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Somatization Risk Factors

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1. Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer

that there will be 22,530 new cases of ovarian cancer diagnosed in 2019 in the United States, and despite advances in treatment, an estimated 13,980 women will die of the disease. Ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system. A woman’s risk of getting ovarian cancer during her lifetime is approximately 1 in 78. Her lifetime chance of dying from ovarian cancer is approximately 1 in 108. The strongest risk factor for ovarian (...) and/or a lack of resources and strategies for how to best incorporate genomic testing into their practice. THE BOTTOM LINE Germline And Somatic Tumor Testing In Epithelial Ovarian Cancer: ASCO Guideline Guideline Questions In which individuals should risk evaluation, counseling, and genomic testing for germline and somatic tumor alterations be performed? Which genomic alterations have demonstrated clinical utility to direct therapy for women with ovarian cancer? What are the most appropriate sequencing

2020 American Society of Clinical Oncology Guidelines

2. Conversion and somatic symptom disorders

are psychiatric conditions where patients experience distressing physical symptoms that are not fully explained by other medical, neurological, or psychiatric disorders, as well as abnormal thoughts, feelings, and behaviours in response to these symptoms. They may result from psychological stress that is unconsciously (without awareness) expressed somatically, though the underlying cause is not fully understood. Risk factors include being female, having a history of abuse or adverse childhood events (...) psychiatric conditions benefit overall functioning and recovery. Long-term management involves interrupting perpetuating factors, maintaining the same doctor, and providing strategies for self-efficacy, distress tolerance, coping, and modulating the interaction of anxiety, stress, and physical symptoms. Definition Conversion and somatic symptom disorders are psychiatric conditions that fall under the somatic symptoms and related disorders category of the DSM-5. Somatic symptom and related disorders

2018 BMJ Best Practice

3. Risk Factors for Endometrial Cancer - A review of the evidence

not express oestrogen or progesterone receptors. 13 Hence risk factors for type I and II cancers are not identical. For instance, women with type II tumours are more likely to be parous than nulliparous and risk of type II tumours due to obesity is less pronounced compared with type I. 14 Type II endometrial cancers typically arise in atrophic endometrium or an endometrial polyp in older adult women. 1.2.2.2 Genomic changes The majority of endometrial carcinomas arise sporadically via acquired somatic (...) Risk Factors for Endometrial Cancer - A review of the evidence Risk factors for endometrial cancer: A review of the evidence 2019 Endometrial cancer risk factors: A review of the evidence i Risk factors for endometrial cancer: A review of the evidence was prepared and produced by: Cancer Australia Locked Bag 3 Strawberry Hills NSW 2012 Australia Tel: +61 2 9357 9400 Fax: +61 2 9357 9477 canceraustralia.gov.au © Cancer Australia 2019. ISBN Online: 978–1–74127–342–7 Recommended citation Cancer

2019 Cancer Australia

4. Somatization Risk Factors

Somatization Risk Factors Somatization Risk Factors Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Somatization Risk Factors (...) Somatization Risk Factors Aka: Somatization Risk Factors , Somatization Causes , Multiple Somatic Complaint Risk Factors , Multiple Somatic Complaint Causes From Related Chapters II. Risk Factors: Young Patients Overwork Failing Relationships Major unresolved decisions Chronic anxiety Hepatitis Rheumatic or Endocrine Disease Toxins Tumor III. Risk Factors: Geriatric Patients Cardiac Disease Renal Disease Hepatic disease Medication use or medication adverse effects s medications (e.g s) s Images: Related

2018 FP Notebook

5. Do negative childhood conditions increase the risk of somatic symptoms in adolescence? - a prospective cohort study. Full Text available with Trip Pro

Do negative childhood conditions increase the risk of somatic symptoms in adolescence? - a prospective cohort study. In order to prevent health and social problems later in life, it is important to identify childhood conditions related to the development of somatic symptoms. This prospective study expands on previous research by investigating whether negative childhood conditions are related to somatization later in life, taking other risk factors into account. This study aims to investigate (...) , and parental reports of somatic symptoms as well as register information about parental socioeconomic background. Generalized linear models for the binomial family were used and the results were presented as relative risks (RR) and risk differences (RD) with 95% confidence intervals (95%-CI).Experiencing poor family functioning at age 15 showed associations with somatic symptoms at age 15 (RR 1.75, 95%-CI, 1.43-2.14 and RD 18, 95%-CI, 11-25%) and 18 (RR 1.32, 95%-CI, 1.00-1.75 and RD 7, 95%-CI, 0.2-14

