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Spinal Shock

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141. Respiratory Motor Control and Blood Pressure Regulation After Spinal Cord Injury

interfere with RMT; no clinically significant depression, psychiatric disorders or ongoing drug abuse; clear indications that the period of spinal shock is concluded determined by presence of muscle tone, deep tendon reflexes or muscle spasms; no current anti-spasticity medication regimen; non-progressive C3-T5 American Spinal Cord Injury Association Designation of A-D SCI; not ventilator dependent for respiration; sustained SCI at least 6 months prior to entering the study; at least 15%-deficit (...) Respiratory Motor Control and Blood Pressure Regulation After Spinal Cord Injury Respiratory Motor Control and Blood Pressure Regulation After Spinal Cord Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2015 Clinical Trials

142. Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position

Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results (...) information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study

2015 Clinical Trials

143. Spinal cord injury: Incidence, prognosis and outcome - an analysis of the TraumaRegister DGU<sup>®</sup>. (PubMed)

injury, shock on scene, and severity of injury (ISS per point).Spinal cord injury with a neurologic deficit could be found in every 13th patient with polytrauma. Over half of the patients with SCI suffer from complete cord lesion. In polytrauma patients, SCI only has a limited influence on the mortality, with exception of AIS 6 lesions. Complications such as multiorgan failure or sepsis and extended hospital length of stay are more frequent in SCI.Copyright © 2015 Elsevier Inc. All rights reserved. (...) Spinal cord injury: Incidence, prognosis and outcome - an analysis of the TraumaRegister DGU®. Little is known about the incidence of spinal cord injury (SCI) in polytrauma patients.The purpose of this study was to analyze incidence, prognosis, and outcome of SCI in polytrauma patients.This is a retrospective multicenter cohort study.A total of 57,310 patients of TraumaRegister DGU (2002-2012) of the German Trauma Society were included. Aim of this large multicentre database

2015 The Spine Journal

144. Preconditioning crush increases the survival rate of motor neurons after spinal root avulsion (PubMed)

Preconditioning crush increases the survival rate of motor neurons after spinal root avulsion In a previous study, heat shock protein 27 was persistently upregulated in ventral motor neurons following nerve root avulsion or crush. Here, we examined whether the upregulation of heat shock protein 27 would increase the survival rate of motor neurons. Rats were divided into two groups: an avulsion-only group (avulsion of the L4 lumbar nerve root only) and a crush-avulsion group (the L4 lumbar nerve (...) root was crushed 1 week prior to the avulsion). Immunofluorescent staining revealed that the survival rate of motor neurons was significantly greater in the crush-avulsion group than in the avulsion-only group, and this difference remained for at least 5 weeks after avulsion. The higher neuronal survival rate may be explained by the upregulation of heat shock protein 27 expression in motor neurons in the crush-avulsion group. Furthermore, preconditioning crush greatly attenuated the expression

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2014 Neural Regeneration Research

145. Study to Determine Pharmacodynamic Effects and Pharmacokinetics of KUC 7483 CL in Patients With Spinal Cord Injury and Neurogenic Detrusor Overactivity

cord injury practicing intermittent catheterization under stable condition as determined by the investigator Recovery from spinal shock in posttraumatic patients Aged 18 - 70 years BMI range ≥ 18.5 and < 29.9 kg/m2 Documented neurogenic detrusor overactivity as shown by urodynamics within the last 12 months prior to study start and confirmation by the baseline urodynamics (day 2). Detrusor overactivity is defined as a non-volitional increase in detrusor pressure of > 6 cm H2O. Detrusor sphincter (...) Study to Determine Pharmacodynamic Effects and Pharmacokinetics of KUC 7483 CL in Patients With Spinal Cord Injury and Neurogenic Detrusor Overactivity Study to Determine Pharmacodynamic Effects and Pharmacokinetics of KUC 7483 CL in Patients With Spinal Cord Injury and Neurogenic Detrusor Overactivity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved

2014 Clinical Trials

146. Pain Relief After Colorectal Surgery: Spinal Combined With Painbuster® vs Painbuster® Alone.

Pain Relief After Colorectal Surgery: Spinal Combined With Painbuster® vs Painbuster® Alone. Pain Relief After Colorectal Surgery: Spinal Combined With Painbuster® vs Painbuster® Alone. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Pain Relief After Colorectal Surgery: Spinal Combined With Painbuster® vs Painbuster® Alone. (PROSP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02210260 Recruitment Status : Completed First Posted : August 6, 2014 Last Update Posted : September 14, 2016 Sponsor

2014 Clinical Trials

147. Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment

Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02034669 Recruitment Status : Unknown Verified January 2014 by Tri Phuoc Biotechnology., JSC. Recruitment status

2014 Clinical Trials

148. Evaluation of Autologous Mesenchymal Stem Cell Transplantation in Chronic Spinal Cord Injury: a Pilot Study

Volunteers: No Criteria Inclusion Criteria: Closed spinal cord injury at thoracic or thoracolumbar level bellow T8, or open spinal cord injury, at the same level, provided that the mechanism of the lesion is a spinal shock, ischemia or hematoma ASIA class A Signing the written consent Exclusion Criteria: Anatomical transection of the spinal cord Spinal cord lesion by sharp objects Ongoing infections Terminal, neurodegenerative or primary hematological diseases Osteopathies which determine a higher risc (...) Evaluation of Autologous Mesenchymal Stem Cell Transplantation in Chronic Spinal Cord Injury: a Pilot Study Evaluation of Autologous Mesenchymal Stem Cell Transplantation in Chronic Spinal Cord Injury: a Pilot Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2014 Clinical Trials

149. Predict Fluid Responsiveness in Spinal Anesthesia

Predict Fluid Responsiveness in Spinal Anesthesia Predict Fluid Responsiveness in Spinal Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Predict Fluid Responsiveness in Spinal Anesthesia (CERU (...) Ospedaliero Cantonale, Bellinzona Information provided by (Responsible Party): Samuele Ceruti, Ente Ospedaliero Cantonale, Bellinzona Study Details Study Description Go to Brief Summary: Spinal anesthesia is still the regional anesthesia technique most widely employed in everyday clinical practice. The most feared and common of its well known side effects consist in an abrupt reduction of systemic vascular resistances, with consequence risk of systemic hypotension. To prevent this potentially severe

2014 Clinical Trials

150. Treadmill training stimulates BDNF mRNA expression in motor neurons of the lumbar spinal cord in spinally transected rats (PubMed)

spinal cord transections as neonates (n=20) and one month later, received four weeks of either a low (100 steps/training session; n=10) or high (1000 steps/training session; n=10) amount of robotic-assisted treadmill training. Using combined non-radioactive in situ hybridization and immunohistochemical techniques, we found BDNF mRNA expression in heat shock protein 27-labeled motor neurons and in non-motor neuron cells was greater after 1000 steps/training session compared to the 100 steps/training (...) Treadmill training stimulates BDNF mRNA expression in motor neurons of the lumbar spinal cord in spinally transected rats Brain-derived neurotrophic factor (BDNF) induces plasticity within the lumbar spinal circuits thereby improving locomotor recovery in spinal cord-injured animals. We examined whether lumbar spinal cord motor neurons and other ventral horn cells of spinally transected (ST) rats were stimulated to produce BDNF mRNA in response to treadmill training. Rats received complete

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2012 Neuroscience

151. Autonomic Dysreflexia in Spinal Cord Injury (Follow-up)

. [ ] The occurrence of autonomic dysreflexia increases as the patient evolves out of spinal shock. With the return of sacral reflexes, the possibility of autonomic dysreflexia increases. [ ] Autonomic dysreflexia occurs during labor in approximately two thirds of pregnant women with spinal cord injury above the level of T6. Spinal epidural anesthesia can help reduce the risks of autonomic dysreflexia during pregnancy. The male-to-female ratio for sustaining spinal cord injury is 4:1; however, autonomic (...) Autonomic Dysreflexia in Spinal Cord Injury (Follow-up) Autonomic Dysreflexia in Spinal Cord Injury: Overview, Pathophysiology, Causes of Autonomic Dysreflexia Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

