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Splenic Injury

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161. Are Procedures Codes in Claims Data a Reliable Indicator of Intraoperative Splenic Injury Compared with Clinical Registry Data? (Abstract)

Are Procedures Codes in Claims Data a Reliable Indicator of Intraoperative Splenic Injury Compared with Clinical Registry Data? Identifying iatrogenic injuries using existing data sources is important for improved transparency in the occurrence of intraoperative events. There is evidence that procedure codes are reliably recorded in claims data. The objective of this study was to assess whether concurrent splenic procedure codes in patients undergoing colectomy procedures are reliably coded (...) 114 patients (1%) who had a concurrent splenic procedure code recorded in either ACS NSQIP or Medicare inpatient claims. There were 7 patients who had a splenic injury diagnosis code recorded in either data source. Agreement of splenic procedure codes between the data sources was substantial (κ statistic 0.72; 95% CI, 0.64-0.79). Medicare inpatient claims identified 81% of the splenic procedure codes recorded in ACS NSQIP, and 99% of the patients without a splenic procedure code.It is feasible

2014 Journal of the American College of Surgeons

162. Role of spleen-derived monocytes/macrophages in acute ischemic brain injury. Full Text available with Trip Pro

Role of spleen-derived monocytes/macrophages in acute ischemic brain injury. Monocytes/macrophages (MMs), mononuclear phagocytes, have been implicated in stroke-induced inflammation and injury. However, the presence of pro-inflammatory Ly-6C(high) and antiinflammatory Ly-6C(low) monocyte subsets raises uncertainty regarding their role in stroke pathologic assessment. With recent identification of the spleen as an immediate reservoir of MMs, this current study addresses whether the spleen (...) -derived MMs are required for stroke pathologic assessment. We observed that the spleen was contracted in poststroke animals and the contraction was accompanied by decreased number of Ly-6C(high) and Ly-6C(low) subsets in the spleen. The deployment of these subsets from the spleen temporally coincided with respective increases in the ischemic brain. Compared to mice with the spleen, mice receiving a splenectomy just before the stroke displayed less accumulation of Ly-6C(high) and Ly-6C(low) MMs

2014 Journal of Cerebral Blood Flow and Metabolism

163. Splenic injury after blunt abdominal trauma during a soccer (football) game. Full Text available with Trip Pro

Splenic injury after blunt abdominal trauma during a soccer (football) game. The spleen is the most commonly injured abdominal organ in children who sustain blunt abdominal trauma, and pediatric splenic injury may result from minor mechanisms of injury, including sports participation. We present 2 cases of splenic injury in soccer goalies because of blunt abdominal trauma sustained during game play. Although abdominal organ injuries are uncommon in soccer, emergency medicine and primary care

2014 Pediatric Emergency Care

164. I. The Surgery of the Pancreas: I. Injuries to the Pancreas in the Course of Operations on the Stomach. II. Injuries to the Pancreas in the Course of Operations on the Spleen. III. Resection of Half the Pancreas for Tumor Full Text available with Trip Pro

I. The Surgery of the Pancreas: I. Injuries to the Pancreas in the Course of Operations on the Stomach. II. Injuries to the Pancreas in the Course of Operations on the Spleen. III. Resection of Half the Pancreas for Tumor 17863043 2007 09 17 2008 11 20 0003-4932 58 2 1913 Aug Annals of surgery Ann. Surg. I. The Surgery of the Pancreas: I. Injuries to the Pancreas in the Course of Operations on the Stomach. II. Injuries to the Pancreas in the Course of Operations on the Spleen. III. Resection

1913 Annals of Surgery

165. Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice. Full Text available with Trip Pro

into clinical practice. Therefore, we aimed to examine whether the nanoparticle-mediated administration of TAK-242, a chemical inhibitor of TLR4, attenuates myocardial IR injury in a clinically feasible protocol in a mouse model.We have prepared poly-(lactic-co-glycolic acid) nanoparticles containing TAK-242 (TAK-242-NP). TAK-242-NP significantly enhanced the drug delivery to monocytes/macrophages in the spleen, blood and the heart in mice. Intravenous administration of TAK-242-NP (containing 1.0 or 3.0 mg (...) Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice. Myocardial ischaemia-reperfusion (IR) injury hampers the therapeutic effect of revascularization in patients with acute myocardial infarction. Innate immunity for damage-associated protein patterns promotes the process of IR injury; however, the blockade of Toll-like receptor 4 (TLR4) in myocardial IR injury has not been translated