2019 BMC Public Health

6. Risk factors for breast cancer: A review of the evidence 2018

Risk factors for breast cancer: A review of the evidence 2018 Risk factors for breast cancer: A review of the evidence 2018 Breast cancer risk factors: A review of the evidence i Risk factors for breast cancer: A review of the evidence was prepared and produced by: Cancer Australia Locked Bag 3 Strawberry Hills NSW 2012 Australia Tel: +61 2 9357 9400 Fax: +61 2 9357 9477 canceraustralia.gov.au © Cancer Australia 2018. ISBN Print: 978–1–74127–336–6 ISBN Online: 978–1–74127–337–3 Recommended (...) citation Cancer Australia, 2018. Risk factors for breast cancer: A review of the evidence, Cancer Australia, Surry Hills, NSW. Risk factors for breast cancer: A review of the evidence can be downloaded from the Cancer Australia website: canceraustralia.gov.au Copyright statements Internet sites This work is copyright. You may download, display, print and reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within

2018 Cancer Australia

7. Room for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men. Full Text available with Trip Pro

Room for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men. Depressed mood and exhaustion (DEEX) have gained attention as a risk predictor for cardiovascular disease (CVD). Studies to estimate its ranking in prediction models are sparse.The study included 3428 men aged 45-74 years who participated in one of three population-based MONICA/KORA Augsburg surveys conducted between 1984 (...) and 1995. Within a follow-up time of 10 years (31,791 person-years), 557 cases of all-cause mortality and 269 fatal CVD events were observed. Adjusted Cox proportional hazards models were used to assess mortality risks for DEEX and five classical cardiovascular risk factors. The predictive ability was evaluated by the area under the receiver-operating characteristic curve, the integrated discrimination improvement statistics and the net classification improvement.The (crude) absolute mortality risk

2016 Atherosclerosis

8. Cohort study: Combined infant regulatory problems and early maternal psychiatric illness predict risk of functional somatic symptoms in later childhood

settle babies with high levels of feeding/sleeping/tactile reactivity may help prevent the development of functional somatic symptoms (FSS) in children. Further research is required to identify additional risk factors for FSS and the evaluation of preventative interventions. Context FSS in children are physical symptoms that cannot be ascribed to a medical disease. FSS affect approximately 10% of children and adolescents: when frequent and causing impairment they can lead to unproductive and costly (...) Cohort study: Combined infant regulatory problems and early maternal psychiatric illness predict risk of functional somatic symptoms in later childhood Combined infant regulatory problems and early maternal psychiatric illness predict risk of functional somatic symptoms in later childhood | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use

2014 Evidence-Based Nursing

9. Role of Somatic, Genetic and Psychological Risk Factors in Postsurgical Pain

Role of Somatic, Genetic and Psychological Risk Factors in Postsurgical Pain Genetic, Neurophysiological and Psychological Risk Factors for Neuropathic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more (...) . Genetic, Neurophysiological and Psychological Risk Factors for Neuropathic Pain The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02368275 Recruitment Status : Recruiting First Posted : February 23, 2015 Last Update Posted

2015 Clinical Trials

10. Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy. Full Text available with Trip Pro

Variants in FAT1 and COL9A1 genes in male population with or without substance use to assess the risk factors for oral malignancy. A number of genetic variants were suggested to be associated with oral malignancy, few variants can be replicated. The aim of this study was to identify significant variants that enhanced personal risk prediction for oral malignancy. A total of 360 patients diagnosed with oral squamous cell carcinoma, 486 controls and 17 newly diagnosed patients with OPMD including (...) leukoplakia or oral submucous fibrosis were recruited. Fifteen tagSNPs which were derived from somatic mutations were genotyped and examined in associations with the occurrence of oral malignancy. Environmental variables along with the SNPs data were used to developed risk predictive models for oral malignancy occurrence. The stepwise model analysis was conducted to fit the best model in an economically efficient way. Two tagSNPs, rs28647489 in FAT1 gene and rs550675 in COL9A1 gene, were significantly

2019 PLoS ONE

11. Risk and protective factors for drug dependence in two Moroccan high-risk male populations Full Text available with Trip Pro

Risk and protective factors for drug dependence in two Moroccan high-risk male populations Substance use is linked to biological, environmental, and social factors. This study provides insights on protective and risk factors for drug dependence in two Moroccan, high-risk, male samples.Data from the "Mental and Somatic Health without borders" (MeSHe) survey were utilized in the present study. The MeSHe survey assesses somatic and mental health parameters by self-report from prison inmates (n (...) dependence" group, while the presence of mental health problems was typical among the "Drug dependence" group (47.4%). A multivariable regression model (χ2 (df = 5, N = 156) = 63.90, p < 0.001) revealed that the presence of depression diagnosis remains a significant risk factor, while a higher level of education, having a child, and being employed are protective factors from drug dependence.Findings support the importance of increasing academic competence and treating depression as prevention from

