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Splenic Injury

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121. Experimental Stroke Differentially Affects Discrete Subpopulations of Splenic Macrophages Full Text available with Trip Pro

Experimental Stroke Differentially Affects Discrete Subpopulations of Splenic Macrophages Changes to the immune system after stroke are complex and can result in both pro-inflammatory and immunosuppressive consequences. Following ischemic stroke, brain resident microglia are activated and circulating monocytes are recruited to the injury site. In contrast, there is a systemic deactivation of monocytes/macrophages that may contribute to immunosuppression and the high incidence of bacterial (...) infection experienced by stroke patients. The manipulation of macrophage subsets may be a useful therapeutic strategy to reduce infection and improve outcome in patients after stroke. Recent research has enhanced our understanding of the heterogeneity of macrophages even within the same tissue. The spleen is the largest natural reservoir of immune cells, many of which are mobilized to the site of injury after ischemic stroke and is notable for the diversity of its functionally distinct macrophage

2018 Frontiers in immunology

122. Splenic responses play an important role in remote ischemic preconditioning-mediated neuroprotection against stroke Full Text available with Trip Pro

volume with an expansion of splenic lymphocytes 3 days after MCAO. Furthermore, the removal of the spleen 1 day or 2 weeks before RIPC and MCAO reduced the protective effect of RIPC on ischemic brain injury and reversed the effects of RIPC on circulating immune cell composition. RIPC significantly reduced brain infiltration of Tc and NKT cells. Prior splenectomy showed no effect on immune cell infiltration after RIPC and stroke.These results reveal an immunomodulatory effect of the spleen, effecting (...) Splenic responses play an important role in remote ischemic preconditioning-mediated neuroprotection against stroke Remote ischemic preconditioning (RIPC) of a limb has been reported to protect against ischemic stroke. Our previous results demonstrated that the RIPC-mediated neuroprotection is associated with alterations in circulating immune cell populations. Here, we evaluated the effect of the spleen, the largest reservoir of immune cells, on RIPC-mediated neuroprotection against

2018 Journal of neuroinflammation

123. To save a child's spleen: 50 years from Toronto to ATOMAC. Full Text available with Trip Pro

To save a child's spleen: 50 years from Toronto to ATOMAC. Pediatric surgeons brought forth non-operative treatment for children with blunt spleen injury more than 50 years ago. At the time, this proposal was deemed reckless by many adult surgeons, and debate ensued for decades. Despite criticisms, pediatric surgeons refined the clinical pathways for children with spleen injury leading to current safe and efficient outcomes. These outcomes are defined by rare splenectomies, few blood (...) transfusions, and short length of hospital stay. This review will address the role of the spleen through historical perceptions and scientific evidence. In addition, evolution of contemporary clinical pathways will be outlined.Copyright © 2018 Elsevier Inc. All rights reserved.

2018 Journal of Pediatric Surgery

124. A delayed presentation of splenic laceration and hemoperitoneum following an elective colonoscopy: A rare complication with uncertain risk factors Full Text available with Trip Pro

colonoscopy. The patient was treated conservatively. Traditionally perceived risk factors such as intra-abdominal adhesions, splenomegaly, anticoagulation use, biopsy, polypectomy, a technically challenging procedure, and anesthesia assistance have not been clearly shown to increase the incidence of splenic injury following a colonoscopy. Since the risk factors of splenic injury remain unclear, the clinical presentation is nonspecific, and the consequences can be serious, the endoscopist should make (...) A delayed presentation of splenic laceration and hemoperitoneum following an elective colonoscopy: A rare complication with uncertain risk factors Splenic laceration is a rare yet often underreported complication of colonoscopy that is infrequently discussed with the patient during the consent process. Most cases present within 48 h after the inciting colonoscopy; a delayed presentation is rare. We present a case of splenic laceration with hemoperitoneum that manifested 5 days after the initial

