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Splenic Injury

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41. Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling Full Text available with Trip Pro

Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling Calf Spleen Extractive Injection (CSEI), extracted from the spleen of healthy cows (within 24 hours of birth), is a small-peptide-enriched extraction and often used as an ancillary agent in cancer therapy. This study evaluated the hematopoietic function of CSEI and its underlying mechanisms, principally in CHRF, K562 cells, BMNCs and a mouse model (...) of cyclophosphamide (CTX)-induced hematopoietic suppression. CSEI promoted the proliferation and differentiation of CHRF and K562 cells, activated hematopoietic- and proliferation-related factors RSK1p90, ELK1 and c-Myc, and facilitated the expression of differentiation- and maturation-related transcription factors GATA-1, GATA-2. In the mice with hematopoietic suppression, 3 weeks of CSEI administration enhanced the bodyweights and thymus indices, suppressed the spleen indices and strongly elevated

2017 Scientific reports

42. Distal embolization versus combined embolization techniques for blunt splenic injuries: comparison of the efficacy and complications Full Text available with Trip Pro

Distal embolization versus combined embolization techniques for blunt splenic injuries: comparison of the efficacy and complications Comparable failure rates of distal or proximal transcatheter arterial embolization (TAE) techniques for blunt splenic injuries have been reported. This study is to investigate the efficacy and complication of combining both TAE techniques. We included 26 patients of blunt splenic injuries for TAE therapy and randomized them into distal TAE and combined TAE groups (...) . They were considered failures in distal TAE group as opposed to all successes in combined TAE group. The risk difference of failure of distal TAE was 17.6%. None developed post-TAE splenic abscess, massive splenic infarct or pancreatitis. The mean splenic infarct volume of distal TAE (10.9%) versus combined TAE groups (6.6%) was not significant (p = 0.481). Combined TAE is effective and safe to decrease the failure rates of non-operative management for blunt splenic injuries.

2017 Oncotarget Controlled trial quality: uncertain

43. Expression of pro-inflammatory genes in lesions, spleens and blood neutrophils after burn injuries in mice treated with silver sulfodiazine Full Text available with Trip Pro

Expression of pro-inflammatory genes in lesions, spleens and blood neutrophils after burn injuries in mice treated with silver sulfodiazine It is now supposed that cytokines released during the burn injuries have a great impact on the immunological and pathological responses after the burn. The main objective of this study was to investigate the expression of some pro-inflammatory genes in the wound, spleen and blood neutrophils during the healing process of burn wounds in a murine model.The (...) expression of ten pro-inflammatory genes were examined in wounds, spleens and blood neutrophils of mice with burn injuries treated with either silver sulfodiazine or phosphate-buffered saline (PBS) using RT-PCR at the end of the first and second weeks after injuries.None of the pro-inflammatory genes were expressed in the skin, spleen and blood neutrophils of healthy mice. In the group control, IL-12P35, IL-12P40, CCR5, IL-1β and IFN-γ were expressed in the spleen and blood neutrophils in the first week

2017 Iranian journal of basic medical sciences

44. Splenic Injury Following Endoscopic Retrograde Cholangiopancreatography: A Case Report and Literature Review Full Text available with Trip Pro

Splenic Injury Following Endoscopic Retrograde Cholangiopancreatography: A Case Report and Literature Review Splenic injury following endoscopy is a rare but potentially fatal complication. While this has been found to occur more frequently after colonoscopy, splenic injury following endoscopic retrograde cholangiopancreatography (ERCP) remains highly uncommon since its first reported case in 1989. Indeed, there have been only 19 such cases reported in the English, German, and Spanish (...) literature collectively over the past 27 years. We report on a 59-year-old woman who developed a peri-splenic haematoma diagnosed on abdominal computed tomography the day following ERCP and stenting for Mirizzi syndrome. The patient was treated conservatively and made a full recovery. We reviewed all cases of post-ERCP splenic injuries reported to date and discuss the published opinions on the likely mechanism of injury, predisposing factors, presenting features, investigation, and treatment options

2017 Case reports in gastroenterology

45. Natural history of splenic vascular abnormalities after blunt injury: A Western Trauma Association multicenter trial. (Abstract)

Natural history of splenic vascular abnormalities after blunt injury: A Western Trauma Association multicenter trial. Following blunt splenic injury, there is conflicting evidence regarding the natural history and appropriate management of patients with vascular injuries of the spleen such as pseudoaneurysms or blushes. The purpose of this study was to describe the current management and outcomes of patients with pseudoaneurysm or blush.Data were collected on adult (aged ≥18 years) patients (...) with blunt splenic injury and a splenic vascular injury from 17 trauma centers. Demographic, physiologic, radiographic, and injury characteristics were gathered. Management and outcomes were collected. Univariate and multivariable analyses were used to determine factors associated with splenectomy.Two hundred patients with a vascular abnormality on computed tomography scan were enrolled. Of those, 14.5% were managed with early splenectomy. Of the remaining patients, 59% underwent angiography

