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Spinal Shock

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121. Clinical Study of NeuroRegen Scaffold Combined with Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury Full Text available with Trip Pro

Clinical Study of NeuroRegen Scaffold Combined with Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury Regeneration of damaged neurons and recovery of sensation and motor function after complete spinal cord injury (SCI) are challenging. We previously developed a collagen scaffold, NeuroRegen, to promote axonal growth along collagen fibers and inhibit glial scar formation after SCI. When functionalized with multiple biomolecules, this scaffold promoted (...) into the resection sites. No adverse events (infection, fever, headache, allergic reaction, shock, perioperative complications, aggravation of neurological status, or cancer) were observed during 1 year of follow-up. Primary efficacy outcomes, including expansion of sensation level and motor-evoked potential (MEP)-responsive area, increased finger activity, enhanced trunk stability, defecation sensation, and autonomic neural function recovery, were observed in some patients. Our findings suggest that combined

2017 Cell transplantation

122. Autophagy plays a protective role in motor neuron degeneration following spinal cord ischemia/reperfusion-induced spastic paralysis Full Text available with Trip Pro

Autophagy plays a protective role in motor neuron degeneration following spinal cord ischemia/reperfusion-induced spastic paralysis Spinal cord ischemia and reperfusion (SCIR) injury can lead to neurologic dysfunction and paraplegia, which are serious complications after shock or thoracoabdominal aortic surgery. Autophagy is a fundamental cellular process in eukaryotes, and homeostasis of autophagic activities in the cytoplasm is critical for the maintenance of neuronal function. To date (...) , no studies have addressed the involvement of autophagy in the regulation of motor neurons in the ventral horn of the spinal cord area following SCIR-induced spastic paralysis or the underlying mechanisms of this process. In this study, we investigated spastic paralysis in rats following SCIR injury. The number of autophagosomes increased 3 h following the injury, and subsequently decreased slowly to near-normal levels in the sham group as indicated by the autophagy markers microtubule-associated protein

2017 American journal of translational research

123. Feasibility and Complications of Spinal Anaesthesia in Percutaneous Nephrolithotomy: Our Experience Full Text available with Trip Pro

Feasibility and Complications of Spinal Anaesthesia in Percutaneous Nephrolithotomy: Our Experience Percutaneous Nephrolithotomy (PCNL) is the treatment modality used for the extraction of large renal stones, or multiple calculi or stones resistant to shock wave lithotripsy. The General Anaesthesia (GA) is the standard modality for PCNL. However, few studies conclude that Spinal Anaesthesia (SA) can be an alternative method of anaesthesia with similar incidence of complications.In our study we (...) evaluated the feasibility of spinal anaesthesia in terms of intraoperative and postoperative results in patients undergoing PCNL.The total 1298 PCNL operations were done for kidney stone from January 2013 to December 2016, out of which 1160 patients underwent PCNL under SA while remaining 138 operations were carried out under GA in the prone position. We retrospectively collected data from the patient's documents. The intraoperative haemodynamic stability was primary objective, and average fall

2017 Journal of clinical and diagnostic research : JCDR

124. Ephedrine and Phenylephrine for Spinal Hypotension

, sitting up for 9 min resulted in the need for rescue epidural anesthesia without additional benefit. Phenylephrine Treatment of vascular failure in shock, shock-like states, drug-induced hypotension or hypersensitivity; correction of paroxysmal supraventricular tachycardia; prolongation of spinal anesthesia; vasoconstriction in regional analgesia; maintenance of adequate level of BP during spinal and inhalation anesthesia. It has a number of important attributes for treating spinal hypotension: (i (...) Ephedrine and Phenylephrine for Spinal Hypotension Ephedrine and Phenylephrine for Spinal Hypotension - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ephedrine and Phenylephrine for Spinal Hypotension

