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Spondyloarthropathy

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1. Chronic Back Pain: Suspected Sacroiliitis/Spondyloarthropathy

Chronic Back Pain: Suspected Sacroiliitis/Spondyloarthropathy Date of origin: 2016 ACR Appropriateness Criteria ® 1 Chronic Back Pain American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Chronic Back Pain: Suspected Sacroiliitis/Spondyloarthropathy Variant 1: Inflammatory sacroiliac or back symptoms. Suspected axial spondyloarthropathy. Initial evaluation. Radiologic Procedure Rating Comments RRL* X-ray sacroiliac joints 9 ?? X-ray spine 9 Complementary examination (...) with SPECT spine 1 ??? FDG-PET CT whole body 1 ???? US sacroiliac joints 1 O Rating Scale: 1,2,3 Usually not appropriate; 4,5,6 May be appropriate; 7,8,9 Usually appropriate *Relative Radiation Level ACR Appropriateness Criteria ® 2 Chronic Back Pain Clinical Condition: Chronic Back Pain: Suspected Sacroiliitis/Spondyloarthropathy Variant 2: Inflammatory sacroiliac symptoms. Suspected axial spondyloarthropathy. Radiographs negative or equivocal. Radiologic Procedure Rating Comments RRL* MRI sacroiliac

2016 American College of Radiology

2. Management of a pseudarthrosis with sagittal malalignment in a patient with ochronotic spondyloarthropathy. (PubMed)

Management of a pseudarthrosis with sagittal malalignment in a patient with ochronotic spondyloarthropathy. Ochronotic spondyloarthropathy is an uncommon disease, and its association to sagittal malalignment in the context of a pseudarthrosis has never been described.We present the case of a 56-year-old female, who underwent previously L4L5 laminectomy for central canal stenosis and started later on to complain of progressively severe low back pain with a significant forward imbalance while (...) spondyloarthropathy was established.The patient underwent surgery with a posterior-only approach with a long-segment pedicle screw construct from T10 to the pelvis with a 360° fusion with a cage at L4L5. Samples taken from the disc and ligaments confirmed the diagnosis of ochronotic spondyloarthropathy macroscopically and microscopically. She could walk on day 2 with a satisfactory clinical and radiological result at 2 years.This is the first case in the literature to describe a post-laminectomy pseudarthrosis

2019 European Spine Journal

3. Multimorbidity is Common in Axial Spondyloarthropathy and is Associated with Worse Disease Outcomes: Results from the ASRI cohort. (PubMed)

Multimorbidity is Common in Axial Spondyloarthropathy and is Associated with Worse Disease Outcomes: Results from the ASRI cohort. Multimorbidity, the co-existence of 2 or more conditions in an individual, is associated with morbidity and mortality in the general population. This study aims to describe the prevalence of multimorbidity in axial spondyloarthropathy (axSpA) and assess its association with disease outcome measures.This cross-sectional study was conducted within the Ankylosing

2019 Journal of Rheumatology

4. Epidemiology of arthritis, chronic back pain, gout, osteoporosis, spondyloarthropathies and rheumatoid arthritis among 1.5 million patients in Australian general practice: NPS MedicineWise MedicineInsight dataset. (PubMed)

Epidemiology of arthritis, chronic back pain, gout, osteoporosis, spondyloarthropathies and rheumatoid arthritis among 1.5 million patients in Australian general practice: NPS MedicineWise MedicineInsight dataset. Previous estimates for the prevalence of musculoskeletal conditions (MSK) and chronic pain in Australia have been based on self-report. We aimed to determine the prevalence and distribution of arthritis, chronic back pain, gout, osteoporosis, spondyloarthropathies and rheumatoid (...) electronic medical record data from 'active' patients in over 550 practices. Three main groups of outcomes were investigated: 1) "prevalence" of arthritis, chronic back pain, gout, osteoporosis, spondyloarthropathies, and/or rheumatoid arthritis between 2000 and 2016; 2) "current" diagnosis/encounter for the same conditions occurring between 2013 and 2016, and; 3) "current" consultations for chronic pain of any type occurring between 2013 and 2016.The combined "prevalence" of the investigated MSK

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2018 BMC Musculoskeletal Disorders

5. Detection of Crohn Disease in Patients with Spondyloarthropathy: The SpACE Capsule Study. (PubMed)

Detection of Crohn Disease in Patients with Spondyloarthropathy: The SpACE Capsule Study. Inflammatory bowel disease (IBD) is generally reported to be associated with spondylarthropathies (SpA) in 5%-15% of cases. Systematic colonoscopic assessment by protocol demonstrated mucosal inflammation characteristic of Crohn disease (CD) in up to one-third of patients with SpA. Video capsule endoscopy (CE) is a superior diagnostic tool to detect small bowel mucosal disease. Our study compared

2018 Journal of Rheumatology

6. Interethnic Variations and Clinical Features of Spondyloarthropathies in a Middle Eastern Country (PubMed)

Interethnic Variations and Clinical Features of Spondyloarthropathies in a Middle Eastern Country The study aimed to demonstrate the interethnic differences and clinical features of Spondyloarthropathy(SpA) patients in a diverse Middle Eastern Country.A retrospective review of medical records to collect the required data was conducted for SpA patients at two study institutions in the United Arab Emirates.Of 141 SpA patients found, 88 AS(Ankylosing Spondylitis) patients and 53 'other SpA

