease: A Population-based Study Spondyloarthritis (SpA) is an extraintestinal manifestation of inflammatory bowel disease with significant clinical effects, although the frequency is uncertain. We assessed the cumulative incidence and clinical spectrum of SpA in patients with Crohn's disease (CD) in a population-based cohort.The medical records of a population-based cohort of Olmsted County, Minnesota, residents diagnosed with CD

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2013 EvidenceUpdates

36. Interventions, pharmacological and non-pharmacological, for managing bone health in axial spondyloarthropathy patients: a systematic review and meta-analysis

Interventions, pharmacological and non-pharmacological, for managing bone health in axial spondyloarthropathy patients: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr

2018 PROSPERO

37. Association between TNF-α (-308 A/G, -238 A/G, -857 C/T) polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis. (PubMed)

Association between TNF-α (-308 A/G, -238 A/G, -857 C/T) polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis. The aim of this study is to investigate whether TNF-α polymorphisms are associated with the responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease.We conducted a meta-analysis on the association between the TNF-α polymorphisms and responsiveness of patients.The meta

2015 Pharmacogenomics

38. Isotretinoin-induced Spondyloarthropathy-related Symptoms: A Prospective Study. (PubMed)

Isotretinoin-induced Spondyloarthropathy-related Symptoms: A Prospective Study. Acne vulgaris is a chronic inflammatory disease involving the pilosebaceous unit of the skin. Isotretinoin is a systemic retinoid that is often used as an effective treatment option for severe and treatment-resistant acne. Isotretinoin may also cause rheumatologic symptoms. The aim of this prospective observational study was to present followup results regarding the rheumatologic symptoms of patients who received (...) patient. Inflammatory back pain developed in 6 patients in the isotretinoin group.To our knowledge, this was the first prospective observational study that assessed the rheumatologic symptoms of isotretinoin treatment. The spondyloarthropathy findings were identified in 23.1% of the patients who used isotretinoin.

2015 Journal of Rheumatology

39. Juvenile spondyloarthropathy: an important clinical lesson to remember (PubMed)

Juvenile spondyloarthropathy: an important clinical lesson to remember Spondyloarthropathy (SpA) is a group of inflammatory conditions that include spondylitis, sacroiliitis, asymmetrical peripheral arthritis and enthesitis. This condition is known as juvenile SpA when the diagnosis is made in patients up to 16 years of age. Enthesitis is a highly specific feature that occurs more often in juvenile SpA than in the adult form. In contrast to adult onset SpA, the initial manifestation of juvenile

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2015 BMJ case reports

40. Diagnostics of Sacroiliitis According to ASAS Criteria: A Comparative Evaluation of Conventional Radiographs and MRI in Patients with a Clinical Suspicion of Spondyloarthropathy. Preliminary Results (PubMed)

Diagnostics of Sacroiliitis According to ASAS Criteria: A Comparative Evaluation of Conventional Radiographs and MRI in Patients with a Clinical Suspicion of Spondyloarthropathy. Preliminary Results The objective of this study was a comparative evaluation of radiography and MRI in the diagnostics of sacroiliitis in patients with a clinical diagnosis of spondyloartropathy, according to the current ASAS criteria.Sacroiliac joints radiograms and MRI were conducted in 101 consecutive patients, aged

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2015 Polish Journal of Radiology

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