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Speech Delay

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21. Group and individual variability in speech production networks during delayed auditory feedback (Full text)

Group and individual variability in speech production networks during delayed auditory feedback Altering reafferent sensory information can have a profound effect on motor output. Introducing a short delay [delayed auditory feedback (DAF)] during speech production results in modulations of voice and loudness, and produces a range of speech dysfluencies. The ability of speakers to resist the effects of delayed feedback is variable yet it is unclear what neural processes underlie differences (...) in susceptibility to DAF. Here, susceptibility to DAF is investigated by looking at the neural basis of within and between subject changes in speech fluency under 50 and 200 ms delay conditions. Using functional magnetic resonance imaging, networks involved in producing speech under two levels of DAF were identified, lying largely within networks active during normal speech production. Independent of condition, fluency ratings were associated with midbrain activity corresponding to periaqueductal grey matter

2018 The Journal of the Acoustical Society of America PubMed abstract

22. Development of the Mental Synthesis Evaluation Checklist (MSEC): A Parent-Report Tool for Mental Synthesis Ability Assessment in Children with Language Delay (Full text)

Development of the Mental Synthesis Evaluation Checklist (MSEC): A Parent-Report Tool for Mental Synthesis Ability Assessment in Children with Language Delay Mental synthesis is the conscious purposeful process of synthesizing novel mental images from objects stored in memory. Mental synthesis ability is essential for understanding complex syntax, spatial prepositions, and verb tenses. In typical children, the timeline of mental synthesis acquisition is highly correlated with an increasing (...) that the addition of MSEC will make the combined assessment more sensitive to small steps in a child's development. As MSEC does not rely on productive language, it may be an especially useful tool for assessing the development of nonverbal and minimally verbal children.

2018 Children PubMed abstract

23. Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias (Full text)

Sensitivity of Speech Output to Delayed Auditory Feedback in Primary Progressive Aphasias Delayed auditory feedback (DAF) is a classical paradigm for probing sensori-motor interactions in speech output and has been studied in various disorders associated with speech dysfluency and aphasia. However, little information is available concerning the effects of DAF on degenerating language networks in primary progressive aphasia: the paradigmatic "language-led dementias." Here we studied two forms (...) of speech output (reading aloud and propositional speech) under natural listening conditions (no feedback delay) and under DAF at 200 ms, in a cohort of 19 patients representing all major primary progressive aphasia syndromes vs. healthy older individuals and patients with other canonical dementia syndromes (typical Alzheimer's disease and behavioral variant frontotemporal dementia). Healthy controls and most syndromic groups showed a quantitatively or qualitatively similar profile of reduced speech

2018 Frontiers in neurology PubMed abstract

24. Variants in PUS7 Cause Intellectual Disability with Speech Delay, Microcephaly, Short Stature, and Aggressive Behavior. (Full text)

Variants in PUS7 Cause Intellectual Disability with Speech Delay, Microcephaly, Short Stature, and Aggressive Behavior. We describe six persons from three families with three homozygous protein truncating variants in PUS7: c.89_90del (p.Thr30Lysfs∗20), c.1348C>T (p.Arg450∗), and a deletion of the penultimate exon 15. All these individuals have intellectual disability with speech delay, short stature, microcephaly, and aggressive behavior. PUS7 encodes the RNA-independent pseudouridylate

2018 American Journal of Human Genetics PubMed abstract

25. Language delay aggregates in toddler siblings of children with autism spectrum disorder (Full text)

Language delay aggregates in toddler siblings of children with autism spectrum disorder Language delay is extremely common in children with autism spectrum disorder (ASD), yet it is unclear whether measurable variation in early language is associated with genetic liability for ASD. Assessment of language development in unaffected siblings of children with ASD can inform whether decreased early language ability aggregates with inherited risk for ASD and serves as an ASD endophenotype.We (...) implemented two approaches: (1) a meta-analysis of studies comparing language delay, a categorical indicator of language function, and language scores, a continuous metric, in unaffected toddlers at high and low familial risk for ASD, and (2) a parallel analysis of 350 unaffected 24-month-olds in the Infant Brain Imaging Study (IBIS), a prospective study of infants at high and low familial risk for ASD. An advantage of the former was its detection of group differences from pooled data across unique