2018 PeerJ

12. Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer Full Text available with Trip Pro

Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer Helicobacter pylori-related high-risk gastritis (HRG) is a severe risk factor for gastric cancer (GC). The link between HRG and long-term risk for GC may involve genetic and epigenetic alterations underlying a field defect, i.e. a region of the mucosa prone to cancer development. Global DNA hypomethylation is a pervasive alteration (...) distribution of the differences in methylation between tumor and normal tissues, associated with a more invasive (P=0.005) and advanced stage (P=0.017) type of GC.Universal DNA demethylation in normal gastric mucosa in GC patients appears sporadic rather than familial. Genomic hypomethylation in HRG possibly contributes to a field defect for cancerization that is not reversed by bacterial eradication. Enhanced somatic hypomethylation may stratify GC for prognostic purposes.

2015 Clinical and translational gastroenterology

13. The effectiveness of various computer-based interventions for patients with chronic pain or functional somatic syndromes: A systematic review and meta-analysis. Full Text available with Trip Pro

relative to passive and active control conditions, and explores patient and intervention factors. Controlled studies were identified from MEDLINE, EMBASE, PsychInfo, Web of Science, and Cochrane Library. Pooled standardized mean differences by comparison type, and somatic symptom, health-related quality of life, functional interference, catastrophizing, and depression outcomes were calculated at post-treatment and at 6 or more months follow-up. Risk of bias was assessed. Sub-group analyses were (...) The effectiveness of various computer-based interventions for patients with chronic pain or functional somatic syndromes: A systematic review and meta-analysis. Computer-based interventions target improvement of physical and emotional functioning in patients with chronic pain and functional somatic syndromes. However, it is unclear to what extent which interventions work and for whom. This systematic review and meta-analysis (registered at PROSPERO, 2016: CRD42016050839) assesses efficacy

2018 PLoS ONE

14. Association between somatic symptom burden and health-related quality of life in people with chronic low back pain. Full Text available with Trip Pro

Association between somatic symptom burden and health-related quality of life in people with chronic low back pain. Depression is a relevant risk factor for low back pain and is associated with the outcomes of low back pain. Depression also often overlaps with somatisation. As previous studies have suggested that somatisation or a higher somatic symptom burden has a role in the outcomes of low back pain, the aim of the present cross-sectional study was to examine whether somatic symptom burden (...) was associated with health-related quality of life in individuals with chronic low back pain independent of depression. We analyzed internet survey data on physical and mental health in Japanese adults aged 20-64 years with chronic low back pain (n = 3,100). Health-related quality of life was assessed using the EuroQol five dimensions (EQ-5D) questionnaire. Somatic symptom burden and depression were assessed using the Somatic Symptom Scale-8 (SSS-8) and the Patient Health Questionnaire-2 (PHQ-2

2018 PLoS ONE

15. Somatic Cough Syndrome (Previously Referred to as Psychogenic Cough) and Tic Cough (Previously Referred to as Habit Cough) in Adults and Children

Somatic Cough Syndrome (Previously Referred to as Psychogenic Cough) and Tic Cough (Previously Referred to as Habit Cough) in Adults and Children 24 Evidence-Based Medicine [ 148#1 CHEST JULY 2015 ] S o ma tic C o ug h S y ndr o me (P r e vio u sl y Ref er r ed t o as Psychogenic Cough) and Tic Cough (Previously Referred to as Habit Cough) in Adults and Children CHEST Guideline and Expert Panel Report Anne E. Vertigan , PhD, MBA, BAppSc(SpPath) ; Mohammad H. Murad , MD, MPH ; Tamara Pringsheim (...) psychologic, psychiatric, and neurologic criteria ( Diagnostic and Statistical Manual of Mental Disorders , 5th edition and tic disorder guidelines), the committee suggests that the terms psychogenic and habit cough are out of date and inaccurate. CONCLUSIONS: Compared with the 2006 CHEST Cough Guidelines, the major change in suggestions is that the terms psychogenic and habit cough be abandoned in favor of somatic cough syndrome and tic cough, respectively, even though the evidence to do so at this time

2015 American College of Chest Physicians

16. Effects of cognitive-behavioral stress management training in individuals with functional somatic symptoms - an exploratory randomized controlled trial. (Abstract)

