How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,853 results for

Splenic Injury

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

101. Splenic Injury in Situs Inversus Totalis – A Surgical Challenge Full Text available with Trip Pro

Splenic Injury in Situs Inversus Totalis – A Surgical Challenge Situs inversus totalis is a rare congenital anomaly in which position of the heart and all abdominal viscera is reversed. Situs abnormalities usually go unnoticed but may be recognized by radiography or ultrasonography as an incidental finding or during evaluation for congenital heart diseases. We present such an extremely rare and to the best of our knowledge the third reported case of an injured spleen in the right

2015 Journal of clinical and diagnostic research : JCDR

102. Long-term risk of acute coronary syndrome in splenectomized patients due to splenic injury. Full Text available with Trip Pro

Long-term risk of acute coronary syndrome in splenectomized patients due to splenic injury. We aimed to assess the magnitude and duration of risk of acute coronary syndrome (ACS) associated with splenectomy for splenic injury.We identified 5139 splenectomized patients (the splenectomy cohort) to compare with 2 other cohorts for assessing the magnitude and risk of ACS: the first cohort comprising subjects without splenic injury and without splenectomy (control cohort), and the second cohort (...) comprising nonsplenectomized patients with splenic injury (nonsplenectomy cohort; n = 6391). For each splenic injury patient (n = 11530), 4 control comparisons were frequency-matched by the year of index date, age, and sex (n = 46120).The adjusted risk of ACS was significantly higher in the splenectomy group than in the control group (2.08 vs 1.68 per 1000 person-years; adjusted hazard ratio [HR], 1.30; 95% confidence interval [CI], 1.01-1.68). The sex-specific data showed that the adjusted HR

2015 Medicine

103. Does laparoscopy reduce splenic injuries during colorectal resections? An assessment from the ACS-NSQIP database. (Abstract)

Does laparoscopy reduce splenic injuries during colorectal resections? An assessment from the ACS-NSQIP database. Nearly half of all incidental splenectomies caused by iatrogenic splenic injury occur during colorectal surgery. This study evaluates factors associated with incidental splenic procedures during colorectal surgery and their impact on short-term outcomes using a nationwide database.Patients who underwent colorectal resections between 2005 and 2012 were identified from the American (...) College of Surgeons National Surgical Quality Improvement Program database according to Current Procedural Terminology codes. Patients were classified into two groups based on whether they underwent a concurrent incidental splenic procedure at the time of the colorectal procedure. All splenic procedures except a preoperatively intended splenectomy performed in conjunction with colon or rectal resections were considered as incidental. Perioperative and short-term (30 day) outcomes were compared between

2015 Surgical endoscopy

104. Spleen injury following left extracorporeal shockwave lithotripsy (ESWL). Full Text available with Trip Pro

Spleen injury following left extracorporeal shockwave lithotripsy (ESWL). A splenic rupture associated with extracorporeal shockwave lithotripsy (ESWL) is exceedingly rare. We report a case of stage 3 splenic laceration, hemoperitoneum and subsequent splenic rupture following an ESWL for a left mid polar renal calculus.During the ESWL, although the patient's pain was controlled the gentleman was very nervous and had to be repositioned eight individual times. Approximately 6 hours after the ESWL (...) , the patient phoned the urologist complaining of severe left flank pain unlike any previous episode of renal colic. A computerized tomography (CT) scan demonstrated a stage 3 splenic injury with hemoperitoneum. The patient decompensated and an emergent splenectomy was then performed and the patient experienced an uneventful recovery.Splenic injury likely results from unintentional movement during the sound wave administration for the stone fragmentation procedure. Utilizing noise cancelling headphones

2015 BMC Urology

105. Increased Risk of Hemorrhagic and Ischemic Strokes in Patients With Splenic Injury and Splenectomy: A Nationwide Cohort Study. Full Text available with Trip Pro

