How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,728 results for

Splenic Injury

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

61. Splenic Artery Ligation for Iatrogenic Injury in Esophagectomy Operations. Full Text available with Trip Pro

Splenic Artery Ligation for Iatrogenic Injury in Esophagectomy Operations. Studies have shown that splenic artery ligation without splenectomy can successfully control hemorrhage and preserve the spleen in splenic trauma. The short gastric arteries and left gastroepiploic arteries may be the most important part of the collateral blood supply to the spleen. Moreover, that the human spleen can also survive even if most of the short gastric arteries have been ligated along with the splenic artery (...) has also been proven. Revascularization of the spleen by collateral vessels from the superior mesenteric, pancreatic, and left inferior phrenic arteries has been demonstrated by celiac angiography. Thus, splenic artery ligation could be also an alternative to splenectomy for iatrogenic spleen injury in esophagectomy operations.Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

2016 Annals of Thoracic Surgery

62. Beneficial effect of Punica granatum peel extract on murine malaria-induced spleen injury. Full Text available with Trip Pro

Beneficial effect of Punica granatum peel extract on murine malaria-induced spleen injury. Multiple drug-resistant malaria parasites have been widely detected, which has encouraged research studies focused on discovering alternative therapies. Medicinal plants such as pomegranate, Punica granatum, have been proven to exhibit antiprotozoal effects and therefore, we examined its effects on murine malaria-induced splenic injury and oxidative stress in this study.Mice were divided into three groups (...) , a vehicle control and two groups that were infected with 10(6) Plasmodium chabaudi-parasitized red blood cells (RBCs). The third group was gavaged with 100 μL of 300 mg/kg pomegranate peel extract for 6 days. All mice were euthanized on day 6 post-infection.The results revealed the potential antimalarial, antioxidant, and anti-inflammatory effects of pomegranate. Furthermore, pomegranate peel extracts significantly reduced parasitemia and spleen index of the treated mice compared to the untreated group

2016 BMC Complementary and Alternative Medicine

63. Non-Operative Management Is As Effective As Immediate Splenectomy For Adult Patients with High-Grade Blunt Splenic Injury. (Abstract)

Non-Operative Management Is As Effective As Immediate Splenectomy For Adult Patients with High-Grade Blunt Splenic Injury. The comparative effectiveness of nonoperative management (NOM) vs immediate splenectomy (IS) for hemodynamically stable adult patients with grade IV or V blunt splenic injury (BSI) has not been clearly established in the literature.We performed a retrospective analysis of adult patients, from the 2013 to 2014 American College of Surgeons Trauma Quality Improvement Program (...) was not different between the IS and NOM patients (11.5% vs 10.0%, p = 0.33), although IS patients had a higher incidence of infectious complications (21.4% vs 16.9%, p = 0.02). The rate of NOM failure in our sample was 20.1%. Independent predictors of failed NOM included the presence of a bleeding disorder, early blood transfusion requirement, and grade V injury. Splenic artery embolization was associated with a decreased risk of NOM failure. Patients who had failed NOM had a lower in-hospital mortality rate

2016 Journal of the American College of Surgeons

64. The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury Full Text available with Trip Pro

The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury Macrophages have been shown to play a role in acetaminophen (APAP)-induced hepatotoxicity, contributing to both pro- and anti-inflammatory processes. In these studies, we analyzed the role of the spleen as an extramedullary source of hepatic macrophages. APAP administration (300mg/kg, i.p.) to control mice resulted in an increase in CD11b(+) infiltrating Ly6G(+) granulocytic and Ly6G (...) (-) monocytic cells in the spleen and the liver. The majority of the Ly6G(+) cells were also positive for the monocyte/macrophage activation marker, Ly6C, suggesting a myeloid derived suppressor cell (MDSC) phenotype. By comparison, Ly6G(-) cells consisted of 3 subpopulations expressing high, intermediate, and low levels of Ly6C. Splenectomy was associated with increases in mature (F4/80(+)) and immature (F4/80(-)) pro-inflammatory Ly6C(hi) macrophages and mature anti-inflammatory (Ly6C(lo)) macrophages

2016 Toxicology and applied pharmacology

65. Laparascopic Splenectomy Due to Splenic Injury after Colonoscopy Full Text available with Trip Pro

Laparascopic Splenectomy Due to Splenic Injury after Colonoscopy Colonoscopy, which is routinely performed in diagnosis and treatment of colorectal disorders, is a reliable procedure. Its most frequent complications are bleeding and perforation. Splenic rupture is a very rarely met complication of colonoscopy, and delay in its diagnosis leads to increased morbidity and mortality. We presented a 69 years old female patient, who was diagnosed by computerized abdominal tomography, performed (...) bleeding, in other words, if there is a sub-capsular hematoma of the spleen, medical management by monitoring the vital signs may be preferred. Then, splenectomy should be performed at an appropriate time.

