How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,743 results for

Splenic Injury

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

121. Emergency treatment of splenic injury in a novel mobile minimally invasive interventional shelter following disaster: a feasibility study. Full Text available with Trip Pro

to cure serious vascular injury of solid organs nowadays. Spleen is the most vulnerable abdominal organ, severe arterial hemorrhage of which can cause death if untreated timely. In this research, we aimed to study the possibility of performing emergency surgical intervention in mobile minimally invasive interventional shelter for splenic injury in the case of natural disasters.First, the mobile minimally invasive interventional shelter was unfolded in the field, and then disinfection and preoperative (...) rate of embolization was 87.5%. The two-week survival rate in all animal models of splenic injury was 100%.Our findings in the current study demonstrate that the mobile minimally invasive interventional shelter can be adapted to the field perfectly and complete emergency surgical intervention for splenic injury efficiently and safely. Therefore, on-spot emergency interventional TAE for vascular injury of solid organs (e.g. spleen) in mobile minimally invasive interventional shelter is available

2014 Scandinavian journal of trauma, resuscitation and emergency medicine

122. Splenic injury after blunt abdominal trauma during a soccer (football) game. Full Text available with Trip Pro

Splenic injury after blunt abdominal trauma during a soccer (football) game. The spleen is the most commonly injured abdominal organ in children who sustain blunt abdominal trauma, and pediatric splenic injury may result from minor mechanisms of injury, including sports participation. We present 2 cases of splenic injury in soccer goalies because of blunt abdominal trauma sustained during game play. Although abdominal organ injuries are uncommon in soccer, emergency medicine and primary care

2014 Pediatric Emergency Care

123. Pleural effusion following blunt splenic injury in the pediatric trauma population. (Abstract)

Pleural effusion following blunt splenic injury in the pediatric trauma population. Pleural effusion is a potential complication following blunt splenic injury. The incidence, risk factors, and clinical management are not well described in children.Ten-year retrospective review (January 2000-December 2010) of an institutional pediatric trauma registry identified 318 children with blunt splenic injury.Of 274 evaluable nonoperatively managed pediatric blunt splenic injures, 12 patients (4.4 (...) ), respectively. In multivariate analysis, high-grade splenic injury (IV-V) (OR 16.5, p=0.001) was associated with higher odds of developing a pleural effusion compared to low-grade splenic injury (I-III).Pleural effusion following pediatric blunt splenic injury has an incidence of 4.4% and is associated with high-grade splenic injuries and longer lengths of stay. While some symptomatic patients may be successfully managed medically, many require tube thoracostomy for progressive respiratory

2014 Journal of Pediatric Surgery

124. Are Procedures Codes in Claims Data a Reliable Indicator of Intraoperative Splenic Injury Compared with Clinical Registry Data? (Abstract)

Are Procedures Codes in Claims Data a Reliable Indicator of Intraoperative Splenic Injury Compared with Clinical Registry Data? Identifying iatrogenic injuries using existing data sources is important for improved transparency in the occurrence of intraoperative events. There is evidence that procedure codes are reliably recorded in claims data. The objective of this study was to assess whether concurrent splenic procedure codes in patients undergoing colectomy procedures are reliably coded (...) 114 patients (1%) who had a concurrent splenic procedure code recorded in either ACS NSQIP or Medicare inpatient claims. There were 7 patients who had a splenic injury diagnosis code recorded in either data source. Agreement of splenic procedure codes between the data sources was substantial (κ statistic 0.72; 95% CI, 0.64-0.79). Medicare inpatient claims identified 81% of the splenic procedure codes recorded in ACS NSQIP, and 99% of the patients without a splenic procedure code.It is feasible

2014 Journal of the American College of Surgeons

125. Role of spleen-derived monocytes/macrophages in acute ischemic brain injury. Full Text available with Trip Pro

Role of spleen-derived monocytes/macrophages in acute ischemic brain injury. Monocytes/macrophages (MMs), mononuclear phagocytes, have been implicated in stroke-induced inflammation and injury. However, the presence of pro-inflammatory Ly-6C(high) and antiinflammatory Ly-6C(low) monocyte subsets raises uncertainty regarding their role in stroke pathologic assessment. With recent identification of the spleen as an immediate reservoir of MMs, this current study addresses whether the spleen (...) -derived MMs are required for stroke pathologic assessment. We observed that the spleen was contracted in poststroke animals and the contraction was accompanied by decreased number of Ly-6C(high) and Ly-6C(low) subsets in the spleen. The deployment of these subsets from the spleen temporally coincided with respective increases in the ischemic brain. Compared to mice with the spleen, mice receiving a splenectomy just before the stroke displayed less accumulation of Ly-6C(high) and Ly-6C(low) MMs

