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Speech Delay

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181. Editorial: Early intervention in response to language delays - is there a danger of putting too many eggs in the wrong basket? (PubMed)

Psychol Psychiatry 0375361 0021-9630 IM J Child Psychol Psychiatry. 2015 Aug;56(8):848-56 25557322 Female Humans Language Development Literacy statistics & numerical data Male Vocabulary Early intervention child development early language delays language skills predictors speech-language therapy 2015 7 7 6 0 2015 7 7 6 0 2016 4 8 6 0 ppublish 26147695 10.1111/jcpp.12446 (...) Editorial: Early intervention in response to language delays - is there a danger of putting too many eggs in the wrong basket? 26147695 2016 04 07 2018 12 03 1469-7610 56 8 2015 Aug Journal of child psychology and psychiatry, and allied disciplines J Child Psychol Psychiatry Editorial: Early intervention in response to language delays--is there a danger of putting too many eggs in the wrong basket? 835-6 10.1111/jcpp.12446 Norbury Courtenay Frazier CF eng Editorial Comment England J Child

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2015 Journal of Child Psychology and Psychiatry

182. Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy. (PubMed)

Delayed low frequency hearing loss caused by cochlear implantation interventions via the round window but not cochleostomy. Cochlear implant recipients show improved speech perception and music appreciation when residual acoustic hearing is combined with the cochlear implant. However, up to one third of patients lose their pre-operative residual hearing weeks to months after implantation, for reasons that are not well understood. This study tested whether this "delayed" hearing loss (...) condition was assessed histologically, with cochleae three-dimensionally reconstructed to plot electrode paths and estimate tissue response. Electrode array trajectories matched their intended paths. Arrays inserted via the round window were situated nearer to the basilar membrane and organ of Corti over the majority of their intrascalar path compared with arrays inserted via cochleostomy. Round window interventions exhibited delayed, low frequency hearing loss that was not seen after cochleostomy

2015 Hearing Research

183. De Novo Nonsense Mutations in KAT6A, a Lysine Acetyl-Transferase Gene, Cause a Syndrome Including Microcephaly and Global Developmental Delay. (PubMed)

exomes or in public databases. Common features among all four probands include primary microcephaly, global developmental delay including profound speech delay, and craniofacial dysmorphism, as well as more varied features such as feeding difficulties, cardiac defects, and ocular anomalies. We further demonstrate that KAT6A mutations result in dysregulation of H3K9 and H3K18 acetylation and altered P53 signaling. Through histone and non-histone acetylation, KAT6A affects multiple cellular processes (...) De Novo Nonsense Mutations in KAT6A, a Lysine Acetyl-Transferase Gene, Cause a Syndrome Including Microcephaly and Global Developmental Delay. Chromatin remodeling through histone acetyltransferase (HAT) and histone deactylase (HDAC) enzymes affects fundamental cellular processes including the cell-cycle, cell differentiation, metabolism, and apoptosis. Nonsense mutations in genes that are involved in histone acetylation and deacetylation result in multiple congenital anomalies with most

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2015 American Journal of Human Genetics

184. Delayed prelingual cochlear implantation in childhood and puberty. (PubMed)

Delayed prelingual cochlear implantation in childhood and puberty. To evaluate the results of delayed cochlear impantion performed in childhood and puberty in the light of speech language pathology assessments.Totally 49 children with prelingual profound hearing loss were included in the study. All children received a cochlear implant between the ages of 5 and 19 years (Group 1 aged between 5 and 9 years, group 2 aged between 10 and 14 years, group 3 aged between and 15 and 19 years). The MAIS (...) of communication was not statistically significant in group 3 (p>0.05).The decision of delayed cochlear implantation in children can be made in the light of following parameters. A good family support is most important. The patients must be wearing hearing aids regularly since early childhood, and preferably use the auditory verbal communication. Evaluation of the patient with MAIS, MUSS and PLS is important to understand the level of receptive and expressive communication level.Copyright © 2014 Elsevier

2015 International Journal of Pediatric Otorhinolaryngology

185. A case report of primary ciliary dyskinesia, laterality defects and developmental delay caused by the co-existence of a single gene and chromosome disorder. (PubMed)

-causing PCD genes in the Irish Traveller population; RSPH4A, DYX1C1 and CCNO. We have since assessed an additional Irish Traveller family with a complex phenotype involving PCD who did not have any of the previously identified PCD mutations.In this study we report on a family with three children with PCD and various laterality defects. In addition, one child (V:1) has mild-to-moderate developmental delay and one child has speech delay (V:2). Developmental delay is not usually associated with PCD (...) A case report of primary ciliary dyskinesia, laterality defects and developmental delay caused by the co-existence of a single gene and chromosome disorder. Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder characterised by abnormal ciliary motion and impaired mucociliary clearance, leading to recurrent respiratory infections, sinusitis, otitis media and male infertility. Some patients also have laterality defects. We recently reported the identification of three disease