2016 The Eurasian journal of medicine

66. Salmonella typhi Splenic Abscess Following Blunt Abdominal Injury: A Case Report Full Text available with Trip Pro

Salmonella typhi Splenic Abscess Following Blunt Abdominal Injury: A Case Report Splenic abscess as a complication of enteric fever due to Salmonella typhi is a rare entity. Here, we are presenting a case of splenic abscess caused by Salmonella typhi with a blunt injury to the abdomen as the predisposing factor. The patient underwent total splenectomy due to failure of conservative management. Splenic abscess is a potential life threatening disease if left untreated. In spite of its rarity

2016 Journal of clinical and diagnostic research : JCDR

67. Editor’s Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury Full Text available with Trip Pro

Editor’s Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury Macrophages and inflammatory mediators have been implicated in ozone toxicity. In these studies, we used splenectomized (SPX) mice to assess the contribution of splenic monocytes to pulmonary inflammation and injury induced by ozone. Cells and tissue were collected 24-72 h after exposure of mice to air or ozone (0.8 ppm, 3 h). Following ozone exposure, increased numbers of pro-inflammatory (...) ozone toxicity, as measured by decreases in bronchoalveolar lavage protein content and reduced 4-hydroxynonenal expression in the lung. These data suggest that the spleen is a source of pro-inflammatory/cytotoxic macrophages that contribute to ozone-induced lung injury, inflammation, and oxidative stress.© The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

2016 Toxicological Sciences

68. Noninvasive management for iatrogenic splenic injury caused by chest tube insertion: a case report Full Text available with Trip Pro

Noninvasive management for iatrogenic splenic injury caused by chest tube insertion: a case report Splenic injury is one of the most critical complications of chest tube insertion and often requires invasive emergency management. However, noninvasive management such as delayed removal of the malpositioned tube may be considered for a stable patient without severe adverse event.

2016 Clinical Case Reports

69. Organ crushing tackle: pancreatic, bowel and splenic artery injury from blunt abdominal trauma playing rugby union Full Text available with Trip Pro

Organ crushing tackle: pancreatic, bowel and splenic artery injury from blunt abdominal trauma playing rugby union 26786533 2016 12 13 2018 11 13 1757-790X 2016 2016 Jan 19 BMJ case reports BMJ Case Rep Organ crushing tackle: pancreatic, bowel and splenic artery injury from blunt abdominal trauma playing rugby union. 10.1136/bcr-2015-214124 bcr2015214124 Moore Timothy T NSW Health, Manly, New South Wales, Australia. eng Case Reports Journal Article 2016 01 19 England BMJ Case Rep 101526291 1757 (...) -790X IM Abdominal Injuries diagnostic imaging etiology pathology surgery Adult Colectomy Football injuries Humans Laparotomy methods Male Pancreas injuries surgery Pancreatectomy Shock, Hemorrhagic diagnosis etiology Splenectomy Splenic Artery injuries surgery Wounds, Nonpenetrating diagnosis etiology pathology surgery 2016 1 21 6 0 2016 1 21 6 0 2016 12 15 6 0 epublish 26786533 bcr-2015-214124 10.1136/bcr-2015-214124 PMC4735394 Acta Radiol. 2015 Apr;56(4):387-96 24760286 N Engl J Med. 1994 Oct

2016 BMJ case reports

70. Comparison of MDCT protocols in trauma patients with suspected splenic injury: superior results with protocol that includes arterial and portal venous phase imaging Full Text available with Trip Pro

Comparison of MDCT protocols in trauma patients with suspected splenic injury: superior results with protocol that includes arterial and portal venous phase imaging We aimed to determine which intravenous contrast-enhanced multidetector computed tomography (MDCT) protocol produced the most accurate results for the detection of splenic vascular injury in hemodynamically stable patients who had sustained blunt abdominal trauma.We retrospectively reviewed 88 patients from 2003 to 2011 who (...) , which includes the arterial phase, in patients with suspected splenic injury and question the utility of obtaining a delayed sequence.

