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Speckled Lentiginous Nevus

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1. Speckled lentiginous nevus: understanding the process of development and regression. (Abstract)

Speckled lentiginous nevus: understanding the process of development and regression. 29315489 2018 06 13 1365-2133 178 6 2018 Jun The British journal of dermatology Br. J. Dermatol. Speckled lentiginous naevus: understanding the process of development and regression. 1447-1448 10.1111/bjd.16319 Iwatsuki K K http://orcid.org/0000-0003-4666-3179 Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama

2018 British Journal of Dermatology

2. Speckled Lentiginous Nevus

Speckled Lentiginous Nevus Speckled Lentiginous Nevus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Speckled Lentiginous Nevus (...) Speckled Lentiginous Nevus Aka: Speckled Lentiginous Nevus , Nevus Spilus II. Pathophysiology Variant of III. Signs less round to irregularly shaped brown nevus Larger nevus contains 1-3 mm dots of dark brown pigmentation (may be elevated) Diameter ranges from 1-20 cm IV. Management Malignant transformation is uncommon but can occur Size of lesion directs management - follow the same protocols for based on size below Observe and biopsy or excise lesions if atypical V. Reference Habif (2003) Clinical

2018 FP Notebook

3. Congenital Melanocytic Nevus Admixed with Speckled Lentiginous Nevus Full Text available with Trip Pro

Congenital Melanocytic Nevus Admixed with Speckled Lentiginous Nevus 23716838 2013 05 30 2018 11 13 1998-3611 58 2 2013 Mar Indian journal of dermatology Indian J Dermatol Congenital melanocytic nevus admixed with speckled lentiginous nevus. 161 10.4103/0019-5154.108091 Jeong Nam-Ji NJ Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea. E-mail: im1177@hanmail.net. Park Seung-Bae SB Lee Young Y Seo Young-Joon YJ Lee Jeung-Hoon JH Im Myung M eng Journal

2013 Indian journal of dermatology

4. Speckled Lentiginous Nevus (Overview)

. Speckled lentiginous nevus syndrome: delineation of a new distinct neurocutaneous phenotype. Eur J Dermatol . 2002 Mar-Apr. 12(2):133-5. . Jordaan HF, Happle R. Phacomatosis spilorosea associated with lymphoedema. Br J Dermatol . 2008 Aug. 159(2):489-91. . Kopf AW, Levine LJ, Rigel DS, Friedman RJ, Levenstein M. Prevalence of congenital-nevus-like nevi, nevi spili, and cafe au lait spots. Arch Dermatol . 1985 Jun. 121(6):766-9. . Borrego L, Hernandez Santana J, Baez O, Hernandez Hernandez B. Naevus (...) Speckled Lentiginous Nevus (Overview) Speckled Lentiginous Nevus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MTk5MC1vdmVydmlldw== processing > Speckled Lentiginous

2014 eMedicine.com

5. Speckled Lentiginous Nevus (Treatment)

Speckled Lentiginous Nevus (Treatment) Speckled Lentiginous Nevus Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MTk5MC10cmVhdG1lbnQ (...) = processing > Speckled Lentiginous Nevus Treatment & Management Updated: Apr 07, 2017 Author: Rossitza Lazova, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Speckled Lentiginous Nevus Treatment Medical Care Photography and observation are the best clinical approaches for assessing the development of atypical features or the transformation to cutaneous melanoma. Speckled lentiginous nevi are evaluated and treated with the same level of concern as would be warranted

2014 eMedicine.com

6. Speckled Lentiginous Nevus (Follow-up)

Speckled Lentiginous Nevus (Follow-up) Speckled Lentiginous Nevus Treatment & Management: Medical Care, Surgical Care, Consultations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MTk5MC10cmVhdG1lbnQ (...) = processing > Speckled Lentiginous Nevus Treatment & Management Updated: Apr 07, 2017 Author: Rossitza Lazova, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Speckled Lentiginous Nevus Treatment Medical Care Photography and observation are the best clinical approaches for assessing the development of atypical features or the transformation to cutaneous melanoma. Speckled lentiginous nevi are evaluated and treated with the same level of concern as would be warranted

2014 eMedicine.com

7. Speckled Lentiginous Nevus (Diagnosis)

Speckled Lentiginous Nevus (Diagnosis) Speckled Lentiginous Nevus: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2MTk5MC1vdmVydmlldw== processing > Speckled (...) Lentiginous Nevus Updated: Apr 07, 2017 Author: Rossitza Lazova, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Speckled Lentiginous Nevus Overview Background Speckled lentiginous nevus is a patch of hyperpigmentation that can be seen on any area of the body. This patch contains a variable number of darkly pigmented macules and papules. Some authorities believe that speckled lentiginous nevus is a subtype of congenital melanocytic nevus. [ , , ] Next

