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Spine XRay in Osteoarthritis

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1. Characterisation of the correlation between standing lordosis and degenerative joint disease in the lower lumbar spine in women and men: a radiographic study. Full Text available with Trip Pro

Characterisation of the correlation between standing lordosis and degenerative joint disease in the lower lumbar spine in women and men: a radiographic study. Degenerative joint disease (DJD) in the lumbar spine is a common condition that is associated with chronic low back pain. Excessive loading of lumbar joints is a risk factor for DJD. Changes in lumbar lordosis significantly redistribute the forces of weight-bearing on the facet joints and the intervertebral discs. However (...) in older men.Both hypo- and hyper-lordosis correlate with DJD in the lumbar spine, particularly in women and in older men. These findings may well be of relevance to spinal pain management and spinal rehabilitation.

2017 BMC Musculoskeletal Disorders

2. Preoperative dual-energy X-ray absorptiometry and FRAX in patients with lumbar spinal stenosis Full Text available with Trip Pro

Preoperative dual-energy X-ray absorptiometry and FRAX in patients with lumbar spinal stenosis Osteoporosis implies an increased risk of complications after orthopedic surgery. For the mostly elderly group of patients undergoing lumbar spinal stenosis surgery (LSS), it is important to include skeletal health evaluation in the preoperative planning. The aim of this study was to assess spine and femoral neck (FN) bone mineral density (BMD) in LSS patients and to evaluate whether the World Health (...) Organization (WHO) fracture risk assessment tool (FRAX) can identify patients with reduced BMD levels in the spine.The study involved 65 LSS patients and 53 patients with hip osteoarthritis (HOA) for comparison. BMD was measured with dual-energy X-ray absorptiometry (DXA) in the lumbar spine in three projections: anterior-posterior (AP), lateral and lateral-mid (the mid-portion of the vertebrae), and FN. The LSS patients filled out the FRAX questionnaire.In the LSS group, 43% of the women and 8% of the men

2018 Journal of orthopaedic surgery and research

3. Spine XRay in Osteoarthritis

Spine XRay in Osteoarthritis Aka: Spine XRay in Osteoarthritis , Osteoarthritis Spine XRay II. Views Lateral Spine XRay Anteroposterior Spine XRay (AP Spine) III. Joints Affected spared in IV. Findings Less Joint space between superior and inferior facets Subchondral sclerosis Subchondral cyst formation Osteophyte formation Associated with neural foraminal narrowing V. References Brower (1998) Black and White, Saunders Klippel (1997) Primer Rheumatic Diseases, AF Images: Related links to external (...) Spine XRay in Osteoarthritis Spine XRay in Osteoarthritis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Spine XRay in Osteoarthritis

2018 FP Notebook

4. Associated Factors for Lumbar Degenerative Spondylolisthesis in Japanese Patients with Osteoarthritis of the Hip: A Radiographic Study Full Text available with Trip Pro

Associated Factors for Lumbar Degenerative Spondylolisthesis in Japanese Patients with Osteoarthritis of the Hip: A Radiographic Study Retrospective study.To determine the presence and frequency of factors for degenerative spondylolisthesis (DS) in patients with hip osteoarthritis (OA).OA of the hip joint (hip OA) in Japanese patients is associated with a high incidence of degenerative lumbar spondylolisthesis (DS). However the associated factors for DS in patients with hip OA are unclear.The (...) study included 518 patients (59 men and 459 women) with a mean age of 63.8 years who underwent total hip arthroplasty for hip OA at our hospital between January 2004 and May 2014. The presence of DS was assessed using preoperative standing lateral radiographs of the hip joint including the lower lumbar spine. To identify the associated factors for DS in patients with hip OA, multiple logistic regression analysis was conducted in which the presence or absence of DS was used as a dependent variable

2016 Asian spine journal

5. Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 5: Correlation between radiographic outcome and function

arthrodesis procedures performed in the treatment of lumbar spinal degenerative disease. Additional information regarding the methodologies and criteria used to evaluate the evidence discussed below is Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 5: Correlation between radiographic outcome and function Sanjay S. Dhall , M.D., 1 Tanvir F. Chou Dhri , M.D., 2 j a Son C. ECk , D.o ., M.S., 3 MiCha El W. Gro FF, M.D., 4 Zoh Er Gho GaWala , M.D (...) Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 5: Correlation between radiographic outcome and function J Neurosurg Spine 21:31–36, 2014 31 ©AANS, 2014 J Neurosurg: Spine / Volume 21 / July 2014 Recommendations Grade B When performing lumbar arthrodesis for degenera- tive lumbar disease, strategies to achieve successful ra- diographic fusion should be considered, as there appears to be a correlation between successful fusion and im

