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Splenic Injury

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181. Optimizing Trauma Multidetector CT Protocol for Blunt Splenic Injury: Need for Arterial and Portal Venous Phase Scans. Full Text available with Trip Pro

Optimizing Trauma Multidetector CT Protocol for Blunt Splenic Injury: Need for Arterial and Portal Venous Phase Scans. To retrospectively compare the diagnostic performance of arterial, portal venous, and dual-phase computed tomography (CT) for blunt traumatic splenic injury.Informed consent was waived for this institutional review board-approved, HIPAA-compliant study. Retrospective record review identified 120 blunt trauma patients (87 male [72.5%] 33 female [27.5%]; age range, 18-94 years (...) ) who had undergone dual-phase abdominal CT within 5 years, including 30 without splenic injury, 30 with parenchymal injury only, 30 with splenic active bleeding, and 30 with intrasplenic pseudoaneurysm. Six radiologists each performed blinded review of 20 different cases, and scored the presence of pseudoaneurysm, active bleeding, parenchymal injury, and hematoma; 20 cases were interpreted by all radiologists. Data analysis included calculation of diagnostic performance measures with confidence

2013 Radiology

182. Active Hemorrhage and Vascular Injuries in Splenic Trauma: Utility of the Arterial Phase in Multidetector CT. Full Text available with Trip Pro

Active Hemorrhage and Vascular Injuries in Splenic Trauma: Utility of the Arterial Phase in Multidetector CT. To determine whether the addition of arterial phase computed tomography (CT) to the standard combination of portal venous and delayed phase imaging increases sensitivity in the diagnosis of active hemorrhage and/or contained vascular injuries in patients with splenic trauma.The institutional review board approved this HIPAA-compliant retrospective study; the requirement to obtain (...) informed consent was waived. The study included all patients aged 15 years and older who sustained a splenic injury from blunt or penetrating trauma and who underwent CT in the arterial and portal venous phases of image acquisition during a 74-month period (September 2005 to November 2011). CT scans were reviewed by three radiologists, and a consensus interpretation was made to classify the splenic injuries according to the American Association for the Surgery of Trauma splenic injury scale. One

2013 Radiology

183. Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway. Full Text available with Trip Pro

Ultrasound Prevents Renal Ischemia-Reperfusion Injury by Stimulating the Splenic Cholinergic Anti-Inflammatory Pathway. AKI affects both quality of life and health care costs and is an independent risk factor for mortality. At present, there are few effective treatment options for AKI. Here, we describe a nonpharmacologic, noninvasive, ultrasound-based method to prevent renal ischemia-reperfusion injury in mice, which is a model for human AKI. We exposed anesthetized mice to an ultrasound (...) protocol 24 hours before renal ischemia. After 24 hours of reperfusion, ultrasound-treated mice exhibited preserved kidney morphology and function compared with sham-treated mice. Ultrasound exposure before renal ischemia reduced the accumulation of CD11b(+)Ly6G(high) neutrophils and CD11b(+)F4/80(high) myeloid cells in kidney tissue. Furthermore, splenectomy and adoptive transfer studies revealed that the spleen and CD4(+) T cells mediated the protective effects of ultrasound. Last, blockade

2013 Journal of the American Society of Nephrology

184. Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-kappa B and spleen tyrosine kinase activation. Full Text available with Trip Pro

Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-kappa B and spleen tyrosine kinase activation. Inflammatory response has a critical role in neuronal damage after retinal ischemia-reperfusion (I/R) injury, and is regulated tightly by the toll-like receptor (TLR) 4. This study aimed to determine whether TLR4 is involved with injury in an ocular ischemic syndrome mice model and to clarify the downstream pathway of TLR4.To cause retinal ischemia, we ligated (...) the unilateral external carotid artery and the pterygopalatine artery of mice for 5 hours. Five days after reperfusion, retinal histologic analysis was performed. To examine the downstream pathway of TLR4, we analyzed the changes in phosphorylation of nuclear factor-κB (NF-κB) by Western blotting. In addition, we evaluated the expression of phosphorylated spleen tyrosine kinase (Syk), which is an adaptor protein of TLR4, and the effects of a Syk inhibitor (piceatannol) against the retinal ischemic damage

