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Speech Delay

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121. Cognitive Reserve and Second Language Acquisition

: University of Toronto Information provided by (Responsible Party): Jed A. Meltzer, Ph.D, Rotman Research Institute at Baycrest Study Details Study Description Go to Brief Summary: Bilingualism has been shown to have a strong protective effect against dementia, delaying the diagnosis of Alzheimer's disease by up to 4 years. The purpose of the study is to test whether learning a second language using Duolingo software could improve cognitive functions in older adults. Condition or disease Intervention (...) Secondary Outcome Measures : Change in attention abilities [ Time Frame: change from baseline to 16 weeks ] Attention assessed by the Test of Everyday Attention (TEA) Change in language abilities [ Time Frame: change from baseline to 16 weeks ] Winterlight designed battery assessing paragraph reading and recall, picture description and object naming. change in verbal fluency [ Time Frame: change from baseline to 16 weeks ] semantic and phonological fluency tasks executive function assessed

2018 Clinical Trials

122. A Language Intervention Study of Preterm Infants

Language Delay Mother-Infant Interaction Maternal Behavior Behavioral: Reading intervention Behavioral: Infant bonding Behavioral: LENA recording Behavioral: LENA linguistic feedback Behavioral: LENA summary Not Applicable Detailed Description: This project aims to examine how an educational reading intervention in the NICU can impact preterm infant language development and examine the impact of reading on mother-infant autonomic systems. Investigators plan to determine the effects of parent reading (...) A Language Intervention Study of Preterm Infants A Language Intervention Study of Preterm Infants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Language Intervention Study of Preterm Infants The safety

2018 Clinical Trials

123. Language in 2-year-old children born preterm and term: a cohort study. (Abstract)

on MRI, medical risk and oromotor concerns at 12 months.Children born <30 weeks performed more poorly on the CSBS:DP (particularly the social and symbolic composites) and the language scale of the Bayley-3 at 2 years than term-born peers. Lower gestational age at birth, male sex, hearing loss and multilingualism predicted poorer language scores.Despite improvements in medical management, children born very preterm exhibit language delays at 2 years of age, with specific deficits in social (...) Language in 2-year-old children born preterm and term: a cohort study. Language skills are critical. Children born very preterm are vulnerable to language problems, but further work is needed to determine characteristics and specific predictors of language problems in this population. We aimed to compare language outcomes between 2-year-old children born <30 weeks and their term-born peers; and to explore risk factors for language difficulties in this cohort.Language at 2 years was examined

2018 Archives of Disease in Childhood

124. Slurring of Speech and Lip Paresthesia: Symptoms of Levodopa End of Dose Wearing Off in Parkinson's Disease Full Text available with Trip Pro

Slurring of Speech and Lip Paresthesia: Symptoms of Levodopa End of Dose Wearing Off in Parkinson's Disease The prolonged use of levodopa for treating Parkinson's disease is associated with motor and nonmotor complications. These include wearing-off, delayed-on, partial-on, no-on, and on-off phenomena. In the wearing-off effect, symptoms return before a patient's next scheduled dose of levodopa. Patients may present with motor, sensory, or autonomic fluctuations. In this report, we present (...) a female patient experiencing numbness of lips and slurred speech as a symptom of wearing-off effect. The major differential for sudden numbness of lips and slurred speech includes transient ischemic attacks. Therefore, it is imperative to identify the cause of these episodes so that appropriate treatment can be initiated. Our patient underwent extensive cardiac and neurological investigations, the findings of which were unremarkable. Her symptoms were likely due to levodopa wearing-off. Her condition

2018 Cureus

125. Gestational age and birth weight variations in young children with language impairment at an early communication intervention clinic Full Text available with Trip Pro

Gestational age and birth weight variations in young children with language impairment at an early communication intervention clinic  South Africa presents with high preterm birth (PTB) and low birth weight (LBW) rates (14.17%). Numerous conditions characterised by language impairment are associated with LBW and/or PTB. Speech-language therapists may fail to identify older children whose language impairment may have originated from LBW and/or PTB. To describe the frequency of LBW and/or PTB (...) impairment was prevalent, associated with genetic conditions and global developmental delay. The frequency of LBW and/or PTB was unexpectedly high, drawing attention to the origins of language impairment in almost 40% of the caseload at the ECI clinic.