2014 Congress of Neurological Surgeons

6. Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 4: Radiographic assessment of fusion status

scanning. R a d io lo g y 162:803–805, 1987 9. Cleveland M, Bosworth DM, Thompson FR: Pseudarthrosis in the lumbosacral spine. J Bone Joint Surg Am 30A:302– 312, 1948 10. Fogel GR, Toohey JS, Neidre A, Brantigan JW: Fusion assess- ment of posterior lumbar interbody fusion using radiolucent cages: X-ray films and helical computed tomography scans compared with surgical exploration of fusion. Spine J 8:570– 577, 2008 11. Hilibrand AS, Dina TS: The use of diagnostic imaging to as- sess spinal arthrodesis (...) Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 4: Radiographic assessment of fusion status J Neurosurg Spine 21:23–30, 2014 23 ©AANS, 2014 J Neurosurg: Spine / Volume 21 / July 2014 Recommendations There is no evidence that conflicts with the previous recommendations in the original version of the “Guide- lines for the performance of fusion procedures for degen- erative disease of the lumbar spine.” Grade A Following lumbar fusion

2014 Congress of Neurological Surgeons

7. Sagittal alignment and mobility of the thoracolumbar spine are associated with radiographic progression of secondary hip osteoarthritis. Full Text available with Trip Pro

Sagittal alignment and mobility of the thoracolumbar spine are associated with radiographic progression of secondary hip osteoarthritis. To identify predictors of radiographic progression of hip osteoarthritis (OA) over 12 months among functional hip impairments and spinal alignment and mobility.Fifty female patients with secondary hip OA, excluding those with end-stage hip OA, participated in this prospective cohort study. Joint space width (JSW) of the hip was measured at baseline and 12 (...) months later. With radiographic progression of hip OA over 12 months (>0.5 mm in JSW) as dependent variable, logistic regression analyses were performed to identify predictors for hip OA progression among functional impairments of the hip and spine with and without adjustment for age, body mass index (BMI), and minimum JSW at baseline. The independent variables were hip pain, Harris hip score (HHS), hip morphological parameters, hip passive range of motion (ROM) and muscle strength, and alignment

2017 Osteoarthritis and Cartilage

8. Lumbosacral Spine XRay

Spine Intervertebral foramen Intervertebral disc space height shortening Lumbosacral disc disease (degenerative) (anterior slippage of L5 on S1) V. Views: Specific (typically low yield) Oblique L-S Spine (tube angled at 45 degrees) Neural foramina narrowing Spinal tumor Facet hypertrophy Flexion and extension views Used to assess ligamentous and bony injury Contraindications Other XRay abnormalities are present VI. References Images: Related links to external sites (from Bing) These images (...) are a random sampling from a Bing search on the term "Lumbosacral Spine XRay." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Diagnostic radiography of lumbar spine (C0203170) Concepts Diagnostic Procedure ( T060 ) SnomedCT 145770005 , 145764004 , 168570001 , 90805008 English Lumbar spine X-ray , Lumbar spine X-ray (procedure) , x-ray lumbar spine (procedure) , x-ray lumbar spine , Diagnostic radiography of lumbar spine

2018 FP Notebook

9. Candidate gene investigation of spinal degenerative osteoarthritis in greek population. (Abstract)

Candidate gene investigation of spinal degenerative osteoarthritis in greek population. Few data exist concerning the natural history of degenerative osteoarthritis (OA) of the spine and its associated gene investigation. Degenerative spinal OA demonstrates an international prevalence of 15% in the general population.The aim of this Greek case-control study is to examine gene polymorphisms that have been previously shown or hypothesized to be correlated to degenerative OA. Gene polymorphisms (...) degenerative OA and 243 control subjects (138 women and 105 men).All patients presented with chronic pain at the spine (cervical, thoracic or lumbar) caused by sympomatic osteophytes or disc narrowing, whereas clinical diagnosis of OA was based on the presence of both joint symptoms and evidence of structural changes seen on plain conventional X-rays.We investigated genetic variation across candidate OA gene GDF5, CDMP1, CDMP2, Asporin, SMAD3, and chromosomal region 7q22, in a sample of 258 patients

2017 The Spine Journal

10. Evaluation of X-ray, Acetabular Guides and CT in THR

to the patient's surgery, a CT scan of the patient's pelvis & legs is performed, and the images are used to produce a 3D computer model of the patient as they stand with a "virtual" hip replacement in place. Four additional X-rays of the pelvis and lumbar spine are also taken, with the patient adopting various predetermined "functional" positions (e.g. sitting in a chair, about to stand up). From these X-rays, the changes in the pelvic and femoral orientations can be measured for these functional positions (...) of total hip replacement. Condition or disease Intervention/treatment Phase Total Hip Replacement Device: Corin OPS™ Other: 2D X-ray templating technology Not Applicable Detailed Description: Total hip replacement is one of the most successful surgical procedures of modern times, with over 80,000 performed each year in the UK. The vast majority of patients experience dramatic pain relief and improvement in function for many years. Despite this, however, there remains a significant risk of complications