2018 SAGE Open Medical Case Reports

125. The splenic response to stroke: from rodents to stroke subjects Full Text available with Trip Pro

secondary neural injury after stroke. Splenectomy 2 weeks prior to ischemic and hemorrhagic stroke in mice and rats shows decreased infarct volumes. Additionally, the spleen decreases in size following stroke in rodents. Pro-inflammatory mediators are also increased in the spleen and subsequently the brain after stroke. These data in preclinical models of stroke have led stroke neurologists to look at the splenic response in stroke subjects. The outcomes of these studies suggest the spleen is responding (...) The splenic response to stroke: from rodents to stroke subjects Stroke is the fifth leading cause of death and the leading cause of long-term disability in the USA, costing $40.2 billion in direct and indirect costs. Globally, stroke is the second leading cause of death and has a higher prevalence in lower- and middle-income countries compared to high-income countries. The role of the spleen in stroke has been studied in rodent models of stroke and is seen as a major contributor to increased

2018 Journal of neuroinflammation

126. Embolization in Splenic Trauma

at Birmingham Study Details Study Description Go to Brief Summary: Randomized, prospective, feasibility study to begin evaluating the efficacy, safety, and cost of using either coils or vascular plugs (VPs) for proximal splenic artery embolization in the setting of traumatic splenic injury. Condition or disease Intervention/treatment Phase Trauma to the Spleen Device: Splenic artery embolization with vascular embolic coils Device: Splenic artery embolization with vascular embolic plugs Not Applicable (...) Detailed Description: Splenic preservation rates are improved for participants with high-grade splenic injuries (defined as Grade III-V injuries by the AAST guidelines) when non-operative management is supplemented by image-guided, trans-catheter splenic artery embolization (SAE). SAE is currently the standard of care for hemodynamically stable participants with high-grade splenic injuries. In proximal SAE (pSAE), the mid-splenic artery is embolized between the origins of the dorsal pancreatic artery

2018 Clinical Trials

127. Biological Effects of Ultrasound Insonification of the Spleen

or exhibiting any of the following: surgery in the past 90 days previous surgery of the spleen or splenectomy, esophagus, lungs, stomach, duodenum, or liver recent traumatic injury, including intracerebral hemorrhage and visceral injury end stage renal disease and/or uremia active malignancy previous leukemia and/or lymphoma human immunodeficiency virus infection or AIDS rheumatoid arthritis or other immune-mediated diseases (e.g. inflammatory bowel disease) arrhythmias, including but not limited to, atrial (...) Biological Effects of Ultrasound Insonification of the Spleen Biological Effects of Ultrasound Insonification of the Spleen - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Biological Effects of Ultrasound

2018 Clinical Trials

128. Bilateral visual loss and cerebral infarction after spleen embolization in a trauma patient with idiopathic thrombocytopenic purpura: A case report. Full Text available with Trip Pro

Bilateral visual loss and cerebral infarction after spleen embolization in a trauma patient with idiopathic thrombocytopenic purpura: A case report. Splenic artery embolization (SAE) is a common procedure in trauma patients with blunt splenic injuries. We report a case of acute ischemic stroke following orthopedic surgery in a patient with post-SAE reactive thrombocytosis.A 37-year-old woman with idiopathic thrombocytopenic purpura (ITP) suffered from multiple trauma scheduled for open

2018 Medicine

129. Non-operative management for penetrating splenic trauma: how far can we go to save splenic function? Full Text available with Trip Pro

Non-operative management for penetrating splenic trauma: how far can we go to save splenic function? Selective non-operative management (NOM) for the treatment of blunt splenic trauma is safe. Currently, the feasibility of selective NOM for penetrating splenic injury (PSI) is unclear. Unfortunately, little is known about the success rate of spleen-preserving surgical procedures. The aim of this study was to investigate the outcome of selective NOM for penetrating splenic injuries.A dual-centre (...) study is performed in two level-one trauma centres. All identified patients treated for PSI were identified. Patients were grouped based on the treatment they received. Group one consisted of splenectomised patients, the second group included patients treated by a spleen-preserving surgical intervention, and group three included those patients who were treated by NOM.A total of 118 patients with a median age of 27 and a median ISS of 25 (interquartile range (IQR) 16-34) were included. Ninety-six