2017 Clinical Trials

125. Recovery of Bladder and Sexual Function After Spinal Cord Injury

that would contraindicate locomotor training, stand, or non-weight bearing training no painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore or urinary tract infection that might interfere with training no clinically significant depression or ongoing drug abuse; clear indications that the period of spinal shock is concluded determined by presence of muscle tone, deep tendon reflexes or muscle spasms and discharged from standard inpatient rehabilitation non- progressive (...) that the period of spinal shock has not concluded and not discharged from standard inpatient rehabilitation progressive spinal cord injury no bladder and sexual dysfunction as a result of spinal cord injury Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number

2017 Clinical Trials

126. Acupuncture in Spinal Cord Injury Subjects

between 18 and 75 complete (AIS A) or incomplete SCI (AIS B-D) of the cervical, thoracic or lumbar spine from blunt or penetrating trauma ability to understand verbal and written English Exclusion Criteria: a history of peripheral neuropathy medical diagnoses or conditions that preclude them from active participation (for example, moderate or severe traumatic brain injury) receipt of acupuncture in the last three months prior to enrollment presence of skin breakdown or infection over the extremities (...) Acupuncture in Spinal Cord Injury Subjects Acupuncture in Spinal Cord Injury Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Acupuncture in Spinal Cord Injury Subjects The safety and scientific

2017 Clinical Trials

127. ‘Pseudofailure’ of spinal cord stimulation for neuropathic pain following a new severe noxious stimulus: learning points from a case series of failed spinal cord stimulation for complex regional pain syndrome and failed back surgery syndrome Full Text available with Trip Pro

‘Pseudofailure’ of spinal cord stimulation for neuropathic pain following a new severe noxious stimulus: learning points from a case series of failed spinal cord stimulation for complex regional pain syndrome and failed back surgery syndrome Failure of spinal cord stimulation (SCS) may be due to hardware problems, migration of electrodes and, in the long-term, plasticity in the spinal cord with habituation to the stimulation current. We describe a series of seven patients who experienced (...) syndrome. In all seven cases, there was cessation of the pain relief afforded by SCS following an acute painful event: four patients had trauma, two patients had domestic electric shock and one patient suffered shingles (varicella zoster infection). We excluded hardware-related problems in all cases. In two patients, SCS effects could be regained by an initial attempt at reprogramming. In the remaining five cases reprogramming was unsuccessful, and stimulation was switched off for several months before

2016 British journal of pain

128. Learning about Time within the Spinal Cord II: Evidence that Temporal Regularity Is Encoded by a Spinal Oscillator Full Text available with Trip Pro

Learning about Time within the Spinal Cord II: Evidence that Temporal Regularity Is Encoded by a Spinal Oscillator How a stimulus impacts spinal cord function depends upon temporal relations. When intermittent noxious stimulation (shock) is applied and the interval between shock pulses is varied (unpredictable), it induces a lasting alteration that inhibits adaptive learning. If the same stimulus is applied in a temporally regular (predictable) manner, the capacity to learn is preserved (...) and a protective/restorative effect is engaged that counters the adverse effect of variable stimulation. Sensitivity to temporal relations implies a capacity to encode time. This study explores how spinal neurons discriminate variable and fixed spaced stimulation. Communication with the brain was blocked by means of a spinal transection and adaptive capacity was tested using an instrumental learning task. In this task, subjects must learn to maintain a hind limb in a flexed position to minimize shock exposure

2016 Frontiers in behavioral neuroscience

129. A Neurogenic Factor in Experimental Traumatic Shock: A Summary of Recent Studies Including Observations on Procainized and Spinal Dogs Full Text available with Trip Pro

