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Speech Delay

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101. Assessment of Neurocognitive Impairment and Speech Functioning Before Head and Neck Cancer Treatment. Full Text available with Trip Pro

function.To document neurocognitive functioning in patients with HNC before treatment and to investigate the association between neurocognitive and speech functioning.Prospective cohort study of newly diagnosed patients with HNC before treatment using a large sample obtained in a nationwide, multicenter setting (Netherlands Quality of Life and Biomedical Cohort Study in Head and Neck Cancer [NET-QUBIC] project).Objective neuropsychological measures of delayed recall, letter fluency, and executive (...) in 12.3% (26 of 212) to 26.2% (56 of 214) of patients. The most altered domains were delayed recall and letter fluency. Seven percent (15 of 208) of the patients reported high levels of everyday neurocognitive failure, and 42.6% (89 of 209) reported speech problems. Objective neurocognitive function was not significantly associated with patient-reported neurocognitive or speech functioning, but the results from patient-reported outcome measures were significantly correlated.Results of this study

2019 JAMA otolaryngology-- head & neck surgery

102. Left temporal plane growth predicts language development in newborns with congenital heart disease. (Abstract)

Left temporal plane growth predicts language development in newborns with congenital heart disease. Congenital heart defects are the most common congenital anomalies, accounting for a third of all congenital anomaly cases. While surgical correction dramatically improved survival rates, the lag behind normal neurodevelopment appears to persist. Deficits in higher cognitive functions are particularly common, including developmental delay in communication and oral-motor apraxia. It remains unclear (...) whether the varying degree of cognitive developmental delay is reflected in variability in brain growth patterns. To answer this question, we aimed to investigate whether the rate of regional brain growth is correlated with later life neurodevelopment. Forty-four newborns were included in our study, of whom 33 were diagnosed with dextro-transposition of the great arteries and 11 with other forms of severe congenital heart defects. During the first month of life, neonates underwent corrective

2019 Brain

103. Effect of competing noise on cortical auditory evoked potentials elicited by speech sounds in 7- to 25-year-old listeners. Full Text available with Trip Pro

during an active speech-syllable discrimination task in 58 normal-hearing participants (age 7-25 years). Speech syllables were presented in quiet and embedded in competing speech noise (4-talker babble, +15 dB signal-to-noise ratio; SNR). While noise was expected to similarly reduce amplitude and delay latencies of N1 and P2 peaks in all listeners, it was hypothesized that effects of noise on the P3b peak would be inversely related to age due to the maturation of top-down processing abilities (...) throughout childhood. Consistent with previous work, results showed that a +15 dB SNR reduces amplitudes and delays latencies of CAEPs for listeners of all ages, affecting speech-sound processing, delaying stimulus evaluation, and causing a reduction in behavioral speech-sound discrimination. Contrary to expectations, findings suggest that competing speech noise at a +15 dB SNR may have similar effects on various stages of speech-sound processing for listeners of all ages. Future research directions

2019 Hearing Research

104. Varubi (rolapitant) - To prevent delayed phase chemotherapy-induced nausea and vomiting (emesis)

Varubi (rolapitant) - To prevent delayed phase chemotherapy-induced nausea and vomiting (emesis) Varubi (rolapitant) Tablets U.S. Department of Health and Human Services Search FDA Submit search Varubi (rolapitant) Tablets Varubi (rolapitant) Tablets Company: TESARO, Inc. Application No.: 206500 Approval Date: 09/01/2015 Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF) (PDF (...) ) (PDF) (PDF) (PDF) Date created: October 9, 2015 Vision impaired people having problems accessing certain pages of a PDF file may call (301) 796-3634 for assistance. Note: Documents in PDF format require the . Note: If you need help accessing information in different file formats, see . Language Assistance Available: | | | | | | | | | | | | | | | FDA Popular Content Product Areas

2015 FDA - Drug Approval Package

105. Developmental rheumatology in children. Scenario: Delayed walking in children

neuromuscular diseases and neurological disorders such as cerebral palsy, particularly if there is also global delay with speech, hearing, vision, and fine motor milestones [ ; ]. Spina bifida and lysosomal storage disorders can cause delayed motor milestones, and hypermobility and developmental hip dysplasia may also present with delayed walking [ ; ]. Limp Limp For more information on managing a limping child, see the CKS topic on . Out-toeing Out-toeing Out-toeing describes lateral or external rotation (...) Developmental rheumatology in children. Scenario: Delayed walking in children Developmental rheumatology in children - NICE CKS Share Developmental rheumatology in children: Summary Musculoskeletal complaints are a common cause of visits to primary care, but a large proportion of these are for children and adolescents who are entirely healthy or who are developmentally within a normal physiological range. Presentations in children include: Back pain — in school-age children and adolescents