2018 The South African Journal of Communication Disorders

126. Relating resting-state hemodynamic changes to the variable language profiles in post-stroke aphasia Full Text available with Trip Pro

with the structural integrity of the left superior temporal, angular gyrus, supramarginal gyrus and arcuate fasciculus regions and hemodynamic advance in the left intra-parietal sulcus. Speech fluency related to integrity of premotor regions, plus hemodynamic advance in the left middle/superior temporal gyrus, left middle occipital gyrus, and right angular gyrus. Semantic performance reflected a combination of medial ventral temporal lobe status and hemodynamic delay in the left posterior middle temporal gyrus (...) . Finally, executive abilities correlated with hemodynamic delay in the left middle/inferior frontal gyrus, right rolandic operculum, bilateral supplementary motor areas/middle cingulum areas, and bilateral thalamus/caudate. Following stroke, patients' patterns of chronic language abilities reflects a combination of structural and functional integrity across a distributed network of brain regions. The correlation between hemodynamic changes and behaviours may have clinical importance.

2018 NeuroImage : Clinical

127. Morpho-Syntactic Abilities of Unbalanced Bilingual Children: A Closer Look at the Weaker Language Full Text available with Trip Pro

to the languages of balanced bilinguals and the Dominant Language in unbalanced bilinguals, albeit delayed or influenced by the Dominant Language to a larger extent. Conversely, the study brings evidence that linguistic profiles of unbalanced bilinguals with TLD in the Weaker Language and bilinguals with SLI differ, pointing at a deviant pattern of acquisition in children with SLI. (...) Morpho-Syntactic Abilities of Unbalanced Bilingual Children: A Closer Look at the Weaker Language Previous studies evaluating morpho-syntactic abilities in the Weaker Language of unbalanced bilingual children are scarce; and they bring inconclusive evidence on the nature of the Weaker Language development. The current study looked into morpho-syntactic profiles of bilingual Russian-Hebrew speaking children in the Weaker Language [the Weaker Heritage Language (HL-Russian) and the Weaker Societal

2018 Frontiers in psychology

128. The cerebral hemodynamic response to phonetic changes of speech in preterm and term infants: The impact of postmenstrual age Full Text available with Trip Pro

The cerebral hemodynamic response to phonetic changes of speech in preterm and term infants: The impact of postmenstrual age Higher brain dysfunction, such as language delay, is a major concern among preterm infants. Cerebral substrates of cognitive development in preterm infants remain elusive, partly because of limited methods. The present study focuses on hemodynamic response patterns for brain function by using near-infrared spectroscopy. Specifically, the study investigates gestational (...) differences in the hemodynamic response pattern evoked in response to phonetic changes of speech and cerebral hemispheric specialization of the auditory area in preterm infants (n = 60) and term infants (n = 20). Eighty neonates born between 26 and 41 weeks of gestational age (GA) were tested from 33 to 41 weeks of postmenstrual age (PMA). We analyzed the hemodynamic response pattern to phonemic and prosodic contrasts for multiple channels on temporal regions and the laterality index of the auditory area

2018 NeuroImage : Clinical

129. Abnormal language-related oscillatory responses in primary progressive aphasia Full Text available with Trip Pro

that delayed peak latencies of oscillatory responses were associated with lower accuracy for detecting semantic anomalies, suggesting that language deficits observed in PPA may be linked to delayed or slowed information processing. (...) Abnormal language-related oscillatory responses in primary progressive aphasia Patients with Primary Progressive Aphasia (PPA) may react to linguistic stimuli differently than healthy controls, reflecting degeneration of language networks and engagement of compensatory mechanisms. We used magnetoencephalography (MEG) to evaluate oscillatory neural responses in sentence comprehension, in patients with PPA and age-matched controls. Participants viewed sentences containing semantically

2018 NeuroImage : Clinical

130. Language and Cognitive Impairment Associated with a Novel p.Cys63Arg Change in the MED13L Transcriptional Regulator Full Text available with Trip Pro

) who exhibits profound language impairment in the expressive domain, cognitive delay, behavioral disturbances, and an autism-like phenotype. Because of the brain areas in which MED13L is expressed and because of the functional links between MED13L and the products of selected candidate genes for cognitive disorders involving language deficits, the proband's linguistic phenotype may result from changes in a functional network important for language development and evolution. (...) Language and Cognitive Impairment Associated with a Novel p.Cys63Arg Change in the MED13L Transcriptional Regulator Mutations in the MED13L gene, which encodes a subunit of a transcriptional regulatory complex, result in a complex phenotype entailing physical and cognitive anomalies. Deep language impairment has been reported in affected individuals, mostly in patients with copy number variations. We report on a child with a nonsynonymous p.Cys63Arg change in MED13L (chr12:116675396A>G, GRCh37

2018 Molecular syndromology

131. Distinct ERP profiles for auditory processing in infants at-risk for autism and language impairment Full Text available with Trip Pro

Distinct ERP profiles for auditory processing in infants at-risk for autism and language impairment Early identification of autism spectrum disorder (ASD) is crucial for the formulation of effective intervention programs. Language deficits may be a hallmark feature of ASD and language delay observed in ASD shows striking similarities to that observed in children with language impairment (LI). Auditory processing deficits are seen in both LI and ASD, however, they have not previously been (...) auditory processing and language/ASD-related outcomes. In both HR-ASD and HR-LI, mismatch response latency was delayed compared to controls, whereas only HR-ASD showed overall larger P3 amplitude compared to controls. Interestingly, these ERP measures correlated with later expressive vocabulary and M-CHAT critical items in the whole sample. These results may support the use of objective measurement of auditory processing to delineate pathophysiological mechanisms in ASD, as compared to LI.