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2018 The open rheumatology journal

7. The Evolution of Central Retinal and Choroidal Thickness in Acute Anterior Uveitic Patients with Spondyloarthropathy (PubMed)

The Evolution of Central Retinal and Choroidal Thickness in Acute Anterior Uveitic Patients with Spondyloarthropathy To describe and correlate the degree of anterior segment inflammation with central retinal and choroidal thickness throughout the treatment period (in the course of follow-up) in the eyes affected with acute anterior uveitis in the patients with seronegative spondyloarthropathy (subgroup: ankylosing spondylitis).Thirty eyes of 30 consecutive Caucasian patients with HLA-B27 (...) (p < 0.001).The retina and choroid may play a biomarker function in the anterior segment inflammation of the eye in the patients with seronegative spondyloarthropathy.

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2018 Journal of ophthalmology

8. Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the sub-pathway method (PubMed)

Identification of pathways significantly associated with spondyloarthropathy/ankylosing spondylitis using the sub-pathway method The aim of the present study was to extract potential sub‑pathway biomarkers for spondyloarthropathy (SpA)/ankylosing spondylitis (AS) using a sub‑pathway strategy. SpA/AS‑relevant data, reference pathways and long non‑coding (lnc)RNA‑micro (mi)RNA‑mRNA interactions were downloaded. The seed pathways based on Kyoto Encyclopedia of Genes and Genomes pathways

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2018 Molecular medicine reports

9. Ocular features of the HLA-B27-positive seronegative spondyloarthropathies. (PubMed)

Ocular features of the HLA-B27-positive seronegative spondyloarthropathies. The seronegative spondyloarthropathies are a closely related group of inflammatory diseases that include ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthritis, inflammatory bowel disease and undifferentiated spondyloarthritis. This review focuses on the spectrum of ocular manifestations associated with these diseases and the current approaches in treating these ocular manifestations (...) . It also highlights the role ophthalmologists can play in identifying and appropriately treating human leukocyte antigen B27 (HLA-B27) associated uveitis and the associated spondyloarthropathies in order to limit ocular and systemic morbidity.Evolving treatment paradigms for the seronegative spondyloarthropathies should direct the choice in therapeutic agent for difficult to control associated uveitis. Biologic therapies, particularly tumor necrosis factor inhibitors, are playing an increasing role

2018 Current Opinion in Ophthalmology

10. Contribution of ancient human remains analysis to the understanding of the variability in HLA-B gene variants in relation to the diagnosis of spondyloarthropathies. (PubMed)

Contribution of ancient human remains analysis to the understanding of the variability in HLA-B gene variants in relation to the diagnosis of spondyloarthropathies. Genetic investigations on ancient human remains affected by rheumatological pathologies are a research field of particular interest for identifying the pathogenesis of diseases, especially those having an autoimmune background such as spondyloarthopaties (SpA). Reliable studies concerning this topic require collaboration between

2018 Journal of Autoimmunity

11. Role of Interleukin- (IL-) 17 in the Pathogenesis and Targeted Therapies in Spondyloarthropathies (PubMed)

Role of Interleukin- (IL-) 17 in the Pathogenesis and Targeted Therapies in Spondyloarthropathies Spondyloarthropathy (SpA) is a unique type of joint inflammation characterized by coexisting erosive bone damage and pathological new bone formation. Previous genetic association studies have demonstrated that several cytokine pathways play a critical role in the pathogenesis of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and other types of SpA. In addition to several well-known

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2018 Mediators of inflammation

12. A Study of Golimumab in the Treatment of Indian Participants With Active Spondyloarthropathy of Ankylosing Spondylitis or Psoriatic Arthritis

A Study of Golimumab in the Treatment of Indian Participants With Active Spondyloarthropathy of Ankylosing Spondylitis or Psoriatic Arthritis A Study of Golimumab in the Treatment of Indian Participants With Active Spondyloarthropathy of Ankylosing Spondylitis or Psoriatic Arthritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save (...) this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Study of Golimumab in the Treatment of Indian Participants With Active Spondyloarthropathy of Ankylosing Spondylitis or Psoriatic Arthritis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your

2018 Clinical Trials

13. Quantifying the genetic risk for the development of axial spondyloarthropathy: could this become a diagnostic tool? (PubMed)

Quantifying the genetic risk for the development of axial spondyloarthropathy: could this become a diagnostic tool? To assess the utility of recent genetic findings in ankylosing spondylitis (AS) and axial spondyloarthropathy (SpA) in relation to diagnostic testing, prognosis and responses to biologic treatment and the development of new therapies.AS and other forms of SpA are polygenic with more than 100 genes contributing to disease susceptibility. The role of genes in determining the outcome

2018 Current Opinion in Rheumatology

14. Quadriplegia caused by an epidural abscess occurring at the same level of cervical destructive spondyloarthropathy: a case report. (PubMed)

