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Spinal Shock

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61. Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy. (PubMed)

Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy. Spinal and bulbar muscular atrophy, also known as Kennedy's disease, is an adult-onset hereditary neurodegenerative disorder caused by an expansion of the polyglutamine repeat in the first exon in the androgen receptor gene. Pathologically, the disease is defined by selective loss of spinal and bulbar motor neurons causing bulbar, facial (...) a motor deficit characterized by a reduction in muscle force, abnormal muscle contractile characteristics, loss of functional motor units and motor neuron degeneration. We have previously shown that treatment with arimoclomol, a co-inducer of the heat shock stress response, delays disease progression in the mutant superoxide dismutase 1 mouse model of amyotrophic lateral sclerosis, a fatal motor neuron disease. We therefore evaluated the therapeutic potential of arimoclomol in mice with spinal

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2013 Brain

62. Segmental reflex pathways in spinal shock and spinal spasticity in man (PubMed)

Segmental reflex pathways in spinal shock and spinal spasticity in man Activity in three segmental pathways was compared in normal subjects, patients with spinal shock, and patients with established spinal spasticity. The Achilles tendon reflex (ATR) was used to estimate transmission in the Ia monosynaptic pathway. Evidence is produced implying that vibration activates motoneurones principally through a polysynaptic pathway. The tonic vibration reflex (TVR) was used to estimate transmission (...) in this Ia polysynaptic pathway. The percentage of the motoneurone pool (M-response) that could be activated by these pathways was used as a measure of transmission. The H reflex (vibration)/H reflex (control) ratio was used as an estimate of the degree of presynaptic inhibition of the Ia monosynaptic pathway. The findings led to the following conclusions. (1) In spinal shock presynaptic inhibition is greater than normal, transmission in the Ia monosynaptic pathway is reduced, and in the Ia polysynaptic

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1974 Journal of neurology, neurosurgery, and psychiatry

63. Recovery of Bladder and Sexual Function After Spinal Cord Injury

that would contraindicate locomotor training, stand, or non-weight bearing training no painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore or urinary tract infection that might interfere with training no clinically significant depression or ongoing drug abuse; clear indications that the period of spinal shock is concluded determined by presence of muscle tone, deep tendon reflexes or muscle spasms and discharged from standard inpatient rehabilitation non- progressive (...) that the period of spinal shock has not concluded and not discharged from standard inpatient rehabilitation progressive spinal cord injury no bladder and sexual dysfunction as a result of spinal cord injury Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number

2017 Clinical Trials

64. Ephedrine and Phenylephrine for Spinal Hypotension

, sitting up for 9 min resulted in the need for rescue epidural anesthesia without additional benefit. Phenylephrine Treatment of vascular failure in shock, shock-like states, drug-induced hypotension or hypersensitivity; correction of paroxysmal supraventricular tachycardia; prolongation of spinal anesthesia; vasoconstriction in regional analgesia; maintenance of adequate level of BP during spinal and inhalation anesthesia. It has a number of important attributes for treating spinal hypotension: (i (...) Ephedrine and Phenylephrine for Spinal Hypotension Ephedrine and Phenylephrine for Spinal Hypotension - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Ephedrine and Phenylephrine for Spinal Hypotension

2017 Clinical Trials

65. Clinical and imaging features of spinal cord type of neuro Behçet disease: A case report and systematic review. (PubMed)

or lower chest (29.4%). The number of cells was slightly increased or the protein level was increased in cerebrospinal fluid test. And the water channel protein antibody and oligoclonal band of serum levels were all negative. The spinal cord injury involved more than 3 vertebral bodies in 10 cases, and involved more than half of spinal cord in sagittal plane in 8 cases. In acute stage, shock therapy with large dose of glucocorticoid was generally applied both in China and abroad.The clinical features (...) Clinical and imaging features of spinal cord type of neuro Behçet disease: A case report and systematic review. To investigate the clinical and MRI characteristics of spinal cord nerve Behçet's disease.One patient with spinal cord nerve Behçet's disease was admitted to our hospital at October 20, 2015.Spinal cord nerve Behçet's disease.Retrospective analysis was performed on such case as well as 16 cases of spinal cord nerve Behçet's disease reported in China or abroad.Seventeen cases