152. Rehabilitation of Persons With Spinal Cord Injuries (Follow-up)

Rehabilitation of Persons With Spinal Cord Injuries (Follow-up) Rehabilitation of Persons With Spinal Cord Injuries: Background, Common Medical Problems, Thromboembolic Disease Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI2NTIwOS1vdmVydmlldw== processing > Rehabilitation of Persons With Spinal Cord Injuries Updated: Mar 07, 2019 Author: Michael F Saulino, MD, PhD; Chief Editor: Jeffrey A Goldstein, MD Share Email Print Feedback Close Sections Sections Rehabilitation of Persons With Spinal Cord Injuries Background Traumatic spinal cord injury (SCI) is perhaps the most devastating orthopedic injury, and with prolonged survival being the rule, rehabilitation of these injuries has an increasingly important role. The primary goals

2014 eMedicine Surgery

153. Autonomic Dysreflexia in Spinal Cord Injury (Overview)

. [ ] The occurrence of autonomic dysreflexia increases as the patient evolves out of spinal shock. With the return of sacral reflexes, the possibility of autonomic dysreflexia increases. [ ] Autonomic dysreflexia occurs during labor in approximately two thirds of pregnant women with spinal cord injury above the level of T6. Spinal epidural anesthesia can help reduce the risks of autonomic dysreflexia during pregnancy. The male-to-female ratio for sustaining spinal cord injury is 4:1; however, autonomic (...) Autonomic Dysreflexia in Spinal Cord Injury (Overview) Autonomic Dysreflexia in Spinal Cord Injury: Overview, Pathophysiology, Causes of Autonomic Dysreflexia Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

154. Rehabilitation of Persons With Spinal Cord Injuries (Overview)

Rehabilitation of Persons With Spinal Cord Injuries (Overview) Rehabilitation of Persons With Spinal Cord Injuries: Background, Common Medical Problems, Thromboembolic Disease Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI2NTIwOS1vdmVydmlldw== processing > Rehabilitation of Persons With Spinal Cord Injuries Updated: Mar 07, 2019 Author: Michael F Saulino, MD, PhD; Chief Editor: Jeffrey A Goldstein, MD Share Email Print Feedback Close Sections Sections Rehabilitation of Persons With Spinal Cord Injuries Background Traumatic spinal cord injury (SCI) is perhaps the most devastating orthopedic injury, and with prolonged survival being the rule, rehabilitation of these injuries has an increasingly important role. The primary goals

2014 eMedicine Surgery

155. Rehabilitation of Persons With Spinal Cord Injuries (Diagnosis)

Rehabilitation of Persons With Spinal Cord Injuries (Diagnosis) Rehabilitation of Persons With Spinal Cord Injuries: Background, Common Medical Problems, Thromboembolic Disease Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTI2NTIwOS1vdmVydmlldw== processing > Rehabilitation of Persons With Spinal Cord Injuries Updated: Mar 07, 2019 Author: Michael F Saulino, MD, PhD; Chief Editor: Jeffrey A Goldstein, MD Share Email Print Feedback Close Sections Sections Rehabilitation of Persons With Spinal Cord Injuries Background Traumatic spinal cord injury (SCI) is perhaps the most devastating orthopedic injury, and with prolonged survival being the rule, rehabilitation of these injuries has an increasingly important role. The primary goals

2014 eMedicine Surgery

156. Spinal Orthotics (Follow-up)

of the patient's cervical spine is a potential pitfall. Hypotension, hemorrhage, and shock Hypotension may be hemorrhagic and/or neurogenic in acute spinal cord injury. Because of the vital sign confusion in acute spinal cord injury and the high incidence of associated injuries, a diligent search for occult sources of hemorrhage must be made. The most common sources of occult hemorrhage are injuries to the chest, abdomen, and retroperitoneum and fractures of the pelvis or long-bones. Appropriate investigations (...) Spinal Orthotics (Follow-up) Spinal Cord Injuries Treatment & Management: Approach Considerations, Prehospital Management, Emergency Department Management Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

