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Spinal Shock

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1. Age-related changes in shock absorption capacity of the human spinal column Full Text available with Trip Pro

Age-related changes in shock absorption capacity of the human spinal column The spinal column possesses shock absorption properties, mainly provided by the intervertebral discs. However, with the process of senescence, all structures of the spine, including the discs, undergo degenerative changes. It may lead to alteration of the mechanical properties of the spinal motion segment and diminished capacity for vibration attenuation.The objective of this study was to investigate the age-related (...) changes in shock absorption properties of the spine.A total of 112 individuals divided into three groups according to age (third, fifth, and seventh decades of life) were enrolled in this study. The transmissibility of vibrations through the spine was measured in a standing position on a vibration platform by accelerometers mounted at the levels of S2 and C0. Registered signals were described using four parameters: VMS (variability), peak-to-peak amplitude (PPA), and spectral activity in two bands F2

2018 Clinical interventions in aging

2. Lateral interbody fusion in the lumbar spine for low back pain

be done by surgeons with specific training in the technique, who should carry out their initial procedures with an experienced mentor. 1.3 Clinicians should enter details about all patients having lateral interbody fusion in the lumbar spine for low back pain onto the British Spine Registry. 2 2 Indications and current treatments Indications and current treatments 2.1 Chronic low back pain may result from degenerative changes in the intervertebral discs or spinal facet joints. Conservative treatments (...) include analgesics, non-steroidal anti-inflammatory medication and manual therapy. 2.2 For people with severe, life-limiting, chronic low back pain that does not respond to conservative treatments, surgery may be appropriate. This may include bony fusion of vertebrae (to immobilise segments of the vertebral column thought to be responsible for back pain, using either a posterior or anterior approach) or inserting a prosthetic intervertebral disc (which preserves lumbar mobility to reduce the risk

2017 National Institute for Health and Clinical Excellence - Interventional Procedures

3. Revisit Spinal Shock: Pattern of Reflex Evolution during Spinal Shock Full Text available with Trip Pro

Revisit Spinal Shock: Pattern of Reflex Evolution during Spinal Shock When the spinal cord is suddenly severed, all the fundamental functions of the spinal cord below the level of injury including the spinal cord reflexes are immediately depressed, which is referred to as spinal shock. The resolution of spinal shock occurs over a period of days to months, and spinal shock slowly transitions to spasticity. The definition of spinal shock and the pattern of reflex recovery or evolution remains (...) as an issue of debate and controversy. The identification of clinical signs that determine the duration of spinal shock is controversial. The underlying mechanisms of spinal shock are also not clearly defined. Various authors have defined the termination of spinal shock as the appearance of the bulbocavernosus reflex, the recovery of deep tendon reflexes, or the return of reflexic detrusor activity. However, many questions remain to be answered, such as: When should we define spinal shock as the end? What

2018 Korean Journal of Neurotrauma

4. Efficacy of extracorporeal shock wave combined spinal core decompression for the treatment of patients with femoral head necrosis: A protocol for systematic review and meta-analysis. Full Text available with Trip Pro

Efficacy of extracorporeal shock wave combined spinal core decompression for the treatment of patients with femoral head necrosis: A protocol for systematic review and meta-analysis. Previous studies have reported that extracorporeal shock wave (EPSW) combined spinal core decompression (SCD) has been used for the treatment of patients with femoral head necrosis (FHN) effectively. However, their results are still inconsistent. Therefore, this study will systematically assess the efficacy

2020 Medicine

5. Analysis of complications following posterior vertebral column resection for the treatment of severe angular kyphosis greater than 100° Full Text available with Trip Pro