Increased Risk of Hemorrhagic and Ischemic Strokes in Patients With Splenic Injury and Splenectomy: A Nationwide Cohort Study. The spleen is a crucial organ in humans. Little is known about the association between stroke and splenic injury or splenectomy. The aim of this study was to determine the risk of stroke in patients with splenic injury and splenectomy.A nationwide cohort study was conducted by analyzing the National Health Insurance Research Database in Taiwan. For comparison, control (...) patients were selected and matched with splenic injury patients in a ratio of 4:1 according to age, sex, and the year of hospitalization. We analyzed the risks of stroke using a Cox proportional-hazards regression analysis.A total of 11,273 splenic injury patients, including 5294 splenectomized and 5979 nonsplenectomized patients, and 45,092 control patients were included in this study. The incidence rates of stroke were 8.05, 6.53, and 4.25 per 1000 person-years in splenic injury patients

2015 Medicine

106. Risk of venous thromboembolism in patients with splenic injury and splenectomy. A nationwide cohort study. (Abstract)

Risk of venous thromboembolism in patients with splenic injury and splenectomy. A nationwide cohort study. The spleen is a crucial organ in humans. However, little is known about the association of venous thromboembolism (VTE) with splenic injury and splenectomy in trauma patients. The aim of this study was to determine the subsequent risk of VTE following splenic injury and splenectomy. A nationwide retrospective cohort study was conducted by analysing data from the National Health Insurance (...) Research Database in Taiwan. We included 6,162 splenic injury patients (3,033 splenectomised and 3,129 nonsplenectomised patients) and 24,648 comparison patients who were selected by frequency match based on sex, age, and the index year during 2000-2006. All patients were followed until the occurrence of VTE, 31 December, 2011, death, or withdrawal from the insurance program. The age of patients with splenic injury was 41.93 ± 16.44 years. The incidence rates of VTE were 11.81, 8.46, and 5.21 per

2015 Thrombosis and haemostasis

107. Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury. Full Text available with Trip Pro

Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury. The plasticity of dendritic cells (DCs) permits phenotypic modulation ex vivo by gene expression or pharmacologic agents, and these modified DCs can exert therapeutic immunosuppressive effects in vivo through direct interactions with T cells, either inducing T regulatory cells (T(REG)s) or causing anergy. Sphingosine 1-phosphate (S1P) is a sphingolipid and the natural ligand (...) )-dependent protection against IRI in an allogeneic mouse model. In summary, adoptively transferred S1pr3(-/-) BMDCs prevent kidney IRI through interactions within the spleen and expansion of splenic CD4(+)Foxp3(+) T(REG)s. We conclude that genetically induced deficiency of S1pr3 in allogenic BMDCs could serve as a therapeutic approach to prevent IRI-induced AKI.Copyright © 2016 by the American Society of Nephrology.

2015 Journal of the American Society of Nephrology

108. Observation Versus Embolization in Patients with Blunt Splenic Injury After Trauma: A Propensity Score Analysis. Full Text available with Trip Pro

Observation Versus Embolization in Patients with Blunt Splenic Injury After Trauma: A Propensity Score Analysis. Non-operative management (NOM) is the standard of care in hemodynamically stable patients with blunt splenic injury after trauma. Splenic artery embolization (SAE) is reported to increase observation success rate. Studies demonstrating improved splenic salvage rates with SAE primarily compared SAE with historical controls. The aim of this study was to investigate whether SAE improves (...) success rate compared to observation alone in contemporaneous patients with blunt splenic injury.We included adult patients with blunt splenic injury admitted to five Level 1 Trauma Centers between January 2009 and December 2012 and selected for NOM. Successful treatment was defined as splenic salvage and no splenic re-intervention. We calculated propensity scores, expressing the probability of undergoing SAE, using multivariable logistic regression and created five strata based on the quintiles