2014 eMedicine.com

8. Speckled Lentiginous Nevus

Speckled Lentiginous Nevus Speckled Lentiginous Nevus Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Speckled Lentiginous Nevus (...) Speckled Lentiginous Nevus Aka: Speckled Lentiginous Nevus , Nevus Spilus II. Pathophysiology Variant of III. Signs less round to irregularly shaped brown nevus Larger nevus contains 1-3 mm dots of dark brown pigmentation (may be elevated) Diameter ranges from 1-20 cm IV. Management Malignant transformation is uncommon but can occur Size of lesion directs management - follow the same protocols for based on size below Observe and biopsy or excise lesions if atypical V. Reference Habif (2003) Clinical

2015 FP Notebook

9. Congenital Melanocytic Nevus

centimeters to involving an entire region of the body is variably present Typically with uniform pigmentation V. Types: Speckled Lentiginous Nevus (Nevus Spilus) Variant of Congenital Nevi less round to irregularly shaped brown nevus Larger nevus contains 1-3 mm dots of dark brown pigmentation (may be elevated) Diameter ranges from 1-20 cm Malignant transformation is uncommon but can occur Size of lesion directs management - follow the same protocols for Congenital Nevi based on size below Observe (...) . Concepts Neoplastic Process ( T191 ) SnomedCT 254203006 , 84953004 , 400151006 , 398696001 , 398943008 English Congen melanocytic naevus skin , Congen melanocytic nevus skin , Congen pigmented naevus skin , Congen pigmented nevus skin , Congenital Nevus of the Skin , Congenital Nevus of Skin , Congenital Skin Nevus , Congenital Melanocytic Nevus , congenital pigmented naevus , congenital melanocytic naevus , congenital melanocytic nevus , nevus pigmented congenital , congenital pigmented nevus

2018 FP Notebook

10. Epidermal Nevus Syndrome (Overview)

) congenital hemidysplasia with ichthyosiform nevus and limb defect, (3) phakomatosis pigmentokeratotica, (4) sebaceous nevus, (5) Becker nevus, and (6) nevus comedonicus [ ] syndromes. Phacomatosis pigmentokeratotica is characterized by the presence of multiple organoid nevi with sebaceous differentiation, a speckled lentiginous nevus, and skeletal and neurologic abnormalities. [ ] It may or may not be associated with extracutaneous involvement. One patient with it developed basal cell carcinoma (...) A . 2010 Nov. 152A(11):2816-9. . Happle R. Epidermal nevus syndromes. Semin Dermatol . 1995 Jun. 14(2):111-21. . Rogers M, McCrossin I, Commens C. Epidermal nevi and the epidermal nevus syndrome. A review of 131 cases. J Am Acad Dermatol . 1989 Mar. 20(3):476-88. . Ball EA, Hussain M, Moss AL. Squamous cell carcinoma and basal cell carcinoma arising in a naevus sebaceous of Jadassohn: case report and literature review. Clin Exp Dermatol . 2005 May. 30(3):259-60. . Wu ZW, Shi WM, Sun Y, Li XJ, Song J

2014 eMedicine.com

11. Epidermal Nevus Syndrome (Diagnosis)

) congenital hemidysplasia with ichthyosiform nevus and limb defect, (3) phakomatosis pigmentokeratotica, (4) sebaceous nevus, (5) Becker nevus, and (6) nevus comedonicus [ ] syndromes. Phacomatosis pigmentokeratotica is characterized by the presence of multiple organoid nevi with sebaceous differentiation, a speckled lentiginous nevus, and skeletal and neurologic abnormalities. [ ] It may or may not be associated with extracutaneous involvement. One patient with it developed basal cell carcinoma (...) A . 2010 Nov. 152A(11):2816-9. . Happle R. Epidermal nevus syndromes. Semin Dermatol . 1995 Jun. 14(2):111-21. . Rogers M, McCrossin I, Commens C. Epidermal nevi and the epidermal nevus syndrome. A review of 131 cases. J Am Acad Dermatol . 1989 Mar. 20(3):476-88. . Ball EA, Hussain M, Moss AL. Squamous cell carcinoma and basal cell carcinoma arising in a naevus sebaceous of Jadassohn: case report and literature review. Clin Exp Dermatol . 2005 May. 30(3):259-60. . Wu ZW, Shi WM, Sun Y, Li XJ, Song J