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2015 BMC Medical Genetics

186. Delayed Stream Segregation in Older Adults: More Than Just Informational Masking. (PubMed)

Delayed Stream Segregation in Older Adults: More Than Just Informational Masking. To determine whether the time course for the buildup of auditory stream segregation differs between younger and older adults.Word recognition thresholds were determined for the first and last keywords in semantically anomalous but syntactically correct sentences (e.g., "A rose could paint a fish") when the target sentences were masked by speech-spectrum noise, 3-band vocoded speech, 16-band vocoded speech, intact (...) and colocated speech, and intact and spatially separated speech. A significant reduction in thresholds from the first to the last keyword was interpreted as indicating that stream segregation improved with time.The buildup of stream segregation is slowed for both age groups when the masker is intact, colocated speech.Older adults are more disadvantaged; for them, stream segregation is also slowed even when a speech masker is spatially separated, conveys little meaning (3-band vocoding), and vocal fine

2015 Ear and hearing

187. Very Preterm Children With Language Delay and Parent Intervention

: Lille Catholic University Collaborator: Ministry of Health, France Information provided by (Responsible Party): Lille Catholic University Study Details Study Description Go to Brief Summary: In studies of children born at term, language delay at the age of 2 years exhibits a spontaneously favourable course in 30 to 50% by the age of 3 years. In France, there is no recommendation for speech therapy before the age of 3 years. However, for term-born children, parent-implemented language interventions (...) of early language delay. Currently, there is an opportunity to partly nest an intervention trial in a national prospective population-based cohort of very preterm children, the EPIPAGE (Etude EPIdémiologique sur les Petits Ages GEstationnels) 2 cohort, which has included 5 000 babies born alive in France in 2011. This situation provides considerable methodological advantages. Condition or disease Intervention/treatment Phase Preterm Birth Language Development Speech Therapy Behavioral: Parent

2014 Clinical Trials

188. Effects of Work Shop for Children With Developmental Delays

Information provided by (Responsible Party): Taipei Medical University Study Details Study Description Go to Brief Summary: To identify the effects of family work shop for children with speech developmental delays. Condition or disease Intervention/treatment Phase Developmental Delays Other: family work shop Not Applicable Detailed Description: To assess the improvement of functional performance of children with speech developmental delays by 2-3 hours per session, one session per week, a total of 6 weeks (...) of family work shop Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 30 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Health Services Research Official Title: Effects of Family Work Shop for Children With Speech Developmental Delays Study Start Date : June 2014 Estimated Primary Completion Date : January 2015 Estimated Study Completion Date : January 2015 Arms and Interventions

2014 Clinical Trials

189. On Track: Monitoring Development of Children With Cerebral Palsy or Gross Motor Delay

On Track: Monitoring Development of Children With Cerebral Palsy or Gross Motor Delay On Track: Monitoring Development of Children With Cerebral Palsy or Gross Motor Delay - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. On Track: Monitoring Development of Children With Cerebral Palsy or Gross Motor Delay The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02391948 Recruitment Status : Unknown Verified October 2016 by Sarah Westcott McCoy, University of Washington. Recruitment status was: Active

2014 Clinical Trials

190. A rare case of pituitrin-induced delayed encephalopathy (PubMed)

A rare case of pituitrin-induced delayed encephalopathy A 26-year-old girl was admitted to the Neurological Department of The First Teaching Hospital of Jilin University with complaints of rapidly deteriorating speech clumsiness for 18 days. Five Days before her attack she had undergone intramuscular pituitrin therapy on account of recurrent haemoptysis. Cranial MRI revealed multiple abnormal signals in bilateral hemisphere and symmetric abnormal signal in bilateral caudate nucleus and putamen (...) . Serum electrolyte analysis revealed mild hyponatremia. The abnormal signals in bilateral hemisphere almost disappeared after 7 days of cerebral circulation ameliorating and serum electrolyte turbulence correcting therapy, whereas the symmetric abnormal signals in bilateral caudate nucleus and putamen still existed. A diagnosis of delayed encephalopathy was made and we presume the encephalopathy was associated with pituitrin therapy.