2015 World Journal of Surgery

109. The treatment of spleen injuries: a retrospective study. Full Text available with Trip Pro

The treatment of spleen injuries: a retrospective study. Hemorrhage after blunt trauma is a major contributor to death after trauma. In the abdomen, an injured spleen is the most frequent cause of major bleeding. Splenectomy is historically the treatment of choice. In 2007, non-operative management (NOM) with splenic artery embolization (SAE) was introduced in our institution. The indication for SAE is hemodynamically stable patients with extravasation of contrast, or grade 3-5 spleen injury (...) according to the Abbreviated Organ Injury Scale 2005, Update 2008. We wanted to examine if the introduction of SAE increased the rate of salvaged spleens in our trauma center.All patients discharged with the diagnosis of splenic injury in the period 01.01.2000 - 31.12.2013 from the University Hospital of North Norway Tromsø were included in the study. Patients admitted for rehabilitation purposes or with an iatrogenic injury were excluded.A total of 109 patients were included in the study. In the period

2015 Scandinavian journal of trauma, resuscitation and emergency medicine

110. Molecular mechanisms involved in drug-induced liver injury caused by urate-lowering Chinese herbs: A network pharmacology study and biology experiments. Full Text available with Trip Pro

Molecular mechanisms involved in drug-induced liver injury caused by urate-lowering Chinese herbs: A network pharmacology study and biology experiments. As an important part of the comprehensive treatment methods, the urate-lowering Chinese herbs could provide favorable clinical effects on hyperuricemia in its ability to invigorate spleen and remove dampness. Owing to the long-term duration, it brought up the potential adverse reactions (ADRs) and concerns about the drug-induced liver injury (...) from these herbs. To address this problem, the bioinformatics approaches which combined the network pharmacology, computer simulation and molecular biology experiments were undertaken to elucidate the underlying drug-induced liver injury molecular mechanisms of urate-lowering Chinese herbs. Several electronic databases were searched to identify the potential liver injury compounds in published research. Then, the putative target profile of liver injury was predicted, and the interaction network

2019 PLoS ONE

111. Loss of hypoxia inducible factor‐1α aggravates γδ T‐cell‐mediated inflammation during acetaminophen‐induced liver injury Full Text available with Trip Pro

Loss of hypoxia inducible factor‐1α aggravates γδ T‐cell‐mediated inflammation during acetaminophen‐induced liver injury Acetaminophen (APAP)-induced liver injury is closely associated with acute hepatic inflammation. Hypoxia-inducible factor-1 (HIF-1) is activated during immunological processes and regulates gene expressions in various types of immune cells. Although HIF-1 controls the differentiation and functions of conventional T cells in chronic inflammation, the pathological (...) importance of HIF-1 in innate-like T cells during acute inflammation remains unknown. Here, we investigated the role of HIF-1 in innate-like γδ T cells during APAP-induced acute liver injury. In response to APAP administration, T-cell-specific Hif-1α gene knockout mice sustained severe liver damage compared to wild-type control mice but without any impacts on the initial hepatic insult. This severe liver damage was accompanied by excessive neutrophil infiltration into the liver, increased serum

2018 Hepatology communications

112. Neutrophils alleviate fibrosis in the CCl4‐induced mouse chronic liver injury model Full Text available with Trip Pro

Neutrophils alleviate fibrosis in the CCl4‐induced mouse chronic liver injury model Tribbles pseudokinase 1 (Trib1) is a negative regulator of CCAAT/enhancer binding protein α (C/EBPα) and is known to induce granulopoiesis while suppressing monocyte differentiation. Loss of Trib1 was previously shown to increase the neutrophil population in the spleen but lead to M2-like macrophage reduction. Because M2 macrophages are anti-inflammatory and promote tissue repair by producing fibrogenic (...) factors, we investigated liver fibrosis in Trib1-deficient mice. Interestingly, loss of Trib1 suppressed fibrosis in the CCl4-induced chronic liver injury model. Trib1 knockout increased neutrophils but had a minimal effect on the macrophage population in the liver. Hepatic expressions of neutrophil matrix metalloproteinases (Mmp)8 and Mmp9 were increased, but the production of fibrogenic factors, including transforming growth factor β1, was not affected by loss of Trib1. These results suggest