2017 The journal of trauma and acute care surgery Controlled trial quality: uncertain

46. Traumatic Splenic Injury and Management (SPLENIQ Study)

: literature search and conducting the retrospective study and analyses. Years 1-3: inclusion prospective study and follow-up of patients. Year 4: finishing follow-up data collection and analysing. Condition or disease Intervention/treatment Quality of Life Spleen Injury Trauma Splenic Artery Embolization Other: Questionnaires Diagnostic Test: MRI abdomen Study Design Go to Layout table for study information Study Type : Observational Actual Enrollment : 106 participants Observational Model: Cohort Time (...) Perspective: Prospective Official Title: Traumatic Splenic Injury and Management (SPLENIQ Study) Quality of Life and Clinical Outcomes of Treatment for Splenic Injury After Trauma Actual Study Start Date : March 1, 2017 Estimated Primary Completion Date : December 31, 2019 Estimated Study Completion Date : December 31, 2019 Groups and Cohorts Go to Group/Cohort Intervention/treatment Non-Operative Management (NOM)/Observational Patients "treated" observationally for (traumatic) spleen injury. Other

2017 Clinical Trials

47. Splenic Injury Embolization

objective is to compare the failure rate due to splenic bleeding between the patients undergoing pre-emptive SAE as part of NOM and the patients not undergoing SAE. The primary endpoint is the proportion of subjects failing NOM due to spleen related bleeding within 7 days of injury. All analyses will be based on an intention to treat analysis. Secondary Outcome Measures : Delayed bleeding episode [ Time Frame: 6-12 weeks ] Incidence. Delayed bleeding episode is defined as hemodynamically unstable (...) Splenic Injury Embolization Splenic Injury Embolization - the Question About NOM (SInE Qua NOM) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Splenic Injury Embolization - the Question About NOM (SInE Qua

2017 Clinical Trials

48. The spleen as a bidirectional signal transducer in acute kidney injury. (Abstract)

The spleen as a bidirectional signal transducer in acute kidney injury. In acute kidney injury models, the lung is damaged through an interleukin-6-dependent inflammatory response. Clinically, development of lung injury requiring mechanical ventilation markedly increases in-hospital acute kidney injury mortality. Andres-Hernando et al. demonstrate that the spleen coordinates interleukin-6-dependent interleukin-10 production, which lessens lung injury during experimental acute kidney injury (...) . This study highlights the beneficial influence of the spleen on the lung, and dovetails with other recent publications, to demonstrate the integral role of the spleen in acute kidney injury.Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

2017 Kidney International

49. A Novel Case of Splenic Injury After Shockwave Lithotripsy. (Abstract)

A Novel Case of Splenic Injury After Shockwave Lithotripsy. Emergency departments (EDs) are gateways for patients presenting after minor surgical procedures, particularly shockwave lithotripsy. Complications include renal and extrarenal tissue injuries, with the latter having potentially serious consequences if not detected early.We describe a 70-year-old male presenting to the ED for syncope. The patient underwent shockwave lithotripsy (SWL) for left kidney stones 1 day prior. Upon initial (...) evaluation, the patient had normal vital signs and a normal physical examination, without complaints of abdominal pain. Close observation and regular patient re-evaluation led to the diagnosis of life-threatening injuries that included splenic rupture. Although this is a rare complication of SWL, with only eight published cases found in the literature, the patient's initial presentation of syncope without complaints of abdominal pain presented a unique diagnostic challenge. WHY SHOULD AN EMERGENCY

2017 Journal of Emergency Medicine

50. Association between pediatric blunt splenic injury volume and the splenectomy rate. (Abstract)

Association between pediatric blunt splenic injury volume and the splenectomy rate. While pediatric trauma centers are shown to have lower splenectomy rate as compared to adult trauma centers, it remains unknown whether other institutional factors such as case volumes would have an impact on the splenectomy rate in pediatric blunt splenic injury (BSI).Pediatric patients who sustained BSI were identified from the National Trauma Data Bank 2007-2014. A hierarchical logistic regression model (...) -0.83, 0.44-0.95 for Groups 3 and 4, respectively) with an additional survival benefit in Group 4 (OR 0.452, 95%CI 0.257-0.793) when compared to the lowest volume centers (Group 1).Higher pediatric BSI case volume was associated with lower splenectomy rate with an additional survival benefit. Trauma centers' volume in pediatric BSI may be an important factor for the improved splenic preservation.Retrospective comparative study, Level III.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 Journal of Pediatric Surgery

