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Somatization Risk Factors

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1. Room for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men. (Full text)

Room for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men. Depressed mood and exhaustion (DEEX) have gained attention as a risk predictor for cardiovascular disease (CVD). Studies to estimate its ranking in prediction models are sparse.The study included 3428 men aged 45-74 years who participated in one of three population-based MONICA/KORA Augsburg surveys conducted between 1984 (...) and 1995. Within a follow-up time of 10 years (31,791 person-years), 557 cases of all-cause mortality and 269 fatal CVD events were observed. Adjusted Cox proportional hazards models were used to assess mortality risks for DEEX and five classical cardiovascular risk factors. The predictive ability was evaluated by the area under the receiver-operating characteristic curve, the integrated discrimination improvement statistics and the net classification improvement.The (crude) absolute mortality risk

2016 Atherosclerosis PubMed

2. Do negative childhood conditions increase the risk of somatic symptoms in adolescence? - a prospective cohort study. (Full text)

Do negative childhood conditions increase the risk of somatic symptoms in adolescence? - a prospective cohort study. In order to prevent health and social problems later in life, it is important to identify childhood conditions related to the development of somatic symptoms. This prospective study expands on previous research by investigating whether negative childhood conditions are related to somatization later in life, taking other risk factors into account. This study aims to investigate (...) , and parental reports of somatic symptoms as well as register information about parental socioeconomic background. Generalized linear models for the binomial family were used and the results were presented as relative risks (RR) and risk differences (RD) with 95% confidence intervals (95%-CI).Experiencing poor family functioning at age 15 showed associations with somatic symptoms at age 15 (RR 1.75, 95%-CI, 1.43-2.14 and RD 18, 95%-CI, 11-25%) and 18 (RR 1.32, 95%-CI, 1.00-1.75 and RD 7, 95%-CI, 0.2-14

2019 BMC Public Health PubMed

3. Somatization Risk Factors

Somatization Risk Factors Somatization Risk Factors Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Somatization Risk Factors (...) Somatization Risk Factors Aka: Somatization Risk Factors , Somatization Causes , Multiple Somatic Complaint Risk Factors , Multiple Somatic Complaint Causes From Related Chapters II. Risk Factors: Young Patients Overwork Failing Relationships Major unresolved decisions Chronic anxiety Hepatitis Rheumatic or Endocrine Disease Toxins Tumor III. Risk Factors: Geriatric Patients Cardiac Disease Renal Disease Hepatic disease Medication use or medication adverse effects s medications (e.g s) s Images: Related

2018 FP Notebook

4. Conversion and somatic symptom disorders

are psychiatric conditions where patients experience distressing physical symptoms that are not fully explained by other medical, neurological, or psychiatric disorders, as well as abnormal thoughts, feelings, and behaviours in response to these symptoms. They may result from psychological stress that is unconsciously (without awareness) expressed somatically, though the underlying cause is not fully understood. Risk factors include being female, having a history of abuse or adverse childhood events (...) psychiatric conditions benefit overall functioning and recovery. Long-term management involves interrupting perpetuating factors, maintaining the same doctor, and providing strategies for self-efficacy, distress tolerance, coping, and modulating the interaction of anxiety, stress, and physical symptoms. Definition Conversion and somatic symptom disorders are psychiatric conditions that fall under the somatic symptoms and related disorders category of the DSM-5. Somatic symptom and related disorders

2018 BMJ Best Practice

5. Risk factors for breast cancer: A review of the evidence 2018

Risk factors for breast cancer: A review of the evidence 2018 Risk factors for breast cancer: A review of the evidence 2018 Breast cancer risk factors: A review of the evidence i Risk factors for breast cancer: A review of the evidence was prepared and produced by: Cancer Australia Locked Bag 3 Strawberry Hills NSW 2012 Australia Tel: +61 2 9357 9400 Fax: +61 2 9357 9477 canceraustralia.gov.au © Cancer Australia 2018. ISBN Print: 978–1–74127–336–6 ISBN Online: 978–1–74127–337–3 Recommended (...) citation Cancer Australia, 2018. Risk factors for breast cancer: A review of the evidence, Cancer Australia, Surry Hills, NSW. Risk factors for breast cancer: A review of the evidence can be downloaded from the Cancer Australia website: canceraustralia.gov.au Copyright statements Internet sites This work is copyright. You may download, display, print and reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within