2013 Investigative Ophthalmology & Visual Science

185. Follow up of prospective validation of an abbreviated bedrest protocol in the management of blunt spleen and liver injury in children. (Abstract)

Follow up of prospective validation of an abbreviated bedrest protocol in the management of blunt spleen and liver injury in children. Current APSA recommendations for blunt spleen/liver injury (BSLI) entail bedrest equal to grade of injury plus one. We reported our experience 3 years ago with a prospectively implemented abbreviated protocol, one concern of which was that more numbers would be needed to support the safety of such a protocol. We are now reporting the final experience (...) with this protocol as we move forward with further investigation.Following IRB approval, data were collected prospectively in all patients with BSLI up to 8 weeks after discharge. There were no exclusion criteria, and patient accrual was consecutive. Bedrest was restricted to one night for Grade I & II injuries and two nights for Grade ≥ III.Between 11/2006 and 10/2012, 249 patients were admitted with BSLI. Mean age and weight were 10.3±4.8 years and 40.1±19.8 kg, respectively. Injuries included isolated spleen

2013 Journal of Pediatric Surgery

186. Roentgenologic Examination of the Abdomen as an Aid in the Early Diagnosis of Splenic Injury Full Text available with Trip Pro

Roentgenologic Examination of the Abdomen as an Aid in the Early Diagnosis of Splenic Injury 17858547 2007 09 17 2008 11 20 0003-4932 121 1 1945 Jan Annals of surgery Ann. Surg. Roentgenologic Examination of the Abdomen as an Aid in the Early Diagnosis of Splenic Injury. 111-9 O'neill J F JF Rousseau J P JP eng Journal Article United States Ann Surg 0372354 0003-4932 1945 1 1 0 0 1945 1 1 0 1 1945 1 1 0 0 ppublish 17858547 PMC1618069

1945 Annals of Surgery

187. Boxing Injury: Rupture of Spleen in Infectious Mononucleosis Full Text available with Trip Pro

Boxing Injury: Rupture of Spleen in Infectious Mononucleosis 13240585 2003 05 01 2018 12 01 0008-4409 73 3 1955 Aug 01 Canadian Medical Association journal Can Med Assoc J Boxing injury: rupture of spleen in infectious mononucleosis. 213-4 MARIEN B B CULLEN P P LONG R C RC eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 OM Boxing Infectious Mononucleosis complications Rupture Spleen Splenic Rupture Sports pathology Wounds and Injuries 5528:52228:63:296:529:614 ATHLETICS/pathology (...) INFECTIOUS MONONUCLEOSIS/complications SPLEEN/rupture WOUNDS AND INJURIES 1955 8 1 1955 8 1 0 1 1955 8 1 0 0 ppublish 13240585 PMC1826043 J Lab Clin Med. 1955 May;45(5):684-96 14368035 J Am Med Assoc. 1951 Aug 18;146(16):1506-11 14850329 N Engl J Med. 1952 Feb 28;246(9):335-9 14899640

1955 Canadian Medical Association Journal

188. Traumatic Rupture of the Spleen from Nonpenetrating Injuries Full Text available with Trip Pro

Traumatic Rupture of the Spleen from Nonpenetrating Injuries 13498642 2000 07 01 2018 12 01 0003-4932 147 2 1958 Feb Annals of surgery Ann. Surg. Traumatic rupture of the spleen from nonpenetrating injuries. 214-23 PARSONS L L THOMPSON J E JE eng Journal Article United States Ann Surg 0372354 0003-4932 OM Abdomen Abdominal Injuries Humans Rupture Spleen Wounds, Nonpenetrating 5833:41744:1:477 ABDOMEN/wounds and injuries SPLEEN/rupture 1958 2 1 1958 2 1 0 1 1958 2 1 0 0 ppublish 13498642