2018 Hepatology communications

113. Pancreatic Injuries

, Kazigo J, Gunduz Y, Stahl WM. The spleen at risk after penetrating trauma. J Trauma . 1993;35(3):409–414. Pachter HL, Hofstetter SR, Liang HG, Hoballah J. Traumatic injuries to the pancreas: the role of distal pancreatectomy with splenic preservation. J Trauma . 1989;29(10):1352–1355. Sriussadaporn S. Management of pancreatic injuries. J Med Assoc Thai . 1994;77(11):580–587. Yadav TD, Natarajan SK, Kishore VM, Lyngdoh S, Wig JD. Spleen-preserving distal pancreatectomy for pancreatic trauma: a series (...) to the OR for bleeding from the splenic vein and required a delayed splenectomy. Recommendations No recommendation is given. Existing data do not support either treatment modality, although splenic preservation was only considered for stable patients. If either the stability of the patient or the surgeon’s ability to safely preserve the spleen is in doubt, a distal pancreatectomy with splenectomy is a reasonable choice. Using These Guidelines in Clinical Practice These guidelines represent a detailed summary

2017 Eastern Association for the Surgery of Trauma

114. Can we predict delayed undesirable events after blunt injury to the torso visceral organs? Full Text available with Trip Pro

Can we predict delayed undesirable events after blunt injury to the torso visceral organs? Blunt injuries to visceral organs have the potential to lead to delayed pseudoaneurysm formation or organ rupture, but current trauma and surgical guidelines do not recommend repetitive imaging. This study examined the incidence and timing of delayed undesirable events and established advisable timing for follow-up imaging and appropriate observational admission.Patients with blunt splenic (S), liver (L (...) ), or kidney (K) injury treated with non-operative management (NOM) in our institution were included and retrospectively reviewed.From January 2013 to January 2017, 57 patients were admitted with documented blunt visceral organ injuries and 22 patients were excluded. Of 35 patients (L, 10; S, 17; K, 6; L & S, 1; S & K, 1) treated with NOM, 14 (L, 4; S, 9; K, 1) patients underwent transcatheter arterial embolization. Delayed undesirable events occurred in four patients: three patients with splenic

2018 Acute medicine & surgery

115. Splenosis: The Autotransplantation of Splenic Tissue Following Injury to the Spleen : Report of Two Cases and Review of the Literature Full Text available with Trip Pro

Splenosis: The Autotransplantation of Splenic Tissue Following Injury to the Spleen : Report of Two Cases and Review of the Literature 13627998 2000 07 01 2018 12 01 0003-4932 149 3 1959 Mar Annals of surgery Ann. Surg. Splenosis: the autotransplantation of splenic tissue following injury to the spleen; report of two cases and review of the literature. 402-14 COTLAR A M AM CERISE E J EJ eng Journal Article United States Ann Surg 0372354 0003-4932 OM Humans Spleen Splenosis Transplantation (...) , Autologous 5936:1778:504 SPLEEN 1959 3 1 1959 3 1 0 1 1959 3 1 0 0 ppublish 13627998 PMC1451006 Br Med J. 1956 Jun 2;1(4978):1271-2 13316128 Am J Anat. 1950 Nov;87(3):459-503 14789742 Ann Surg. 1954 Jul;140(1):107-12 13159150 J Am Med Assoc. 1953 Jul 25;152(13):1227-8 13061249 Am J Pathol. 1945 Jan;21(1):81-5 19970805 Ann Surg. 1953 Apr;137(4):551-7 13031495 Can Med Assoc J. 1947 Apr;56(4):374-7 20286939 Am J Pathol. 1936 Sep;12(5):665-676.3 19970293 Mem Acad Chir (Paris). 1954 Jun 2-9;80(19-20):520-2