2016 Diagnostic and Interventional Radiology

71. Variation in ICU Utilization and Mortality After Blunt Splenic Injury Full Text available with Trip Pro

Variation in ICU Utilization and Mortality After Blunt Splenic Injury Although trauma patients are frequently cared for in the intensive care unit (ICU), admission triage criteria are unclear and may vary among providers and institutions. The benefits of close monitoring must be weighed against the economic and opportunity costs of an ICU admission.We conducted a retrospective cohort study of patients treated for blunt splenic injuries from 2011-2014 at 30 level I and II Pennsylvania trauma (...) centers.Of 2587 patients with blunt splenic injuries, 63.9% (1654) were admitted to the ICU. Median injury severity score was 17 overall, 13 for non-ICU patients and 17 for ICU patients (P < 0.001). In multivariable logistic regression, ICU admission was not significantly associated with mortality. Center-level risk-adjusted ICU admission rates ranged from 17.9%-87.3%. Risk-adjusted mortality rates ranged from 1.2%-9.6%. There was no correlation between observed-to-expected ratios for ICU utilization

2016 The Journal of surgical research

72. Colonoscopic Splenic Injury: A Simplified Radiologic Approach Full Text available with Trip Pro

Colonoscopic Splenic Injury: A Simplified Radiologic Approach Colonoscopy is a commonly performed procedure for diagnosis and treatment of large bowel diseases. Recognized complications include bleeding and perforation. Splenic injury during colonoscopy is a rare complication. We report a case of a 73-year-old woman who presented with left-sided abdominal pain after colonoscopy with finding of splenic injury on CT scan. She was managed conservatively. We discuss the diagnostic and therapeutic (...) approach to colonoscopic splenic injury.

2016 Case reports in gastrointestinal medicine

73. Splenic injury following elective colonoscopy: a rare complication Full Text available with Trip Pro

Splenic injury following elective colonoscopy: a rare complication Splenic injury is an extremely rare, yet serious, complication related to colonoscopy. So far, less than 80 cases have been reported worldwide since 1970. With the increasing use of colonoscopy, endoscopists, surgeons and radiologists are more likely to encounter this unusual complication. Increased splenocolic adhesions, splenomegaly or underlying splenic disease might, inter alia, constitute a predisposing factor. However (...) , it might also occur in patients without significant adhesions or underlying splenic pathology. Patients with abdominal pain, hypotension and a fall in hematocrit without rectal bleeding after colonoscopy, should be suspected of having splenic injury. Most patients present with symptoms within 24 hours after colonoscopy, nevertheless, delayed presentations have been described as well. We report such a case of splenic injury secondary to colonoscopy. The patient was presented with hemorrhagic shock

2016 Journal of surgical case reports

74. Iatrogenic splenic injury: review of the literature and medico-legal issues Full Text available with Trip Pro

Iatrogenic splenic injury: review of the literature and medico-legal issues Iatrogenic splenic injury is a recognized complication in abdominal surgery. The aim of this paper is to understand the medico-legal issues of iatrogenic splenic injuries. We performed a literature review on PubMed and Scopus using iatrogenic splenic or spleen injury and iatrogenic splenic rupture as keywords. Iatrogenic splenic injury cases were identified. Most cases were related to colonoscopy, but we also identified (...) cases related to upper gastrointestinal procedures, colonic surgery, ERCP, left nephrectomy and/or adrenalectomy, percutaneous nephrolithotomy, vascular operations involving the abdominal aorta, gynecological operation, left lung biopsy, chest drain, very rarely spinal surgery and even cardiopulmonary resuscitation. There are several surgical procedures that can lead to a splenic injury. However, from a medico-legal point of view, it is important to assess whether the cause can be attributed

2016 Open Medicine

75. Observation Versus Embolization in Patients with Blunt Splenic Injury After Trauma: A Propensity Score Analysis. Full Text available with Trip Pro

Observation Versus Embolization in Patients with Blunt Splenic Injury After Trauma: A Propensity Score Analysis. Non-operative management (NOM) is the standard of care in hemodynamically stable patients with blunt splenic injury after trauma. Splenic artery embolization (SAE) is reported to increase observation success rate. Studies demonstrating improved splenic salvage rates with SAE primarily compared SAE with historical controls. The aim of this study was to investigate whether SAE improves (...) success rate compared to observation alone in contemporaneous patients with blunt splenic injury.We included adult patients with blunt splenic injury admitted to five Level 1 Trauma Centers between January 2009 and December 2012 and selected for NOM. Successful treatment was defined as splenic salvage and no splenic re-intervention. We calculated propensity scores, expressing the probability of undergoing SAE, using multivariable logistic regression and created five strata based on the quintiles

