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Spitz Nevus

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1. Clinical and dermoscopic features of Spitz nevus by sex, age and anatomical site: a study of 913 Spitz naevi. (PubMed)

Clinical and dermoscopic features of Spitz nevus by sex, age and anatomical site: a study of 913 Spitz naevi. 29569227 2018 09 17 1365-2133 179 3 2018 Sep The British journal of dermatology Br. J. Dermatol. Clinical and dermoscopic features of Spitz naevus by sex, age and anatomical site: a study of 913 Spitz naevi. 769-770 10.1111/bjd.16564 Scalvenzi M M Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Via Pansini, 5

2018 British Journal of Dermatology

2. Mosaic pathogenic HRAS variant in a patient with nevus spilus with agminated Spitz nevi and parametrial-uterine rhabdomyosarcoma. (PubMed)

Mosaic pathogenic HRAS variant in a patient with nevus spilus with agminated Spitz nevi and parametrial-uterine rhabdomyosarcoma. 29193020 2019 02 19 1365-2133 178 3 2018 03 The British journal of dermatology Br. J. Dermatol. Mosaic pathogenic HRAS variant in a patient with nevus spilus with agminated Spitz nevi and parametrial-uterine rhabdomyosarcoma. 804-806 10.1111/bjd.16155 Nemeth K K Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, U.S.A. Szabo S S Division

2017 British Journal of Dermatology

3. Parallel ridge dermoscopic pattern in plantar atypical Spitz nevus. (PubMed)

Parallel ridge dermoscopic pattern in plantar atypical Spitz nevus. 28862772 2018 03 14 1468-3083 32 3 2018 Mar Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Parallel ridge dermoscopic pattern in plantar atypical Spitz nevus. e101-e102 10.1111/jdv.14575 Jurakić Tončić R R University Department of Dermatology and Venereology, School of Medicine, University Hospital Center, Zagreb, Croatia. Bradamante M M University Department of Dermatology

2017 Journal of the European Academy of Dermatology and Venereology

4. The diagnosis and management of the Spitz nevus in the pediatric population: a systematic review and meta-analysis protocol. (PubMed)

The diagnosis and management of the Spitz nevus in the pediatric population: a systematic review and meta-analysis protocol. Spitz nevi are uncommon melanocytic neoplasms found in children. Historically, the diagnosis and management of these tumors has lacked consensus among oncologists, pathologists, plastic surgeons, and dermatologists. Once interpreted and treated as a "juvenile melanoma", many have argued for the benignancy of such tumors in certain patient age groups, encouraging (...) will be used to assess differences between Spitz nevi and the tumor of comparison. Additionally, data extraction and summarization using tables will be performed. This review has been registered with PROSPERO (CRD42016034045).This review will systematically and comprehensively review diagnostic and management practices associated with the Spitz nevus. This overview of current literature will hopefully provide the foundation for future standardization of clinical practice.PROSPERO CRD42016034045.

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2017 Systematic reviews

5. THE FAST CLINICAL EVOLUTION OF A SPITZ NEVUS: THREE-YEAR FOLLOW-UP OF A CHILD (PubMed)

THE FAST CLINICAL EVOLUTION OF A SPITZ NEVUS: THREE-YEAR FOLLOW-UP OF A CHILD To report the clinical evolution and handling of a Spitz nevus, from its initial flat feature to becoming an irregular, nodular, reddish lesion.Female child, phototype II, with a small congenital nevus on the left lower limb and other sustained small nevi. The patient went through annual clinical and dermoscopic evaluations between the ages of three and seven, period during which the nevi located on the left thigh (...) grew rapidly. The clinical hypothesis was Spitz nevus, with indication of surgical removal with a safety margin and anatomopathological study. Considering patient's age and clinical/histological aspects, the diagnosis of Spitz nevus was confirmed.Initial globular pattern and size under 5 mm upon dermoscopy allowed clinical follow-up. However, onset of hyperchromia and rapid growing of the lesion, along with aesthetic concerns, possibility of trauma in the region, and risk of malignancy at puberty

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2017 Revista Paulista de Pediatria

6. Spitz Nevus

Spitz Nevus Spitz Nevus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Spitz Nevus Spitz Nevus Aka: Spitz Nevus , Benign Juvenile (...) Melanoma II. Epidemiology Most common in children III. Pathophysiology Not a cancer (named only for it's similarity of histology to ) Increased vascular supply gives the lesion its color IV. Signs less Red to red-brown dome-shaped s to s Variable surface (smooth to verrucous) Size varies from 0.3 to 1.5 cm Typically of sudden onset V. Management Excise due to histologic similarities to Alert pathologist to the gross examination findings suggestive of Spitz Nevus VI. Reference Habif (2003) Clinical