1958 Annals of Surgery

189. Scintigraphic Diagnosis of Splenic Injuries Full Text available with Trip Pro

Scintigraphic Diagnosis of Splenic Injuries 18747584 2010 06 30 2018 11 13 0093-0415 123 5 1975 Nov The Western journal of medicine West. J. Med. Scintigraphic diagnosis of splenic injuries. 390-1 Siemsen J K JK Telfer N N eng Journal Article United States West J Med 0410504 0093-0415 1975 11 1 0 0 1975 11 1 0 1 1975 11 1 0 0 ppublish 18747584 PMC1129925 Surg Clin North Am. 1972 Jun;52(3):667-85 5037648 Radiology. 1974 Mar;110(3):609-14 4811682 J Trauma. 1974 Mar;14(3):197-9 4814395

1975 Western Journal of Medicine

190. Bilateral diaphragmatic hernia from blunt injury causing a Budd-Chiari syndrome: use of liver and spleen scan in demonstrating the defects. Full Text available with Trip Pro

Bilateral diaphragmatic hernia from blunt injury causing a Budd-Chiari syndrome: use of liver and spleen scan in demonstrating the defects. 5100104 1971 03 24 2018 11 13 0003-4932 173 2 1971 Feb Annals of surgery Ann. Surg. Bilateral diaphragmatic hernia from blunt injury causing a Budd-Chiari syndrome: use of liver and spleen scan in demonstrating the defects. 321-4 Clay M G MG Munro A I AI eng Journal Article United States Ann Surg 0372354 0003-4932 AIM IM Adult Hernia, Diaphragmatic

1971 Annals of Surgery

191. INJURY TO THE SPLEEN: DELAYED HAEMORRHAGE Full Text available with Trip Pro

INJURY TO THE SPLEEN: DELAYED HAEMORRHAGE 20771363 2011 03 31 2011 03 31 0007-1447 2 3282 1923 Nov 24 British medical journal Br Med J INJURY TO THE SPLEEN: DELAYED HAEMORRHAGE. 962-3 Taylor C R CR Taylor C J CJ eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1923 11 24 0 0 1923 11 24 0 1 ppublish 20771363 PMC2317450

1923 British medical journal

192. Microglia-like Cells and their Reaction Following Injury to the Liver, Spleen and Kidney Full Text available with Trip Pro

Microglia-like Cells and their Reaction Following Injury to the Liver, Spleen and Kidney 19970147 2010 06 23 2018 11 13 0002-9440 10 3 1934 May The American journal of pathology Am. J. Pathol. Microglia-like Cells and their Reaction Following Injury to the Liver, Spleen and Kidney. 343-348.7 Dunning H S HS Stevenson L L eng Journal Article United States Am J Pathol 0370502 0002-9440 2009 12 9 6 0 1934 5 1 0 0 1934 5 1 0 1 ppublish 19970147 PMC2062826 Am J Pathol. 1929 Sep;5(5):451-458.3

1934 The American journal of pathology

193. Pelvic Injury CPG full report

source is 32%. 2;6;12;15;19;20;28;30 Seventy-eight per cent of intraperitoneal injuries result in haemorrhage including; the spleen (22%), the liver (20%), the bladder (15%), the bowel mesentery (10%) and diaphragmatic lesions (4%). Renal haemorrhage is found in 7% of cases. 5;12;19;28;30;45 The remaining 22% of intraperitoneal injuries are not associated with bleeding. Investigations Diagnostic Peritoneal Aspiration (DPA) and Focused Abdominal Sonography in Trauma (FAST) are the preferred diagnostic (...) Pelvic Injury CPG full report ADULT TRAUMA CLINICAL PRACTICE GUIDELINES :: Management of haemodynamically unstable patients with a Pelvic Fracture PELVIC FRACTURE GUIDELINE PelvicFracture_FullRCvR.qxd 3/2/07 12:09 PM Page 1Suggested citation: Dr Martin Heetveld 2007, The Management of Haemodynamically Unstable Patients with a Pelvic Fracture, NSW Institute of Trauma and Injury Management. Author Dr Martin Heetveld, Trauma Fellow, Trauma Service, Liverpool Hospital Editorial team NSW ITIM