51. Hypotension and the need for transfusion in pediatric blunt spleen and liver injury: An ATOMAC+ prospective study. (Abstract)

Hypotension and the need for transfusion in pediatric blunt spleen and liver injury: An ATOMAC+ prospective study. Children with blunt liver or spleen injury (BLSI) requiring early transfusion may present without hypotension despite significant hypovolemia. This study sought to determine the relationship between early transfusion in pediatric BLSI and hypotension.Secondary analysis of a 10-institution prospective observational study was performed of patients 18years and younger presenting (...) with BLSI. Patients with central nervous system (CNS) injury were excluded. Children receiving blood transfusion within 4h of injury were evaluated. Time to first transfusion, vital signs, and physical exams were analyzed. Patients with hypotension were compared to those without hypotension.Of 1008 patients with BLSI, 47 patients met inclusion criteria. 22 (47%) had documented hypotension. There was no statistical difference in median time to first transfusion for those with or without hypotension (2h

2017 Journal of Pediatric Surgery

52. Inhibition of spleen tyrosine kinase reduces renal allograft injury in a rat model of acute antibody-mediated rejection in sensitized recipients. (Abstract)

Inhibition of spleen tyrosine kinase reduces renal allograft injury in a rat model of acute antibody-mediated rejection in sensitized recipients. Organ transplantation into sensitized patients with preexisting donor-specific antibodies (DSA) is very challenging. Spleen tyrosine kinase (Syk) promotes leukocyte recruitment and activation via signaling through various cell surface receptors. We investigated whether a selective Syk inhibitor (GS-492429) could suppress antibody-mediated rejection (...) (AMR) in a rat model of AMR in sensitized recipients.Recipient Lewis rats (RT1) were immunized with donor (Dark Agouti, RT1) spleen cells (day -5). Recipients underwent bilateral nephrectomy and orthotopic renal transplantation (day 0). Cellular rejection was minimized by tacrolimus treatment from day -1. Groups received GS-492429 (30 mg/kg, twice a day) (n = 11) or vehicle (n = 12) from 1 hour before transplantation until being killed on day 3.Vehicle-treated recipients developed graft dysfunction

2017 Transplantation

53. Overall Splenectomy Rates Stable Despite Increasing Usage of Angiography in the Management of High-grade Blunt Splenic Injury. Full Text available with Trip Pro

Overall Splenectomy Rates Stable Despite Increasing Usage of Angiography in the Management of High-grade Blunt Splenic Injury. The purpose of this study was to understand the contemporary trends of splenectomy in blunt splenic injury (BSI) and to determine if angiography and embolization (ANGIO) may be impacting the splenectomy rate.The approach to BSI has shifted to increasing use of nonoperative management, with a greater reliance on ANGIO. However, the impact ANGIO has on splenic salvage (...) remains unclear with little contemporary data.The National Trauma Data Bank was used to identify patients 18 years and older with high-grade BSI (Abbreviated Injury Scale >II) treated at Level I or II trauma centers between 2008 and 2014. Primary outcomes included yearly rates of splenectomy, which was defined as early if performed within 6 hours of ED admission and delayed if greater than 6 hours, ANGIO, and mortality. Trends were studied over time with hierarchical regression models.There were

2017 Annals of Surgery

54. Interventional Radiology service provision and practice for the management of traumatic splenic injury across the Regional Trauma Networks of England. (Abstract)

Interventional Radiology service provision and practice for the management of traumatic splenic injury across the Regional Trauma Networks of England. The management of blunt splenic injuries (BSI) has evolved toward strategies that avoid splenectomy. There is growing adoption of interventional radiology (IR) techniques in non-operative management of BSI, with evidence suggesting a corresponding reduction in emergency laparotomy requirements and increased splenic preservation rates. Currently (...) there are no UK national guidelines for the management of blunt splenic injury. This may lead to variations in management, despite the reorganisation of trauma services in England in 2012.A survey was distributed through the British Society of Interventional Radiologists to all UK members aiming to identify availability of IR services in England, radiologists' practice, and attitudes toward management of BSI.116 responses from respondents working in 23 of the 26 Regional Trauma Networks in England were

2017 Injury

55. Robotic spleen-preserving splenic hilar lymph node dissection during total gastrectomy for gastric cancer. (Abstract)

, the number of harvested LNs in total and at the splenic hilum, and 5-year overall survival were analyzed, retrospectively.Among the 92 patients, robotic spleen-preserving splenic hilar lymphadenectomy was successfully performed in 91 patients except one who experienced intraoperative splenic artery injury which demanded splenectomy to be performed simultaneously. The overall mean operation time and console time were 287.2 ± 66.0 and 180.2 ± 47.2 min, respectively. Mean estimated blood loss was 141.1 (...) Robotic spleen-preserving splenic hilar lymph node dissection during total gastrectomy for gastric cancer. Robotic system may have potential advantages to facilitate the technically challenging splenic hilar lymphadenectomy during gastrectomy for gastric cancer. However, robotic spleen-preserving splenic hilar lymphadenectomy is performed infrequently not only because of the limited availability of the robot but also because of its technical difficulty. In this study, we describe our technique

