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Spinal Shock

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161. Extracorporeal Shock Wave Therapy for Painful Chronic Neurogenic Heterotopic Ossification After Traumatic Brain Injury: A Case Report Full Text available with Trip Pro

Extracorporeal Shock Wave Therapy for Painful Chronic Neurogenic Heterotopic Ossification After Traumatic Brain Injury: A Case Report Neurogenic heterotopic ossification (NHO) is a process of benign bone formation and growth in soft tissues surrounding major synovial joints and is associated with central nervous system (CNS) injuries. It is a common complication in major CNS injuries, such as traumatic brain injury, spinal cord injury, and stroke. Here, we report the case of a 72-year-old male (...) , who experienced a traumatic brain injury and painful chronic NHO around the left hip joint. Three applications of extracorporeal shock wave therapy (ESWT) were administered to the area of NHO, which resulted in pain relief and an improvement in the loss of motion in the left hip joint. Improvements were also noted in walking performance and activities of daily living, although the size of NHO remained unchanged. Therapeutic effects of ESWT lasted for 12 weeks.

2015 Annals of rehabilitation medicine

162. Sensory Symptom Profiles of Patients with Neuropathic Pain after Spinal Cord Injury. (Abstract)

Sensory Symptom Profiles of Patients with Neuropathic Pain after Spinal Cord Injury. Individuals experiencing neuropathic pain (NP) after spinal cord injury (SCI) present with a variety of pain descriptors in different combinations and at different intensities. These sensory features form distinct patterns, known as sensory symptom profiles.In the present cross-sectional study, we have used a multivariate statistical method (multiple correspondence analysis) to categorize the sensory symptom (...) with at-level and below-level NP. The most frequent pattern observed in patients with cervical SCI consisted predominantly of electric shocks and tingling, without burning, pressure pain, or allodynia.Classification of SCI-NP patients into the 5 groups identified in the present study based on their distinct sensory symptom profiles may allow identification of those most likely to respond to a specific analgesic approach.

2016 Clinical Journal of Pain

163. Spinal Epidural Hematoma Due To Tyre Blast Injury: A Case Report. (Abstract)

Spinal Epidural Hematoma Due To Tyre Blast Injury: A Case Report. A retrospective case report.The objective of this article is to report a spinal epidural hematoma (SEH) due to shock wave.SEH is an infrequent condition. Most of SEH's are spontaneous. We have reported an SEH traumatic case without bone lesions due to exploding truck tire. A different category of blast injuries is the one related with exploding tyres. Shock waves are the main mechanism that is responsible for blast injuries. We (...) are presenting the first report of acute SEH due to shock wave.A 33-year-old man was brought to the emergency department with complaints of weakness and numbness of the upper extremities. There was an epidural high-signal density without osseous lesion in computerized tomography from the level of C2 to C5, and there was a T2-weighted hyperintense lesion in magnetic resonance imaging from the level of C2 to C5 with compression of the spinal cord the anterior and posterior which proved to be an SEH.The patient

2016 Spine

164. Does pain catastrophizing contribute to threat-evoked amplification of pain and spinal nociception? Full Text available with Trip Pro

Does pain catastrophizing contribute to threat-evoked amplification of pain and spinal nociception? Unpredictable threat amplifies pain and spinal nociception (as measured by the nociceptive flexion reflex, NFR), but it is unknown whether pain catastrophizing mediates this threat-related amplification. To examine this, the present study experimentally reduced catastrophizing and examined the effect on threat-evoked pain/NFR facilitation. Healthy pain-free participants (N = 113) were randomly (...) assigned to a brief 30-minute intervention designed to reduce catastrophic thoughts or a control intervention that involved education about pain neurobiology. Before the interventions, participants underwent a block of 8 pseudorandomly ordered periods of safe (no abdominal shock) and threat (abdominal shock possible) during which pain and NFR were evoked by electric stimulations to the ankle. After the safe/threat periods, participants rated pain intensity, pain unpleasantness, and situation-specific

2016 Pain Controlled trial quality: uncertain

165. Allicin protects traumatic spinal cord injury through regulating the HSP70/Akt/iNOS pathway in mice Full Text available with Trip Pro