2018 Cancer Australia

6. Cohort study: Combined infant regulatory problems and early maternal psychiatric illness predict risk of functional somatic symptoms in later childhood

settle babies with high levels of feeding/sleeping/tactile reactivity may help prevent the development of functional somatic symptoms (FSS) in children. Further research is required to identify additional risk factors for FSS and the evaluation of preventative interventions. Context FSS in children are physical symptoms that cannot be ascribed to a medical disease. FSS affect approximately 10% of children and adolescents: when frequent and causing impairment they can lead to unproductive and costly (...) Cohort study: Combined infant regulatory problems and early maternal psychiatric illness predict risk of functional somatic symptoms in later childhood Combined infant regulatory problems and early maternal psychiatric illness predict risk of functional somatic symptoms in later childhood | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use

2014 Evidence-Based Nursing

7. Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy. (Full text)

Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy. A number of genetic variants were suggested to be associated with oral malignancy, few variants can be replicated. The aim of this study was to identify significant variants that enhanced personal risk prediction for oral malignancy. A total of 360 patients diagnosed with oral squamous cell carcinoma, 486 controls and 17 newly diagnosed patients with OPMD including (...) leukoplakia or oral submucous fibrosis were recruited. Fifteen tagSNPs which were derived from somatic mutations were genotyped and examined in associations with the occurrence of oral malignancy. Environmental variables along with the SNPs data were used to developed risk predictive models for oral malignancy occurrence. The stepwise model analysis was conducted to fit the best model in an economically efficient way. Two tagSNPs, rs28647489 in FAT1 gene and rs550675 in COL9A1 gene, were significantly

2019 PLoS ONE PubMed

8. Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours (Full text)

Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours Cancer development is presumed to be an evolutionary process that is influenced by genetic background and environment. In laboratory animals, genetics and environment are variables that can largely be held constant. In humans, it is possible to compare independent tumours that have developed in the same patient, effectively constraining genetic and environmental variation and leaving only (...) stochastic processes. Patients affected with von Hippel-Lindau disease are at risk of developing multiple independent clear cell renal carcinomas. Here we perform whole-genome sequencing on 40 tumours from six von Hippel-Lindau patients. We confirm that the tumours are clonally independent, having distinct somatic single-nucleotide variants. Although tumours from the same patient show many differences, within-patient patterns are discernible. Single-nucleotide substitution type rates are significantly

2016 Nature communications PubMed

9. Somatic alterations in lung cancer: Do environmental factors matter? (PubMed)

Somatic alterations in lung cancer: Do environmental factors matter? Lung cancer is the leading cause of cancer-related death worldwide and smoking tobacco is now definitively established as the dominant risk factor for the malignancy. However, lung cancer can and does occur in never smokers, thus illustrating the existence of other risk factors. Many of these latter are environmental, such as workplace and home carcinogens, air pollution, radon and certain infectious agents. One of the most (...) remarkable advances in thoracic oncology is the recent identification of somatic oncogenic molecular abnormalities, some of which are candidates for targeted therapies. Active smoking is now known to cause a particular somatic profile distinct from that found in never-smokers. This has logically led researchers to consider the possibility that exposure to other lung cancer risk factors may also engender a unique somatic profile. Thus, with the present work, we sought to review current knowledge

2016 Lung Cancer

10. Stressful life events and leucocyte telomere length: Do lifestyle factors, somatic and mental health, or low grade inflammation mediate this relationship? Results from a cohort of Danish men born in 1953. (PubMed)

Stressful life events and leucocyte telomere length: Do lifestyle factors, somatic and mental health, or low grade inflammation mediate this relationship? Results from a cohort of Danish men born in 1953. Exposure to psychosocial stress is associated with increased risk of a number of somatic and mental disorders with relation to immune system functioning. We aimed to explore whether stressful events in early and recent life was associated with leucocyte telomere length (TL), which is assumed (...) in 2010 and a subset of 324 also had a quantitative PCR-based measurement of TL. The relation between stressful life events and TL was analysed using structural equation modelling, which also provided an estimate of the proportion of the total effect mediated by somatic and mental health (cardiovascular disease, body mass and depressive mood), lifestyle factors, and low grade inflammation (C-reactive protein (CRP), interleukin (IL)-6 and IL-10). Total number of stressful events experienced during

2016 Brain, behavior, and immunity

11. Are somatic mutations predictive of response to erythropoiesis stimulating agents in lower risk myelodysplastic syndromes? (Full text)