2019 Cardiovascular Research

166. Sepsis: mechanisms of bacterial injury to the patient. Full Text available with Trip Pro

Sepsis: mechanisms of bacterial injury to the patient. In bacteremia the majority of bacterial species are killed by oxidation on the surface of erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing bacteria overcome this mechanism of human innate immunity by versatile respiration, production of antioxidant enzymes, hemolysins, exo- and endotoxins, exopolymers and other factors that suppress host defense and provide bacterial survival. Entering

2019 Scandinavian journal of trauma, resuscitation and emergency medicine

167. Ameliorative effect of supercritical fluid extract of Chrysanthemum indicum Linnén against D-galactose induced brain and liver injury in senescent mice via suppression of oxidative stress, inflammation and apoptosis. (Abstract)

Ameliorative effect of supercritical fluid extract of Chrysanthemum indicum Linnén against D-galactose induced brain and liver injury in senescent mice via suppression of oxidative stress, inflammation and apoptosis. Chrysanthemum indicum Linne (C. indicum), a healthy food and folk medicine in China for thousands of years, has been reported to exert heat-clearing and detoxifying effects and extensively applied to treat various symptoms such as inflammation diseases, hepatitis and headache.The (...) , histological examination and western blot analysis. The body weight, spleen and thymus indexes, alanine transaminase (ALT), aspartate transaminase (AST), total antioxidant capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), malondialdehyde (MDA) in brain and liver, interleukin-1β (IL-1β), interleukin-6 (IL-6), and necrosis factor-α (TNF-α) were detected. Besides, the expressions of Bax, Bcl-2 and cleaved caspase-3 were determined by western blot assay.The results

2019 Journal of Ethnopharmacology

168. Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice. Full Text available with Trip Pro

-month-old) and aged (18-month-old) male C57Bl/6 mice were subjected to moderate-level controlled cortical impact or sham surgery, and neurological function was evaluated. At 72 hours after injury, brain, blood, and spleen leukocyte counts were assessed ex vivo using flow cytometry. Aged mice demonstrated more severe deficits in forelimb grip strength, balance and motor coordination, spontaneous locomotor activity, and anxiety-like behavior. These animals also exhibited more robust microglial (...) Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice. After traumatic brain injury (TBI), individuals aged over 65 years show increased mortality and worse functional outcomes compared with younger persons. As neuroinflammation is a key pathobiological mechanism of secondary injury after TBI, we examined how aging affects post-traumatic microglial responses and functional outcomes. Young (3

2019 Neurobiology of Aging

169. The origin, fate, and contribution of macrophages to spinal cord injury pathology. Full Text available with Trip Pro

effects have been largely attributed to environmental cues, such as specific cytokines, that influence the macrophage polarization state. In this review, we also consider the possibility that different macrophage origins, including the spleen, bone marrow, and local self-renewal, may also affect macrophage fate, and ultimately their function that contribute to the complex pathobiology of spinal cord injury. (...) The origin, fate, and contribution of macrophages to spinal cord injury pathology. Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia and are capable of mediating both harmful and beneficial effects after injury. These divergent

2019 Acta neuropathologica

170. Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney. Full Text available with Trip Pro

injury including ischemia/reperfusion injury (IRI). The canonical CAP pathway involves activation of splenic alpha7-nicotinic acetylcholine receptor (α7nAChR)-positive macrophages by splenic β2-adrenergic receptor-positive CD4+ T cells. Here we demonstrate that ultrasound or vagus nerve stimulation also activated α7nAChR-positive peritoneal macrophages, and that adoptive transfer of these activated peritoneal macrophages reduced IRI in recipient mice. The protective effect required α7nAChR, and did (...) Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney. The cholinergic anti-inflammatory pathway (CAP) links the nervous and immune systems and modulates innate and adaptive immunity. Activation of the CAP by vagus nerve stimulation exerts protective effects in a wide variety of clinical disorders including rheumatoid arthritis and Crohn's disease, and in murine models of acute kidney

2019 Kidney International

171. Lessons learned from isolated blunt major pancreatic injury: Surgical experience in one trauma centre. Full Text available with Trip Pro

procedures, and complications between the two groups. Eight patients with IBMPI underwent endoscopic retrograde pancreatography, and 5 patients with complete major pancreatic duct (MPD) disruption underwent pancreatectomy eventually. The remaining 3 patients had partial MPD injury and two of them received a pancreatic duct stent for the treatment of existing postoperative pancreatic fistula. Spleen-sacrificing distal pancreatectomy (SSDP) was performed in 13 patient with IBMPI, followed by spleen (...) Lessons learned from isolated blunt major pancreatic injury: Surgical experience in one trauma centre. The aim of this study was to present our surgical experience of isolated blunt major pancreatic injury (IBMPI), and to compare its characteristic outcomes with that of multi-organ injury.From 1994-2015, 31 patients with IBMPI and 54 patients with multi-organ injury, who underwent surgery, were retrospectively studied.Of the 31 patients with IBMPI, 22 were male and 9 were female. The median age