2017 World journal of emergency surgery : WJES

130. Mast cells (MCs) induce ductular reaction mimicking liver injury in mice via MC-derived TGF-β1 signaling. (Abstract)

Mast cells (MCs) induce ductular reaction mimicking liver injury in mice via MC-derived TGF-β1 signaling. Following liver injury, mast cells (MCs) migrate into the liver and are activated in cholestatic patients. Inhibition of MC mediators decreases ductular reaction (DR) and liver fibrosis. TGF-β1 contributes to fibrosis and promotes liver disease.To demonstrate that reintroduction of MCs induces cholestatic injury via TGF-β1.Wild-type, KitW-sh (MC-deficient), and Mdr2-/- mice lacking l (...) -histidine decarboxylase were injected with vehicle or PKH26-tagged murine MCs pretreated with 0.01% DMSO or the TGF-βR inhibitor, LY2109761 (TGF-βRi, 10 μM) three days prior to sac. Hepatic damage was assessed by H&E and serum chemistry. Injected MCs were detected in liver, spleen and lung by immunofluorescence (IF). DR was measured by CK-19 immunohistochemistry (IHC) and F4/80 staining coupled with qPCR for IL-1β, IL-33 and F4/80; biliary senescence evaluated by IF or qPCR for p16, p18 and p21

2020 Hepatology

131. Thoracic vertebrae fracture: Is it an indicator of abdominal injury? (Abstract)

and 61.9% were males. The most common mechanism of injury was fall following by MVC. The patients with TVF had significantly higher rates of increased ISS score (ISS > 16, 28.45% vs. 10.42%, p < 0.001) and higher mortality rate (3.5% vs. 2%, p < 0.0001). Patients with TVF had 2-3 times more intraabdominal organ injuries (p < 0.001). The most commonly injured organ was spleen (3.28%); followed by liver (2.64%) and kidney (1.47%). An analysis of non-isolated thoracic spine fractures showed same (...) Thoracic vertebrae fracture: Is it an indicator of abdominal injury? Traumatic vertebral fracture accounts for 10-15% of trauma related admissions. While the correlation between lumbar vertebral fractures and abdominal injuries is well established, the relationship between thoracic vertebral fractures (TVF) and abdominal injuries is comparatively less well elucidated. Using a large national trauma database, we aimed to examine the incidence and severity of associated abdominal injuries in blunt

2020 American Journal of Emergency Medicine

132. Incidence and significance of injuries on secondary CT imaging after initial selective imaging in blunt trauma patients. (Abstract)

(12%) had at least one minor management change. Rib fracture(s) was the most common injury on secondary scans [45/143 (32%)]. The major management changes were: tube thoracostomy for pneumothorax (4 patients), blood transfusion for hemoperitoneum (1 patient), surgery for acetabular fracture (1 patient), thoracolumbar brace for spine fracture (2 patients) and angiography for splenic injury (1 patient).While a significant proportion of patients (18%) had injuries on secondary CT, only 1.7 (...) Incidence and significance of injuries on secondary CT imaging after initial selective imaging in blunt trauma patients. It is unclear if additional computerized tomography (CT) imaging is warranted after injuries are identified on CT in blunt trauma patients. The objective of this study was to determine the incidence and significance of injuries identified on secondary CT imaging after identification of injuries on initial CTs in blunt trauma patients.This was a retrospective cohort study

2020 American Journal of Emergency Medicine

133. Wenyang Lishui Decoction Ameliorates Podocyte Injury in Membranous Nephropathy Rat and Cell Models by Regulating p53 and Bcl-2. Full Text available with Trip Pro

