How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,400 results for

Spinal Shock

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

61. CRACKCast E043 – Spinal Injuries

, ETOH and failure to use restraints Other common causes in order: falls, violence, sporting activities 80% of spinal injuries are men 1) Describe the anatomical contents of the anterior, middle and posterior spinal columns (aka 3 column model of Denis) Anterior: alternative vertebral bodies and intervertebral disks surrounded by annulus fibrosis and anterior longitudinal ligament Middle: posterior portion of annulus and post vertebral wall, posterior longitudinal ligament, spinal cord, paired (...) Stable provided posterior column remains intact and loss of no more than half vertebral height or multiple in a row Flexion teardrop – flexion forces cause anterior displacement of small wedge Highly unstable – usually involves anterior and posterior ligament disruption Clay-Shoveler’s fracture: named as such for miner lifting a heavy shovelful in forced flexion, now MC is forced deceleration in MVC’s Oblique fracture of base of spinous process – stable as single column Spinal subluxation – pure

2016 CandiEM

62. Test Efficacy With Bioresorbable Polymer Coating Versus Bioresorbable Polymer Backbone (ISAR-RESORB)

Test Efficacy With Bioresorbable Polymer Coating Versus Bioresorbable Polymer Backbone (ISAR-RESORB) Test Efficacy With Bioresorbable Polymer Coating Versus Bioresorbable Polymer Backbone (ISAR-RESORB) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Test Efficacy With Bioresorbable Polymer Coating Versus Bioresorbable Polymer Backbone (ISAR-RESORB) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02421016 Recruitment Status : Unknown Verified April 2015 by Deutsches Herzzentrum Muenchen. Recruitment

2015 Clinical Trials

63. Antibiotic Prophylaxis in Spine Surgery (Revised 2013)

of recommendations, these recommendations will be operation- alized into performance measures. Multidisciplinary Collaboration With the goal of ensuring the best possible care for adult patients suffering with spinal disorders, NASS is committed to multidis - ciplinary involvement in the process of guideline and perfor- mance measure development. To this end, NASS has ensured that representatives from medical, interventional and surgical spine specialties have participated in the development and re- view of all (...) in answering different questions within this guideline. How a given question was asked might influence how a study was evaluated and interpreted as to its level of evidence in answer- ing that particular question. For example, a randomized control trial reviewed to evaluate the differences between the outcomes of surgically treated versus untreated patients with lumbar spinal stenosis might be a well designed and implemented Level I ther- apeutic study. This same study, however, might be classified

2013 North American Spine Society

64. Intrathecal morphine combined with ropivacaine induces spinal myoclonus in cancer patients with an implanted intrathecal drug delivery system: Three case reports. Full Text available with Trip Pro

Intrathecal morphine combined with ropivacaine induces spinal myoclonus in cancer patients with an implanted intrathecal drug delivery system: Three case reports. Although intrathecal opioid infusion has been used for decades for the treatment of severe pain, myoclonus as one of the complications of this therapeutic modality is now beginning to be recognized more.Here, we report three patients who developed myoclonus after dose adjustment in intrathecal drug delivery system for the treatment (...) of refractory cancer pain.Spinal myoclonus is a sudden, brief, shock-like muscle contractions originating from the central nervous system. In our cases, it occurred after opioid administration via intrathecal delivery system with no abnormality found in laboratory or imaging examinations.Spinal myoclonus can be treated effectively by reducing the dose or infusion rate as described in case 1, or changing from an intrathecal to systemic administration in case 2, or correcting infusion and bolus parameters

2019 Medicine

65. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): Zone I Balloon Occlusion Time Affects Spinal Cord Injury in the Nonhuman Primate Model. (Abstract)

hemorrhagic shock. However, unopposed balloon inflation in the distal thoracic aorta for 60 minutes results in high rates of spinal cord ischemia, an effect mitigated by limiting balloon inflation to 30 minutes. (...) Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): Zone I Balloon Occlusion Time Affects Spinal Cord Injury in the Nonhuman Primate Model. Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) has been used clinically to limit torso bleeding and restore central perfusion. The objective of this study was to determine the sequelae of prolonged REBOA in a nonhuman primate animal model.Prolonged duration of REBOA is associated with adverse clinical outcomes. Threshold

2019 Annals of Surgery

66. Dose Extracorporeal Shock Wave Introduce Alteration of Microenvironment in cell Therapy for Chronic Spinal Cord Injury? (Abstract)