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2014 Pakistan Journal Of Medical Sciences

191. Early augmented language intervention for children with developmental delays: potential secondary motor outcomes. (PubMed)

Early augmented language intervention for children with developmental delays: potential secondary motor outcomes. This exploratory study examined the potential secondary outcome of an early augmented language intervention that incorporates speech-generating devices (SGD) on motor skill use for children with developmental delays. The data presented are from a longitudinal study by Romski and colleagues. Toddlers in the augmented language interventions were either required (Augmented

2014 Augmentative and alternative communication (Baltimore, Md. : 1985) Controlled trial quality: uncertain

192. Speech and Language Development in 2 Year Old Children with Cerebral Palsy (PubMed)

talkers (15% of the sample). Group differences were evident on all variables except receptive language skills.85% of 2-year-old children with CP in this study had clinical speech and/or language delays relative to age expectations. Findings suggest that children with CP should receive speech and language assessment and treatment at or before 2 years of age. (...) Speech and Language Development in 2 Year Old Children with Cerebral Palsy We examined early speech and language development in children who had cerebral palsy. Questions addressed whether children could be classified into early profile groups on the basis of speech and language skills and whether there were differences on selected speech and language measures among groups.Speech and language assessments were completed on 27 children with CP who were between the ages of 24 and 30 months (mean

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2013 Developmental neurorehabilitation

193. Hemisphere Differences in Speech-Sound Event-Related Potentials in Intensive Care Neonates: Associations and Predictive Value for Development in Infancy (PubMed)

Hemisphere Differences in Speech-Sound Event-Related Potentials in Intensive Care Neonates: Associations and Predictive Value for Development in Infancy Neurodevelopmental delays in intensive care neonates are common but difficult to predict. In children, hemisphere differences in cortical processing of speech are predictive of cognitive performance. We hypothesized that hemisphere differences in auditory event-related potentials in intensive care neonates are predictive of neurodevelopment (...) in infancy, even in those born preterm. Event-related potentials to speech sounds were prospectively recorded in 57 infants (gestational age 24-40 weeks) prior to discharge. The Developmental Assessment of Young Children was performed at 6 and 12 months. Hemisphere differences in mean amplitudes increased with postnatal age (P < .01) but not with gestational age. Greater hemisphere differences were associated with improved communication and cognitive scores at 6 and 12 months, but decreased

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2013 Journal of child neurology

194. Speech and language outcomes of cochlear implantation in children with isolated auditory neuropathy versus cochlear hearing loss. (PubMed)

Speech and language outcomes of cochlear implantation in children with isolated auditory neuropathy versus cochlear hearing loss. Children with auditory neuropathy (AN) have variable hearing on pure tone testing, and the presence of speech and language delays often play a major role in the decision to offer cochlear implantation (CI) in this population. Despite this fact, the speech and language outcomes in this group after CI are not well described. This study compares speech and language (...) outcomes after CI in a subset of the pediatric AN population that does not have a confounding cognitive disorder with those of their peers with cochlear hearing loss (CoHL).Retrospective chart review.Tertiary referral center.Seventeen pediatric patients with AN who received a CI and a group of children with CoHL who received a CI were the subjects of this study. The 2 groups demonstrated similar ages at implant. Children with cognitive delays were excluded from each group.Cochlear implantation.All

2013 Otology and Neurotology

195. Effects of Aural Atresia on Speech Development and Learning: Retrospective Analysis From a Multidisciplinary Craniofacial Clinic. (PubMed)

problems exists among children with AA. DESIGN Retrospective medical record review. SETTING Multidisciplinary craniofacial clinic. PARTICIPANTS Children with unilateral or bilateral AA. INTERVENTIONS Records review, including evaluations by audiologists, speech pathologists, and psychologists. MAIN OUTCOME MEASURES Rates of speech and/or language delay, prevalence of speech therapy and educational interventions, and parental report of psychosocial problems. RESULTS A total of 74 patients were (...) Effects of Aural Atresia on Speech Development and Learning: Retrospective Analysis From a Multidisciplinary Craniofacial Clinic. IMPORTANCE Aural atresia (AA) is associated with maximal conductive hearing loss in affected ears, and children with bilateral AA require amplification. Some recent research has suggested an increased risk for speech and learning problems among children with unilateral sensorineural hearing loss. OBJECTIVE To investigate whether increased risk for speech and learning

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2013 JAMA otolaryngology-- head & neck surgery

196. Cortical speech sound differentiation in the neonatal intensive care unit predicts cognitive and language development in the first 2 years of life. (PubMed)