Are somatic mutations predictive of response to erythropoiesis stimulating agents in lower risk myelodysplastic syndromes? 27056923 2018 01 24 2018 11 13 1592-8721 101 7 2016 07 Haematologica Haematologica Are somatic mutations predictive of response to erythropoiesis stimulating agents in lower risk myelodysplastic syndromes? e280-3 10.3324/haematol.2016.142695 Kosmider Olivier O Hématologie Biologique, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), France. Passet Marie M (...) Alpes, Université Grenoble Alpes, Clinique Universitaire d'hématologie, Grenoble, France spark@chu-grenoble.fr. GFM, FISM AND D-MDS eng Clinical Trial Letter Multicenter Study Research Support, Non-U.S. Gov't 2016 04 07 Italy Haematologica 0417435 0390-6078 0 Hematinics IM Disease-Free Survival Female Hematinics administration & dosage Humans Male Mutation Myelodysplastic Syndromes drug therapy genetics mortality Risk Factors Survival Rate cytogenetics and molecular genetics myelodysplastic

2016 Haematologica PubMed

12. Role of Somatic, Genetic and Psychological Risk Factors in Postsurgical Pain

Role of Somatic, Genetic and Psychological Risk Factors in Postsurgical Pain Genetic, Neurophysiological and Psychological Risk Factors for Neuropathic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Genetic, Neurophysiological and Psychological Risk Factors for Neuropathic Pain The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02368275 Recruitment Status : Recruiting First Posted : February 23, 2015 Last Update Posted

2015 Clinical Trials

13. Risk and protective factors for drug dependence in two Moroccan high-risk male populations (Full text)

Risk and protective factors for drug dependence in two Moroccan high-risk male populations Substance use is linked to biological, environmental, and social factors. This study provides insights on protective and risk factors for drug dependence in two Moroccan, high-risk, male samples.Data from the "Mental and Somatic Health without borders" (MeSHe) survey were utilized in the present study. The MeSHe survey assesses somatic and mental health parameters by self-report from prison inmates (n (...) dependence" group, while the presence of mental health problems was typical among the "Drug dependence" group (47.4%). A multivariable regression model (χ2 (df = 5, N = 156) = 63.90, p < 0.001) revealed that the presence of depression diagnosis remains a significant risk factor, while a higher level of education, having a child, and being employed are protective factors from drug dependence.Findings support the importance of increasing academic competence and treating depression as prevention from

2018 PeerJ PubMed

14. Apathy: Risk Factor for Mortality in Nursing Home Patients

Apathy: Risk Factor for Mortality in Nursing Home Patients To determine the prognostic value of apathy for mortality in patients of somatic (SC) and dementia special care (DSC) nursing home (NH) units.Longitudinal design, secondary analyses of a 2-year, cluster-randomized trial with six measurements, approximately 4 months in between.SC and DSC-units of Dutch NHs.NH-patients of seventeen SC-units (n = 342) and sixteen DCS-units (n = 371).Data were available for 713 NH-patients, 266 of whom died (...) during the study. Apathy was assessed using the 10-item Apathy Evaluation Scale (AES-10) and applied as categorical variable using known cut-off scores as well as dimensional variable. Additionally, depressive symptoms were assessed using the Cornell Scale for Depression in Dementia.Mixed effects cox models using the coxme package in R revealed a higher risk of mortality between two measurements, if apathy was present (hazard ratio (HR) = 1.77; 95% confidence interval (CI] = 1.35-2.31, P < .001

2017 EvidenceUpdates

15. Chronic diseases and social risk factors in relation to specific symptoms of depression: Evidence from the U.S. national health and nutrition examination surveys. (PubMed)

with somatic and cognitive/affective symptoms of depression.Cross-sectional analyses were based on individual-level data from the 31,191 participants of six cross-sectional U.S. National Health and Nutrition Examination Surveys (NHANES) carried out between 2005 and 2016. Depressive symptoms were assessed using the 9-item Patient Health Questionnaire. Information on chronic diseases and social risk factors was self-reported by participants.After adjustment for sex, age, race/ethnicity, and all the of other (...) symptoms besides the outcome symptom, higher number of chronic diseases was independently related to fatigue, psychomotor retardation/agitation, and sleep problems in a dose-response pattern (range of odds ratios: 1.21 to 2.59). Except for concentration problems, social risk factors were associated with almost all of the cognitive/affective symptoms (range of odds ratios: 1.02 to 2.09) but only sporadically with somatic symptoms.All measures were self-reported by the participants, which may have