2013 Agency for Clinical Innovation

194. Preventing murine transfusion-related acute lung injury by expansion of CD4<sup>+</sup> CD25<sup>+</sup> FoxP3<sup>+</sup> Tregs using IL-2/anti-IL-2 complexes. (Abstract)

Preventing murine transfusion-related acute lung injury by expansion of CD4+ CD25+ FoxP3+ Tregs using IL-2/anti-IL-2 complexes. Transfusion-related acute lung injury (TRALI) is one of the most serious adverse events following transfusion, and there is no specific treatment in clinical practice. However, regulatory T cells (Tregs) have been suggested to play a potential role in the treatment of TRALI. This study investigated whether interleukin (IL)-2 or IL-2 (...) aggregation in the lungs. Furthermore, the percentage of CD4+ CD25+ FoxP3+ Tregs was expanded in vivo using IL-2 and IL-2c compared to TRALI mice, as was confirmed through analysis of the spleen, blood, and lung.This study validates that the protective mechanisms against TRALI involve CD4+ CD25+ FoxP3+ Tregs, which can be expanded in vivo by IL-2 and IL-2c. This results in increased IL-10 levels and decreased IL-17A, thereby prophylactically preventing antibody-mediated murine TRALI.© 2018 AABB.

2018 Transfusion

195. Shedding of the endothelial glycocalyx is quantitatively proportional to burn injury severity Full Text available with Trip Pro

spleen syndecan-1 immunostaining in burned animals compared to controls at all time points. Burn injury causes shedding of syndecan-1 in a murine model, with levels correlated to injury severity and loss of the glycocalyx in lung and spleen. This work provides further insight into quantification and temporality of glycocalyx damage and systemic response to burn. (...) Shedding of the endothelial glycocalyx is quantitatively proportional to burn injury severity Limited information exists regarding endothelial dysfunction following burn injury. This project aims to evaluate whether thermal injury results in shedding of the endothelial glycocalyx in a manner quantitatively proportional to injury severity, and whether theloss of intact glycocalyx is measurable in end organs. C57BL/6 mice were grouped as uninjured controls, 10% or 25% Total Body Surface Area

2018 Annals of burns and fire disasters

196. Management of intra-abdominal vascular injury in trauma laparotomy: a South African experience Full Text available with Trip Pro

and 17 mesenteric) and 74 venous injuries (including 21 renal and 17 inferior vena caval). Combined venous and arterial injuries were found in almost one-third of patients (34 [30.9%]). Fifty-seven patients (51.8%) required intensive care admission. The overall mortality rate was 28.2% (31 patients); the rate was 62% for aortic injuries and 47% for inferior vena cava injuries. Liver injury, large bowel injury, splenic injury and elevated lactate level were all associated with a statistically (...) Management of intra-abdominal vascular injury in trauma laparotomy: a South African experience Intra-abdominal vascular injury (IAVI) is uncommon but continues to be associated with high mortality rates despite technological advances in the past decades. In light of these ongoing developments, we reviewed our contemporary experience with IAVI in an attempt to clarify and refine our management strategies and the outcome of these patients.We retrospectively reviewed the charts of all patients

2018 Canadian Journal of Surgery

197. Ghrelin therapy mitigates bone marrow injury and splenocytopenia by sustaining circulating G-CSF and KC increases after irradiation combined with wound Full Text available with Trip Pro