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2017 Medicine

66. Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns in male rats. (PubMed)

Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns in male rats. We have recently reported that a short course of morphine, starting 10days after sciatic chronic constriction injury (CCI), prolonged the duration of mechanical allodynia for months after morphine ceased. Maintenance of this morphine-induced persistent sensitization was dependent on spinal NOD-like receptor protein 3 (NLRP3) inflammasomes-protein complexes that proteolytically (...) activate interleukin-1β (IL-1β) via caspase-1. However, it is still unclear how NLRP3 inflammasome signaling is maintained long after morphine is cleared. Here, we demonstrate that spinal levels of the damage associated molecular patterns (DAMPs) high mobility group box 1 (HMGB1) and biglycan are elevated during morphine-induced persistent sensitization in male rats; that is, 5weeks after cessation of morphine dosing. We also show that HMGB1 and biglycan levels are at least partly dependent

2017 Brain, behavior, and immunity

67. Acupuncture in Spinal Cord Injury Subjects

Acupuncture in Spinal Cord Injury Subjects Acupuncture in Spinal Cord Injury Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Acupuncture in Spinal Cord Injury Subjects The safety and scientific (...) Information provided by (Responsible Party): Deborah Stein, University of Maryland Study Details Study Description Go to Brief Summary: Of the more than 250,000 Americans with severe spinal cord injury (SCI), 42,000 are military veterans. The Department of Veterans Affairs is the largest single network of SCI care providers in the nation. Patients with SCI experience functional disabilities as well as chronic pain. Studies show that individuals with SCI report pain refractory to conventional treatments

2017 Clinical Trials

68. Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Adult Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia

Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Adult Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Adult Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration (...) or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Adult Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia The safety and scientific validity of this study is the responsibility of the study sponsor

2017 Clinical Trials

69. A case of bulbospinal muscular atrophy with large fasciculation manifesting as spinal myoclonus (PubMed)

the knees were kept in mild flexion in the supine position, fasciculation of the thigh adductor muscles was so large that it caused shock-like involuntary movements of the legs, corresponding to spinal myoclonus. A genetic test revealed 41 repeats of CAG in the androgen receptor gene, and the diagnosis of BSMA was made.The present case suggests that extremely large fasciculation can cause spinal myoclonus. (...) A case of bulbospinal muscular atrophy with large fasciculation manifesting as spinal myoclonus This paper reports a patient with bulbospinal muscular atrophy (BSMA) who presented with spinal myoclonus, documented by video and surface electromyography.A 66-year-old man had progressive gait disturbance, dysphagia, and easy fatigability of all extremities over a period of 4 years. Neurologically, muscle atrophy, fasciculation, and weakness were observed in the bulbar and limb muscles. When

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2017 Clinical Neurophysiology Practice

70. Clinical Study of NeuroRegen Scaffold Combined with Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury (PubMed)

Clinical Study of NeuroRegen Scaffold Combined with Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury Regeneration of damaged neurons and recovery of sensation and motor function after complete spinal cord injury (SCI) are challenging. We previously developed a collagen scaffold, NeuroRegen, to promote axonal growth along collagen fibers and inhibit glial scar formation after SCI. When functionalized with multiple biomolecules, this scaffold promoted (...) into the resection sites. No adverse events (infection, fever, headache, allergic reaction, shock, perioperative complications, aggravation of neurological status, or cancer) were observed during 1 year of follow-up. Primary efficacy outcomes, including expansion of sensation level and motor-evoked potential (MEP)-responsive area, increased finger activity, enhanced trunk stability, defecation sensation, and autonomic neural function recovery, were observed in some patients. Our findings suggest that combined