2019 NICE Clinical Knowledge Summaries

106. Recognizing and appraising symptoms of breast cancer as a reason for delayed presentation in Ghanaian women: A qualitative study. Full Text available with Trip Pro

Recognizing and appraising symptoms of breast cancer as a reason for delayed presentation in Ghanaian women: A qualitative study. The burden of late presentation is well established in women presenting with advanced breast cancer in Africa. This paper aims to explore the reasons for delayed presentation in Ghanaian women with breast cancer.Eleven (11) women diagnosed with advanced breast cancer were purposively sampled within three years of diagnosis at the palliative care clinic of the Komfo (...) Anokye Teaching Hospital, Ghana. Participation was voluntary. Data was collected through in-depth interviews using a self-devised semi-structured interview guide. The interviews were conducted in "Twi" (local language), audio-tape recorded and covered the women's journey from symptom discovery to their intention to seek help. All audio-taped interviews were transcribed based on the meaning of the respondents' comments. The data was managed using Nvivo version 11 qualitative software. Data

2019 PLoS ONE

107. Bi-allelic <i>TTC5</i> variants cause delayed developmental milestones and intellectual disability. (Abstract)

sequencing for all available family members was completed. Identity-by-descent (IBD) mapping was carried out for patients in two Egyptian families harbouring an identical variant. RNA was extracted from blood cells of Turkish participants, followed by cDNA synthesis and real-time PCR for TTC5.Phenotype comparisons of patients revealed shared clinical features of moderate-to-severe ID, corpus callosum agenesis, mild ventriculomegaly, simplified gyral pattern, cerebral atrophy, delayed motor and verbal (...) Bi-allelic TTC5 variants cause delayed developmental milestones and intellectual disability. Intellectual disability syndromes (IDSs) with or without developmental delays affect up to 3% of the world population. We sought to clinically and genetically characterise a novel IDS segregating in five unrelated consanguineous families.Clinical analyses were performed for eight patients with intellectual disability (ID). Whole-exome sequencing for selected participants followed by Sanger

2020 Journal of Medical Genetics

108. Pathogenic variants in <i>TNRC6B</i> cause a genetic disorder characterised by developmental delay/intellectual disability and a spectrum of neurobehavioural phenotypes including autism and ADHD. (Abstract)

, but no full phenotypic characterisation was described.Clinical and molecular characterisation was performed on 17 patients with TNRC6B variants. Clinical data were obtained by retrospective chart review, parent interviews, direct patient interaction with providers and formal neuropsychological evaluation.Clinical findings included DD/ID (17/17) (speech delay in 94% (16/17), fine motor delay in 82% (14/17) and gross motor delay in 71% (12/17) of subjects), autism or autistic traits (13/17), attention (...) Pathogenic variants in TNRC6B cause a genetic disorder characterised by developmental delay/intellectual disability and a spectrum of neurobehavioural phenotypes including autism and ADHD. Rare variants in hundreds of genes have been implicated in developmental delay (DD), intellectual disability (ID) and neurobehavioural phenotypes. TNRC6B encodes a protein important for RNA silencing. Heterozygous truncating variants have been reported in three patients from large cohorts with autism

2020 Journal of Medical Genetics

109. Predictors of Phrase and Fluent Speech in Children With Autism and Severe Language Delay. Full Text available with Trip Pro

Predictors of Phrase and Fluent Speech in Children With Autism and Severe Language Delay. To examine the prevalence and predictors of language attainment in children with autism spectrum disorder (ASD) and severe language delay. We hypothesized greater autism symptomatology and lower intelligence among children who do not attain phrase/fluent speech, with nonverbal intelligence and social engagement emerging as the strongest predictors of outcome.Data used for the current study were from 535 (...) attainment after age 4, whereas slightly older age and increased internalizing symptoms were associated with fluent speech. In the multivariate analyses, higher nonverbal IQ and less social impairment were both independently associated with the acquisition of phrase and fluent speech, as well as earlier age at acquisition. Stereotyped behavior/repetitive interests and sensory interests were not associated with delayed speech acquisition.This study highlights that many severely language-delayed children