2014 eMedicine.com

12. Congenital Melanocytic Nevus

centimeters to involving an entire region of the body is variably present Typically with uniform pigmentation V. Types: Speckled Lentiginous Nevus (Nevus Spilus) Variant of Congenital Nevi less round to irregularly shaped brown nevus Larger nevus contains 1-3 mm dots of dark brown pigmentation (may be elevated) Diameter ranges from 1-20 cm Malignant transformation is uncommon but can occur Size of lesion directs management - follow the same protocols for Congenital Nevi based on size below Observe (...) . Concepts Neoplastic Process ( T191 ) SnomedCT 254203006 , 84953004 , 400151006 , 398696001 , 398943008 English Congen melanocytic naevus skin , Congen melanocytic nevus skin , Congen pigmented naevus skin , Congen pigmented nevus skin , Congenital Nevus of the Skin , Congenital Nevus of Skin , Congenital Skin Nevus , Congenital Melanocytic Nevus , congenital pigmented naevus , congenital melanocytic naevus , congenital melanocytic nevus , nevus pigmented congenital , congenital pigmented nevus

2015 FP Notebook

13. More on Speckled Lentiginous Nevus Syndrome. Full Text available with Trip Pro

More on Speckled Lentiginous Nevus Syndrome. 21071924 2011 04 20 2010 12 23 1421-9832 221 4 2010 Dermatology (Basel, Switzerland) Dermatology (Basel) More on speckled lentiginous nevus syndrome. 324-5 10.1159/000321473 Torchia Daniele D eng Case Reports Letter 2010 11 11 Switzerland Dermatology 9203244 1018-8665 IM Adolescent Adult Child Female Humans Hyperhidrosis diagnosis Male Musculoskeletal Abnormalities diagnosis Nevus, Pigmented diagnosis Paresthesia diagnosis Skin Neoplasms diagnosis

2010 Dermatology

14. Melanoma and pigmented lesions

Melanoma and pigmented lesions Melanoma and pigmented lesions - NICE CKS Share Melanoma and pigmented lesions: Summary A melanoma of the skin is a malignant tumour arising from melanocytes in the skin. There are four common subtypes — superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma, and acral lentiginous melanoma. Other types of pigmented lesions include: Moles (naevi) — including blue naevi, halo naevi, and Meyerson's naevi. Seborrhoeic keratoses. Dermatofibromas (...) and have malignant potential, with a 9–12% chance of developing melanoma (the risk is greatest before puberty). Naevus spilus is a type of congenital naevus, usually measuring 1–10 cm in diameter. It is a benign lesion which becomes progressively speckled during childhood, with small dark-brown macules and papules within a larger pale brown pigmented patch. Images of moles are available at [ ; ; ; ]. Diagnosis Diagnosis of melanoma and pigmented lesions Assessment How should I assess a lesion? The key

2017 NICE Clinical Knowledge Summaries

15. Phacomatosis pigmentokeratotica: a case of HRAS mosaicism causing rhabdomyosarcoma. (Abstract)

Phacomatosis pigmentokeratotica: a case of HRAS mosaicism causing rhabdomyosarcoma. A 17-year-old male presented with a large sebaceous naevus (SN) comprising part of his right face and scalp and a speckled lentiginous naevus (SLN) on his left trunk, hip, neck and scalp with a checkerboard pattern. His right oral hemimucosa showed extensive papillomatous lesions, which were contiguous with the upper-lip SN lesions. He also showed extracutaneous manifestations including cardiac, musculoskeletal (...) and ocular alterations. Internally, he had developed two primary rhabdomyosarcomas. DNA samples of the SN, SLN, oral papillomatous hyperplasia and both rhabdomyosarcomas were analysed by Sanger sequencing. An HRAS c.37G>C mutation was detected in all of them. Skin and blood DNA were wild-type. Phacomatosis pigmentokeratotica (PPK) is characterized by the association of an SN with a papular naevus spilus and extracutaneous manifestations. Until recently, the aetiopathogenetic hypothesis of didymosis

2018 British Journal of Dermatology

16. Phacomatosis pigmentokeratotica or the Schimmelpenning‐Feuerstein‐Mims syndrome? Full Text available with Trip Pro

Phacomatosis pigmentokeratotica or the Schimmelpenning‐Feuerstein‐Mims syndrome? Cutaneous symptoms in some patients with clinical picture of Schimmelpenning-Feuerstein-Mims syndrome can include a speckled lentiginous nevus, also known as nevus spilus. Recent investigations show that somatic heterozygous HRAS mutations are present in the sebaceous and speckled lentiginous nevus tissues of patients with combination of two nevi.