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2017 Cell transplantation

71. Feasibility and Complications of Spinal Anaesthesia in Percutaneous Nephrolithotomy: Our Experience (PubMed)

Feasibility and Complications of Spinal Anaesthesia in Percutaneous Nephrolithotomy: Our Experience Percutaneous Nephrolithotomy (PCNL) is the treatment modality used for the extraction of large renal stones, or multiple calculi or stones resistant to shock wave lithotripsy. The General Anaesthesia (GA) is the standard modality for PCNL. However, few studies conclude that Spinal Anaesthesia (SA) can be an alternative method of anaesthesia with similar incidence of complications.In our study we (...) evaluated the feasibility of spinal anaesthesia in terms of intraoperative and postoperative results in patients undergoing PCNL.The total 1298 PCNL operations were done for kidney stone from January 2013 to December 2016, out of which 1160 patients underwent PCNL under SA while remaining 138 operations were carried out under GA in the prone position. We retrospectively collected data from the patient's documents. The intraoperative haemodynamic stability was primary objective, and average fall

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2017 Journal of clinical and diagnostic research : JCDR

72. Neglected Necrotizing Fasciitis - A Rare Complication of Spinal Anaesthesia (PubMed)

NF of the back starting from the site of spinal needle insertion. She was referred to our center after 21 days of surgery with extensive NF. She underwent serial debridement but succumbed to septic shock secondary to gram negative and fungal sepsis. (...) Neglected Necrotizing Fasciitis - A Rare Complication of Spinal Anaesthesia Necrotizing Fasciitis (NF) is a rare, rapidly progressive severe bacterial soft tissue infection with a high mortality rate. NF classically involves the trunk, groin/perineum, lower limbs, and postoperative wound sites. NF secondary to spinal anaesthesia in a young postpartum female is extremely rare. Here we are describing a young postpartum female who underwent cesarean section for the delivery of child but developed

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2017 Journal of clinical and diagnostic research : JCDR

73. Inadvertent Intrathecal Administration of Local Anesthetics Leading to Spinal Paralysis with Lipid Emulsion Rescue (PubMed)

an unusual case of administering intravenous lipid emulsion (ILE) as part of resuscitative efforts to hasten neurological recovery from spinal shock. (...) Inadvertent Intrathecal Administration of Local Anesthetics Leading to Spinal Paralysis with Lipid Emulsion Rescue Bupivacaine and ropivacaine are local anesthetics frequently used for interscalene nerve blocks, which are generally well tolerated; however, some complications include pneumothorax, Horner syndrome, nerve injury and cardiovascular toxicity from vascular injection. On rare occasions, it may be associated with spinal paralysis. While the treatment is mostly supportive, we report

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2017 Clinical Practice and Cases in Emergency Medicine

74. Autophagy plays a protective role in motor neuron degeneration following spinal cord ischemia/reperfusion-induced spastic paralysis (PubMed)

Autophagy plays a protective role in motor neuron degeneration following spinal cord ischemia/reperfusion-induced spastic paralysis Spinal cord ischemia and reperfusion (SCIR) injury can lead to neurologic dysfunction and paraplegia, which are serious complications after shock or thoracoabdominal aortic surgery. Autophagy is a fundamental cellular process in eukaryotes, and homeostasis of autophagic activities in the cytoplasm is critical for the maintenance of neuronal function. To date (...) , no studies have addressed the involvement of autophagy in the regulation of motor neurons in the ventral horn of the spinal cord area following SCIR-induced spastic paralysis or the underlying mechanisms of this process. In this study, we investigated spastic paralysis in rats following SCIR injury. The number of autophagosomes increased 3 h following the injury, and subsequently decreased slowly to near-normal levels in the sham group as indicated by the autophagy markers microtubule-associated protein

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2017 American journal of translational research

75. Low-Intensity Extracorporeal Shock Wave Treatment for Erectile Dysfunction: A Randomized, Controlled, Double Blind Trial