1959 Annals of Surgery

116. Assessment of blunt splenic trauma: Which imaging scoring system is superior? Full Text available with Trip Pro

Assessment of blunt splenic trauma: Which imaging scoring system is superior? Spleen is the most common viscera that may be hurt in blunt abdominal trauma. Operative or nonoperative management of splenic injury is a dilemma. The American Association for the Surgery of Trauma (AAST) is the most common grading system which has been used for the management of blunt splenic injuries. The new recommended grading system assesses other aspects of splenic injury such as contrast extravasation (...) , pseudoaneurysm, arteriovenous fistula, and severity of hemoperitoneum, as well. The aim of this study is to compare and prioritize the cutoff of AAST grading system with the new recommended one.This is a cross-sectional study on patients with splenic injury caused by abdominal blunt trauma referred to Isfahan University of Medical Sciences affiliated Hospitals, Iran, in 2013-2016. All patients underwent abdominopelvic computed tomography scanning with intravenous (IV) contrast. All images were reported

2018 Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

117. Splenic abscess complicating endoscopic retrograde cholangiopancreatography Full Text available with Trip Pro

Splenic abscess complicating endoscopic retrograde cholangiopancreatography We present a case of splenic abscess as a probable complication following endoscopic retrograde cholangiopancreatography (ERCP). Based on a literature review, there have been 11 documented cases of splenic injury following ERCP; however, only one of those involved splenic abscess. Proposed mechanisms of injury and abscess are likely a combination of complicating factors, including manipulation of the endoscope

2018 Proceedings (Baylor University. Medical Center)

118. Comparison of Bran-Processed and Crude Atractylodes Lancea Effects on Spleen Deficiency Syndrome in Rats Full Text available with Trip Pro

Comparison of Bran-Processed and Crude Atractylodes Lancea Effects on Spleen Deficiency Syndrome in Rats The rhizome of Atractylodes lancea (AL) is usually used for the treatment of various diseases such as spleen deficiency syndrome (SDS). Both bran-processed and crude AL is included in Chinese Pharmacopoeia. The different efficacies of bran-processed and crude AL on SDS are largely unknown, and the mechanisms of AL effects have not been fully elucidated.The objective of the study (...) ).The injury of SDS was alleviated by the treatment of bran-processed and crude AL. Compared to model group, the indexes of trypsin (TRY), amylase (AMS), vasoactive intestinal peptide (VIP), somatostatin (SS), gastrin (GAS), substance P (SP), Na+-K+-ATPase, and succinic dehydrogenase in serum of each administration group were increased by ELISA, and the mRNA expressions of VIP, SS, GAS, and SP in small intestinal tissues were increased by RT-PCR. Furthermore, in a dose-dependent manner, the bran-processed

2018 Pharmacognosy magazine

119. Etiologies and risks of splenic decapsulation after endoscopic retrograde cholangiopancreatography: case report and literature review Full Text available with Trip Pro

bleeding, and perforation. A rare, but potentially life-threatening complication of ERCP is splenic injury. We report the case of a 60-year-old female with choledocholithiasis who sustained splenic decapsulation following ERCP. The exact causes of splenic injury are unknown, although several mechanisms are postulated. A literature review of splenic injuries post-ERCP shows that there are only 3 cases with post-ERCP splenic decapsulation. Our patient is the first one in whom splenic decapsulation (...) occurred without any risk factors or technical difficulties during the procedure. A high index of suspicion for splenic injury is required in any patient who has severe pain, anemia, or hemorrhagic shock after ERCP.

2018 Endoscopy international open

120. Splenic Trauma during Colonoscopy: The Role of Intra-Abdominal Adhesions Full Text available with Trip Pro

Splenic Trauma during Colonoscopy: The Role of Intra-Abdominal Adhesions Splenic rupture following colonoscopy is rare, first reported in 1974, with incidence of 1-21/100,000. It is critical to anticipate splenic trauma during colonoscopy as one of the causes of abdominal pain after colonoscopy especially when located in the left upper quadrant or left shoulder. Postoperative adhesions is a predisposing factor for splenic injury, and management is either operative or nonoperative, based (...) on hemodynamic stability and/or extravasation which can be seen on contrast-enhanced CT scan of the abdomen. We present a case of a splenic rupture after colonoscopy in a patient with splenocolic adhesions, requiring splenectomy as definite treatment.

2018 Case reports in gastrointestinal medicine

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>