2018 Journal of neurodevelopmental disorders PubMed abstract

26. The effect of linguistic comprehension instruction on generalized language and reading comprehension skills: A systematic review (Full text)

as inferential skills) appeared to assess the same underlying construct. Similarly, a study by Lervåg et al. ( ) found that a latent language factor defined by vocabulary, grammar, verbal working memory, and inference skills was a clear predictor of the variation in “listening comprehension” measured by oral comprehension tests (explaining 95% of the variation in listening comprehension). Overall, these findings suggest that different language outcomes share a lot of common variance and that language skills (...) reading (Gough & Tunmer, ). While decoding is an important predictor of reading skills in the early reading phase, linguistic comprehension is understood as an essential predictor for the further development of reading comprehension (Hoover & Gough, ; Muter et al., ; Storch & Whitehurst, ). Studies on both second‐language learners and monolingual children with language delays have shown that the challenges they experience related to the understanding of texts are not characterized by a lack

2019 Campbell Collaboration PubMed abstract

27. Parent-mediated interventions for promoting communication and language development in young children with Down syndrome. (Full text)

) and quasi-RCTs that compared parent-mediated interventions designed to improve communication and language versus teaching/treatment as usual (TAU) or no treatment or delayed (wait-listed) treatment, in children with Down syndrome aged between birth and six years. We included studies delivering the parent-mediated intervention in conjunction with a clinician-mediated intervention, as long as the intervention group was the only group to receive the former and both groups received the latter.We used (...) Parent-mediated interventions for promoting communication and language development in young children with Down syndrome. Communication and language development are areas of particular weakness for young children with Down syndrome. Caregivers' interaction with children influences language development, so many early interventions involve training parents how best to respond to their children and provide appropriate language stimulation. Thus, these interventions are mediated through parents, who

2018 Cochrane PubMed abstract

28. Early Speech and Language Development in Children With Nonsyndromic Cleft Lip and/or Palate: A Meta-Analysis. (Full text)

reports and observational language measures (estimated effect size = -0.74) were significantly lower than those from standardized norm-referenced tests (estimated effect size = -0.45). Conclusions These findings suggest that young children with NSCL/P experience delays relative to their peers across multiple speech and language constructs. Differences between children with NSCL/P and their typically developing peers appear to decrease with age. Supplemental Material https://doi.org/10.23641/asha (...) Early Speech and Language Development in Children With Nonsyndromic Cleft Lip and/or Palate: A Meta-Analysis. Objective The aim of the study was to conduct a meta-analysis of research examining the early speech and language functioning of young children, birth to age 8;11 (years;months), with nonsyndromic cleft lip and/or palate (NSCL/P) compared to their peers without NSCL/P. Method We conducted a random-effects metaregression using 241 effect sizes from 31 studies comparing 955 young children

2020 Journal of speech, language, and hearing research : JSLHR PubMed abstract

29. Speech and language development of children born following assisted reproductive technologies. (Abstract)

. Then, the language and speech performance of the participants were compared in terms of gestational age, birth weight, number of children per birth, and sex in the current research and they are categorized as normal or having delay in language and speech development.The participants had statistically significant difference for the receptive language in terms of gestational age (χ2 (1) = 5.76, p = 0.01) and birth weight (χ2 (1) = 8.22, p = 0.004) but in terms of the number of children per birth (χ2 (1) = 7.11, p (...) Speech and language development of children born following assisted reproductive technologies. Studies which targeted communication skills of children born following assisted reproductive technologies have reported contradictory results. Concerning the increasing rates of children born in these technologies and the importance of some factors as risk factors like birth weight, gestational age, and the number of children per birth in these procedures, studying speech and language skills

2020 International Journal of Pediatric Otorhinolaryngology

30. Language Delays and Child Depressive Symptoms: the Role of Early Stimulation in the Home. (Abstract)

Language Delays and Child Depressive Symptoms: the Role of Early Stimulation in the Home. The present study investigated the role of early stimulation in the home and child language delays in the emergence of depressive symptoms. Data were from a longitudinal study of at-risk children in Hawaii (n = 587). Low learning stimulation in the home at age 3 and language delays in first grade both significantly increased risk for child depressive symptoms in third grade. Structural equation modeling (...) supported the hypothesized path models from home learning environment at age 3 to depressive symptoms in third grade controlling for a host of correlated constructs (maternal depression, child temperament, and child internalizing symptoms). Total language skills in the first grade mediated the effect of home learning environment on depressive symptoms. The study and findings fit well with a nurturing environment perspective. Implications for understanding the etiology of child depression

2017 Prevention science : the official journal of the Society for Prevention Research Controlled trial quality: uncertain

31. Altered human voice processing in the frontal cortex and a developmental language delay in 3- to 5-year-old children with autism spectrum disorder (Full text)