Analysis of complications following posterior vertebral column resection for the treatment of severe angular kyphosis greater than 100° The aim of this study was to evaluate the complications, efficacy and safety of posterior vertebral column resection (PVCR) in severe angular kyphosis (SAK) greater than 100°.The medical records of 17 patients (mean age 17.9 (range, 9-27) years) with SAK who underwent PVCR, were reviewed. Mean follow-up period was 32.2 (range, 24-64) months. Diagnosis (...) angle (LKA) was 71.5° at postoperatively evaluation (p < 0.05). Complications were detected in 12 patients (70.6%) with spinal shock in 4 patients, hemothorax in 3 patients, postoperative infection in 2 patients, dural laceration in 2 patients, neurological deficit in 2 patients (1 paraplegia and 1 root injury), the shifted cage in 2 patients and rod fracture in 2 patients. Neurological events occurred in six patients (35%) with temporary neurological deficit in 5 patients and permanent neurological

2017 Acta orthopaedica et traumatologica turcica

6. Traumatic lumbar artery rupture after lumbar spinal fracture dislocation causing hypovolemic shock: An endovascular treatment. (Abstract)

Traumatic lumbar artery rupture after lumbar spinal fracture dislocation causing hypovolemic shock: An endovascular treatment. Recently, we observed a case of lumbar artery injury after trauma, which was treated by endovascular embolization. A 67-year-old woman who was injured in a traffic accident was brought to the emergency room. She was conscious and her hemodynamic condition was stable, but she had paraplegia below L1 dermatome. Contrast-enhanced computed tomography scan of abdomen (...) of retroperitoneal hemorrhage. On the angiographic images, there was an active extravasation from ruptured left 3rd lumbar artery, and we performed complete embolization with GELFOAM and coil. Lumbar artery injury after trauma is rare and endovascular treatment is useful in case of hemodynamic instability.

2015 British Journal of Neurosurgery

7. Rates of Mortality in Lumbar Spine Surgery and Factors Associated With Its Occurrence Over a 10-Year Period: A Study of 803,949 Patients in the Nationwide Inpatient Sample Full Text available with Trip Pro

and improving outcomes. Additionally, mortality rates can be influenced by procedure type and patient profile, including demographics and comorbidities. The purpose of this study is to assess rates and risk factors associated with mortality in surgical procedures involving the lumbar spine using a large national database.The Nationwide Inpatient Sample database was reviewed from 2003 to 2012. A total of 803,949 patients age 18 years or older were identified by ICD-9CM procedure codes for spinal fusion (...) disease and congestive heart failure (OR: 4.57; CI: 3.77-5.53). The complications with the highest mortality rates were shock (OR: 20.67; CI: 13.89-30.56) and pulmonary embolism (OR: 20.15; CI: 14.01-29.00).From 2003 to 2012, the overall mortality rate in 803,949 lumbar spine surgery patients was 0.13%. Risk factors that were significantly associated with increased mortality rates were male gender, black race, and ages 65-74 and 75+. Comorbidities associated with an increased mortality rate were mild

2018 International journal of spine surgery

8. Bowel injury in lumbar spine surgery: a review of the literature Full Text available with Trip Pro

Bowel injury in lumbar spine surgery: a review of the literature Although rarely documented in the medical literature, bowel perforation injury can be a severe complication of spine surgery. Our goal was to review current literature regarding this complication and study possible methods of avoidance. We conducted a literature search in the PubMed database between January 1960 and March 2016 using the terms abrasion, bowels, bowel, complication, injury, intestine, intra-abdominal sepsis/shock (...) , perforation, lumbar, spine, surgery, visceral. Diagnostic criteria, outcomes, risk factors, surgical approach, and treatment strategy were the parameters extracted from the search results and used for review. Thirty-one patients with bowel injury were recognized in the literature. Bowel injury was more frequent in patients who underwent lumbar discectomy and microdiscectomy (18 of 31 patients, 58.1%). Minimally invasive surgery and lateral techniques involving fusions accounted for 10 of the reported

2018 Journal of Spine Surgery

9. Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis Full Text available with Trip Pro

Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by demyelination, inflammation and neurodegeneration throughout the central nervous system. Although spinal cord pathology is an important factor contributing to disease progression, few studies have examined MS lesions in the spinal cord and how they differ from brain lesions. In this study we have compared (...) brain and spinal cord white (WM) and grey (GM) matter from MS and control tissues, focusing on small heat shock proteins (HSPB) and HSP16.2. Western blotting was used to examine protein levels of HSPB1, HSPB5, HSPB6, HSPB8 and HSP16.2 in brain and spinal cord from MS and age-matched non-neurological controls. Immunohistochemistry was used to examine expression of the HSPs in MS spinal cord lesions and controls. Expression levels were quantified using ImageJ. Western blotting revealed significantly

2018 Clinical and experimental immunology

10. Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice Full Text available with Trip Pro

Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as chondroitin sulfate proteoglycans (CSPG), accumulate. We previously found that matrine, a major alkaloid in Sophora flavescens, enhanced axonal growth in neurons (...) seeded on CSPG coating. The aims of this study were to investigate therapeutic effects of matrine in SCI mice and to clarify the underlying mechanism. Matrine was orally administered to contusion SCI mice. In the matrine-treated mice, motor dysfunction of the hindlimbs was improved, and the density of 5-HT-positive tracts was increased in the injured spinal cord. We explored putative direct binding proteins of matrine in cultured neurons using drug affinity responsive target stability (DARTS

2018 Frontiers in pharmacology

11. Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system Full Text available with Trip Pro

Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system Spinal cord and peripheral nerve injury results in extensive damage to the locally injured cells as well as distant cells that are functionally connected to them. Both primary and secondary damage can cause a broad range of clinical abnormalities, including neuropathic pain and cognitive and memory dysfunction. However, the mechanisms underlying (...) these abnormalities remain unclear, awaiting new methods to identify affected cells to enable examination of their molecular, cellular and physiological characteristics. Here, we report that both primary and secondary damage to cells in mouse models of spinal cord and peripheral nerve injury can be detected in vivo using a novel fluorescent reporter system based on the immediate stress response via activation of Heat Shock Factor 1. We also provide evidence for altered electrophysiological properties of reporter

2018 IBRO Reports

12. Extracorporeal shock wave combined spinal core decompression for femoral head necrosis: a protocol of systematic review and meta-analysis

Extracorporeal shock wave combined spinal core decompression for femoral head necrosis: a protocol of systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration

2020 PROSPERO

13. A protocol of systematic review and meta-analysis of extracorporeal shock wave (EPSW) combined spinal core decompression (SCD) for femoral head necrosis (FHN)

A protocol of systematic review and meta-analysis of extracorporeal shock wave (EPSW) combined spinal core decompression (SCD) for femoral head necrosis (FHN) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2020 PROSPERO

14. Efficacy of extracorporeal shock wave (EPSW) combined spinal core decompression (SCD) for the treatment of patients with femoral head necrosis (FHN)

Efficacy of extracorporeal shock wave (EPSW) combined spinal core decompression (SCD) for the treatment of patients with femoral head necrosis (FHN) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2020 PROSPERO

15. Shock

and tongue swelling urticarial rash pelvic pain/vaginal bleeding in woman of childbearing age increasing age comorbidities myocardial infarction cardiomyopathy heart valve disease arrhythmias trauma gastrointestinal bleeding ruptured abdominal aortic aneurysm burns/heat stroke gastrointestinal losses: diarrhoea and vomiting pancreatitis sepsis anaphylaxis/poisoning spinal or brainstem injury endocrine disease pulmonary embolism cardiac tamponade new medicine (anaphylactic shock) Diagnostic investigations (...) Shock Shock - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Shock Last reviewed: February 2019 Last updated: January 2019 Summary Commonly diagnosed when signs of hypoperfusion are associated with low or declining blood pressure. It may result from a number of disease processes, including pump failure (cardiogenic), loss of intravascular volume (hypovolaemic), failure of vasoregulation (distributive), or obstruction