Ghrelin therapy mitigates bone marrow injury and splenocytopenia by sustaining circulating G-CSF and KC increases after irradiation combined with wound Radiation injury combined wound (CI) enhances acute radiation syndrome and subsequently mortality as compared to radiation injury alone (RI). We previously reported that ghrelin (a 28-amino-acid-peptide secreted from the stomach) treatment significantly increased a 30-day survival, mitigated hematopoietic death, circulating white blood cell (WBC (...) ) and keratinocyte chemoattractant (KC) in blood and bone marrow. Ghrelin therapy was able to enhance and sustain the increases in serum on day 15, probably contributed by spleen and ileum, suggesting the correlation between G-CSF and KC increases and the neutropenia mitigation. Activated caspase-3 levels in bone marrow cells were significantly mitigated by ghrelin therapy on days 3 and 15.Our novel results are the first to suggest that ghrelin therapy effectively decreases hematopoietic death

2018 Cell & bioscience

198. Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury Full Text available with Trip Pro

in postnatal day (PND) 7 rat pups and cells were administered intraperitoneally on PND 8. Behavioral testing was performed 7 days post injury, and then, brains and spleens were collected for analysis.We found in vitro that all UCB cell types, except for EPCs, were immunomodulatory. Perinatal HI brain injury induced significant infiltration of CD4+ T cells into the injured cerebral hemisphere, and this was significantly reduced by all hUCB cell types tested. Compared to HI, UCB, Tregs, and EPCs were able (...) Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury It is well understood that hypoxic-ischemic (HI) brain injury during the highly vulnerable perinatal period can lead to cerebral palsy, the most prevalent cause of chronic disability in children. Recently, human clinical trials have reported safety and some efficacy following treatment of cerebral palsy using umbilical cord blood (UCB) cells. UCB is made up of many

2018 Journal of neuroinflammation

199. Tracking of transplanted human umbilical cord-derived mesenchymal stem cells labeled with fluorescent probe in a mouse model of acute lung injury Full Text available with Trip Pro

Tracking of transplanted human umbilical cord-derived mesenchymal stem cells labeled with fluorescent probe in a mouse model of acute lung injury The aim of the present study was topreliminarily visualize the distribution of humanumbilical cord‑derivedmesenchymal stem cells (hUC‑MSCs) in treating acute lung injury (ALI) using a targeted fluorescent technique. Anovel fluorescent molecule probe was first synthesized via the specific binding of antigen and antibody in vitro to label the hUC‑MSCs (...) . Two groups of mice, comprising a normal saline (NS)+MSC group and lipopolysaccharide (LPS)+MSC group, were subjected to optical imaging. At 4 h following ALI mouse model construction, the labeled hUC‑MSCs were transplanted into the mice in the NS+MSC group and LPS+MSC group by tail vein injection. The mice were sacrificed 30 min, 1 day, 3 days and 7 days following injection of the labeled hUC‑MSCs, and the lungs, heart, spleen, kidneys and liver were removed. The excised lungs, heart, spleen

2018 International journal of molecular medicine

200. Matrix Remodeling Associated 7 Deficiency Alleviates Carbon Tetrachloride-Induced Acute Liver Injury in Mice Full Text available with Trip Pro

of vehicle or MXRA7-harboring plasmids were challenged with a single dose of CCl4 for injury induction. The sera, spleens, and livers were harvested from mice for assay of cytokines/chemokines expression, cellular responses, or histological features. We found that MXRA7 deficiency alleviated, and MXRA7 overexpression aggravated liver damage in CCl4-challenged mice. FACS analysis showed that MXRA7 deficiency reduced the recruitment of neutrophils through downregulation the expression of CXCL1 and CXCL2 (...) Matrix Remodeling Associated 7 Deficiency Alleviates Carbon Tetrachloride-Induced Acute Liver Injury in Mice Matrix remodeling associated 7 (MXRA7) was first noted to co-express with a group of matrix remodeling related genes, and its biological functions had remained unclear. In this study, we investigated the presumed function of MXRA7 in a carbon tetrachloride (CCl4)-induced acute liver injury model in mice. Wild-type, MXRA7-/- mice, and mice that were pulsed with hydrodynamic injection

2018 Frontiers in immunology

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