Effects of cognitive-behavioral stress management training in individuals with functional somatic symptoms - an exploratory randomized controlled trial. Stress is discussed as a risk factor in the manifestation and maintenance of functional somatic (FS) symptoms. However, there is a lack of evidence regarding the effects of cognitive-behavioral stress management training (CBSM) on FS symptoms and the (potentially mediating) role of the neuroendocrine system. This study aims to examine stress

2019 Stress (Amsterdam, Netherlands) Controlled trial quality: uncertain

17. Somatic <i>SF3B1</i> mutations in myelodysplastic syndrome with ring sideroblasts and chronic lymphocytic leukaemia. (Abstract)

Somatic SF3B1 mutations in myelodysplastic syndrome with ring sideroblasts and chronic lymphocytic leukaemia. SF3B1 is the largest subunit of the Spliceosome Factor 3b (SF3B) complex and part of the U2 small nuclear ribosomal protein. It functions as an important part of spliceosomal assembly, converting precursor messenger RNA (mRNA) to mRNA ready for ribosomal translation. Mutations of SF3B1 are commonly seen in myelodysplastic syndromes with ring sideroblasts (MDS-RS)and MDS (...) /myeloproliferative neoplasm (MPN-RS-T). These mutations are typically heterozygous missense substitutions, of which, 55% involve K700E. MDS-RS and MDS/MPN-RS-T usually carry a more favourable prognosis than other subtypes of MDS. SF3B1 itself does not influence survival in these conditions, but does correlate with increased thrombotic risk. Mutated SF3B1 is present in 9%-15% of chronic lymphocytic leukaemia cases and on its own correlates with improved responsiveness to ibrutinib, but is associated

2019 Journal of Clinical Pathology

18. Somatic comorbidity in children and adolescents with psychiatric disorders. Full Text available with Trip Pro

Somatic comorbidity in children and adolescents with psychiatric disorders. In the adult population, psychiatric disorders are associated with somatic illness. Explanatory life style factors have been found, but also a failure to recognize somatic illness in this group. Another factor is side effects from long-term use of antipsychotic drugs. Given the psychiatric-somatic comorbidity in the adult population, it is of interest to investigate whether an association exists already during childhood (...) to test the association between psychiatric and somatic diagnoses. Anxiety and behavioral disorders were associated with all somatic conditions investigated at nearly all ages. The same applied to substance use, investigated at age 9-18 years. Affective disorders were associated with all somatic conditions at age 12-18 years. Psychotic conditions were associated with asthma, bowel disorders and myalgia in adolescents. Children with psychiatric disorders are at remarkably high risk for concurrent

2019 European child & adolescent psychiatry

19. Completing the genetic spectrum influencing coronary artery disease: from germline to somatic variation. (Abstract)

Completing the genetic spectrum influencing coronary artery disease: from germline to somatic variation. Genetic and environmental factors influence the development of coronary artery disease (CAD). Genetic analyses of families and the population continue to yield important fundamental insights for CAD. For the past four decades, CAD human genetic research focused largely on the study of germline genetic variation in CAD and its risk factors. The first genes associated with CAD were discovered (...) using basic Mendelian principles and pedigree analysis. Mapping of the human genome and advancement in sequencing technology sparked further discovery of novel genetic associations through exome sequencing and genome wide association analysis in increasingly larger populations. While prior work implicated in situ DNA damage as a feature of atherosclerosis, more recently, somatic mutagenesis in and clonal expansion of hematopoietic stem cells was found to influence risk of CAD. Mutations observed

2019 Cardiovascular Research

20. Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrence. Full Text available with Trip Pro

Genomic sequencing identifies WNK2 as a driver in hepatocellular carcinoma and a risk factor for early recurrence. Early recurrence of hepatocellular carcinoma (HCC) after curative resection is common. However, the association between genetic mechanisms and early HCC recurrence, especially in Chinese patients, remains largely unknown.We performed whole-genome sequencing (49 cases), whole-exome sequencing (18 cases), and deep targeted sequencing (115 cases) on 182 primary HCC samples. Focusing (...) on WNK2, we used Sanger sequencing and qPCR to evaluate all the coding exons and copy numbers of that gene in an additional 554 HCC samples. We also explored the functional effect and mechanism of WNK2 on tumor growth and metastasis.We identified 5 genes (WNK2, RUNX1T1, CTNNB1, TSC1, and TP53) harboring somatic mutations that correlated with early tumor recurrence after curative resection in 182 primary HCC samples. Focusing on WNK2, the overall somatic mutation and copy number loss occurred in 5.3

2019 Journal of Hepatology

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