Wenyang Lishui Decoction Ameliorates Podocyte Injury in Membranous Nephropathy Rat and Cell Models by Regulating p53 and Bcl-2. Wenyang Lishui decoction (WYD) has been frequently used to treat patients with membranous nephropathy (MN) in China. Our previous study in vitro showed that WYD aqueous extract could alleviate F-actin reorganization of podocytes induced by serum from idiopathic membranous nephropathy (IMN) patients. This study aims to investigate the effects and molecular mechanisms (...) measured. Hematoxylin-eosin and electron microscopy analyses were performed. Mouse podocytes were induced to develop cell models by serum from IMN patients with antibody to the M-type phospholipase A2 receptor and spleen and kidney Yang deficiency syndrome. They were divided into five groups: control, model, 2 mg/ml WYD, 4 mg/ml WYD, and 8 mg/ml WYD. CCK-8 assays, flow cytometry, qRT-PCR, and Western blot analyses were performed. In the animal experiment, side effects of WYD were not found. Also

2020 Evidence-based Complementary and Alternative Medicine (eCAM)

134. Alternatively activated macrophages promote resolution of necrosis following acute liver injury. Full Text available with Trip Pro

Alternatively activated macrophages promote resolution of necrosis following acute liver injury. Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially leading to acute liver failure, systemic inflammation, and death. Macrophages influence the progression and resolution of ALI due to their innate immunological function and paracrine activity. Syngeneic primary bone marrow-derived macrophages (...) (BMDMs) were tested as a cell-based therapy in a mouse model of APAP-induced ALI (APAP-ALI).Several phenotypically distinct BMDM populations were delivered intravenously to APAP-ALI mice when hepatic necrosis was established, and then evaluated based on their effects on injury, inflammation, immunity, and regeneration. In vivo phagocytosis assays were used to interrogate the phenotype and function of alternatively activated BMDMs (AAMs) post-injection. Finally, primary human AAMs sourced from healthy

2020 Journal of Hepatology

135. Prognostic Role of IL-18 in Various Human Cancers and Radiation Injuries: A Meta-Analysis Full Text available with Trip Pro

Prognostic Role of IL-18 in Various Human Cancers and Radiation Injuries: A Meta-Analysis Prognostic Role of IL-18 in Various Human Cancers and Radiation Injuries: A Meta-Analysis - Zhen Yao, Minyan Zhao, Guangyu Gao, Jiawen Yang, Zhenzhen Wang, Yulong Liu, 2020 Intended for healthcare professionals Cookies Notification This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies. MENU IN THIS JOURNAL Sign In Institution Society Access Options You can (...) . Please read and accept the and check the box to generate a sharing link. I have read and accept the terms and conditions Share URL copied to clipboard View permissions information for this article Prognostic Role of IL-18 in Various Human Cancers and Radiation Injuries: A Meta-Analysis .entryAuthor" data-author-container-selector=".NLM_contrib-group"> Show all authors 1 Department of Nuclear Accident Medical Emergency, the Second Affiliated Hospital of Soochow University, Suzhou, China by this author

2020 Dose-Response

136. Ferroportin inhibition attenuates plasma iron, oxidant stress, and renal injury following red blood cell transfusion in guinea pigs. (Abstract)

Ferroportin inhibition attenuates plasma iron, oxidant stress, and renal injury following red blood cell transfusion in guinea pigs. Red blood cell (RBC) transfusions result in the sequestration and metabolism of storage-damaged RBCs within the spleen and liver. These events are followed by increased plasma iron concentrations that can contribute to oxidant stress and cellular injury. We hypothesized that administration of a ferroportin inhibitor (FPN-INH) immediately after acute RBC exchange (...) -bound iron (NTBI) and plasma hemoglobin (Hb) were evaluated. End-study spleen, liver, and kidney organ iron levels, as well as renal tissue oxidation and injury, were measured acutely (24-hr after transfusion).RBC transfusion increased plasma NTBI, with maximal concentrations occurring 8 hours after transfusion. Posttransfusion iron accumulation resulted in tubule oxidation and acute kidney injury. FPN inhibition increased spleen and liver parenchymal/macrophage iron accumulation, but attenuated