Low-Intensity Extracorporeal Shock Wave Treatment for Erectile Dysfunction: A Randomized, Controlled, Double Blind Trial Low-Intensity Extracorporeal Shock Wave Treatment for Erectile Dysfunction: A Randomized, Controlled, Double Blind Trial - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Low-Intensity Extracorporeal Shock Wave Treatment for Erectile Dysfunction: A Randomized, Controlled, Double Blind Trial The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2016 Clinical Trials

76. Effectiveness And Safety Of Two Protocols For The Treatment Of Erectile Dysfunction With Low-Density Shock Waves

Effectiveness And Safety Of Two Protocols For The Treatment Of Erectile Dysfunction With Low-Density Shock Waves Effectiveness And Safety Of Two Protocols For The Treatment Of Erectile Dysfunction With Low-Density Shock Waves - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Effectiveness And Safety Of Two Protocols For The Treatment Of Erectile Dysfunction With Low-Density Shock Waves The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02683044 Recruitment Status : Unknown Verified July 2016 by Instituto

2016 Clinical Trials

77. Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine

Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Trial of Heat Shock (...) & Robert H Lurie Children's Hospital of Chicago Collaborator: Northwestern University Information provided by (Responsible Party): Stewart Goldman, Ann & Robert H Lurie Children's Hospital of Chicago Study Details Study Description Go to Brief Summary: The purpose of this study is to determine whether Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine is an feasible and safe treatment for pediatric patients with newly-diagnosed High-Grade Gliomas or recurrent, resectable High-Grade Gliomas

2016 Clinical Trials

78. Extracorporeal Focused Shock Wave Therapy for Primary Knee Osteoarthritis

Extracorporeal Focused Shock Wave Therapy for Primary Knee Osteoarthritis Extracorporeal Focused Shock Wave Therapy for Primary Knee Osteoarthritis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Extracorporeal Focused Shock Wave Therapy for Primary Knee Osteoarthritis The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02904785 Recruitment Status : Unknown Verified September 2016 by Linamara Rizzo Battistella, MD PhD, University of Sao Paulo General Hospital. Recruitment status was: Recruiting First

2016 Clinical Trials

79. Presentation of neurogenic shock within the emergency department. (PubMed)

Presentation of neurogenic shock within the emergency department. Injury to the spinal cord can result in loss of sympathetic innervation causing a drop in BP and HR, this condition is known as neurogenic shock. There is debate among the literature on how and when neurogenic shock presents and what values of HR and BP should be used to define it. Previous studies do not take into account multiple prehospital and emergency department recordings.To improve understanding of how neurogenic shock (...) presents in humans, allowing better identification and treatment.The Trauma Audit and Research Network database for an adult major trauma centre was used to isolate patients with a spinal cord injury. Qualifying patients had all available BPs and HRs collated into a database. Patients with neurogenic shock were isolated, allowing data analysis.Out of 3069 trauma patients, 33 met the inclusion criteria, of which 15 experienced neurogenic shock. 87% of the patients who had neurogenic shock experienced

2016 Emergency Medicine Journal

80. Neurogenic Shock

Shock , Vasogenic Shock From Related Chapters II. Definitions Neurogenic Shock Distributive shock from neurogenic vasodilation mediated by loss of sympathetic tone Follows cerebral or spinal cord injury (above T6) affecting sympathtic nervous system In contrast to Neurogenic Shock, is not a true shock syndrome Results in and loss below level of spinal cord injury III. Pathophysiology Results from or upper spine injury (above T6) Peripheral denervation results in ungoverned activity Loss of vasomotor (...) tone (vasodilation) leading to distributive shock Loss of cardiac activity, leads to paradoxical IV. Causes (above T6) V. Signs Secondary to and vasodilation Narrow is absent Lack of typical sympathetic response (increased SVR and diastolic BP) Paradoxical Expected response is a reflex (a sympathetic response) Decreased vascular tone (vasodilation) Warm extremities VI. Associated Conditions See See See See and loss below level of spinal cord injury Diaphragm Paralysis C3-5 resulting in phrenic

2018 FP Notebook

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