A Neurogenic Factor in Experimental Traumatic Shock: A Summary of Recent Studies Including Observations on Procainized and Spinal Dogs 17859300 2007 09 17 2018 12 01 0003-4932 129 2 1949 Feb Annals of surgery Ann. Surg. A Neurogenic Factor in Experimental Traumatic Shock: A Summary of Recent Studies Including Observations on Procainized and Spinal Dogs. 207-22 Wang S C SC Overman R R RR eng Journal Article United States Ann Surg 0372354 0003-4932 OM Animals Dogs Humans Shock etiology Shock (...) , Traumatic 4916:549f SHOCK/etiology and pathogenesis 1949 2 1 0 0 1949 2 1 0 1 1949 2 1 0 0 ppublish 17859300 PMC1513954 J Clin Invest. 1938 May;17(3):359-68 16694580 J Clin Invest. 1945 Nov;24(6):829-34 16695277 J Clin Invest. 1945 Nov;24(6):839-44 16695279 J Clin Invest. 1945 Nov;24(6):845-9 16695280 J Clin Invest. 1945 Nov;24(6):856-63 16695282 J Clin Invest. 1946 Mar;25(2):158-71 16695305 J Physiol. 1933 Jul 10;78(4):339-69 16994426 Ann Surg. 1944 Jan;119(1):26-63 17858337

1949 Annals of Surgery

130. ACUTE ABDOMINAL PAIN, ASSOCIATED WITH SPINAL CORD SHOCK Full Text available with Trip Pro

ACUTE ABDOMINAL PAIN, ASSOCIATED WITH SPINAL CORD SHOCK 17866198 2007 09 17 2008 11 20 0003-4932 90 4 1929 Oct Annals of surgery Ann. Surg. ACUTE ABDOMINAL PAIN, ASSOCIATED WITH SPINAL CORD SHOCK. 769-75 Rodman J S JS eng Journal Article United States Ann Surg 0372354 0003-4932 1929 10 1 0 0 1929 10 1 0 1 1929 10 1 0 0 ppublish 17866198 PMC1399075

1929 Annals of Surgery

131. SHELL SHOCK AND ITS TREATMENT BY CEREBRO-SPINAL GALVANISM Full Text available with Trip Pro

SHELL SHOCK AND ITS TREATMENT BY CEREBRO-SPINAL GALVANISM 20768345 2011 03 29 2011 03 29 0007-1447 2 2913 1916 Oct 28 British medical journal Br Med J SHELL SHOCK AND ITS TREATMENT BY CEREBRO-SPINAL GALVANISM. 584-6 Garton W W eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1916 10 28 0 0 1916 10 28 0 1 ppublish 20768345 PMC2354907

1916 British medical journal

132. Progressive Spinal Muscular Atrophy (Duchenne-Aran) following Electric Shock; Positive Wassermann Reaction Full Text available with Trip Pro

Progressive Spinal Muscular Atrophy (Duchenne-Aran) following Electric Shock; Positive Wassermann Reaction 19979570 2010 06 24 2010 06 24 0035-9157 10 Clin Sect 1917 Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Progressive Spinal Muscular Atrophy (Duchenne-Aran) following Electric Shock; Positive Wassermann Reaction. 4-6 Weber F P FP eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1917 1 1 0 0 1917 1 1 0 1 ppublish 19979570 PMC2017685

1917 Proceedings of the Royal Society of Medicine

133. Single-shock excitation and inhibition of contralateral extension in the spinal cat Full Text available with Trip Pro

Single-shock excitation and inhibition of contralateral extension in the spinal cat 16994389 2007 02 05 2018 11 13 0022-3751 77 3 1933 Feb 08 The Journal of physiology J. Physiol. (Lond.) Single-shock excitation and inhibition of contralateral extension in the spinal cat. 258-70 Matthes K K Ruch T C TC eng Journal Article England J Physiol 0266262 0022-3751 1933 2 8 0 0 1933 2 8 0 1 1933 2 8 0 0 ppublish 16994389 PMC1394773 J Physiol. 1910 Apr 26;40(1-2):28-121 16993027 J Physiol. 1915 Jul 5;49