2018 Scientific reports

132. Cognitive and Language Deficits in Multiple Sclerosis: Comparison of Relapsing Remitting and Secondary Progressive Subtypes Full Text available with Trip Pro

. The two clinical groups (RRMS; SPMS) did not differ on overall global cognitive impairment but differed in the initial encoding of verbal material, mental processing speed, response inhibition and set-shifting. RRMS patients differed from controls in the initial encoding of verbal material, learning curve, delayed recall of verbal information, processing speed, and response inhibition. SPMS patients differed in all utilized measures compared to controls. Moreover, we noted increased impairment (...) Cognitive and Language Deficits in Multiple Sclerosis: Comparison of Relapsing Remitting and Secondary Progressive Subtypes The objective of this study was to investigate the pattern and severity of cognitive and language impairment in Greek patients with Relapsing-remitting (RRMS) and Secondary Progressive Multiple Sclerosis (SPMS), relative to control participants.A prospective study was conducted in 27 patients with multiple sclerosis (PwMS), (N= 15) with RRMS, (N= 12) with SPMS, and (N= 12

2018 The open neurology journal

133. An Initial Investigation of the Neural Correlates of Word Processing in Preschoolers With Specific Language Impairment Full Text available with Trip Pro

preschoolers with SLI were presented with pictures followed after a brief delay by an auditory label that did or did not match. Event-related brain potentials were time locked to the onset of the auditory labels. Children provided verbal judgments of whether the label matched the picture.There were no group differences in the accuracy of identifying when pictures and labels matched or mismatched. Event-related brain potential data revealed that mismatch trials elicited a robust N400 in both groups (...) An Initial Investigation of the Neural Correlates of Word Processing in Preschoolers With Specific Language Impairment Previous behavioral studies have found deficits in lexical-semantic abilities in children with specific language impairment (SLI), including reduced depth and breadth of word knowledge. This study explored the neural correlates of early emerging familiar word processing in preschoolers with SLI and typical development.Fifteen preschoolers with typical development and 15

2018 Journal of speech, language, and hearing research : JSLHR

134. Intervention for bilingual speech sound disorders: A case study of an isiXhosa–English-speaking child Full Text available with Trip Pro

Intervention for bilingual speech sound disorders: A case study of an isiXhosa–English-speaking child  Bilingualism is common in South Africa, with many children acquiring isiXhosa as a home language and learning English from a young age in nursery or crèche. IsiXhosa is a local language, part of the Bantu language family, widely spoken in the country. Aims: To describe changes in a bilingual child's speech following intervention based on a theoretically motivated and tailored intervention (...) plan. Methods and procedures: This study describes a female isiXhosa-English bilingual child, named Gcobisa (pseudonym) (chronological age 4 years and 2 months) with a speech sound disorder. Gcobisa's speech was assessed and her difficulties categorised according to Dodd's (2005) diagnostic framework. From this, intervention was planned and the language of intervention was selected. Following intervention, Gcobisa's speech was reassessed. Outcomes and results: Gcobisa's speech was categorised

2018 The South African Journal of Communication Disorders

135. Narrowing the Genetic Causes of Language Dysfunction in the 1q21.1 Microduplication Syndrome Full Text available with Trip Pro

Narrowing the Genetic Causes of Language Dysfunction in the 1q21.1 Microduplication Syndrome The chromosome 1q21.1 duplication syndrome (OMIM# 612475) is characterized by head anomalies, mild facial dysmorphisms, and cognitive problems, including autistic features, mental retardation, developmental delay, and learning disabilities. Speech and language development are sometimes impaired, but no detailed characterization of language problems in this condition has been provided to date. We report (...) in detail on the cognitive and language phenotype of a child who presents with a duplication in 1q21.1 (arr[hg19] 1q21.1q21.2(145,764,455-147,824,207) × 3), and who exhibits cognitive delay and behavioral disturbances. Language is significantly perturbed, being the expressive domain the most impaired area (with significant dysphemic features in absence of pure motor speech deficits), although language comprehension and use (pragmatics) are also affected. Among the genes found duplicated in the child