2014 Journal of Cerebral Blood Flow and Metabolism

126. Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients

Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02232191 Recruitment Status : Recruiting First Posted : September 5

2014 Clinical Trials

127. Simvastatin Reduces Burn Injury-Induced Splenic Apoptosis via Downregulation of the TNF-α/NF-кB Pathway. Full Text available with Trip Pro

Simvastatin Reduces Burn Injury-Induced Splenic Apoptosis via Downregulation of the TNF-α/NF-кB Pathway. Recent studies have suggested that epidermal burn injuries are associated with inflammation and immune dysfunction. Simvastatin has been shown to possess potent anti-inflammatory properties. Thus, we hypothesized that simvastatin protects against burn-induced apoptosis in the spleen via its anti-inflammatory activity.Wild-type, tumor necrosis factor alpha knockout (TNF-α KO) and NF-κB KO (...) mice were subjected to full-thickness burn injury or sham treatment. The mice then were treated with or without simvastatin, and the spleen was harvested to measure the extent of apoptosis. Expression levels of TNF-α and NF-κB were also determined in spleen tissue and serum.Burn injury induced significant splenic apoptosis and systemic cytokine production. Simvastatin protected the spleen from apoptosis, reduced cytokine production in the serum, and increased the survival rate. Simvastatin

2014 Annals of Surgery

128. National trends in pediatric blunt spleen and liver injury management and potential benefits of an abbreviated bed rest protocol. (Abstract)

National trends in pediatric blunt spleen and liver injury management and potential benefits of an abbreviated bed rest protocol. Recent reports suggest that an abbreviated bed rest protocol (ABRP) may safely reduce length of stay (LOS) and resource utilization in pediatric blunt spleen and liver injury (BSLI) patients. This study evaluates national temporal trends in BLSI management and estimates national reduction in LOS using an ABRP.Pediatric patients (<18 years old) sustaining BLSI were (...) identified in the Kids' Inpatient Database from 2000 to 2009. Yearly rates of injury and operative intervention were examined and stratified by type of injury. APSA guidelines and the reported ABRP were applied based on abbreviated injury score (AIS) and compared with actual LOS.22,153 patients were identified. Over the study period, operative rates for spleen and liver injuries and overall mortality significantly declined: LOS=3.1 days (±1.6) and 2.7 days (±1.9) for spleen and liver, respectively

2014 Journal of Pediatric Surgery

129. Reducing scheduled phlebotomy in stable pediatric patients with blunt liver or spleen injury. (Abstract)

Reducing scheduled phlebotomy in stable pediatric patients with blunt liver or spleen injury. Although consensus-based guidelines exist for managing pediatric liver/spleen injuries, optimal phlebotomy frequency is unknown. We hypothesize surgeons order more phlebotomy than necessary and propose a pathway with one blood draw, early ambulation and discharge, fewer ICU admissions, and physiology-driven interventions.Records of 120 children with solid organ injury from two hospital registries (2008 (...) -2012) were analyzed. We compared resource utilization between our current management and management if the proposed pathway were in place. Paired t-test was used for statistical analysis.Sixty-one patients were included (35 spleen, 22 liver, 4 combined). Average age was 11.6 (±4.2) years, injury severity score 9 (±5), and median injury grade 3. 51% of children were admitted to the ICU. Average phlebotomy per patient was 5 (±2) and length-of-stay 4.3 (±1.5) days. Three patients became unstable

2014 Journal of Pediatric Surgery

130. Latest Study on the Relationship between Pathological Process of Inflammatory Injury and the Syndrome of Spleen Deficiency and Fluid Retention in Alzheimer's Disease. Full Text available with Trip Pro

Latest Study on the Relationship between Pathological Process of Inflammatory Injury and the Syndrome of Spleen Deficiency and Fluid Retention in Alzheimer's Disease. Inflammation exists throughout the incidence and progression of Alzheimer's disease (AD). Traditional Chinese medicine (TCM) differentiates the pathogenesis of AD as kidney essence deficiency and qi and blood deficiency as well as blood stasis in syndromes, whose action mechanisms are all associated with the intervention in its (...) inflammatory process. Our preliminary studies both in clinic and in vitro have demonstrated that the syndrome of spleen deficiency and fluid retention has also been an important pathogenesis for the incidence and development of AD. Hence, the paper aims to further illustrate the correlation between inflammatory process in AD and the syndrome of spleen deficiency and fluid retention, laying solid foundation for the application of invigorating the spleen and eliminating the dampness in clinic, and enriching