Allicin protects traumatic spinal cord injury through regulating the HSP70/Akt/iNOS pathway in mice Allicin is a major component of garlic, extracted as an oily liquid. The present study was designed to investigate the beneficial effects of allicin on traumatic spinal cord injury (TSCI) in mice, and whether the effects are mediated via regulation of the heat shock protein 70 (HSP70), v‑akt murine thymoma viral oncogene homolog 1 (Akt) and inducible nitric oxide synthase (iNOS) pathways. Adult (...) BALB/c mice (30‑40 g) received a laminectomy at the T9 vertebral level as a model of TSCI. In the present study, treatment of the TSCI mice with allicin significantly increased their Basso, Beattie and Bresnahan (BBB) scores (P<0.01) and reduced the spinal cord water content (P<0.01). This protective effect was associated with the inhibition of oxidative stress and inflammatory responses in TSCI mice. Western blot analysis demonstrated that allicin increased the protein levels of HSP70, increased

2016 Molecular medicine reports

166. Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons Full Text available with Trip Pro

Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons Spinal cord injury (SCI) is a debilitating disease, effective prevention measures are in desperate need. Our previous work found that hyperbaric oxygen (HBO) preconditioning significantly protected rats from SCI after stimulated diving, and in vitro study further testified that HBO protected primary cultured rat spinal neurons from oxidative insult and oxygen glucose deprivation injury via heat shock

2016 Redox biology

167. Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration Full Text available with Trip Pro

. TSC1 treatment for 4 and 8 h increased the number of nestin-expressing cells around the lesion site and prevented Wallerian degeneration. Treatment with TSC1 for 4 h significantly increased heat shock protein (HSP)-32 and HSP-70 expression 1 and 2 mm from lesion site (both, caudal and rostral). Conversely, the number of HSP-32 positive cells decreased after an 8-h TSC1 treatment, although it was still higher than in both, non-treated SCI and intact spinal cord animals. Furthermore, TSC1 increased (...) Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration Trophic factor treatment has been shown to improve the recovery of brain and spinal cord injury (SCI). In this study, we examined the effects of TSC1 (a combination of insulin-like growth factor 1 and transferrin) 4 and 8 h after SCI at the thoracic segment level (T12) in nestin-GFP transgenic mice

2016 Neurochemical Research

168. Vasopressor administration in spinal cord injury: should we apply a universal standard to all injury patterns? Full Text available with Trip Pro

Vasopressor administration in spinal cord injury: should we apply a universal standard to all injury patterns? 27127478 2016 04 29 2018 11 13 1673-5374 11 3 2016 Mar Neural regeneration research Neural Regen Res Vasopressor administration in spinal cord injury: should we apply a universal standard to all injury patterns? 420-1 10.4103/1673-5374.179051 Readdy William J WJ Department of Neurological Surgery, University of California, San Francisco, CA, USA; Robert Wood Johnson Medical School, New (...) Brunswick, NJ, USA. Dhall Sanjay S SS Department of Neurological Surgery, University of California, San Francisco, CA, USA. eng Journal Article India Neural Regen Res 101316351 1673-5374 2016 4 30 6 0 2016 4 30 6 0 2016 4 30 6 1 ppublish 27127478 10.4103/1673-5374.179051 NRR-11-420 PMC4829004 Neural Regen Res. 2015 Mar;10(3):380-2 25878583 J Neurosurg. 1997 Aug;87(2):239-46 9254087 J Emerg Trauma Shock. 2015 Apr-Jun;8(2):94-8 25949039 J Neurotrauma. 2015 Dec 15;32(24):1958-67 25669633 PLoS One. 2012;7(2

2016 Neural Regeneration Research

169. Pan-spinal infection: a case series and review of the literature Full Text available with Trip Pro

Pan-spinal infection: a case series and review of the literature Panspinal infection usually presents with fever, back pain, neurological deficit, and in advanced cases multi-organ failure and septic shock. The choice of treatment for panspinal infection is challenging because these patients are usually medically unstable with severe neurological compromise. The objective of this study is to review management and long term outcomes for patients with panspinal infection.A retrospective review

2016 Journal of Spine Surgery

170. Ultrasonic measurement of rectal diameter and area in neurogenic bowel with spinal cord injury Full Text available with Trip Pro

in this study. We divided the patients by the type of neurogenic bowel: UMNB, patients with supraconal lesions and recovery state of spinal shock or LMNB, patients with infraconal/caudal lesions or spinal shock state).Ultrasound was applied on the abdomen and measured the diameter and area of the rectum were measured twice each before and after defecation, respectively.We compared rectal diameter and area before/after defecation between the two groups, and significant differences were found in both rectal (...) Ultrasonic measurement of rectal diameter and area in neurogenic bowel with spinal cord injury The aim of this study was to determine the efficacy of measuring the diameter and area of the rectum using ultrasonography as an additional parameter for the evaluation of neurogenic bowel in patients with spinal cord injury (SCI).In total, 32 patients with SCI (16 patients with upper motor neuron neurogenic bowel (UMNB) and 16 patients with lower motor neuron neurogenic bowel (LMNB)) participated