Dose Extracorporeal Shock Wave Introduce Alteration of Microenvironment in cell Therapy for Chronic Spinal Cord Injury? Animal experimental study.To present experimental evidence for cell therapy for spinal cord injury (SCI).In chronic SCI, the efficacy of cell engraftment has been known to be low due to its distinct pathology. Alteration of microenvironment was tried using extracorporeal shock waves (ESW) for chronic SCI, and the efficacy of cell therapy was investigated.A chronic contusive

2014 Spine

67. Incidence of postoperative cognitive dysfunction after general or spinal anaesthesia for extracorporeal shock wave lithotripsy. Full Text available with Trip Pro

Incidence of postoperative cognitive dysfunction after general or spinal anaesthesia for extracorporeal shock wave lithotripsy. Since general anaesthesia invariably accompanies surgery, the contribution of each to the development of postoperative cognitive dysfunction (POCD) has been difficult to identify.A prospective randomized controlled trial was undertaken in elderly patients undergoing extracorporeal shock wave lithotripsy (ESWL). Between 2005 and 2011, 2706 individuals were screened (...) to recruit 100 eligible patients. Patients were randomly assigned to receive general or spinal anaesthesia alone. A battery of eight neuropsychological tests was administered before operation and at 7 days and 3 months after operation. The reliable change index was used to calculate the incidence of POCD. Intention-to-treat analysis was used to compare rates of POCD.Futility analysis led to stopping of the trial after recruitment of 100 patients. Fifty patients were randomly assigned to general

2014 British Journal of Anaesthesia Controlled trial quality: predicted high

68. Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury

Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury (ESWT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02203994 Recruitment Status : Completed First Posted : July 30, 2014 Last

2014 Clinical Trials

69. The potential role of heat shock proteins in acute spinal cord injury. (Abstract)

The potential role of heat shock proteins in acute spinal cord injury. This study aims to investigate the differential expression proteins profile of spinal cord tissues after acute spinal cord injury (ASCI), provide preliminary results for further study and explore the secondary injury mechanisms underlying ASCI.Using Allen's frame to establish ASCI model of Sprague-Dawley rats, then a stable isotope-labelled strategy using isobaric tags for relative and absolute quantitation (iTRAQ) coupled (...) expressed Heat shock proteins (HSPs) namely, Hsp90ab1, Hspa4 and Hspe1 were down-regulated.The differentially expressed proteins of spinal cord tissues after ASCI will provide scientific foundation for further study to explore the secondary injury mechanism of ASCI.

2014 European Spine Journal

70. Low-energy extracorporeal shock wave therapy promotes vascular endothelial growth factor expression and improves locomotor recovery after spinal cord injury. Full Text available with Trip Pro

Low-energy extracorporeal shock wave therapy promotes vascular endothelial growth factor expression and improves locomotor recovery after spinal cord injury. Extracorporeal shock wave therapy (ESWT) is widely used for the clinical treatment of various human diseases. Recent studies have demonstrated that low-energy ESWT upregulates the expression of vascular endothelial growth factor (VEGF) and promotes angiogenesis and functional recovery in myocardial infarction and peripheral artery disease (...) . Many previous reports suggested that VEGF produces a neuroprotective effect to reduce secondary neural tissue damage after spinal cord injury (SCI). The purpose of the present study was to investigate whether low-energy ESWT promotes VEGF expression and neuroprotection and improves locomotor recovery after SCI.Sixty adult female Sprague-Dawley rats were randomly divided into 4 groups: sham group (laminectomy only), sham-SW group (low-energy ESWT applied after laminectomy), SCI group (SCI only

2014 Journal of Neurosurgery

71. Treadmill training stimulates BDNF mRNA expression in motor neurons of the lumbar spinal cord in spinally transected rats Full Text available with Trip Pro

Treadmill training stimulates BDNF mRNA expression in motor neurons of the lumbar spinal cord in spinally transected rats Brain-derived neurotrophic factor (BDNF) induces plasticity within the lumbar spinal circuits thereby improving locomotor recovery in spinal cord-injured animals. We examined whether lumbar spinal cord motor neurons and other ventral horn cells of spinally transected (ST) rats were stimulated to produce BDNF mRNA in response to treadmill training. Rats received complete (...) spinal cord transections as neonates (n=20) and one month later, received four weeks of either a low (100 steps/training session; n=10) or high (1000 steps/training session; n=10) amount of robotic-assisted treadmill training. Using combined non-radioactive in situ hybridization and immunohistochemical techniques, we found BDNF mRNA expression in heat shock protein 27-labeled motor neurons and in non-motor neuron cells was greater after 1000 steps/training session compared to the 100 steps/training