2019 Surgical endoscopy

56. Interventional radiology versus surgical management on mortality for splenic injuries: a systematic review and meta-analysis

Interventional radiology versus surgical management on mortality for splenic injuries: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g. "Dr Smith" or "Joanne

2018 PROSPERO

57. Splenic Injury

, Injury of Spleen , Ruptured Spleen , Splenic Rupture From Related Chapters II. Grading: AAST CT Grade for Splenic Injury Precautions May not accurately correlate with surgical findings Does not consistently predict the need for surgical intervention Grade 1 Subcapsular hematoma <10% surface area OR Splenic <1 cm depth into parenchyma Grade 2 Subcapsular hematoma 10-50% surface area OR Splenic 1-3 cm depth into parenchyma (not involving trabecular vessels) Grade 3 Subcapsular hematoma >50% surface (...) 210196007 , 157342001 , 269157005 , 23589004 English Injury to spleen , Injury to spleen NOS , injury of spleen , injury of spleen (diagnosis) , Splenic injury , Unspecified injury of spleen , Injury of spleen, unspecified , injury splenic , injury to spleen , Injury;spleen , injury spleen , injuries splenic , splenic injury , injuries spleen , spleen injury , Injury to spleen NOS (disorder) , Injury of spleen , Injury of spleen (disorder) , injury; spleen , spleen; injury , Injury of spleen, NOS

2018 FP Notebook

58. Unusual Complications From Babesia Infection: Splenic Infarction and Splenic Rupture in Two Separate Patients. (Abstract)

in patients with splenic injuries and without obvious traditional risk factors.Copyright © 2018 Elsevier Inc. All rights reserved. (...) Unusual Complications From Babesia Infection: Splenic Infarction and Splenic Rupture in Two Separate Patients. Babesiosis is a zoonotic parasitic infection transmitted by the tick, Ixodes scapularis. Splenic infarct and rupture are infrequent complications of Babesia parasitemia, and have not been previously reported in the emergency medicine literature.We present two separate cases seen within 1 month at our institution: a case of splenic rupture and another case of splenic infarction due

2018 Journal of Emergency Medicine

59. How Does the Severity of Injury Vary between Motorcycle and Automobile Accident Victims Who Sustain High-Grade Blunt Hepatic and/or Splenic Injuries? Results of a Retrospective Analysis Full Text available with Trip Pro

How Does the Severity of Injury Vary between Motorcycle and Automobile Accident Victims Who Sustain High-Grade Blunt Hepatic and/or Splenic Injuries? Results of a Retrospective Analysis High-grade blunt hepatic and/or splenic injuries (BHSI) remain a great challenge for trauma surgeons. The main aim of this study was to investigate the characteristics, mortality rates, and outcomes of high-grade BHSI in motorcyclists and car occupants hospitalized for treatment of traumatic injuries in a Level (...) I trauma center in southern Taiwan.High-grade BHSI are defined as grade III-VI blunt hepatic injuries and grade III-V blunt splenic injuries. This retrospective study reviewed the data of 101 motorcyclists and 32 car occupants who experienced a high-grade BHSI from 1 January 2011 to 31 December 2013. Two-sided Fisher's exact or Pearson's chi-square tests were used to compare categorical data, unpaired Student's t-test was used to analyze normally distributed continuous data, and Mann-Whitney's U

2016 International journal of environmental research and public health

60. Blunt splenic injury and severe brain injury: a decision analysis and implications for care Full Text available with Trip Pro

Blunt splenic injury and severe brain injury: a decision analysis and implications for care The initial nonoperative management (NOM) of blunt splenic injuries in hemodynamically stable patients is common. In soldiers who experience blunt splenic injuries with concomitant severe brain injury while on deployment, however, NOM may put the injured soldier at risk for secondary brain injury from prolonged hypotension.We conducted a decision analysis using a Markov process to evaluate 2 strategies (...) for managing hemodynamically stable patients with blunt splenic injuries and severe brain injury--immediate splenectomy and NOM--in the setting of a field hospital with surgical capability but no angiography capabilities. We considered the base case of a 40-year-old man with a life expectancy of 78 years who experienced blunt trauma resulting in a severe traumatic brain injury and an isolated splenic injury with an estimated failure rate of NOM of 19.6%. The primary outcome measured was life expectancy. We

2015 Canadian Journal of Surgery

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