Cortical speech sound differentiation in the neonatal intensive care unit predicts cognitive and language development in the first 2 years of life. Neurodevelopmental delay in childhood is common in infants born preterm, but is difficult to predict before infants leave the neonatal intensive care unit (NICU). We hypothesized that event-related potential (ERP) methodology characterizing the cortical differentiation of speech sounds in hospitalized infants would predict cognitive and language (...) outcomes during early childhood.We conducted a prospective study of 57 infants in NICU (34 male, gestational age at birth 24-40wks), quantifying the amplitude of ERP responses to speech sounds before discharge (median gestational age 37.1wks), followed by standardized neurodevelopmental assessments at 12 months and 24 months. Analyses were performed using ordinary least squares linear regression.Overall validity of constructs using all ERP variables, as well as sex, maternal education, gestational age

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2013 Developmental Medicine and Child Neurology

197. Effects of practice schedules on speech motor learning. (PubMed)

Effects of practice schedules on speech motor learning. The aim of this study was to evaluate the effects of various practice schedules on learning a novel speech task. Forty healthy Cantonese speakers were asked to learn to produce a Cantonese phrase with two target utterance durations (2500 and 3500 milliseconds). They were randomly assigned to one of four learning conditions, each completing a different practice schedule, namely Blocked only, Random only, Blocked-then-Random, and Random (...) -then-Blocked. Two retention tests (one immediate and one delayed) and a transfer test were administered. The four groups of participants showed different patterns of learning, but achieved comparable levels of performance at the end of the acquisition phase. However, participants in the Blocked only condition were less able to differentiate the two target durations than those in the Random only condition during retention. Furthermore, participants who received both blocked and random practice were less

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2013 International journal of speech-language pathology Controlled trial quality: uncertain

198. Chiari I malformation, delayed gross motor skills, severe speech delay, and epileptiform discharges in a child with FOXP1 haploinsufficiency. (PubMed)

Chiari I malformation, delayed gross motor skills, severe speech delay, and epileptiform discharges in a child with FOXP1 haploinsufficiency. Human FOXP2 deficiency has been identified as a cause of hereditary developmental verbal dyspraxia. Another member of the same gene family, FOXP1, has expression patterns that overlap with FOXP2 in some areas of the brain, and FOXP1 and FOXP2 have the ability to form heterodimers. These findings suggest the possibility that FOXP1 may also contribute (...) to proper speech development. However, no such role of FOXP1 has been established to date. Recently, a child was reported who presented with a 3p13-14.1 deletion of four genes, including FOXP1, and a constellation of deficits that included speech delay. In this study, we report the case of a patient with a single deletion of FOXP1. This patient presented with speech and motor developmental delays, a Chiari I malformation, and epileptiform discharges. The nature of the speech deficit is different from

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2010 European Journal of Human Genetics

199. Aging affects neural precision of speech encoding (PubMed)

neurotransmitter levels and delayed neural recovery can contribute to decreases in the temporal precision of the auditory system. Decreased precision may lead to neural timing delays, reductions in neural response magnitude, and a disadvantage in processing the rapid acoustic changes in speech. The auditory brainstem response (ABR), a scalp-recorded electrical potential, is known for its ability to capture precise neural synchrony within subcortical auditory nuclei; therefore, we hypothesized that a loss (...) of temporal precision results in subcortical timing delays and decreases in response consistency and magnitude. To assess this hypothesis, we recorded ABRs to the speech syllable /da/ in normal hearing younger (18-30 years old) and older (60-67 years old) adult humans. Older adults had delayed ABRs, especially in response to the rapidly changing formant transition, and greater response variability. We also found that older adults had decreased phase locking and smaller response magnitudes than younger

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2012 The Journal of neuroscience : the official journal of the Society for Neuroscience

200. Factors affecting predicted speech intelligibility with cochlear implants in an auditory model for electrical stimulation. (PubMed)

Factors affecting predicted speech intelligibility with cochlear implants in an auditory model for electrical stimulation. A model of the auditory response to stimulation with cochlear implants (CIs) was used to predict speech intelligibility in electric hearing. The model consists of an auditory nerve cell population that generates delta pulses as action potentials in response to temporal and spatial excitation with a simulated CI signal processing strategy. The auditory nerve cells (...) are modeled with a leaky integrate-and-fire model with membrane noise. Refractory behavior is introduced by raising the threshold potential with an exponentially decreasing function. Furthermore, the action potentials are delayed to account for latency and jitter. The action potentials are further processed by a central model stage, which includes spatial and temporal integration, resulting in an internal representation of the sound presented. Multiplicative noise is included in the internal

2012 Hearing Research

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