2019 Journal of Affective Disorders

16. Premorbid risk factors influencing labour market attachment after mild traumatic brain injury: a national register study with long-term follow-up. (PubMed)

Premorbid risk factors influencing labour market attachment after mild traumatic brain injury: a national register study with long-term follow-up. Some patients with mild traumatic brain injury (mTBI) experience persistent postconcussive symptoms, influencing the ability to work. This study assessed associations between mTBI and labour market attachment (up to 5 years postinjury) in patients with different premorbid characteristics.Danish national cohort study with 5-year register follow-up.We (...) included hospital admitted patients between 18 and 60 years diagnosed with mTBI (International Classification of Diseases, version 10 diagnosis S06.0) (n=19 732). For each patient, one control was selected matched on age, gender and municipality (n=18 640).Primary outcome was 'not attending ordinary work', and premorbid risk factors were cohabitation status, education, ethnicity, gender, age and comorbidities.The odds of not attending ordinary work increased from 6 months to 5 years. The highest

2019 BMJ open

17. Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study. (Full text)

Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study. This study investigated cause of death, mortality rates and explored if baseline characteristics were associated with risk of death in patients with alcohol use disorder alone or poly-substance use disorders.This was a prospective, longitudinal study of patients followed for 19 years after entering specialized treatment for substance use (...) disorders (p = 0.041).Patients with alcohol use disorder alone died more often from somatic disease than patients with poly-substance use disorders, and all subgroups of patients had an increased risk of death compared with the general population. Men with long-lasting substance use disorders are a priority group to approach with directed preventive measures for somatic health before they reach 50 years of age.

2019 BMC Psychiatry PubMed

18. Completing the genetic spectrum influencing coronary artery disease: from germline to somatic variation. (PubMed)

Completing the genetic spectrum influencing coronary artery disease: from germline to somatic variation. Genetic and environmental factors influence the development of coronary artery disease (CAD). Genetic analyses of families and the population continue to yield important fundamental insights for CAD. For the past four decades, CAD human genetic research focused largely on the study of germline genetic variation in CAD and its risk factors. The first genes associated with CAD were discovered (...) using basic Mendelian principles and pedigree analysis. Mapping of the human genome and advancement in sequencing technology sparked further discovery of novel genetic associations through exome sequencing and genome wide association analysis in increasingly larger populations. While prior work implicated in situ DNA damage as a feature of atherosclerosis, more recently, somatic mutagenesis in and clonal expansion of hematopoietic stem cells was found to influence risk of CAD. Mutations observed

2019 Cardiovascular Research

19. Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer (Full text)

Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer Helicobacter pylori-related high-risk gastritis (HRG) is a severe risk factor for gastric cancer (GC). The link between HRG and long-term risk for GC may involve genetic and epigenetic alterations underlying a field defect, i.e. a region of the mucosa prone to cancer development. Global DNA hypomethylation is a pervasive alteration (...) distribution of the differences in methylation between tumor and normal tissues, associated with a more invasive (P=0.005) and advanced stage (P=0.017) type of GC.Universal DNA demethylation in normal gastric mucosa in GC patients appears sporadic rather than familial. Genomic hypomethylation in HRG possibly contributes to a field defect for cancerization that is not reversed by bacterial eradication. Enhanced somatic hypomethylation may stratify GC for prognostic purposes.

2015 Clinical and translational gastroenterology PubMed

20. Mental health, life functioning and risk factors among people exposed to frequent natural disasters and chronic poverty in Vietnam (Full text)

Mental health, life functioning and risk factors among people exposed to frequent natural disasters and chronic poverty in Vietnam People living in low- and middle-income countries (LMIC) are at increased risk for exposure to major natural disasters, which places them at increased risk for mental health problems. Evidence is less clear, however, regarding the effects of less severe but more frequent natural disasters, which are likely to increase due to global climate change.To examine (...) the mental health and life functioning, and their predictors, of people living in central coastal Vietnam, an area characterized by high risk for natural disasters and poverty.1000 individuals were randomly selected from 5 provinces in central coastal Vietnam. Individuals were assessed cross-sectionally for exposure to major storms and other traumatic events (Post-traumatic Diagnostic Scale; PDS), financial stress (Chronic Financial Stress Scale), depression (PHQ-9), anxiety (GAD-7), PTSD (PDS), somatic

2016 BJPsych open PubMed

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