Quadriplegia caused by an epidural abscess occurring at the same level of cervical destructive spondyloarthropathy: a case report. Destructive spondyloarthropathy (DSA) is one of the major complications in patients undergoing long-term hemodialysis. To the best of our knowledge, an epidural abscess occurring at the level of preexisting cervical DSA has not been well described in the literature. We report a unique case of quadriplegia caused by an epidural abscess occurring at the same level

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2017 BMC Musculoskeletal Disorders

15. The Fascinating Paradox of Osteoporosis in Axial Spondyloarthropathy. (PubMed)

The Fascinating Paradox of Osteoporosis in Axial Spondyloarthropathy. Low bone mineral density (BMD) is a recognized feature of axial spondyloarthropathy (axSpA). However, the osteoproliferation inherent in axSpA can make traditional dual-energy x-ray absorptiometry assessment inaccurate, particularly in structurally advanced disease. As a result, much about osteoporosis in axSpA is unknown. There is a wide variation in prevalence figures for low BMD in the literature. There is also

2017 Journal of Rheumatology

16. Cervical epidural injection in management of refractory pain and stiffness in spondyloarthropathy: A case report series. (PubMed)

Cervical epidural injection in management of refractory pain and stiffness in spondyloarthropathy: A case report series. The primary objective of this case series was to report the use of cervical epidural steroid injection in the management of neck pain and stiffness secondary to spondyloarthropathy in cases refractory to conservative therapy.This was a case report series on three patients with diagnosis of spondyloarthropathy who presented with severe stiffness and non-radicular axial neck (...) pain refractory to conservative therapy. All patients received cervical epidural steroid injections with significant improvement of their axial neck pain and stiffness.Cervical epidural steroid injections may be effective to improve the axial neck pain and stiffness in patients with diagnosis of spondyloarthropathy refractory to conservative management. Thus, we believe that epidural steroid injections should be considered in the management of patients with spondyloarthopathies.© 2017 World

2017 Pain Practice

17. Management of Uveitis in Spondyloarthropathy: Current Trends (PubMed)

Management of Uveitis in Spondyloarthropathy: Current Trends Spondyloarthritis is a chronic inflammatory disease predominantly affecting joints of the axial skeleton. However, as many as 50% of patients with this disease may have extra-articular manifestations, which include uveitis; psoriasis; inflammatory bowel disease such as Crohn disease or ulcerative colitis; cardiovascular manifestations in the form of conduction abnormalities, atherosclerosis, or valvular heart disease; pulmonary (...) agents act early in the disease process and have revolutionized the field of rheumatology, including management of uveitis. This review will focus on the management of ophthalmic manifestations in spondyloarthropathies.

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2017 The Permanente journal

18. Sarcopenia in Axial and Peripheral Spondyloarthropathies

Sarcopenia in Axial and Peripheral Spondyloarthropathies Sarcopenia in Axial and Peripheral Spondyloarthropathies - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Sarcopenia in Axial and Peripheral (...) Spondyloarthropathies (SASPAR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03319264 Recruitment Status : Completed First Posted : October 24, 2017 Last Update Posted : September 7, 2018 Sponsor: Hospices Civils de Lyon Information provided by (Responsible Party): Hospices Civils de Lyon Study Details Study

2017 Clinical Trials

19. Autoimmune Arthritides, Rheumatoid Arthritis, Psoriatic Arthritis, or Peripheral Spondyloarthropathy, Following Lyme Disease (PubMed)

Autoimmune Arthritides, Rheumatoid Arthritis, Psoriatic Arthritis, or Peripheral Spondyloarthropathy, Following Lyme Disease To describe systemic autoimmune joint diseases that develop following Lyme disease, and to compare their clinical features with those of Lyme arthritis (LA).We reviewed records of all adult patients referred to our LA clinic over a 13-year period, in whom we had diagnosed a systemic autoimmune joint disease following Lyme disease. For comparison, records of patients

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2017 Arthritis & rheumatology (Hoboken, N.J.)

20. MRI assessment of sacroiliitis for the diagnosis of axial spondyloarthropathy: comparison of fat-saturated T2, STIR and contrast-enhanced sequences (PubMed)

MRI assessment of sacroiliitis for the diagnosis of axial spondyloarthropathy: comparison of fat-saturated T2, STIR and contrast-enhanced sequences To evaluate whether there are significant differences between contrast-enhanced fat-saturated T1 weighted imaging and non-enhanced fat-suppression imaging for diagnosing sacroiliitis in patients with inflammatory back pain.92 patients, consisting of 46 males and 46 females (mean age: 34 years; range: 15-63 years), who met at least 4 out of 5 (...) marrow edema and osteitis was evaluated from each image set. A decision for sacroiliitis positivity for each image set was made based on the findings. The presence of additional active inflammatory findings of spondyloarthropathy such as synovitis, enthesitis and capsulitis were also evaluated.Interobserver and intersequence agreement for the degree of bone marrow edema and osteitis were good or excellent in all quadrants. Cohen's kappa coefficients for sacroiliitis positivity between the two

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2017 The British journal of radiology

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