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Spinal Shock

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181. Spinal Cord Injuries (Diagnosis)

(ABG) measurements - May be useful to evaluate adequacy of oxygenation and ventilation Lactate levels - To monitor perfusion status; can be helpful in the presence of shock Hemoglobin and/or hematocrit levels - May be measured initially and monitored serially to detect or monitor sources of blood loss Urinalysis - Can be performed to detect any associated genitourinary injury Imaging studies Imaging techniques in spinal cord injury include the following: Plain radiography - Radiographs are only (...) management - The cervical spine must be maintained in neutral alignment at all times; clearing of oral secretions and/or debris is essential to maintaining airway patency and preventing aspiration Hypotension - Hypotension may be hemorrhagic and/or neurogenic in acute spinal cord injury; a diligent search for occult sources of hemorrhage must be made Neurogenic shock - Judicious fluid replacement with isotonic crystalloid solution to a maximum of 2 L is the initial treatment of choice; maintain adequate

2014 eMedicine Emergency Medicine

182. Spinal Cord Injuries (Follow-up)

of the patient's cervical spine is a potential pitfall. Hypotension, hemorrhage, and shock Hypotension may be hemorrhagic and/or neurogenic in acute spinal cord injury. Because of the vital sign confusion in acute spinal cord injury and the high incidence of associated injuries, a diligent search for occult sources of hemorrhage must be made. The most common sources of occult hemorrhage are injuries to the chest, abdomen, and retroperitoneum and fractures of the pelvis or long-bones. Appropriate investigations (...) Spinal Cord Injuries (Follow-up) Spinal Cord Injuries Treatment & Management: Approach Considerations, Prehospital Management, Emergency Department Management Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine Emergency Medicine

183. Spinal Cord Injuries (Overview)

(ABG) measurements - May be useful to evaluate adequacy of oxygenation and ventilation Lactate levels - To monitor perfusion status; can be helpful in the presence of shock Hemoglobin and/or hematocrit levels - May be measured initially and monitored serially to detect or monitor sources of blood loss Urinalysis - Can be performed to detect any associated genitourinary injury Imaging studies Imaging techniques in spinal cord injury include the following: Plain radiography - Radiographs are only (...) management - The cervical spine must be maintained in neutral alignment at all times; clearing of oral secretions and/or debris is essential to maintaining airway patency and preventing aspiration Hypotension - Hypotension may be hemorrhagic and/or neurogenic in acute spinal cord injury; a diligent search for occult sources of hemorrhage must be made Neurogenic shock - Judicious fluid replacement with isotonic crystalloid solution to a maximum of 2 L is the initial treatment of choice; maintain adequate

2014 eMedicine Emergency Medicine

184. Radial Shock Wave and Acupuncture for Myofascial Pain

and trigger point injection. Acupuncture originated from ancient Chinese medicine which involves the insertion of fine needle to stimulate specific points of the body along the 12 meridians. The mechanism of pain relief may be initiated by activation of both spinal segmental and supraspinal centers. Acupuncture is commonly used for pain relief. Recently, radial shock wave has been shown to be effective in the treatment of chronic musculoskeletal pain, including calcific tendinitis, epicondylitis (...) Radial Shock Wave and Acupuncture for Myofascial Pain Radial Shock Wave and Acupuncture for Myofascial Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Radial Shock Wave and Acupuncture for Myofascial

2013 Clinical Trials

185. Radial Extracorporeal Shock Wave Therapy on Chronic Low Back Pain: a Prospective Controlled Study

Radial Extracorporeal Shock Wave Therapy on Chronic Low Back Pain: a Prospective Controlled Study Radial Extracorporeal Shock Wave Therapy on Chronic Low Back Pain: a Prospective Controlled Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Radial Extracorporeal Shock Wave Therapy on Chronic Low Back Pain: a Prospective Controlled Study The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01928784 Recruitment Status : Unknown Verified August 2013 by Cheng Zeng, Beijing Jishuitan Hospital. Recruitment