2020 Transfusion

137. Herbal Medicine for Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Limitations Full Text available with Trip Pro

Herbal Medicine for Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Limitations Frontiers | Herbal Medicine for Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Limitations | Neurology Toggle navigation Section Affiliated Hospital of North Sichuan Medical College, China Reviewed by The University of Hong Kong, Hong Kong University of British Columbia, Canada Xiangya Hospital, Central South (...) University, China The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. TABLE OF CONTENTS total views SHARE ON Systematic Review ARTICLE Front. Neurol., 18 September 2020 | Herbal Medicine for Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Limitations 1 † , 2,3 † , Hyunho Kim 3 , Hee-Geun Jo 3,4 and 5 * 1 Clinical Medicine Division, Korea Institute

2020 Frontiers in neurology

138. Splenic Rupture as a Complication of Colonoscopy Full Text available with Trip Pro

presented abdominal pain and syncope. The diagnosis of splenic rupture was made and a splenectomy was urgently performed. The patient's postoperative recovery was uneventful. Splenic rupture is a rare complication of colonoscopy which cannot be underestimated in the differential diagnosis of abdominal pain after this procedure. Splenic injuries may occur in apparently uncomplicated, easy colonoscopies performed by experienced endoscopists, with no risk factors identified, as in this case. (...) Splenic Rupture as a Complication of Colonoscopy Splenic rupture is a rare but serious complication after colonoscopy, with high global mortality (5%). Diagnosis requires a high index of suspicion because presentation can be subtle, nonspecific, and delayed from hours to days and then not easily attributed to a recent endoscopy. Urgent splenectomy is the most common treatment option. A 73-year-old woman was admitted to the emergency department 8 h following a diagnostic colonoscopy. She

2016 GE Portuguese journal of gastroenterology

139. Delayed Splenic Rupture; Normal Appearing Spleen on the Initial Multidetector Computed Tomography (MDCT) Can Sometimes Be Misleading Full Text available with Trip Pro

we describe an extremely rare condition in a case that presented with a DSR following blunt trauma and had a normal appearing spleen in the initial post trauma MDCT scan.DSR is a serious consequence of trauma and is associated with a significantly higher mortality rate compared with the overall mortality for acute splenic injuries. A High index of suspicion along with the liberal serial utilization of the imaging studies are the essential elements for early detection of DSR. We propose that DSR (...) be considered as a differential diagnosis in patients presenting with hemodynamic instability late post trauma, even when the immediate post trauma MDCT scan has shown a normal appearing spleen. We suggest that every patient with a high impact injury or injuries to peri-splenic organs should have a repeat MDCT scan 2 - 3 days post trauma or before the patients is discharged from hospital.

2016 Trauma monthly

140. Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme Full Text available with Trip Pro

stresses such as myeloablation, blood loss, or pregnancy. Our results demonstrate that, in addition to their intrinsic roles in HSPCs, non-cell autonomous functions of Pbx factors within the splenic niche contribute to the regulation of hematopoiesis, at least in part via the control of KitL/SCF and Cxcl12/SDF-1. Furthermore, our study establishes that abnormal spleen development and hypoplasia have deleterious effects on the efficiency of hematopoietic recovery after bone marrow injury.© 2016 (...) Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme The spleen plays critical roles in immunity and also provides a permissive microenvironment for hematopoiesis. Previous studies have reported that the TALE-class homeodomain transcription factor Pbx1 is essential in hematopoietic stem and progenitor cells (HSPCs) for stem cell maintenance and progenitor expansion. However, the role of Pbx1 in the hematopoietic niche has not been

2016 Journal of anatomy

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