1933 The Journal of physiology

134. Excitability of motor neurones in spinal shock in man. Full Text available with Trip Pro

Excitability of motor neurones in spinal shock in man. 6062993 1968 01 27 2018 11 13 0022-3050 30 5 1967 Oct Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Excitability of motor neurones in spinal shock in man. 427-31 Diamantopoulos E E Zander Olsen P P eng Journal Article England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 IM Adolescent Adult Ankle Electric Stimulation Electrophysiology Female Humans Male Motor Neurons physiopathology Muscle Spasticity (...) physiopathology Reflex Spinal Cord Diseases physiopathology 1967 10 1 1967 10 1 0 1 1967 10 1 0 0 ppublish 6062993 PMC496219 Acta Neurol Scand Suppl. 1965;13 Pt 1:273-4 5214305 J Neurol Neurosurg Psychiatry. 1967 Aug;30(4):325-31 6055341 Am J Physiol. 1961 May;200:963-7 13702403 Arch Neurol. 1963 Aug;9:120-6 14048159 Arch Neurol. 1963 Aug;9:127-32 14048160 Brain. 1959 Sep;82:321-55 14413775

1967 Journal of neurology, neurosurgery, and psychiatry

135. Hemorrhagic Shock and the Nervous System 1. Spinal Chord Reflex Activity and Brain Stem Reticular Formation Full Text available with Trip Pro

Hemorrhagic Shock and the Nervous System 1. Spinal Chord Reflex Activity and Brain Stem Reticular Formation 14274850 1996 12 01 2018 12 01 0003-4932 161 1965 Apr Annals of surgery Ann. Surg. HEMORRHAGIC SHOCK AND THE NERVOUS SYSTEM. I. SPINAL CORD REFLEX ACTIVITY AND BRAIN STEM RETICULAR FORMATION. 485-96 PETERSON C G CG HAUGEN F P FP eng Journal Article United States Ann Surg 0372354 0003-4932 OM Animals Blood Pressure Brain Stem Cats Dogs Electrocardiography Electromyography Hypotension (...) Neurophysiology Reflex Research Reticular Formation Shock, Hemorrhagic Spinal Cord BLOOD PRESSURE CATS DOGS ELECTROCARDIOGRAPHY ELECTROMYOGRAPHY EXPERIMENTAL LAB STUDY HYPOTENSION NEUROPHYSIOLOGY REFLEX RETICULAR FORMATION SHOCK, HEMORRHAGIC SPINAL CORD 1965 4 1 1965 4 1 0 1 1965 4 1 0 0 ppublish 14274850 PMC1408993 Physiol Rev. 1950 Oct;30(4):459-74 14786044 N Engl J Med. 1953 Sep 17;249(12):486-93; concl 13087630 Lancet. 1955 Jul 23;269(6882):151-4 13243673 Physiol Rev. 1955 Jul;35(3):629-63 13245427 Am J

1965 Annals of Surgery

136. Spinal and supraspinal components of the reflex discharges into lumbar and thoracic white rami Full Text available with Trip Pro

Spinal and supraspinal components of the reflex discharges into lumbar and thoracic white rami 1. In chloralose anaesthetized cats reflex discharges in thoracic and lumbar white rami were elicited by single shock stimulation of intercostal, spinal and hind limb nerves.2. In animals with an intact neuraxis single stimuli of sufficient strength usually elicited a white rami mass discharge having two distinct components. Following spinal transection only the late reflex component disappeared.3 (...) . The early (spinal) reflex component had its largest amplitude if the afferent volley entered the spinal cord at the same or an adjacent segment of the white ramus under observation, whereas the size of the late (supraspinal) component was rather independent of the segmental level of the afferent input.4. It was concluded that somatic afferent volleys have a twofold action on the sympathetic nervous system: a more generalized action via the supraspinal sympathetic reflex centres and a more circumscribed

1971 The Journal of physiology

137. Hind leg ataxia of cervical origin and cervico-lumbar spinal interactions with a supratentorial pathway Full Text available with Trip Pro