2019 BMJ Best Practice

16. Management of Pediatric Cervical Spine and Spinal Cord Injuries Full Text available with Trip Pro

further injury to the vertebral column and spinal cord. Immobilization of the child's cervical spine in the neutral position is desired. To achieve neutral alignment of the cervical spine in children < 8 years of age, allowances must be made for the relatively large head compared to the torso, which forces the neck into a position of flexion when the head and torso are supine on a flat surface. Nypaver and Treloar prospectively evaluated 40 children < 8 years of age seen in an emergency room (...) for cervical spine injuries that fail non-operative management. RATIONALE There are distinct, unique aspects of the management of children with potential injuries of the cervical spinal column and cervical spinal cord compared to adult patients that warrant specific recommendations. The methods of pre-hospital immobilization necessary to approximate “neutral” cervical spinal alignment in a young child differ from those methods commonly employed for adults. The spinal injury patterns among young children

2013 Congress of Neurological Surgeons

17. The Alternating Bidirectional Versus The Standard Approach During Shock Wave Lithotripsy For Renal And Upper Lumbar Ureteric Stones

The Alternating Bidirectional Versus The Standard Approach During Shock Wave Lithotripsy For Renal And Upper Lumbar Ureteric Stones The Alternating Bidirectional Versus The Standard Approach During Shock Wave Lithotripsy For Renal And Upper Lumbar Ureteric Stones - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have (...) reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Alternating Bidirectional Versus The Standard Approach During Shock Wave Lithotripsy For Renal And Upper Lumbar Ureteric Stones The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03243682

2017 Clinical Trials

18. Thoracolumbar spine trauma

evaluation involves performing primary survey with ABC assessment with C-spine immobilisation and haemorrhage control. It is important to evaluate and assess thoracolumbar fractures for instability. If the decision to operate is made, this should occur earlier rather than later. Definition Thoracolumbar fractures are breakages in the vertebrae of the spinal column in the thoracic and lumbar regions. They may be associated with disruption of the ligamentous complexes, and can result in instability (...) hyperreflexia or hyporeflexia Hoffman's sign positive Babinski's sign spinal deformity loss of anal sphincter reflex absence of bulbocavernosus reflex (S3-S4) signs of spinal shock (hypotonia or flaccidity that resolves within 24 hours) urinary incontinence painless urinary retention male sex age >65 years concomitant osteoporosis previous vertebral fracture underlying neoplastic lesion underlying metabolic or inflammatory disorders falling from a height motor vehicle accident Diagnostic investigations

2018 BMJ Best Practice

19. Acute cervical spine trauma

interventions. The use of methylprednisolone, while certainly time-sensitive, is an intervention whose efficacy is debated among professionals. Early consultation with a specialist is advisable to avoid delays that may affect patient outcome. This monograph concentrates on cervical spine trauma in adults. Definition Acute cervical spine trauma encompasses a wide range of potential injuries to ligaments, muscles, bones, and spinal cord that follow acute incidents ranging from a seemingly innocuous fall (...) tenderness male sex age 18 to 25 years intoxication numbness, tingling, or weakness of extremities bowel or bladder dysfunction motor weakness sensory loss reduced or painful cervical range of motion (ROM) loss of anorectal tone and perianal sensation spasticity hyper-reflexia Babinski's sign Hoffman's sign neurogenic shock spinal shock respiratory change cranial nerve deficit male sex female sex (whiplash injury) lack of preparation or awareness of collision head rotated at time of collision previous

2018 BMJ Best Practice

20. Shock

and tongue swelling urticarial rash pelvic pain/vaginal bleeding in woman of childbearing age increasing age comorbidities myocardial infarction cardiomyopathy heart valve disease arrhythmias trauma gastrointestinal bleeding ruptured abdominal aortic aneurysm burns/heat stroke gastrointestinal losses: diarrhoea and vomiting pancreatitis sepsis anaphylaxis/poisoning spinal or brainstem injury endocrine disease pulmonary embolism cardiac tamponade new medicine (anaphylactic shock) Diagnostic investigations (...) Shock Shock - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Shock Last reviewed: February 2019 Last updated: January 2019 Summary Commonly diagnosed when signs of hypoperfusion are associated with low or declining blood pressure. It may result from a number of disease processes, including pump failure (cardiogenic), loss of intravascular volume (hypovolaemic), failure of vasoregulation (distributive), or obstruction

2018 BMJ Best Practice

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