2018 FP Notebook

7. Atypical Spitz Tumor Arising on a Congenital Linear Plaque-Type Blue Nevus: A Case Report With a Review of the Literature on Plaque-Type Blue Nevus (PubMed)

Atypical Spitz Tumor Arising on a Congenital Linear Plaque-Type Blue Nevus: A Case Report With a Review of the Literature on Plaque-Type Blue Nevus The plaque-type blue nevus (PTBN) is a rare variant of blue nevus, of which only a few reports are described. A nodular growth within a preexistent PTBN should always alert to the possibility of malignant transformation. The authors report the first case of an atypical Spitz tumor arising on a congenital linear PTBN in a 60-year-old woman (...) . The diagnosis of "atypical Spitz tumor" is here used to describe a microscopic "gray zone" in which it is not possible to differentiate with adequate certainty between a Spitz nevus and a spitzoid melanoma. This report adds to and summarizes the small body of literature describing PTBN and discusses diagnostic and clinical implications.

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2015 The American Journal of dermatopathology

8. Clinico-Dermoscopic Features of Spitz Naevi by Age and Anatomic Site: A Study of 378 Spitz Naevi. (PubMed)

Clinico-Dermoscopic Features of Spitz Naevi by Age and Anatomic Site: A Study of 378 Spitz Naevi. 28346660 2018 08 28 2018 08 28 1365-2133 177 4 2017 10 The British journal of dermatology Br. J. Dermatol. Clinicodermoscopic features of Spitz naevi by age and anatomical site: a study of 378 Spitz naevi. e152-e153 10.1111/bjd.15501 de Mestier Y Y Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. Moscarella E E 0000-0001-5160-8997 Dermatology and Skin Cancer Unit (...) of Dermatology, Medical University of Graz, Graz, Austria. Hofmann-Wellenhof R R Department of Dermatology, Medical University of Graz, Graz, Austria. Argenziano G G Dermatology Unit, Second University of Naples, Naples, Italy. eng Letter Observational Study 2017 10 01 England Br J Dermatol 0004041 0007-0963 IM Adolescent Adult Age Distribution Aged Child Child, Preschool Dermoscopy Female Head and Neck Neoplasms epidemiology pathology Humans Infant Infant, Newborn Italy epidemiology Male Middle Aged Nevus

2017 British Journal of Dermatology

9. Spitz Nevus Arising in the Eyelid of a Teenager. (PubMed)

Spitz Nevus Arising in the Eyelid of a Teenager. A 16-year-old boy developed over a 2-month interval a lightly pigmented left upper eyelid lesion measuring 1.5 mm in greatest diameter that, when excised, microscopically was hypercellular and composed almost exclusively of nonpigmented epithelioid cells that created florid, large intraepidermal junctional nests and sheets and nests of subepidermal cells. The diagnosis was a Spitz nevus. HMB-45, MART-1, and microphthalmia-associated transcription (...) factor were all positive and established the melanocytic nature of the benign tumor. The Ki-67 proliferation index (5%) and 2 mitoses/mm(2) were both low; p16 protein was immunohistochemically identified in the nevoid cells. We review the clinical, histopathologic, and other immunohistochemical features of this entity and provide a brief differential diagnosis (including separation from a Spitzoid melanoma). This is only the third eyelid Spitz nevus reported in the literature and is the most fully

2015 Survey of Ophthalmology

10. Spitz Nevus on the Perianal Area of a Child: An Unusual Location (PubMed)

Spitz Nevus on the Perianal Area of a Child: An Unusual Location 26719661 2015 12 31 2018 11 13 1013-9087 27 6 2015 Dec Annals of dermatology Ann Dermatol Spitz Nevus on the Perianal Area of a Child: An Unusual Location. 787-8 10.5021/ad.2015.27.6.787 Lee Dong Yeup DY Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. Baek Jong Heon JH Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. Kim Dong