2019 Injury

172. Defining the Role of Angioembolization in Pediatric Isolated Blunt Solid Organ Injury. (Abstract)

Defining the Role of Angioembolization in Pediatric Isolated Blunt Solid Organ Injury. To determine the incidence and outcomes of angiography in pediatric patients with blunt solid organ injury (SOI).The National Trauma Data Bank (2010-2014) was queried for patients ≤19 years who experienced isolated blunt SOI. Multivariate logistic regression was used to evaluate characteristics associated with radiological and surgical intervention.Patients with isolated blunt injuries to the spleen (n = 7542 (...) ), liver (n = 4549), and kidney (n = 2640) were identified. Use of angiography increased yearly from 1.6% to 3.1% of cases (p = 0.001) and was associated with older age (OR 2.61 [CI: 1.94-3.50], p < 0.001) and grade III or higher injury (OR 4.63 [CI: 3.11-6.90], p < 0.001). Odds of angiography were 4.9 times higher at adult trauma centers (TCs) than pediatric TCs overall, and almost 9 times higher for isolated splenic trauma (p < 0.001 for each). There was no improvement in splenic salvage after

2019 Journal of Pediatric Surgery

173. Pulsed ultrasound attenuates the hyperglycemic exacerbation of myocardial ischemia-reperfusion injury. (Abstract)

, the cardioprotective effect disappeared in mice that underwent vagotomy. Plasma acetylcholine, β2 adrenergic receptor, and phosphorylated Akt levels were increased after splenic pulsed ultrasound treatment.Pulsed ultrasound treatment of the spleen or neck attenuated the hyperglycemic exacerbation of myocardial ischemia-reperfusion injury leading to a 3-fold decrease in infarct size. Pulsed ultrasound may provide cardioprotection via the cholinergic anti-inflammatory pathway and could be a promising new (...) size in explanted hearts.Splenic pulsed ultrasound significantly decreased infarct size in wild-type C57BL6 mice exposed to acute hyperglycemia and myocardial ischemia-reperfusion injury (5.2% ± 4.4% vs 16.9% ± 12.5% of risk region, P = .013). Knockout of α7nAChR abrogated the beneficial effect of splenic pulsed ultrasound (22.2% ± 12.1%, P = .79 vs control). Neck pulsed ultrasound attenuated the hyperglycemic exacerbation of myocardial infarct size (3.5% ± 4.8%, P = .004 vs control); however

2019 Journal of Thoracic and Cardiovascular Surgery

174. When is It Safe to Start VTE Prophylaxis After Blunt Solid Organ Injury? A Prospective Study from a Level I Trauma Center. (Abstract)

prospectively screened. Patients were included if solid organ injury (liver, spleen, kidney) was diagnosed on admission CT scan and nonoperative management was planned. ED deaths, transfers, patients with pre-existing bleeding disorders or home antiplatelet/anticoagulant medications, and those who did not receive VTE prophylaxis were excluded. Demographics, injury/clinical data, type/timing of VTE prophylaxis initiation, and outcomes were collected. Patients were dichotomized into study groups based on VTE (...) compared with univariate analysis. Multivariate analysis with logistic regression determined independent predictors of late VTE prophylaxis initiation.After exclusions, 118 patients were identified. Median ISS was 22 [IQR 14-26]. Median AAST grade of injury was 2 [IQR 2-3] for liver, 2 [IQR 1-3] for spleen, and 3 [IQR 2-3] for kidney. Compared to late prophylaxis patients (n = 57, 48%), early prophylaxis patients (n = 61, 52%) had significantly fewer DVTs (n = 0, 0% vs n = 5, 9%, p = 0.024) but similar

2019 World Journal of Surgery

175. The Use of Elastography-Ultrasound in Diagnosing Tendinopathy Related Sport Injury : A 10 Years trend Systematic Review Full Text available with Trip Pro