2015 World Journal of Surgery

76. Risk of venous thromboembolism in patients with splenic injury and splenectomy. A nationwide cohort study. (Abstract)

Risk of venous thromboembolism in patients with splenic injury and splenectomy. A nationwide cohort study. The spleen is a crucial organ in humans. However, little is known about the association of venous thromboembolism (VTE) with splenic injury and splenectomy in trauma patients. The aim of this study was to determine the subsequent risk of VTE following splenic injury and splenectomy. A nationwide retrospective cohort study was conducted by analysing data from the National Health Insurance (...) Research Database in Taiwan. We included 6,162 splenic injury patients (3,033 splenectomised and 3,129 nonsplenectomised patients) and 24,648 comparison patients who were selected by frequency match based on sex, age, and the index year during 2000-2006. All patients were followed until the occurrence of VTE, 31 December, 2011, death, or withdrawal from the insurance program. The age of patients with splenic injury was 41.93 ± 16.44 years. The incidence rates of VTE were 11.81, 8.46, and 5.21 per

2015 Thrombosis and haemostasis

77. Increased Risk of Hemorrhagic and Ischemic Strokes in Patients With Splenic Injury and Splenectomy: A Nationwide Cohort Study. Full Text available with Trip Pro

Increased Risk of Hemorrhagic and Ischemic Strokes in Patients With Splenic Injury and Splenectomy: A Nationwide Cohort Study. The spleen is a crucial organ in humans. Little is known about the association between stroke and splenic injury or splenectomy. The aim of this study was to determine the risk of stroke in patients with splenic injury and splenectomy.A nationwide cohort study was conducted by analyzing the National Health Insurance Research Database in Taiwan. For comparison, control (...) patients were selected and matched with splenic injury patients in a ratio of 4:1 according to age, sex, and the year of hospitalization. We analyzed the risks of stroke using a Cox proportional-hazards regression analysis.A total of 11,273 splenic injury patients, including 5294 splenectomized and 5979 nonsplenectomized patients, and 45,092 control patients were included in this study. The incidence rates of stroke were 8.05, 6.53, and 4.25 per 1000 person-years in splenic injury patients

2015 Medicine

78. Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury. Full Text available with Trip Pro

Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury. The plasticity of dendritic cells (DCs) permits phenotypic modulation ex vivo by gene expression or pharmacologic agents, and these modified DCs can exert therapeutic immunosuppressive effects in vivo through direct interactions with T cells, either inducing T regulatory cells (T(REG)s) or causing anergy. Sphingosine 1-phosphate (S1P) is a sphingolipid and the natural ligand (...) )-dependent protection against IRI in an allogeneic mouse model. In summary, adoptively transferred S1pr3(-/-) BMDCs prevent kidney IRI through interactions within the spleen and expansion of splenic CD4(+)Foxp3(+) T(REG)s. We conclude that genetically induced deficiency of S1pr3 in allogenic BMDCs could serve as a therapeutic approach to prevent IRI-induced AKI.Copyright © 2016 by the American Society of Nephrology.

2015 Journal of the American Society of Nephrology

79. Does laparoscopy reduce splenic injuries during colorectal resections? An assessment from the ACS-NSQIP database. (Abstract)

Does laparoscopy reduce splenic injuries during colorectal resections? An assessment from the ACS-NSQIP database. Nearly half of all incidental splenectomies caused by iatrogenic splenic injury occur during colorectal surgery. This study evaluates factors associated with incidental splenic procedures during colorectal surgery and their impact on short-term outcomes using a nationwide database.Patients who underwent colorectal resections between 2005 and 2012 were identified from the American (...) College of Surgeons National Surgical Quality Improvement Program database according to Current Procedural Terminology codes. Patients were classified into two groups based on whether they underwent a concurrent incidental splenic procedure at the time of the colorectal procedure. All splenic procedures except a preoperatively intended splenectomy performed in conjunction with colon or rectal resections were considered as incidental. Perioperative and short-term (30 day) outcomes were compared between

2015 Surgical endoscopy

80. Splenic Injury in Situs Inversus Totalis – A Surgical Challenge Full Text available with Trip Pro

Splenic Injury in Situs Inversus Totalis – A Surgical Challenge Situs inversus totalis is a rare congenital anomaly in which position of the heart and all abdominal viscera is reversed. Situs abnormalities usually go unnoticed but may be recognized by radiography or ultrasonography as an incidental finding or during evaluation for congenital heart diseases. We present such an extremely rare and to the best of our knowledge the third reported case of an injured spleen in the right

2015 Journal of clinical and diagnostic research : JCDR

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>