2013 Clinical Trials

186. Stepwise Shock Wave Lithotripsy in Pediatric Urolithiasis

Stepwise Shock Wave Lithotripsy in Pediatric Urolithiasis Stepwise Shock Wave Lithotripsy in Pediatric Urolithiasis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Stepwise Shock Wave Lithotripsy (...) Study Description Go to Brief Summary: To evaluate and compare the results of conventional and stepwise shock wave lithotripsy treatment modalities in pediatric urinary lithiasis. Condition or disease Intervention/treatment Phase Pediatric Urinary Lithiasis Procedure: Shock wave lithotripsy Not Applicable Detailed Description: Between March 2008 and February 2012, 81 patients were randomized and included in this study. Shock wave lithotripsy was performed by using a Dornier Compact Delta instrument

2013 Clinical Trials

187. Adaptation of motor function after spinal cord injury: novel insights into spinal shock. (PubMed)

Adaptation of motor function after spinal cord injury: novel insights into spinal shock. The mechanisms underlying spinal shock have not been clearly defined. At present, clinical assessment remains the mainstay to describe progression through spinal shock following traumatic spinal cord injury. However, nerve excitability studies in combination with conventional nerve conduction and clinical assessments have the potential to investigate spinal shock at the level of the peripheral axon (...) was assessed using threshold tracking techniques and recordings were compared with data from healthy controls. In addition, concurrent clinical measures of strength, serum electrolytes and nerve conduction were collected. High threshold stimulus-response relationships were apparent from the early phase of spinal shock that coincided with depolarization-like features that reached a peak on Day 16.9 (± 2.7 standard error) for the common peroneal nerve and Day 11.8 (± 2.0 standard error) for the median nerve

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2010 Brain

188. Induction of heat shock proteins in cerebral cortical cultures by celastrol (PubMed)

of cells in the spinal cord. These diseases differ widely in frequency in the human population. Alzheimer's is more frequent than Parkinson's and ALS. Heat shock proteins (Hsps) are 'protein repair agents' that provide a line of defense against misfolded, aggregation-prone proteins. We have suggested that differing levels of constitutively expressed Hsps (Hsc70 and Hsp27) in neural cell populations confer a variable buffering capacity against 'protein misfolding disorders' that correlates (...) Induction of heat shock proteins in cerebral cortical cultures by celastrol Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) are 'protein misfolding disorders' of the mature nervous system that are characterized by the accumulation of protein aggregates and selective cell loss. Different brain regions are impacted, with Alzheimer's affecting cells in the cerebral cortex, Parkinson's targeting dopaminergic cells in the substantia nigra and ALS causing degeneration

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2012 Cell stress & chaperones

189. Efficacy & Safety of a 2nd Series of Low Intensity Shock Waves for ED on Partial Responders to First Treatment

Efficacy & Safety of a 2nd Series of Low Intensity Shock Waves for ED on Partial Responders to First Treatment Efficacy & Safety of a 2nd Series of Low Intensity Shock Waves for ED on Partial Responders to First Treatment - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Efficacy & Safety of a 2nd Series of Low Intensity Shock Waves for ED on Partial Responders to First Treatment The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01601262 Recruitment Status : Unknown Verified July 2012 by Rambam Health

2012 Clinical Trials

190. Serum Vasopressin Levels and Severe Hemorrhagic Shock

for mechanical ventilation other than transiently during orthopedic surgery. Exclusion Criteria: Pregnancy corticosteroid use, prisoners, and/or head trauma as determined by computed tomography (head trauma may itself induce diabetes insipidus, a marker of pituitary damage and vasopressin deficiency), and/or evidence of spinal cord injury (another cause of vasodilatory shock). Patients will also be excluded if pre-hospital provider information cannot be obtained, or indicates that the trauma occurred more (...) Serum Vasopressin Levels and Severe Hemorrhagic Shock Serum Vasopressin Levels and Severe Hemorrhagic Shock - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Serum Vasopressin Levels and Severe Hemorrhagic

2012 Clinical Trials

191. Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot

Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01648036 Recruitment Status : Completed First Posted : July 24, 2012 Last Update Posted : July 10, 2014 Sponsor: University of Manitoba Information provided by (Responsible Party

2012 Clinical Trials

192. Effects of pre-moxibustion at Zusanli (ST36) on heat shock protein 70 expression in rats with gastric mucosal lesions after neurotomy (PubMed)