2014 Evidence-based Complementary and Alternative Medicine (eCAM)

131. Splenic Injury During Resection for Esophageal Cancer: Risk Factors and Consequences. (Abstract)

).The inverse association between surgeon volume and splenic injury supports centralization of esophageal cancer surgery. The increased risk of mortality and severe infections after incidental splenectomy should be kept in mind during surgery, and we should encourage efforts to preserve an injured spleen and stress the relevance of vaccination after splenectomy. (...) Splenic Injury During Resection for Esophageal Cancer: Risk Factors and Consequences. Esophageal cancer surgery carries a risk of splenic injury, which may require splenectomy, but predictors of such events remain uncertain. Moreover, the hypothesis that incidental splenectomy carries a worse prognosis deserves attention.A population-based, nationwide cohort study was conducted on 1679 patients who underwent resection for esophageal cancer in Sweden in 1987 to 2010, with follow-up until

2014 Annals of Surgery

132. Preserved function after angioembolisation of splenic injury in children and adolescents: a case control study. (Abstract)

sized and well perfused spleens in the SAE patients when compared to their controls.This case control study indicates preserved splenic function after SAE for splenic injury in children. Mandatory immunization to prevent severe infections does not seem warranted.Copyright © 2012 Elsevier Ltd. All rights reserved. (...) Preserved function after angioembolisation of splenic injury in children and adolescents: a case control study. Non-operative management for blunt splenic injuries was introduced to reduce the risk of overwhelming post splenectomy infection in children. To increase splenic preservation rates, splenic artery embolization (SAE) was added to our institutional treatment protocol in 2002. In the presence of clinical signs of ongoing bleeding, SAE was considered also in children. To our knowledge

2014 Injury

133. Time to intervention in patients with splenic injury in a Dutch level 1 trauma centre. (Abstract)

Time to intervention in patients with splenic injury in a Dutch level 1 trauma centre. Timely intervention in patients with splenic injury is essential, since delay to treatment is associated with an increased risk of mortality. Transcatheter Arterial Embolisation (TAE) is increasingly used as an adjunct to non-operative management. The aim of this study was to report time intervals between admission to the trauma room and start of intervention (TAE or splenic surgery) in patients with splenic (...) injury.Consecutive patients with splenic injury aged ≥ 16 years admitted between January 2006 and January 2012 were included. Data were reported according to haemodynamic status (stable versus unstable). In haemodynamically (HD) unstable patients, transfusion requirement, intervention-related complications and the need for a re-intervention were compared between the TAE and splenic surgery group.The cohort consisted of 96 adults of whom 16 were HD unstable on admission. In HD stable patients, median time

2014 Injury

134. Reliability of injury grading systems for patients with blunt splenic trauma. (Abstract)

Reliability of injury grading systems for patients with blunt splenic trauma. The most widely used grading system for blunt splenic injury is the American Association for the Surgery of Trauma (AAST) organ injury scale. In 2007 a new grading system was developed. This 'Baltimore CT grading system' is superior to the AAST classification system in predicting the need for angiography and embolization or surgery. The objective of this study was to assess inter- and intraobserver reliability between (...) radiologists in classifying splenic injury according to both grading systems.CT scans of 83 patients with blunt splenic injury admitted between 1998 and 2008 to an academic Level 1 trauma centre were retrospectively reviewed. Inter and intrarater reliability were expressed in Cohen's or weighted Kappa values.Overall weighted interobserver Kappa coefficients for the AAST and 'Baltimore CT grading system' were respectively substantial (kappa=0.80) and almost perfect (kappa=0.85). Average weighted

2014 Injury

135. Population-based analysis of blunt splenic injury management in children: operative rate is an informative quality of care indicator. (Abstract)

-level observed to expected (O/E) ratios for rate of operative management.We identified 3122 children with BSI. The majority (74%) were isolated splenic injuries and the grade of splenic injury was specified in 45% of cases (n=1391, 38% grade I or II; 62% grade III, IV, or V). The overall operative rate was 11% (n=315), of which 9% were total splenectomy and 2% were spleen-preserving operations. After adjusting for age, gender, mechanism of injury, splenic injury grade, ISS, and centre volume (...) Population-based analysis of blunt splenic injury management in children: operative rate is an informative quality of care indicator. In hemodynamically normal children with blunt splenic injury (BSI), the standard of care is non-operative management. Several studies have reported that non-paediatric and non-trauma centres have higher operative rates in children with BSI compared to paediatric hospitals and trauma centres. We investigate the feasibility of using operative rate for BSI

2014 Injury

136. Increasing number of fractured ribs is not predictive of the severity of splenic injury following blunt trauma: an analysis of a National Trauma Registry database. (Abstract)