Altered human voice processing in the frontal cortex and a developmental language delay in 3- to 5-year-old children with autism spectrum disorder The inferior frontal and superior temporal areas in the left hemisphere are crucial for human language processing. In the present study, we investigated the magnetic mismatch field (MMF) evoked by voice stimuli in 3- to 5-year-old typically developing (TD) children and children with autism spectrum disorder (ASD) using child-customized (...) magnetoencephalography (MEG). The children with ASD exhibited significantly decreased activation in the left superior temporal gyrus compared with the TD children for the MMF amplitude. If we classified the children with ASD according to the presence of a speech onset delay (ASD - SOD and ASD - NoSOD, respectively) and compared them with the TD children, both ASD groups exhibited decreased activation in the left superior temporal gyrus compared with the TD children. In contrast, the ASD - SOD group exhibited

2017 Scientific reports PubMed abstract

32. Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features. (Full text)

Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features. Bromodomain PHD finger transcription factor (BPTF) is the largest subunit of nucleosome remodeling factor (NURF), a member of the ISWI chromatin-remodeling complex. However, the clinical consequences of disruption of this complex remain largely uncharacterized. BPTF is required for anterior-posterior axis formation of the mouse embryo and was shown (...) to promote posterior neuroectodermal fate by enhancing Smad2-activated wnt8 expression in zebrafish. Here, we report eight loss-of-function and two missense variants (eight de novo and two of unknown origin) in BPTF on 17q24.2. The BPTF variants were found in unrelated individuals aged between 2.1 and 13 years, who manifest variable degrees of developmental delay/intellectual disability (10/10), speech delay (10/10), postnatal microcephaly (7/9), and dysmorphic features (9/10). Using CRISPR-Cas9 genome

2017 American Journal of Human Genetics PubMed abstract

33. Delayed degeneration of the left fornical crus with verbal memory impairment in a patient with mild traumatic brain injury: A case report. (Full text)

Delayed degeneration of the left fornical crus with verbal memory impairment in a patient with mild traumatic brain injury: A case report. We report on a patient who showed delayed degeneration of the left fornical crus with verbal memory impairment following mild traumatic brain injury (TBI), which was demonstrated by diffusion tensor tractography (DTT). PATIENT CONCERNS:: fter flexion and hyperextension of her head to the opposite side, the patient experienced a dazed feeling for a while (...) , a discontinuation was observed in the left fornical crus.Delayed degeneration of the left fornical crus was demonstrated in a patient who showed delayed onset of verbal memory impairment following mild TBI.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

2017 Medicine PubMed abstract

34. An intragenic deletion within CTNNA2 intron 7 in a boy with short stature and speech delay: A case report (Full text)

An intragenic deletion within CTNNA2 intron 7 in a boy with short stature and speech delay: A case report Deletions on the short arm of chromosome 2 at bands p11 and p12 have been detected in association with short stature, mild mental retardation and speech delay.We describe a 4 year-old boy with some facial dysmorphic traits, congenital malformations and pre- and post-natal growth failure. He also presented marked expressive language problems. The molecular karyotype revealed a 108 Kb (...) deletion within the seventh intron of the CTNNA2 gene at 2p11.2-p12. We observed that some features (short stature, facial dysmorphisms and speech delay) were present in our patient and in patients carrying much larger overlapping deletions.The description of this small intragenic rearrangement might help to elucidate the role of the single genes included in the 2p11.2-p12 critical region.

2017 SAGE Open Medical Case Reports PubMed abstract

35. Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features (Full text)

Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features Impairment of ubiquitin-proteasome system activity involving ubiquitin ligase genes UBE3A, UBE3B, and HUWE1 and deubiquitinating enzyme genes USP7 and USP9X has been reported in patients with neurodevelopmental delays. To date, only a handful of single-nucleotide variants (SNVs) and copy-number variants (CNVs) involving (...) a dramatically decreased level of TRIP12 mRNA in the proband compared to the family controls, indicating a loss-of-function mechanism. The shared clinical features include intellectual disability with or without autistic spectrum disorders, speech delay, and facial dysmorphism. Our findings demonstrate that E3 ubiquitin ligase TRIP12 plays an important role in nervous system development and function. The nine presented pathogenic variants further document that TRIP12 haploinsufficiency causes a childhood

2017 Human Genetics PubMed abstract

36. Deletion of 20p13 and Duplication of 20p13p12.3 in a Patient with Delayed Speech and Development (Full text)

Deletion of 20p13 and Duplication of 20p13p12.3 in a Patient with Delayed Speech and Development 29071826 2019 02 20 2019 03 20 2234-3814 38 1 2018 01 Annals of laboratory medicine Ann Lab Med Deletion of 20p13 and Duplication of 20p13p12.3 in a Patient with Delayed Speech and Development. 77-79 10.3343/alm.2018.38.1.77 Kwon Soon Sung SS Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. Kim Jieun J Department of Laboratory Medicine, Soon Chun Hyang (...) Korea (South) Ann Lab Med 101571172 2234-3806 0 JAG1 protein, human 0 Jagged-1 Protein IM Child, Preschool Chromosome Deletion Chromosomes, Human, Pair 20 genetics Female Gene Duplication Humans Jagged-1 Protein genetics Karyotype Language Development Disorders diagnosis genetics Psychomotor Disorders diagnosis genetics Trisomy The authors have declared no conflict of interest. 2017 02 01 2017 05 10 2017 09 19 2017 10 27 6 0 2017 10 27 6 0 2019 3 21 6 0 ppublish 29071826 38.77 10.3343/alm