2016 Clinical Case Reports

17. Laser Treatment of Benign Pigmented Lesions (Diagnosis)

lesions. A typical treatment response includes purpura lasting 5-7 days, followed by subsequent sloughing of the treated lesion at 7-14 days. The underlying new skin is pink for 2-3 days but fades to normal skin color with rare textural changes or scarring. In another study, 25 patients with solar lentigines showed excellent laser-induced clearing after 1-2 treatments. Fourteen patients with café au lait macules showed complete clearing after 3-6 treatments. Two patients with nevus spilus and 2 (...) clearance, briefer pulse widths and treatment without cryogen cooling both, independently, decreased the fluence threshold. In 2001, Suh et al [ ] reported 71 Korean adult patients with superficial pigmented lesions (lentigines and solar lentigines) who demonstrated a very good response rate to multiple Q-switched Nd:YAG laser treatments. In 2003, Downs et al [ ] noted that the combination of the Q-switched Nd:YAG laser for café au lait spots, Becker nevi, speckled nevi, and congenital melanocytic nevi

2014 eMedicine.com

18. Laser Treatment of Benign Pigmented Lesions (Overview)

lesions. A typical treatment response includes purpura lasting 5-7 days, followed by subsequent sloughing of the treated lesion at 7-14 days. The underlying new skin is pink for 2-3 days but fades to normal skin color with rare textural changes or scarring. In another study, 25 patients with solar lentigines showed excellent laser-induced clearing after 1-2 treatments. Fourteen patients with café au lait macules showed complete clearing after 3-6 treatments. Two patients with nevus spilus and 2 (...) clearance, briefer pulse widths and treatment without cryogen cooling both, independently, decreased the fluence threshold. In 2001, Suh et al [ ] reported 71 Korean adult patients with superficial pigmented lesions (lentigines and solar lentigines) who demonstrated a very good response rate to multiple Q-switched Nd:YAG laser treatments. In 2003, Downs et al [ ] noted that the combination of the Q-switched Nd:YAG laser for café au lait spots, Becker nevi, speckled nevi, and congenital melanocytic nevi

2014 eMedicine.com

19. Dermatologic Manifestations of Gastrointestinal Disease (Treatment)

Upper GI cancer Peutz-Jeghers syndrome Diffuse macular GI polyps GI cancer Cronkhite-Canada Diffuse Hepatomegaly Cirrhosis Hepatocellular carcinoma Hemochromatosis Plaques, acral Hepatitis Necrolytic acral erythema Lichenoid papules/plaques Hepatitis Lichen planus Hepatomegaly [ ] Hepatic lesions Sarcoidosis Papules that heal with atrophic scars Perforation Malignant atrophic papulosis [ ] Vascular malformation GI bleeding Blue rubber bleb nevus syndrome Ulcers with undermined borders Malabsorption (...) with malabsorption eventually may lead to iron or folate-deficient anemia states. Therapy involves the adoption of a gluten-free diet, with avoidance of foods such as wheat, barley, and rye. The initiation of therapy with dapsone or sulfapyridine results in a dramatic improvement in both GI and dermatologic symptoms; a prompt improvement following therapy can confirm the diagnosis. Blue rubber bleb nevus syndrome This is characterized by the combination of cutaneous vascular malformations and GI bleeding due

2014 eMedicine.com

20. Laser Treatment of Benign Pigmented Lesions (Treatment)

lesions. A typical treatment response includes purpura lasting 5-7 days, followed by subsequent sloughing of the treated lesion at 7-14 days. The underlying new skin is pink for 2-3 days but fades to normal skin color with rare textural changes or scarring. In another study, 25 patients with solar lentigines showed excellent laser-induced clearing after 1-2 treatments. Fourteen patients with café au lait macules showed complete clearing after 3-6 treatments. Two patients with nevus spilus and 2 (...) clearance, briefer pulse widths and treatment without cryogen cooling both, independently, decreased the fluence threshold. In 2001, Suh et al [ ] reported 71 Korean adult patients with superficial pigmented lesions (lentigines and solar lentigines) who demonstrated a very good response rate to multiple Q-switched Nd:YAG laser treatments. In 2003, Downs et al [ ] noted that the combination of the Q-switched Nd:YAG laser for café au lait spots, Becker nevi, speckled nevi, and congenital melanocytic nevi

2014 eMedicine.com

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