The Use of Elastography-Ultrasound in Diagnosing Tendinopathy Related Sport Injury : A 10 Years trend Systematic Review The Use of Elastography-Ultrasound in Diagnosing Tendinopathy Related Sport Injury : A 10 Years trend Systematic Review - Richard Afandi, Putu Astawa, 2019 Intended for healthcare professionals Cookies Notification This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. MENU IN THIS JOURNAL Sign In Institution Society Access Options You (...) the page. Create a link to share a read only version of this article with your colleagues and friends. For more information view the page. Please read and accept the and check the box to generate a sharing link. I have read and accept the terms and conditions Share URL copied to clipboard View permissions information for this article The Use of Elastography-Ultrasound in Diagnosing Tendinopathy Related Sport Injury : A 10 Years trend Systematic Review .entryAuthor" data-author-container-selector

2019 Orthopaedic journal of sports medicine

176. Is CT thorax necessary to exclude significant injury in paediatric patients with blunt chest trauma?

pneumothorax, 1 splenic laceration and 1 liver laceration found 2 pts had change in management in that moved to ITU but no pts had surgical intervention. Small study at single centre. Comment(s) It is clear that CT scans are more sensitive than plain CXRs for the detection of thoracic injuries; a more difficult question is whether this additional information is clinically important. The risks of missing a significant injury have to be balanced against the risks of the diagnostic procedure. CT scans involve (...) Is CT thorax necessary to exclude significant injury in paediatric patients with blunt chest trauma? BestBets: Is CT thorax necessary to exclude significant injury in paediatric patients with blunt chest trauma? Is CT thorax necessary to exclude significant injury in paediatric patients with blunt chest trauma? Report By: Craig Ferguson - Consultant in Emergency Medicine Search checked by Katharine de la Morandiere - Consultant in Emergency Medicine Institution: Central Manchester Foundation

2015 BestBETS

177. Splenic injury after colonoscopy requiring splenectomy Full Text available with Trip Pro

Splenic injury after colonoscopy requiring splenectomy We present a case of a middle-aged woman, who presented with abdominal pain less than 24 h following an uneventful colonoscopy for rectal bleeding. Initial diagnosis was thought to be colonic perforation. An urgent CT scan performed owing to dropping haemoglobin and blood pressure revealed a large perisplenic haematoma. An urgent laparotomy was performed in which the patient had a total blood loss of 2500 ml and required splenectomy

2013 BMJ case reports

178. Is non-operative management feasible for splenic injury due to colonoscopy? Full Text available with Trip Pro

Is non-operative management feasible for splenic injury due to colonoscopy? Colonoscopy is a widely used diagnostic and therapeutic procedure. While it is a relatively safe procedure, there is a risk of some complications. Splenic injury after colonoscopy is a very rare but a life-threatening complication; around 105 cases have been reported in the literature so far. Owing to the rarity of this complication, no management standards were defined. In the literature, most of the patients were (...) managed with operative intervention and less frequently with observation. We report a case of splenic injury and massive hemoperitoneum due to colonoscopy treated non-operatively.

2013 BMJ case reports

179. Grade IV blunt splenic injury – the role of proximal angioembolization. A case report and review of literature Full Text available with Trip Pro

Grade IV blunt splenic injury – the role of proximal angioembolization. A case report and review of literature The authors present a case of grade IV traumatic spleen rupture (AAST-OIS) and an Injury Severity Score of 21 and a Revised Trauma Score RTS=7.841, which was managed without surgery, but with proximal splenic angioembolization (SAE), with a positive outcome. Indications, types and side-effects of SAE are also discussed with regard to blunt spleen trauma and the benefits of SAE as non (...) -operative treatment approach. It is the first case of a grade IV splenic laceration non-operatively managed to be published in Romania.

2013 Journal of medicine and life

180. [Clinical observation on repair of lymphocyte injury in patients with diabetic nephropathy treated by regulating spleen-stomach needling]. (Abstract)

[Clinical observation on repair of lymphocyte injury in patients with diabetic nephropathy treated by regulating spleen-stomach needling]. To explore therapeutic effect and action mechanism of regulating spleen-stomach needling on diabetic nephropathy (DN).Using multi-centric, randomized, controlled and blind principles, 144 cases of DN were divided into an observation group and a control group according to random digital tab, 72 cases in each one. Based on regular treatment of diabetes (...) ).The regulating spleen-stomach needling is an effective method for treatment of DN, which cold improve glycometabolism disturbance-induced progressive kidney injury, recover glomerular filtration, reduce urinary albumin excretion rate, restrain overexpression of MCP-1, adjust level of oxidative stress, prohibit oxidation of protein, increase protectiveness of membrane, adjust quantity and activity abnormity of T lymphocyte subgroup, leading to repairing lymphocyte damage and improving immune expression

2013 Zhongguo zhen jiu = Chinese acupuncture & moxibustion Controlled trial quality: uncertain

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