Hind leg ataxia of cervical origin and cervico-lumbar spinal interactions with a supratentorial pathway 1. Unilateral section of the nerves to an extensor muscle of the head, biventer cervicis, leads to an ataxia of the hind legs in cats.2. In chloralose anaesthetized cats, shocks to the central end of the cut biventer cervicis muscle nerves leads to direct discharges over lumbosacral ventral roots, to a facilitation of monosynaptic reflexes in flexor and extensor muscles and to a prolonged (...) inhibition of spino-bulbo-spinal reflexes. Such effects are not unique, but follow stimulation of skin and muscle nerves of the forepaw.3. Supratentorial pathways are involved in descending spinal interactions in the chloralose anaesthetized cat, but are more critical for interactions taking origin in biventer cervicis nerve than in forepaw nerves.4. In non-anaesthetized spinal cats showing interactions from forepaw nerves, no interactions could be found taking origin in biventer cervicis nerves

1969 The Journal of physiology

138. Autologous Mesenchymal Stem Cells Transplantation in Thoracolumbar Chronic and Complete Spinal Cord Injury Spinal Cord Injury

); Liver function tests; Coagulation profile; Metabolic profile (glucose, total cholesterol and fractions); Urine summary and culture; Serology required for blood transfusion and marrow transplant in Brazil; Electrocardiogram; Chest X-Ray; Bone densitometry; Urodynamic studies; Somatosensory evoked potential; Computed tomography of thoracic and lumbar spine; Magnetic resonance imaging of the thoracic and lumbar spine. Also as part of the preoperative evaluation, the patients will respond to questions (...) that the mechanism of injury had been spinal shock, ischemia or hematoma, with at least 12 months of injury; ASIA grade A; Signing of the written consent. Exclusion Criteria: Spinal cord injuries by sharp objects, firearms, and not traumatic or congenital causes, even if at different levels of the spinal cord; Concomitant brain injuries; Diabetes mellitus type 1 or 2 as defined by fasting glucose above 126 mg / use of medication and medical history; Infectious processes in acute and / or chronic course

2015 Clinical Trials

139. Synergistic impact of acute kidney injury and high level of cervical spinal cord injury on the weaning outcome of patients with acute traumatic cervical spinal cord injury. (Abstract)

leukocyte counts. Furthermore, unsuccessful weaning patients had a higher incidence of pneumonia, acute respiratory distress syndrome, shock and acute kidney injury during the intensive care unit stay. Multivariate logistic regression analysis revealed acute kidney injury and high level of cervical spinal cord injury were independent risk factors for failure of weaning. Importantly, patients with both risk factors showed a large increase in odds ratio for unsuccessful weaning from mechanical ventilation (...) Synergistic impact of acute kidney injury and high level of cervical spinal cord injury on the weaning outcome of patients with acute traumatic cervical spinal cord injury. Respiratory neuromuscular impairment severity is known to predict weaning outcome among patients with cervical spinal cord injury; however, the impact of non-neuromuscular complications remains unexplored. This study was to evaluate possible neuromuscular and non-neuromuscular factors that may negatively impact weaning

2015 Injury

140. Unintended Consequences for Patients with Spinal Cord Injury

about this page, enter your email address: Enter Email Address Submit Button Unintended Consequences for Patients with Spinal Cord Injury Posted on December 11, 2018 by CDC's Safe Healthcare Blog Matt Davis, MD Matt Davis, MD, Clinical Medical Director SCI Service Line, TIRR Memorial Hermann The story would have been shocking, if I had not seen the precursors many times before. My patient was paralyzed by a bulging disc in her spine. In an effort to achieve “High Reliability” and reach the goal (...) Unintended Consequences for Patients with Spinal Cord Injury Unintended Consequences for Patients with Spinal Cord Injury | | Blogs | CDC Search Form Controls TOPIC ONLY Search The CDC cancel submit Search Form Controls TOPIC ONLY Search The CDC cancel submit Note: Javascript is disabled or is not supported by your browser. For this reason, some items on this page will be unavailable. For more information about this message, please visit this page: . Get Email Updates To receive email updates

2018 CDC Safe Healthcare blog

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