2016 The journal of spinal cord medicine

171. Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass

Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02840006 Recruitment Status : Completed First Posted : July 21, 2016 Last Update Posted : July 21, 2016 Sponsor: Daniel Gioielli de Castilho Information provided

2016 Clinical Trials

172. Safety and Preliminary Efficacy of FAB117-HC in Patients With Acute Traumatic Spinal Cord Injury

or more studies before adding more. Safety and Preliminary Efficacy of FAB117-HC in Patients With Acute Traumatic Spinal Cord Injury (SPINE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02917291 Recruitment Status (...) Therapy ATMP HC016 adipose mesenchymal stem cell SPINE Additional relevant MeSH terms: Layout table for MeSH terms Wounds and Injuries Spinal Cord Injuries Spinal Cord Diseases Central Nervous System Diseases Nervous System Diseases Trauma, Nervous System

2016 Clinical Trials

173. The Influence of Insurance Status on the Surgical Treatment of Acute Spinal Fractures. Full Text available with Trip Pro

SCI, and the presence of ligamentous and other associated injuries. It is poorly understood how nonclinical factors, such as insurance status, influence the decision for surgical intervention in patients sustaining spinal trauma.Using NTDB admission years 2008 to 2011, we included patients 18 to 64 years old who sustained a fracture of the cervical or thoracolumbar spine. Patients were excluded if they sustained polytrauma (Injury Severity Score ≥27) or a major injury (Abbreviated Injury Scale (...) The Influence of Insurance Status on the Surgical Treatment of Acute Spinal Fractures. A retrospective, propensity score, multivariate analysis of the National Trauma Data Bank (NTDB) between 2008 and 2011.The aim of this study was to determine the relationship between insurance status and rates of surgery for acute spinal fractures with and without spinal cord injury (SCI).The decision for surgery in patients with spinal fractures is often based on fracture pattern and stability, associated

2015 Spine

174. Spinal Cord Infarct During Concomitant Circulatory Support With Intra-Aortic Balloon Pump and Veno-Arterial Extracorporeal Membrane Oxygenation. (Abstract)

with neurologic injury of the lower limbs.Three female patients presented in cardiogenic shock or arrest requiring circulatory support. Intra-aortic balloon pump was inserted, and peripheral veno-arterial extracorporeal membrane oxygenation was initiated with subsequent loss of native ejection in each case. Neurologic signs were noted clinically, and subsequent imaging demonstrated spinal cord infarction and small aortic size for all three patients.The timeline of events suggests a causal relation between (...) Spinal Cord Infarct During Concomitant Circulatory Support With Intra-Aortic Balloon Pump and Veno-Arterial Extracorporeal Membrane Oxygenation. To report a series of three patients who received simultaneous circulatory support with both veno-arterial extracorporeal membrane oxygenation and intra-aortic balloon pump and subsequently developed spinal cord infarction, and present a brief review of the relevant literature.Hospital medical records and MEDLINE and PubMed databases.Any patient who

2015 Critical Care Medicine

175. Respiratory Motor Control and Blood Pressure Regulation After Spinal Cord Injury

interfere with RMT; no clinically significant depression, psychiatric disorders or ongoing drug abuse; clear indications that the period of spinal shock is concluded determined by presence of muscle tone, deep tendon reflexes or muscle spasms; no current anti-spasticity medication regimen; non-progressive C3-T5 American Spinal Cord Injury Association Designation of A-D SCI; not ventilator dependent for respiration; sustained SCI at least 6 months prior to entering the study; at least 15%-deficit (...) Respiratory Motor Control and Blood Pressure Regulation After Spinal Cord Injury Respiratory Motor Control and Blood Pressure Regulation After Spinal Cord Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2015 Clinical Trials

176. Spinal Anesthesia in a Patient With a History of Systemic Capillary Leak Syndrome (Clarkson Disease). (Abstract)

Spinal Anesthesia in a Patient With a History of Systemic Capillary Leak Syndrome (Clarkson Disease). The aim of this study was to review the relative risks, benefits, and anesthetic considerations of neuraxial, regional, and general anesthesia in a patient with known systemic capillary leak syndrome (SCLS) who presents for elective total knee replacement.Systemic capillary leak syndrome (or Clarkson disease) is a rare disorder involving endothelial dysfunction of uncertain pathogenesis (...) characterized by the development of hypotension, hemoconcentration, and hypoalbuminemia in the absence of secondary causes of shock. Literature regarding the anesthetic management of such patients is extremely sparse. To date, all published cases involved those who experienced exacerbations preoperatively, intraoperatively, or postoperatively. There are no reports pertaining to the anesthetic management of patients with a history of the disease who are under remission. We present a case report of a patient