2017 Annals of laboratory medicine PubMed abstract

37. Kinematic Analysis of Speech Sound Sequencing Errors Induced by Delayed Auditory Feedback (Full text)

Kinematic Analysis of Speech Sound Sequencing Errors Induced by Delayed Auditory Feedback Delayed auditory feedback (DAF) causes speakers to become disfluent and make phonological errors. Methods for assessing the kinematics of speech errors are lacking, with most DAF studies relying on auditory perceptual analyses, which may be problematic, as errors judged to be categorical may actually represent blends of sounds or articulatory errors.Eight typical speakers produced nonsense syllable (...) sequences under normal and DAF (200 ms). Lip and tongue kinematics were captured with electromagnetic articulography. Time-locked acoustic recordings were transcribed, and the kinematics of utterances with and without perceived errors were analyzed with existing and novel quantitative methods.New multivariate measures showed that for 5 participants, kinematic variability for productions perceived to be error free was significantly increased under delay; these results were validated by using

2017 Journal of speech, language, and hearing research : JSLHR PubMed abstract

38. Parent-based Intervention for Language Delayed 2 to 3 Year Olds

Trust Information provided by (Responsible Party): Solent NHS Trust Study Details Study Description Go to Brief Summary: The aim of the study is to evaluate the impact of parent based intervention on the language of 2 to 3 year old children from socially disadvantaged populations with a clinical diagnosis of primary language delay. Condition or disease Intervention/treatment Phase Speech and Language Therapy Other: Standard PBI Other: Enhanced Not Applicable Detailed Description: This project (...) : Interventional (Clinical Trial) Estimated Enrollment : 192 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Randomised Controlled Trial of the Effectiveness of Parent-based Models of Speech and Language Therapy Intervention for 2 to 3 Year Old Children With Primary Language Delay in Areas of Social Disadvantage Estimated Study Start Date : October 2017 Estimated Primary Completion Date : March 2020 Estimated

2017 Clinical Trials

39. Which population groups are more likely to delay presentation with cancer symptoms and are more frequently diagnosed with late stage cancer, and why?

outcome".tw. 29 "Early Detection of Cancer"/ 30 27 or 28 or 29 31 (present* adj2 (early or late or later or late-stage or delay*)).tw. 32 Time Factors/ 33 1 and 30 and 31 and 32 34 (children or child).tw. 35 adolescent/ or exp child/ or exp infant/ 36 "case report*".tw. Ovid Medline cont. 37 34 or 35 or 36 38 11 or 25 or 33 39 38 not 37 40 limit 39 to (english language and yr="2008 -Current") Inclusion criteria • delayed cancer presentation • late stage cancer diagnosis • women, men, ethnic minorities (...) Which population groups are more likely to delay presentation with cancer symptoms and are more frequently diagnosed with late stage cancer, and why? Knowledge & Library Services (KLS) Evidence Briefing Which population groups are more likely to delay presentation with cancer symptoms and are more frequently diagnosed with late stage cancer, and why? Anh Tran 29 th March 2019 Which population groups are more likely to delay presentation with cancer symptoms and are more frequently diagnosed

2020 Public Health England - Evidence Briefings

40. Aided Language Stimulation Leading to Functional Communication Gains in Children Using Augmentative and Alternative Communication

) • Children with functional verbal communication skills • Children for whom augmentative and alternative communication is a secondary means of expression and communication • Peer Modeling TARGET USERS FOR THE RECOMMENDATIONS Target users include, but are not limited to, speech-language pathologists caring for inpatients/outpatients, school-based speech-language pathologists, teachers and school-based paraprofessionals, and parents of children with severe communication impairments who are using AAC. Best (...) Evidence Statement (BESt 211) Copyright © 2018 Cincinnati Children's Hospital Medical Center; all rights reserved Page 2 of 15 EVIDENCE –BASED CARE RECOMMENDATION It is recommended that aided language stimulation and related aided language modeling strategies be used to support the learning of functional communication skills and use of speech generating device systems with children in the language acquisition stage of development who have limited to no verbal communication (Binger, 2008 [5b]; Chiang

2018 Cincinnati Children's Hospital Medical Center

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