2017 Clinical Trials

11. Predicting incident radiographic knee osteoarthritis in middle-aged women within 4 years: the importance of knee-level prognostic factors. (Abstract)

Predicting incident radiographic knee osteoarthritis in middle-aged women within 4 years: the importance of knee-level prognostic factors. Develop and internally validate risk models and a clinical risk score tool to predict incident radiographic knee osteoarthritis (RKOA) in middle-aged women.We analysed 649 women in the Chingford 1000 Women study. The outcome was incident RKOA, defined as Kellgren/Lawrence grade 0-1 at baseline and ≥2 at year 5. We estimated predictors' effects on the outcome (...) contained age, quadriceps circumference, and a cartilage degradation marker (CTX-II) as predictors (AUC = 0.692). The radiographic model contained older age, greater quadriceps circumference, knee pain, knee baseline Kellgren/Lawrence grade 1 (versus 0), greater hip α-angle, greater spinal bone mineral density, and contralateral RKOA at baseline as predictors (AUC = 0.797). Calibration tests showed good agreement between the observed and predicted incident RKOA. A clinical risk score tool was developed

2019 Arthritis care & research

12. Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden. Full Text available with Trip Pro

Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden. Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum levels of type IIA procollagen amino terminal propeptide (sPIIANP), a biomarker representing type II collagen synthesis, in osteoarthritis.OA burden was quantified on the basis of radiographic features as total joint faces (...) with an osteophyte, joint space narrowing, or in the spine, disc space narrowing. sPIIANP was measured in 1,235 participants from the Genetics of Generalized Osteoarthritis study using a competitive enzyme-linked immunosorbent assay. Separate multivariable linear regression models, adjusted for age, sex, and body mass index and additionally for ipsilateral osteophytes or joint/disc space narrowing, were used to assess the independent association of sPIIANP with osteophytes and with joint/disc space narrowing

2017 PLoS ONE

13. Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study Full Text available with Trip Pro

Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and its relationship with knee, hip, and lumbar spine OA by race (African American vs. Caucasian).Data were from the Johnston County OA project, collected 2003-2010 (...) . GJH was defined as Beighton score ≥4. OA symptoms were defined as the presence of pain, aching, or stiffness on most days separately at the knee, hip, and lower back. Radiographic OA (rOA) of the knee or hip was defined as Kellgren-Lawrence grade 2-4. Lumbar spine rOA was disc space narrowing grade ≥1 and osteophyte grade ≥2 in ≥ 1 at the same lumbar level. Lumbar spine facet rOA was present in ≥ 1 lumbar levels. Separate logistic regression models stratified by race were used to examine

2018 Arthritis research & therapy

14. Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: The Johnston County Osteoarthritis Project. Full Text available with Trip Pro

Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: The Johnston County Osteoarthritis Project. To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA.A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels (...) discs that contain collagen type II, was associated with a marker reflecting collagen type II degradation (CTX-II). These findings suggest that biomarkers may reflect the different pathophysiologic processes of lumbar spine OA phenotypes.Copyright © 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

2017 Osteoarthritis and Cartilage

15. Increasing the cervical and lumbar lordosis is possible despite overt osteoarthritis and spinal stenosis using extension traction to relieve low back and leg pain in a 66-year-old surgical candidate: a CBP® case report Full Text available with Trip Pro

demonstrated significant reduction of low back pain, leg pain and other health improvements. X-rays showed structural improvements in the cervical and lumbar spine despite advanced osteoarthritis. [Conclusion] Lumbar and cervical hypolordosis subluxation may be increased in those with spinal deformity caused symptoms, despite the presence of osteoarthritis and degenerative stenosis of the spine. Spinal x-rays as used in the assessment and monitoring of patients being treated with contemporary spinal (...) Increasing the cervical and lumbar lordosis is possible despite overt osteoarthritis and spinal stenosis using extension traction to relieve low back and leg pain in a 66-year-old surgical candidate: a CBP® case report [Purpose] To present the case of the dramatic relief of low back pain, leg pain and disability in an older female with osteoarthritis, lumbar spinal stenosis and hypolordosis of the cervical and lumbar spine. [Participant and Methods] A 66-year-old female presented with chronic

2018 Journal of physical therapy science

16. Hidden osteophyte formation on plain x-ray is the predictive factor for development of knee osteoarthritis after 48 months - data from the Osteoarthritis Initiative. Full Text available with Trip Pro