Increasing number of fractured ribs is not predictive of the severity of splenic injury following blunt trauma: an analysis of a National Trauma Registry database. Association between rib fractures and incidence of abdominal solid organs injury is well described. However, the correlation between the number of fractured ribs and severity of splenic injury is not clear. The purpose of this study was to assess whether an increasing number of rib fractures predicts the severity of splenic injury (...) in blunt trauma patients.A retrospective cohort study involving blunt trauma patients with concomitant splenic injuries and rib fractures, between the years 1998 and 2012, registered in the Israeli National Trauma Registry.Of 321,618 patients with blunt mechanism of trauma, 57,130 had torso injuries, and of these 14,651 patients sustained rib fractures, and 3691 patients suffered from splenic injury. Concomitant splenic injury occurred in 1326 of the patients with rib fractures (9.1%), as compared

2014 Injury

137. Ultrasonography of the healing process during a 3-month follow-up after a splenic injury Full Text available with Trip Pro

Ultrasonography of the healing process during a 3-month follow-up after a splenic injury We present a 14-year-old boy with a grade III splenic injury due to a bicycle accident, who was treated conservatively. The boy's medical history included splenomegaly due to thalassemia. The splenic lesion was initially investigated with computed tomography (CT) and then, was followed by ultrasonography for 3 months. CT revealed a large intraparenchymal hematoma which appeared hyperechoic

2014 Ultrasonography

138. Splenosis: The Autotransplantation of Splenic Tissue Following Injury to the Spleen : Report of Two Cases and Review of the Literature Full Text available with Trip Pro

Splenosis: The Autotransplantation of Splenic Tissue Following Injury to the Spleen : Report of Two Cases and Review of the Literature 13627998 2000 07 01 2018 12 01 0003-4932 149 3 1959 Mar Annals of surgery Ann. Surg. Splenosis: the autotransplantation of splenic tissue following injury to the spleen; report of two cases and review of the literature. 402-14 COTLAR A M AM CERISE E J EJ eng Journal Article United States Ann Surg 0372354 0003-4932 OM Humans Spleen Splenosis Transplantation (...) , Autologous 5936:1778:504 SPLEEN 1959 3 1 1959 3 1 0 1 1959 3 1 0 0 ppublish 13627998 PMC1451006 Br Med J. 1956 Jun 2;1(4978):1271-2 13316128 Am J Anat. 1950 Nov;87(3):459-503 14789742 Ann Surg. 1954 Jul;140(1):107-12 13159150 J Am Med Assoc. 1953 Jul 25;152(13):1227-8 13061249 Am J Pathol. 1945 Jan;21(1):81-5 19970805 Ann Surg. 1953 Apr;137(4):551-7 13031495 Can Med Assoc J. 1947 Apr;56(4):374-7 20286939 Am J Pathol. 1936 Sep;12(5):665-676.3 19970293 Mem Acad Chir (Paris). 1954 Jun 2-9;80(19-20):520-2

1959 Annals of Surgery

139. Open splenectomy for Varicella zoster induced spontaneous splenic rupture Full Text available with Trip Pro

Open splenectomy for Varicella zoster induced spontaneous splenic rupture Here we present a case of atraumatic splenic rupture secondary to varicella infection requiring emergency splenectomy. The presentation was as would be expected for epstein barr virus (EBV) related splenic injury, which is well documented in the literature. Dermatological findings however suggested varicella zoster, and viral serology subsequently confirmed the diagnosis.A young Romanian male presented to the emergency (...) department with peritonism without preceding trauma. Free fluid on USS was aspirated as frank blood and cross-sectional imaging demonstrated a ruptured spleen. He underwent emergency splenectomy and recovered well. During his presentation he was noted to have an erythematous rash with different rates of evolution raising the suspicion for Varicella Zoster. This was subsequently confirmed on viral serology.A number of precedents have been identified for spontaneous splenic rupture, however Varicella

2017 International journal of surgery case reports

140. Tips and tricks of splenic vessel preservation during laparoscopic distal pancreatectomy. (Abstract)

Tips and tricks of splenic vessel preservation during laparoscopic distal pancreatectomy. While a laparoscopic approach can minimize postoperative morbidity in splenic vessel preserving (SVP) distal pancreatectomy (DP), this procedure can be technically challenging. A systematic approach to SVP minimizes the chances of vascular injury and maximizes the chances of successful splenic preservation. This video demonstrates a laparoscopic DP with SVP, highlighting technical tips and tricks (...) was uneventful. Pathology confirmed the diagnosis of a pT3N0. SPPT with negative margins.Here we demonstrate a systematic approach to maximize the changes of SVP in DP. This approach, as demonstrated in the video, includes optimal patient and port positioning, dissection to optimize exposure of the distal splenic vessels, techniques to minimize vascular trauma especially splenic venous trauma, as well as supplemental measures to ensure postoperative patency of splenic vessels following completion

2017 Surgical endoscopy

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>