2012 Neuroscience

72. Risk of cement leakage and pulmonary embolism by bone cement augmented pedicle screw fixation of the thoracolumbar spine. (Abstract)

the rate of CAPSI-associated complications.Retrospective cohort study.Patients who underwent CAPSI due to spinal tumors or degenerative spine disease.Cement leakage, pulmonary cement embolism (PCE), mortality rate.Our clinical database was reviewed for patients who underwent CAPSI between January 2012 and June 2015. A total of 165 patients (mean age 71±11.2; range: 46 to 93 years; m=62, f=103) were included. Indications were osteoporotic fractures (n=40), spinal metastases (n=57), degenerative (n=49 (...) ) or infectious spine disease (n=5), and traumatic vertebral fractures (n=14) with an associated osteoporosis. Every patient received between 2 and 21 (mean 8±3.3) cement-augmented pedicle screws in the thoracolumbar and lumbosacral spine. Both intraoperative cement leakage in prevertebral veins, the inferior vena cava, and/or pulmonary arteries, and leakage detected on postoperative imaging were evaluated. We assessed the incidence of clinically symptomatic and asymptomatic events.In 29 of 31 patients

2017 The Spine Journal

73. Segmental reflex pathways in spinal shock and spinal spasticity in man Full Text available with Trip Pro

Segmental reflex pathways in spinal shock and spinal spasticity in man Activity in three segmental pathways was compared in normal subjects, patients with spinal shock, and patients with established spinal spasticity. The Achilles tendon reflex (ATR) was used to estimate transmission in the Ia monosynaptic pathway. Evidence is produced implying that vibration activates motoneurones principally through a polysynaptic pathway. The tonic vibration reflex (TVR) was used to estimate transmission (...) in this Ia polysynaptic pathway. The percentage of the motoneurone pool (M-response) that could be activated by these pathways was used as a measure of transmission. The H reflex (vibration)/H reflex (control) ratio was used as an estimate of the degree of presynaptic inhibition of the Ia monosynaptic pathway. The findings led to the following conclusions. (1) In spinal shock presynaptic inhibition is greater than normal, transmission in the Ia monosynaptic pathway is reduced, and in the Ia polysynaptic

1974 Journal of neurology, neurosurgery, and psychiatry

74. 30-Day Mortality Following Surgery for Spinal Epidural Abscess: Incidence, Risk Factors, Predictive Algorithm, and Associated Complications. (Abstract)

30-Day Mortality Following Surgery for Spinal Epidural Abscess: Incidence, Risk Factors, Predictive Algorithm, and Associated Complications. Retrospective case-control study.To determine incidence and timing of mortality following surgery for spinal epidural abscess (SEA), identify risk factors for mortality, and identify complications associated with mortality.SEA is a serious condition with potentially devastating sequelae. There is a paucity of literature characterizing mortality following (...) (95% CI: 0.683-0.839, p < 0.001). Cardiac arrest (adjusted odds ratio [aOR]: 72.240, 95% confidence interval [CI]: 27.8-187.721, p < 0.001), septic shock (aOR: 15.382, 95% CI: 7.604-31.115, p < 0.001), and pneumonia (aOR: 2.84, 95% CI: 1.109-7.275, p = 0.03) were independently associated with mortality.The 30-day mortality rate following surgery for SEA was 3.7%. Of the mortalities that occurred within 30 days of surgery, the majority occurred within 2 weeks. Independent risk factors for mortality

2018 Spine

75. Effects of ginsenoside Rb1 on oxidative stress injury in rat spinal cords by regulating the eNOS/Nrf2/HO-1 signaling pathway Full Text available with Trip Pro

blot analyses were used to detect eNOS, phosphorylated (p)-eNOS, heat shock protein (HSP)90, Nrf2 and NAD(P)H quinone dehydrogenase 1 (Nqo1) at the mRNA and protein level. Immunohistochemistry was used to detect the expression of Nrf2 and p-eNOS. Compared with the S group, the scores of spinal cord function in the SCI group were significantly lower, and the levels of MDA were significantly increased, while the levels of SOD, CAT and GSH protein in spinal cord were significantly decreased (P<0.05 (...) Effects of ginsenoside Rb1 on oxidative stress injury in rat spinal cords by regulating the eNOS/Nrf2/HO-1 signaling pathway The present study aimed to investigate whether ginsenoside Rb1 (G-Rb1) attenuates spinal cord injury-associated oxidative stress in rats by regulating the endothelial nitric oxide synthase eNOS/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase (HO)-1 signaling pathway. Sprague Dawley rats were randomly divided into the sham operation group (S group