, the ulcer index decreased to different degrees. The results of an enzyme linked immunosorbent assay and western blotting showed significant upregulation of heat shock protein 70 expression in the gastric mucosa and serum. None out of transection of the spinal cord, damage to the nucleus of the solitary tract, neurotomy of the vagal nerve and neurotomy of the common peroneal nerve affected the decrease in ulcer index or the increase in heat shock protein 70 expression in serum after pre-moxibustion (...) Effects of pre-moxibustion at Zusanli (ST36) on heat shock protein 70 expression in rats with gastric mucosal lesions after neurotomy Studies have shown that pre-moxibustion protects the gastric mucosa by up-regulating the expression of heat shock protein 70. However, the signaling pathway underlying this effect remains unclear. Rats were intragastrically administered absolute alcohol, causing obvious lesion of the gastric mucosa. Following pre-moxibustion at Zusanli (ST36) for 8 days

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2012 Neural Regeneration Research

193. Neurogenic Shock

Shock , Vasogenic Shock From Related Chapters II. Definitions Neurogenic Shock Distributive shock from neurogenic vasodilation mediated by loss of sympathetic tone Follows cerebral or spinal cord injury (above T6) affecting sympathtic nervous system In contrast to Neurogenic Shock, is not a true shock syndrome Results in and loss below level of spinal cord injury III. Pathophysiology Results from or upper spine injury (above T6) Peripheral denervation results in ungoverned activity Loss of vasomotor (...) tone (vasodilation) leading to distributive shock Loss of cardiac activity, leads to paradoxical IV. Causes (above T6) V. Signs Secondary to and vasodilation Narrow is absent Lack of typical sympathetic response (increased SVR and diastolic BP) Paradoxical Expected response is a reflex (a sympathetic response) Decreased vascular tone (vasodilation) Warm extremities VI. Associated Conditions See See See See and loss below level of spinal cord injury Diaphragm Paralysis C3-5 resulting in phrenic

2015 FP Notebook

194. Hemorrhagic Shock

or endovascular management CT Spine Consider if suspected XIV. Differential Diagnosis secondary to spinal cord injury does not occur in isolated intracranial injury Other non- tic shock See for approach Hypovolemic (e.g. dehydration) XV. Evaluation (Class I-IV) is unreliable See = ( ) / (Systolic ) >0.9 predicts need for increased transfusion requirements and early mortality risk ( ) Four point score ( , SBP<90 mmHg, >120, positive ) 3 or 4 predicts protocol Associated Severe Hemorrhage (TASH) Based on SBP (...) Hemorrhagic Shock Hemorrhagic Shock Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Hemorrhagic Shock Hemorrhagic Shock Aka

2015 FP Notebook

195. Heat stress and cardiovascular, hormonal, and heat shock proteins in humans. (PubMed)

Heat stress and cardiovascular, hormonal, and heat shock proteins in humans. Conditions such as osteoarthritis, obesity, and spinal cord injury limit the ability of patients to exercise, preventing them from experiencing many well-documented physiologic stressors. Recent evidence indicates that some of these stressors might derive from exercise-induced body temperature increases.To determine whether whole-body heat stress without exercise triggers cardiovascular, hormonal, and extracellular (...) stress.Extracellular heat shock protein (HSP72) and catecholamine plasma concentration, heart rate, blood pressure, and heat perception.After 30 minutes of heat stress, body temperature measured via rectal sensor increased by 0.8°C. Heart rate increased linearly to 131.4 ± 22.4 beats per minute (F₆,₂₄ = 186, P < .001) and systolic and diastolic blood pressure decreased by 16 mm Hg (F₆,₂₄ = 10.1, P < .001) and 5 mm Hg (F₆,₂₄ = 5.4, P < .001), respectively. Norepinephrine (F₁,₁₂ = 12.1, P = .004) and prolactin (F

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2012 Journal of athletic training

196. Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy. (PubMed)

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy. Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease caused by an abnormal expansion of a tandem CAG repeat in exon 1 of the androgen receptor (AR) gene that results in an abnormally long polyglutamine tract (polyQ) in the AR protein. As a result, the mutant AR (ARpolyQ) misfolds, forming cytoplasmic and nuclear aggregates in the affected neurons. Neurotoxicity only (...) appears to be associated with the formation of nuclear aggregates. Thus, improved ARpolyQ cytoplasmic clearance, which indirectly decreases ARpolyQ nuclear accumulation, has beneficial effects on affected motoneurons. In addition, increased ARpolyQ clearance contributes to maintenance of motoneuron proteostasis and viability, preventing the blockage of the proteasome and autophagy pathways that might play a role in the neuropathy in SBMA. The expression of heat shock protein B8 (HspB8), a member