2018 Frontiers in pediatrics

136. Pneumonia mortality and healthcare utilization in young children in rural Bangladesh: a prospective verbal autopsy study Full Text available with Trip Pro

Pneumonia mortality and healthcare utilization in young children in rural Bangladesh: a prospective verbal autopsy study The present study aimed to examine the risk factors for death due to pneumonia in young children and healthcare behaviors of the guardians for children in rural Bangladesh. A prospective autopsy study was conducted among guardians of children aged 4 weeks to 59 months in Mirzapur, Bangladesh, from 2008 to 2012.Pneumonia was the primary cause of death, accounting for 26.4% (n (...)  months old were at 5.5-time (95% confidence interval [CI] 2.5, 12.0) and older infants aged 6-11 months were at 3-time (1.2, 7.5) greater risk of dying from pneumonia than older children aged 12-59 months. Children with a prolonged duration of illness (2-10 days) prior to death were at more risk for death by pneumonia than those who died from other causes (5.8 [2.1, 16.1]). Children who died from pneumonia sought treatment 3.4-time more than children who died from other causes. Delayed treatment

2018 Tropical medicine and health

137. Acute exposure to blue wavelength light during memory consolidation improves verbal memory performance. Full Text available with Trip Pro

of this study was to investigate the effects of a thirty minute pulse of blue light versus placebo (amber light) exposure in healthy normally rested individuals in the morning during verbal memory consolidation (i.e., 1.5 hours after memory acquisition) using an abbreviated version of the California Verbal Learning Test (CVLT-II). At delayed recall, individuals who received blue light (n = 12) during the consolidation period showed significantly better long-delay verbal recall than individuals who received (...) Acute exposure to blue wavelength light during memory consolidation improves verbal memory performance. Acute exposure to light within the blue wavelengths has been shown to enhance alertness and vigilance, and lead to improved speed on reaction time tasks, possibly due to activation of the noradrenergic system. It remains unclear, however, whether the effects of blue light extend beyond simple alertness processes to also enhance other aspects of cognition, such as memory performance. The aim

2017 PLoS ONE Controlled trial quality: uncertain

138. Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort. Full Text available with Trip Pro

Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort. Verbal memory is typically studied using immediate recall (IR) and delayed recall (DR) scores, although DR is dependent on IR capability. Separating these components may be useful for deciphering the genetic variation in age-related memory abilities. This study was conducted to (a) construct individual trajectories in IR and independent aspects of delayed recall, or residualized-DR (rDR (...) from this first U.S. population-based GWAS study conducted on both age-related immediate and delayed verbal memory merit continued examination in other samples and additional measures of verbal memory.

2017 PLoS ONE

139. Emotional speech processing deficits in bipolar disorder: The role of mismatch negativity and P3a. (Abstract)

delayed MMN latency and reduced P3a amplitude in response to the emotional syllables compared to HC.Small sample size, lack of control of psychopharmacological intervention and no inclusion of an affective prosody-labelling task.The finding that changes in emotional speech prosody in the pre-attentive stages of processing (MMN) were unimpaired in individuals with BD; while automatic orientation towards emotionally salient speech (P3a) was reduced compared to HC, suggests that vocal emotional cues may (...) Emotional speech processing deficits in bipolar disorder: The role of mismatch negativity and P3a. Deficits in emotional prosody processing have been observed in bipolar disorder (BD). While recent neural studies have explored impaired processing of facial expressions, little is known about deficits in emotional speech processing, or the specific stages of processing at which they occur. This study examined if pre-attentive detection and attention to emotional speech is impaired in BD, relative

2018 Journal of Affective Disorders

140. Verbal abilities in children of mothers with epilepsy: Association to maternal folate status. Full Text available with Trip Pro

Verbal abilities in children of mothers with epilepsy: Association to maternal folate status. To examine the effect of maternal folic acid supplementation and maternal plasma folate and antiepileptic drug (AED) concentrations on language delay in AED-exposed children of mothers with epilepsy.Children of mothers with and without epilepsy enrolled from 1999 to 2008 in the Norwegian Mother and Child Cohort study were included. Information on medical history, AED use, and folic acid supplementation (...) periconceptional folic acid supplementation, the fully adjusted odds ratio (OR) for language delay in AED-exposed children compared to the controls at 18 months was 3.9 (95% confidence interval [CI] 1.9-7.8, p < 0.001) and at 36 months was 4.7 (95% CI 2.0-10.6, p < 0.001). When folic supplementation was used, the corresponding ORs for language delay were 1.7 (95% CI 1.2-2.6, p = 0.01) and 1.7 (95% CI 0.9-3.2, p = 0.13), respectively. The positive effect of folic acid supplement use on language delay in AED

2018 Neurology

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