157. Spinal Cord Injury: Definition, Epidemiology, Pathophysiology (Follow-up)

of the patient's cervical spine is a potential pitfall. Hypotension, hemorrhage, and shock Hypotension may be hemorrhagic and/or neurogenic in acute spinal cord injury. Because of the vital sign confusion in acute spinal cord injury and the high incidence of associated injuries, a diligent search for occult sources of hemorrhage must be made. The most common sources of occult hemorrhage are injuries to the chest, abdomen, and retroperitoneum and fractures of the pelvis or long-bones. Appropriate investigations (...) Spinal Cord Injury: Definition, Epidemiology, Pathophysiology (Follow-up) Spinal Cord Injuries Treatment & Management: Approach Considerations, Prehospital Management, Emergency Department Management Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

158. Spinal Cord, Topographical and Functional Anatomy (Follow-up)

: Classic Spinal Cord Syndromes The classic syndromes of spinal cord injury are described here. In most instances, however, incomplete forms are far more common. Complete spinal cord transection syndrome In the acute phase, the classic syndrome of complete spinal cord transection at the high cervical level consists of the following: Respiratory insufficiency Quadriplegia Upper and lower extremity areflexia Anesthesia below the affected level Neurogenic shock (hypotension without compensatory tachycardia (...) ) Loss of rectal and bladder sphincter tone Urinary and bowel retention leading to abdominal distention, ileus, and delayed gastric emptying This constellation of symptoms is called spinal shock. [ ] (ie, ipsilateral ptosis, miosis, and anhydrosis) is also present with higher lesions because of interruption of the descending sympathetic pathways originating from the hypothalamus. Patients experience problems with temperature regulation because of the sympathetic impairment, which leads to . Lower

2014 eMedicine.com

159. Cardiovascular Concerns in Spinal Cord Injury (Diagnosis)

. Observe the patient for pallor, flushing, sweating, skin temperature, or piloerection (signs of SNS dysfunction). Comprehensive motor and sensory examination can determine the neurologic level and completeness of the injury and may assist with assessing the risk for SNS dysfunction. Reflex testing, especially below the level of injury, can be done to determine whether spinal shock is still present. Examine for peripheral edema and warmth or tenderness of the extremities. Unilateral extremity swelling (...) discharge. Neurorehabil Neural Repair . 2014 Mar-Apr. 28 (3):219-29. . Frisbie JH. Microvascular instability in tetraplegic patients: preliminary observations. Spinal Cord . 2004 May. 42(5):290-3. . Mathias CJ, Christensen NJ, Frankel HL, et al. Cardiovascular control in recently injured tetraplegics in spinal shock. Q J Med . 1979 Apr. 48(190):273-87. . Mathias CJ, Frankel HL. Clinical manifestations of malfunctioning sympathetic mechanisms in tetraplegia. J Auton Nerv Syst . 1983 Mar-Apr. 7(3-4):303

2014 eMedicine.com

160. Autonomic Dysreflexia in Spinal Cord Injury (Diagnosis)

. [ ] The occurrence of autonomic dysreflexia increases as the patient evolves out of spinal shock. With the return of sacral reflexes, the possibility of autonomic dysreflexia increases. [ ] Autonomic dysreflexia occurs during labor in approximately two thirds of pregnant women with spinal cord injury above the level of T6. Spinal epidural anesthesia can help reduce the risks of autonomic dysreflexia during pregnancy. The male-to-female ratio for sustaining spinal cord injury is 4:1; however, autonomic (...) Autonomic Dysreflexia in Spinal Cord Injury (Diagnosis) Autonomic Dysreflexia in Spinal Cord Injury: Overview, Pathophysiology, Causes of Autonomic Dysreflexia Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

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