2018 Experimental and therapeutic medicine

76. Predicting critical care unit-level complications after long-segment fusion procedures for adult spinal deformity Full Text available with Trip Pro

Predicting critical care unit-level complications after long-segment fusion procedures for adult spinal deformity To identify predictive factors for critical care unit-level complications (CCU complication) after long-segment fusion procedures for adult spinal deformity (ASD).The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database [2010-2014] was reviewed. Only adult patients who underwent fusion of 7 or more spinal levels for ASD were included. CCU (...) complications included intraoperative arrest/infarction, ventilation >48 hours, pulmonary embolism, renal failure requiring dialysis, cardiac arrest, myocardial infarction, unplanned intubation, septic shock, stroke, coma, or new neurological deficit. A stepwise multivariate regression was used to identify independent predictors of CCU complications.Among 826 patients, the rate of CCU complications was 6.4%. On multivariate regression analysis, dependent functional status (P=0.004), combined approach (P

2018 Journal of Spine Surgery

77. Incidence and risk factors of wound complications in long segment instrumented thoracolumbar spinal fusions: a retrospective study Full Text available with Trip Pro

Incidence and risk factors of wound complications in long segment instrumented thoracolumbar spinal fusions: a retrospective study This is a retrospective analysis of prospectively collected data. Our objective was to determine the incidence and assess the risk factors associated with surgical site wound complications in long segment (7+ vertebrae) instrumented thoracolumbar fusions. Surgical site complications lead to patient morbidity, increased financial burden, and further medical (...) intervention. Risk factors for wound complications in spinal surgery include patient factors such as obesity and diabetes, and surgical factors such as operative time and procedure type. Fusion with instrumentation is one of the strongest associated risk factors in the literature.A comprehensive search of the National Surgical Quality Improvement Program (NSQIP) from 2005 to 2014 was performed, selecting cases based on Current Procedural Terminology (CPT) codes. Cases were then stratified based

2018 Journal of Spine Surgery

78. Temporal analysis of cardiovascular control and function following incomplete T3 and T10 spinal cord injury in rodents Full Text available with Trip Pro

Temporal analysis of cardiovascular control and function following incomplete T3 and T10 spinal cord injury in rodents Spinal cord injury (SCI) is a devastating condition that results in whole-body dysfunction, notably cardiovascular (CV) disruption and disease. Injury-induced destruction of autonomic pathways in conjunction with a progressive decline in physical fitness contribute to the poor CV status of SCI individuals. Despite the wide use of exercise training as a therapeutic option (...) animals displayed a drastic decline in heart rate (HR) during the exercise challenge, likely a consequence of neurogenic shock. Furthermore, over time, all groups developed a progressive inability to maintain BP within a narrow range during the exercise challenge despite displaying normal hemodynamic parameters at rest. Echocardiography of T10 animals revealed no persistent signs of cardiac dysfunction; T3 animals exhibited a transient decline in systolic function that returned to preinjury levels

2018 Physiological reports

79. Early neurological care of patients with spinal cord injury. (Abstract)

of SCI patients. Recommendations were developed by consensus and graded using a modified Oxford system which identifies level of evidence (LOE) and grade of recommendation (GOR).Emergency health care providers must address altered mental status, evidence of intoxication, suspected extremity fracture/distracting injury, focal neurological deficit and spinal pain/tenderness to determine the risk of SCI in a trauma patient [LOE 1, GOR A]. Neurogenic shock must be recognized and treated [LOE 3, GOR (...) Early neurological care of patients with spinal cord injury. Considering the major clinical challenges of managing patients with spinal cord injury (SCI), we summarized the relevant aspects of the early (within 1 year after SCI) neurological care emphasizing common standards.This review was performed according to the methodology recommended by the Joint SIU-ICUD International Consultation. Embase and Medline databases were used to identify literature relevant to the early neurological care

2018 World journal of urology

80. Virtual Reality Walking for Neuropathic Pain in Spinal Cord Injury

and neurological lesions. It has components of how the pain feels to the patient (e.g. burning, cold, electrical shocks, tingling, hypoaesthesia). Responses to each item is yes or no, with each yes response equaling one point. Range of scores: 0-10. 4/10 and greater indicate neuropathic pain. Pain Interference specific to spinal cord injury as assessed by International Spinal Cord Injury Pain Basic Data Set version 2.0 [ Time Frame: Baseline - Final assessment (average 1 week post treatment) ] Pain (...) Virtual Reality Walking for Neuropathic Pain in Spinal Cord Injury Virtual Reality Walking for Neuropathic Pain in Spinal Cord Injury - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Virtual Reality Walking

2018 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>