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2013 Neurobiology of Aging

197. Spinal Cord Ischemia After Thoracic Stent-Grafting: Causes Apart From Intercostal Artery Coverage. (PubMed)

Spinal Cord Ischemia After Thoracic Stent-Grafting: Causes Apart From Intercostal Artery Coverage. Examination of a large collective combined with individual case analyses may give new insights into mechanisms and prevention of spinal cord ischemia (SCI) after thoracic endovascular repair.In an 11-year period, stent-grafts were implanted in 406 patients for various aortic pathologic conditions. The mean age was 63 years (15-91 years) and 300 (74%) patients were men; 58 patients underwent staged (...) ischemia, profound hemorrhagic shock, and heparin-induced thrombocytopenia.The incidence of SCI is unexpectedly low despite extensive sacrifice of intercostal arteries. Extended coverage of the thoracic and thoracoabdominal aorta seems to have a higher risk, but other factors may contribute to the individual disaster.Copyright © 2013 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

2013 Annals of Thoracic Surgery

198. Video-assisted thoracoscopic surgery with posterior spinal reconstruction for the resection of upper lobe lung tumors involving the spine. (PubMed)

Video-assisted thoracoscopic surgery with posterior spinal reconstruction for the resection of upper lobe lung tumors involving the spine. Video-assisted thoracoscopic surgery (VATS) is associated with less morbidity and recovery time compared with traditional open thoracotomy (OT) for the resection of early stage non-small cell lung cancer (NSCLC). Local invasion of NSCLC into adjacent vertebrae confers a TNM T status of T4. Anatomical lobectomy by VATS with simultaneous posterior spinal (...) . Mean operative time and blood loss were similar between the groups: VATS: 367±117 minutes versus OT: 518±264 minutes; VATS: 813±463 mL versus OT: 1,250±1,500 mL. Mean follow-up was 16±13 months after surgery. Complications occurred in all eight patients. One OT patient had wound dehiscence requiring a tissue flap, and another suffered from a septic shock. No wound complications developed after VATS. Death secondary to tumor recurrence occurred once in each group. For the six surviving patients, 23

2013 The Spine Journal

199. Priapism in acute spinal cord injury

is unconscious because of a traumatic brain injury, the presence of priapism is an indication of coexisting SCI. (Ref: Sneed RC, Stover SL. Undiagnosed spinal cord injuries in brain-injured children. Am J Dis Child 1988; 142: 965–967.) However, priapism can occur in both: Complete spinal cord injury (anatomical/physical damage to the motor and sensory pathways in the spinal cord) OR Spinal shock (physiological; reversible, typically over several hours or days) Nonetheless, spinal shock is rare; most patients (...) Priapism in acute spinal cord injury Emergency Medicine Blog: Priapism in acute spinal cord injury Sunday, June 16, 2013 Priapism in acute spinal cord injury Why priapism in acute spinal cord injury? The pathophysiology It is assumed that the mechanism of priapism in most patients with SCI is that abrupt loss of sympathetic input to the pelvic vasculature leads to increased parasympathetic input and uncontrolled arterial inflow directly into the penile sinusoidal spaces. The sympathetic outflow

2013 Emergency Medicine Blog

200. Stress protein expression in early phase spinal cord ischemia/reperfusion injury (PubMed)

Stress protein expression in early phase spinal cord ischemia/reperfusion injury Spinal cord ischemia/reperfusion injury is a stress injury to the spinal cord. Our previous studies using differential proteomics identified 21 differentially expressed proteins (n > 2) in rabbits with spinal cord ischemia/reperfusion injury. Of these proteins, stress-related proteins included protein disulfide isomerase A3, stress-induced-phosphoprotein 1 and heat shock cognate protein 70. In this study, we (...) established New Zealand rabbit models of spinal cord ischemia/reperfusion injury by abdominal aorta occlusion. Results demonstrated that hind limb function initially improved after spinal cord ischemia/reperfusion injury, but then deteriorated. The pathological morphology of the spinal cord became aggravated, but lessened 24 hours after reperfusion. However, the numbers of motor neurons and interneurons in the spinal cord gradually decreased. The expression of protein disulfide isomerase A3, stress

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2013 Neural Regeneration Research

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