2015 Regional Anesthesia and Pain Medicine

177. Autologous Mesenchymal Stem Cells Transplantation in Cervical Chronic and Complete Spinal Cord Injury

summary and culture; Serology required for blood transfusion and marrow transplant in Brazil; Electrocardiogram; Chest X-Ray; Bone densitometry; Urodynamic studies; Somatosensory evoked potential; Computed tomography of thoracic and lumbar spine; Magnetic resonance imaging of the thoracic and lumbar spine. Also as part of the preoperative evaluation, the patients will respond to questions from the SF (Short Form) -36 questionnaire (for assessment of quality of life) and the questionnaires (...) Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Blunt spinal cord injury at cervical level, between C5 and C7, or penetrating spinal cord injury, at the same level, provided that the mechanism of injury had been spinal shock, ischemia or hematoma, with at least 12 months of injury; ASIA grade A; Signing of the written consent. Exclusion Criteria: Spinal cord injuries by sharp objects, firearms, and not traumatic or congenital causes, even if at different levels of the spinal cord

2015 Clinical Trials

178. Spinal cord injury: Incidence, prognosis and outcome - an analysis of the TraumaRegister DGU<sup>®</sup>. (Abstract)

five (7.5%) of 57,310 patients sustained SCI. Mean age was 48.9±20.7 years, ISS 28.0±12, and 72.7% were men. Two thousand two hundred twenty two (3.9%) SCIs involved the cervical, 1,388 (2.4%) the thoracic, and 791 (1.4%) the lumbar spine. One hundred fifty-nine (7.2%) cervical spine injuries were associated with transient neurologic deficit (TND) (AIS 3), 612 (27.5%) with an incomplete paraplegia (AIS 4), 1,101 (49.6%) with a complete paraplegia (AIS 5), and 350 (15.8%) with a complete lesion (...) above C3 (AIS 6). Lesions of the thoracic spine showed in 93 (6.7%) of the 1,388 lesions a TND (AIS 3), in 332 (23.9%) an incomplete paraplegia (AIS 4), and in 963 (69.4%) a complete lesion (AIS 5). In the lumbar region, lesions were distributed as follows: TND (AIS 3) 145 (18.3%), incomplete paraplegia (AIS 4) 305 (38.6%), and complete lesion 341 (43.1%). Sepsis and multiorgan failure were found more often in patients with AIS 5/6 lesions (p<.001). The hospital length of stay in SCIs

2015 The Spine Journal

179. Inhibition of micro-ribonucleic acid-320 attenuates neurologic injuries after spinal cord ischemia. Full Text available with Trip Pro

-shock protein 20 (phospho-Hsp20) in the spinal cord were evaluated by quantitative real-time polymerase chain reaction and western blot analysis.The time courses of expressions of miR-320 and phospho-Hsp20 in the spinal cord, after the transient ischemia, indicated that expression of phospho-Hsp20 was negatively correlated with expression of miR-320. Transfection of antagomiR-320 significantly reduced expression of miR-320 in the spinal cord and dramatically up-regulated expression of phospho-Hsp20 (...) . Compared with controls, inhibition of miR-320 markedly improved hind-limb motor function, as evidenced by lower MDI scores, at 6, 12, 24, and 48 hours after reperfusion, and increased the number of intact motor neurons in the lumbar spinal cord.Inhibition of miR-320 induces neuroprotection in the spinal cord, against ischemia-reperfusion injury, possibly via up-regulation of phospho-Hsp20.Copyright © 2015 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

2015 Journal of Thoracic and Cardiovascular Surgery

180. Is temporal summation of pain and spinal nociception altered during normal aging? Full Text available with Trip Pro

Is temporal summation of pain and spinal nociception altered during normal aging? This study examines the effect of normal aging on temporal summation (TS) of pain and the nociceptive flexion reflex (RIII). Two groups of healthy volunteers, young and elderly, received transcutaneous electrical stimulation applied to the right sural nerve to assess pain and the nociceptive flexion reflex (RIII-reflex). Stimulus intensity was adjusted individually to 120% of RIII-reflex threshold, and shocks were

2015 Pain

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