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2015 Annals of dermatology

11. Spitz Nevus (Treatment)

Spitz Nevus (Treatment) Spitz Nevus Treatment & Management: Surgical Care, Consultations, Activity Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1OTYyMy10cmVhdG1lbnQ= processing > Spitz Nevus Treatment (...) & Management Updated: Jan 08, 2018 Author: Zoltan Trizna, MD, PhD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Spitz Nevus Treatment Surgical Care Excision of lesions suspected of being Spitz nevi with histopathologic evaluation of the margins of the specimen is indicated. [ , ] Sentinel lymph node biopsy is not justified for surgical staging. [ ] Next: Consultations Consult a plastic surgeon or head and neck surgeon if the excision requires extensive repair. Previous

2014 eMedicine.com

12. Spitz Nevus (Overview)

Spitz Nevus (Overview) Spitz Nevus: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1OTYyMy1vdmVydmlldw== processing > Spitz Nevus Updated: Jan 08, 2018 Author: Zoltan (...) Trizna, MD, PhD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Spitz Nevus Overview Background Physicians have known for almost a century that some childhood lesions histologically diagnosed as did not show malignant behavior. The terms juvenile melanoma and prepubertal melanoma were used to describe such lesions. Several attempts were made to establish objective criteria that would clearly delineate Spitz nevi and melanomas. The controversial classification

2014 eMedicine.com

13. Spitz Nevus (Follow-up)

Spitz Nevus (Follow-up) Spitz Nevus Treatment & Management: Surgical Care, Consultations, Activity Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1OTYyMy10cmVhdG1lbnQ= processing > Spitz Nevus Treatment (...) & Management Updated: Jan 08, 2018 Author: Zoltan Trizna, MD, PhD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Spitz Nevus Treatment Surgical Care Excision of lesions suspected of being Spitz nevi with histopathologic evaluation of the margins of the specimen is indicated. [ , ] Sentinel lymph node biopsy is not justified for surgical staging. [ ] Next: Consultations Consult a plastic surgeon or head and neck surgeon if the excision requires extensive repair. Previous

2014 eMedicine.com

14. Spitz Nevus (Diagnosis)

Spitz Nevus (Diagnosis) Spitz Nevus: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA1OTYyMy1vdmVydmlldw== processing > Spitz Nevus Updated: Jan 08, 2018 Author: Zoltan (...) Trizna, MD, PhD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Spitz Nevus Overview Background Physicians have known for almost a century that some childhood lesions histologically diagnosed as did not show malignant behavior. The terms juvenile melanoma and prepubertal melanoma were used to describe such lesions. Several attempts were made to establish objective criteria that would clearly delineate Spitz nevi and melanomas. The controversial classification

2014 eMedicine.com

15. Nodular lesions arising in a large congenital melanocytic nevus in a newborn with eruptive disseminated spitz nevi (nodular lesions arising in a congenital melanocytic nevus and eruptive spitz nevi). (PubMed)

Nodular lesions arising in a large congenital melanocytic nevus in a newborn with eruptive disseminated spitz nevi (nodular lesions arising in a congenital melanocytic nevus and eruptive spitz nevi). Congenital malignant melanoma within a pre-existing large congenital melanocytic naevus (CMN) is exceedingly rare. Its incidence is difficult to determine due to the small number of reported cases and because of problems associated with diagnosis. Some benign nodular proliferations (called (...) proliferative nodules) arising in CMN, while rare, are significantly more common and can mimic malignant melanoma clinically or histologically. There are no reported cases of congenital melanoma or benign proliferative nodules in CMN in patients who also had eruptive disseminated Spitz naevi. We describe a girl who was noted to have a dark-brown plaque with several large erythematous nodules affecting the scalp at delivery, in addition to multiple erythematous dome-shaped papules that developed

2011 British Journal of Dermatology

16. Agminated Spitz naevi or metastatic spitzoid melanoma? (PubMed)

Agminated Spitz naevi or metastatic spitzoid melanoma? 29405264 2019 03 20 2019 03 20 1440-0960 59 3 2018 Aug The Australasian journal of dermatology Australas. J. Dermatol. Agminated Spitz naevi or metastatic spitzoid melanoma? e234-e235 10.1111/ajd.12781 van Kester Marloes Sophia MS http://orcid.org/0000-0001-9442-0898 Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands. Eggen Celine C Department of Dermatology, Erasmus Medical Center, Rotterdam (...) Melanoma pathology surgery Neoplasm Recurrence, Local pathology Neoplasms, Second Primary pathology Nevus, Epithelioid and Spindle Cell pathology surgery Positron-Emission Tomography methods Risk Assessment Sentinel Lymph Node Biopsy methods Skin Neoplasms pathology surgery 2018 2 7 6 0 2019 3 21 6 0 2018 2 7 6 0 ppublish 29405264 10.1111/ajd.12781 PMC6099432 Pathology. 2016 Feb;48(2):113-31 27020384 Lancet Oncol. 2014 Apr;15(4):e178-83 24694641 Pediatr Dermatol. 2013 Sep-Oct;30(5):e104-5 23278340 Am J