2013 Pediatrics

110. 12 minute consultation: An evidence based approach to the management of a child with speech and language delay. (Abstract)

12 minute consultation: An evidence based approach to the management of a child with speech and language delay. Speech and language delay is a common developmental disorder. Persistent delay may lead to adverse effects on literacy, educational achievement and psychosocial development. Affected children are commonly referred to the otolaryngologist; hence, a structured management approach is required to facilitate diagnosis and allow for early intervention and improved outcomes.A literature (...) search was performed on 05 November 2012 using the MEDLINE, EMBASE and Cochrane databases with the search terms paediatric, children, speech, language, delay, disorder, investigation and management. Relevant references from selected articles were reviewed after reading the abstract.Speech and language delay may be primary, meaning there is no associated comorbidity to account for the delay, or secondary, where it can be attributed to another condition or syndrome. Secondary causes include hearing

2013 Clinical Otolaryngology

111. Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus

Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus NIHR HSRIC Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation (...) of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Reparixin for prevention of delayed graft function in pancreatic islet transplantation for type 1 diabetes mellitus. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' conclusions Type 1 diabetes happens when the cells that make insulin in the pancreas, the islets, are destroyed. Islet cell transplantation involves extracting islet cells from the pancreas

2016 Health Technology Assessment (HTA) Database.

112. Developmental Delay

of developmental delay and conduct further assessment (or specialist evaluation) as clinically indicated. Clinicians should be aware of factors that may increase the risk for developmental delay, such as low birth weight, premature birth or family history; and are encouraged to remain vigilant for social, economic or environmental factors (such as lower maternal education level, mental illness, neglect or maltreatment, poverty, English as a second language) that might reduce the likelihood for parents to raise (...) Developmental Delay Canadian Task Force on Preventive Health Care | Developmental Delay (2016) English Menu Get Involved Developmental Delay (2016) Developmental Delay (2016) Click to view article Tools Additional Documents Click to see additional documents Screening for Developmental Delay in Children Aged 1 to 4 Years (2016) The recommendation applies only to children aged 1 to 4 years who are not at high risk for developmental delay, have no signs suggestive of a developmental delay

2016 Canadian Task Force on Preventive Health Care

113. Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures

Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc (...) .. Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures. Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors' conclusions Noninvasive electrical bone growth stimulators (EBGS) are external devices that deliver electrical energy to a fracture or bone fusion site. The goal is to induce osteogenesis, stimulate bone growth, and promote healing of fresh, delayed, or nonunion bone fractures and surgical joint fusions. Rationale: In 2010, there were 18.3 million

2016 Health Technology Assessment (HTA) Database.

114. Eculizumab (Soliris) for prevention of delayed graft function after kidney transplantation in adult patients at increased risk - first line

Eculizumab (Soliris) for prevention of delayed graft function after kidney transplantation in adult patients at increased risk - first line Eculizumab (Soliris) for prevention of delayed graft function after kidney transplantation in adult patients at increased risk – first line Eculizumab (Soliris) for prevention of delayed graft function after kidney transplantation in adult patients at increased risk – first line NIHR HSRIC Record Status This is a bibliographic record of a published health (...) technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Eculizumab (Soliris) for prevention of delayed graft function after kidney transplantation in adult patients at increased risk – first line. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2016 Authors' conclusions Eculizumab is a drug to prevent delayed graft function in people who have undergone a kidney transplant and are at a high

2016 Health Technology Assessment (HTA) Database.

115. Feasibility of event-related potential (ERP) biomarker use to study effects of mother's voice exposure on speech sound differentiation of preterm infants. Full Text available with Trip Pro

Feasibility of event-related potential (ERP) biomarker use to study effects of mother's voice exposure on speech sound differentiation of preterm infants. Atypical maturation of auditory neural processing contributes to preterm-born infants' language delays. Event-related potential (ERP) measurement of speech-sound differentiation might fill a gap in treatment-response biomarkers to auditory interventions. We evaluated whether these markers could measure treatment effects in a quasi-randomized (...) prospective study. Hospitalized preterm infants in passive or active, suck-contingent mother's voice exposure groups were not different at baseline. Post-intervention, the active group had greater increases in/du/-/gu/differentiation in left frontal and temporal regions. Infants with brain injury had lower baseline/ba/-/ga/and/du/-/gu/differentiation than those without. ERP provides valid discriminative, responsive, and predictive biomarkers of infant speech-sound differentiation.