Hidden osteophyte formation on plain x-ray is the predictive factor for development of knee osteoarthritis after 48 months - data from the Osteoarthritis Initiative. To examine whether the detection of osteophytes anywhere in the knee could serve as a pre-radiographic biomarker for osteoarthritis (OA) development.Baseline magnetic resonance imaging (MRIs) of 132 participants in the Osteoarthritis Initiative (OAI) were studied. Based on radiographs, 66 knees were assessed as osteoarthritis-free (...) (no-osteoarthritis [NOA], or Kellgren/Lawrence [K/L] severity grade 0/1 both at baseline and 48 months), and another 66 knees were assessed as having radiographic OA changes (pre-radiographic osteoarthritis [PROA], or with K/L grade 0/1 at baseline and grade ≥ 2 at 48 months). Using baseline MRI data, we examined eight sites of osteophyte formation: the medial and lateral femoral condyle (MFC and LFC, respectively); medial and lateral tibial plateau (MTP and LTP, respectively); medial and lateral facets

2014 Osteoarthritis and Cartilage

17. Sagittal alignment of the spine-pelvis-lower extremity axis in patients with severe knee osteoarthritis: A radiographic study Full Text available with Trip Pro

in the pathogenesis of LBP in this patient population.Cite this article: W. J. Wang, F. Liu, Y.W. Zhu, M.H. Sun, Y. Qiu, W. J. Weng. Sagittal alignment of the spine-pelvis-lower extremity axis in patients with severe knee osteoarthritis: A radiographic study. Bone Joint Res 2016;5:198-205. DOI:10.1302/2046-3758.55.2000538.© 2016 Weng et al. (...) Sagittal alignment of the spine-pelvis-lower extremity axis in patients with severe knee osteoarthritis: A radiographic study Normal sagittal spine-pelvis-lower extremity alignment is crucial in humans for maintaining an ergonomic upright standing posture, and pathogenesis in any segment leads to poor balance. The present study aimed to investigate how this sagittal alignment can be affected by severe knee osteoarthritis (KOA), and whether associated changes corresponded with symptoms of lower

2016 Bone & joint research

18. A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis of the Lumbar Spine

, Week 20, and Week 52 ] To evaluate change at Week 20 and 52 in degenerative changes (the worst vertebral level) in lumbar spinal discs in subjects with OA of the lumbar spine as measured by the modified Pfirrmann scoring by magnetic resonance imaging (3D qMRI). Modic Change measured by magnetic resonance imaging (3D qMRI) [ Time Frame: Screening visit, Week 20, and Week 52 ] To evaluate change at Week 20 and 52 in Modic Change in subjects with OA of the lumbar spine as measured by magnetic (...) with Osteoarthritis of the Lumbar Spine. To evaluate the efficacy of X0002 spray compared to placebo for the relief of low back pain disability in subjects with osteoarthritis (OA) of the low back. Condition or disease Intervention/treatment Phase Osteoarthritis of the Lumbar Spine Drug: X0002 Drug: Placebo Phase 3 Detailed Description: After a Screening Period, a subject will be randomly assigned to 1 of 2 treatment groups in a 2:1 ratio of active: placebo (ie, 2 subjects to active treatment and 1 subject

2017 Clinical Trials

19. Spine XRay in Osteoarthritis

Spine XRay in Osteoarthritis Aka: Spine XRay in Osteoarthritis , Osteoarthritis Spine XRay II. Views Lateral Spine XRay Anteroposterior Spine XRay (AP Spine) III. Joints Affected spared in IV. Findings Less Joint space between superior and inferior facets Subchondral sclerosis Subchondral cyst formation Osteophyte formation Associated with neural foraminal narrowing V. References Brower (1998) Black and White, Saunders Klippel (1997) Primer Rheumatic Diseases, AF Images: Related links to external (...) Spine XRay in Osteoarthritis Spine XRay in Osteoarthritis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Spine XRay in Osteoarthritis

2015 FP Notebook

20. A Safety, Tolerability, Pharmacokinetics (PK) and Target Engagement Study in Healthy Volunteers and Subjects With Osteoarthritis (OA)

(defined as acute episodic attacks of swollen, painful joint in a subject with X-Ray chondrocalcinosis or calcium pyrophosphate dehydrate [CPPD] crystals). b) History of gout or pseudogout in any large joint. c) History or evidence of infectious arthritis, Paget's disease, ochronosis, Wilson's disease, primary osteochondromatosis, osteonecrosis and other causes of significant joint disease osteoarthritis as determined by the investigator. d) History of major trauma to the index joint. e) History (...) of fibromyalgia. f) Current immunodeficiency diseases g) Current osteoporosis with symptomatic vertebral or hip fractures. h) Current regional pain syndromes caused by lumbar or cervical compressions with radiculopathy. i) History of significant medical illness in the opinion of the investigator would interfere with the study procedures and / or assessments. j) History of injury in the index knee within 6 months prior to signing informed consent. k) Significant pain in any joint other than the index knee

2018 Clinical Trials

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