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2018 The Australasian journal of dermatology

17. Activating HRAS mutation in agminated Spitz nevi arising in a nevus spilus. (PubMed)

Activating HRAS mutation in agminated Spitz nevi arising in a nevus spilus. Spitz nevi are benign melanocytic proliferations that can sometimes be clinically and histopathologically difficult to distinguish from melanoma. Agminated Spitz nevi have been reported to arise spontaneously, in association with an underlying nevus spilus, or after radiation or chemotherapy. However, to our knowledge, the genetic mechanism for this eruption has not been described.We report a case of agminated Spitz (...) nevi arising in a nevus spilus and use exome sequencing to identify a clonal activating point mutation in HRAS (GenBank 3265) (c.37G→C) in the Spitz nevi and underlying nevus spilus. We also identify a secondary copy number increase involving HRAS on chromosome 11p, which occurs during the development of the Spitz nevi.Our results reveal an activating HRAS mutation in a nevus spilus that predisposes to the formation of Spitz nevi. In addition, we demonstrate a copy number increase in HRAS

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2013 JAMA dermatology (Chicago, Ill.)

18. Genomic Fusions in Pigmented Spindle Cell Nevus of Reed. (PubMed)

Genomic Fusions in Pigmented Spindle Cell Nevus of Reed. Recent molecular studies of spitzoid neoplasms have identified mutually exclusive kinase fusions involving ROS1, ALK, RET, BRAF, NTRK1, MET, and NTRK3 as early initiating genomic events. Pigmented spindle cell nevus (PSCN) of Reed is a morphologic variant of Spitz and may be very diagnostically challenging, having histologic features concerning for melanoma. Their occurrence in younger patients, lack of association to sun exposure (...) , and rapid early growth phase similar to Spitz nevi suggest fusions may also play a significant role in these lesions. However, to date, there is little data in the literature focused on the molecular characterization of PSCN of Reed with next-generation sequencing. We analyzed a total of 129 melanocytic neoplasms with RNA sequencing including 67 spitzoid neoplasms (10 Spitz nevi, 44 atypical Spitz tumors, 13 spitzoid melanomas) and 23 PSCN of Reed. Although only 2 of 67 (3.0%) of spitzoid lesions had

2018 American Journal of Surgical Pathology

19. Dermoscopy of a Spark’s nevus (PubMed)

Dermoscopy of a Spark’s nevus Spark's nevus is a particular type of melanocytic nevus that on histology shows features of both Spitz's and Clark's nevus. Clinically, it is an asymmetric, irregular, multicolored, pigmented lesion that is not clearly distinguishable from melanoma or dysplastic (Clark's) nevus. Dermoscopic features have not been described yet, and one could speculate that they are similar to those of Clark's nevi because the histopathologic architecture of Spark's nevus (...) is similar to that of a Clark's nevus, resembling Spitz's nevi in the epithelioid morphology of melanocytes. We present a 32-year-old woman with a Spark's nevus, who upon dermoscopy showed a pronounced atypical network with accentuation of the blue veil and mostly peripheral dots.

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2018 Dermatology practical & conceptual

20. Evolution of spitz nevi: A dermoscopic and confocal follow-up of 26 cases. (PubMed)

Evolution of spitz nevi: A dermoscopic and confocal follow-up of 26 cases. 27515761 2018 07 02 2018 07 02 1365-2133 176 4 2017 04 The British journal of dermatology Br. J. Dermatol. Evolution of Spitz naevi: a dermoscopic and confocal follow-up of 26 cases. 1098-1100 10.1111/bjd.14952 Ferrari C C Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy. Longo C C Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. Stanganelli I I (...) University of Naples, Naples, Italy. Ribero S S Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy. Moscarella E E Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, Italy. eng Letter 2017 02 07 England Br J Dermatol 0004041 0007-0963 IM Adolescent Child Child, Preschool Dermoscopy Disease Progression Female Follow-Up Studies Humans Infant Male Microscopy, Confocal Nevus, Epithelioid and Spindle Cell pathology Time Factors 2016 8

2016 British Journal of Dermatology

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