2018 Developmental neuropsychology Controlled trial quality: uncertain

116. Sketch and Speak: An Expository Intervention Using Note-Taking and Oral Practice for Children With Language-Related Learning Disabilities. (Abstract)

. The treatment condition received 6 30-min individual or pair sessions from the school of speech-language pathologists (SLPs). Treatment involved reducing statements from grade-level science articles into concise ideas, recording the ideas as pictographic and conventional notes, and expanding from the notes into full oral sentences that are then combined into oral reports. Participants were pretested and posttested on taking notes from grade-level history articles and using the notes to give oral reports (...) Sketch and Speak: An Expository Intervention Using Note-Taking and Oral Practice for Children With Language-Related Learning Disabilities. This preliminary study investigated an intervention procedure employing 2 types of note-taking and oral practice to improve expository reporting skills.Forty-four 4th to 6th graders with language-related learning disabilities from 9 schools were assigned to treatment or control conditions that were balanced for grade, oral language, and other features

2018 Language, speech, and hearing services in schools Controlled trial quality: uncertain

117. Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information. (Abstract)

encoding and/or retrieval of verbal information.Healthy subjects were recruited from the community. Subjects were administered the Rey-Auditory Verbal Learning Test (RAVLT) either before administration of THC (experiment #1) (n=38) or while under the influence of THC (experiment #2) (n=57). Immediate and delayed recall on the RAVLT was compared. Subjects received intravenous THC, in a placebo-controlled, double-blind, randomized manner at doses known to produce behavioral and subjective effects (...) consistent with cannabis intoxication.Total immediate recall, short delayed recall, and long delayed recall were reduced in a statistically significant manner only when the RAVLT was administered to subjects while they were under the influence of THC (experiment #2) and not when the RAVLT was administered prior.THC acutely interferes with encoding of verbal memory without interfering with retrieval. These data suggest that learning information prior to the use of cannabis or cannabinoids is not likely

2018 Progress in neuro-psychopharmacology & biological psychiatry Controlled trial quality: uncertain

118. Validation of Dodd's Model for Differential Diagnosis of childhood speech sound disorders: a longitudinal community cohort study. (Abstract)

children.Data revealed proportions of children across Dodd's diagnostic subgroups as follows: suspected atypical speech motor control (10%); inconsistent phonological disorder (15%); consistent atypical phonological disorder (20%); phonological delay (55%); and articulation disorder alone (0%). The findings are in line with known prevalence of these subgroups in clinical populations.Our findings provide additional support for speech-language pathologists to use this system in clinical practice (...) Validation of Dodd's Model for Differential Diagnosis of childhood speech sound disorders: a longitudinal community cohort study. Dodd's Model for Differential Diagnosis is one of the available clinical diagnostic classification systems of childhood speech sound disorders. Yet we do not understand the validity of this system beyond clinical samples, precluding its application in epidemiological or population-based research. This study aimed to determine the prevalence of subgroups of speech

2018 Developmental Medicine and Child Neurology

119. Evaluation of the Effect of a Speech Detection Tool on the Improvement of Phonation in Neuromuscular Patients Dependent on Mechanical Ventilation

in patients dependant either on NIV or IVT. Condition or disease Intervention/treatment Phase Neuromuscular Diseases Mechanical Ventilation Speech Device: speech trials during different ventilation conditions Other: speech trial Not Applicable Detailed Description: Nowadays, the first line treatment of chronic respiratory failure in neuromuscular disorder is non invasive ventilation (NIV). However, while NIV can compensate the respiratory disability and significantly delays significantly the necessity (...) Evaluation of the Effect of a Speech Detection Tool on the Improvement of Phonation in Neuromuscular Patients Dependent on Mechanical Ventilation Evaluation of the Effect of a Speech Detection Tool on the Improvement of Phonation in Neuromuscular Patients Dependent on Mechanical Ventilation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save

2018 Clinical Trials

120. Combined Conventional Speech Therapy and Functional Electrical Stimulation in Dysphagia Following Stroke

Combined Conventional Speech Therapy and Functional Electrical Stimulation in Dysphagia Following Stroke Combined Conventional Speech Therapy and Functional Electrical Stimulation in Dysphagia Following Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Combined Conventional Speech Therapy and Functional Electrical Stimulation in Dysphagia Following Stroke The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03649295

2018 Clinical Trials

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