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Solar Lentigo

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1. Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial. Full Text available with Trip Pro

Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial. Solar lentigo, benign lesions which mostly appear on chronically, sun-exposed surfaces, are associated with ageing. Patients are increasingly requesting a more uniform skin texture, especially for hands. Treatment options include dermoabrasion, intense pulsed light, cryotherapy, peelings, and laser therapy. Topical compounds can be employed, in alternative or associated (...) with dermatologic procedures. The current study was designed to evaluate solar lentigo hyperpigmentation, skin architecture and clinician and patient assessments comparing a dermocosmetic lightening product (active) with a moisturizing product (control) according to clinical, digital and subjective analyses in 72 lesions over 12-month follow up period. Statistically significant differences were observed between the lesions treated with the active compared to the control in terms of papillary brightness (p

2019 PLoS ONE Controlled trial quality: uncertain

2. Correlation between digital epiluminescence microscopy parameters and histopathological changes in lentigo maligna and solar lentigo: A dermoscopic index for the diagnosis of lentigo maligna. (Abstract)

Correlation between digital epiluminescence microscopy parameters and histopathological changes in lentigo maligna and solar lentigo: A dermoscopic index for the diagnosis of lentigo maligna. The clinical and dermoscopic differentiation between lentigo maligna (LM) and solar lentigo (SL)/initial seborrheic keratosis (SK) may be difficult.Our aim was to identify digital epiluminescence microscopy (DELM)-specific criteria that can be helpful in distinguishing LM from SL/SK and to propose a new

2017 Journal of American Academy of Dermatology

3. Intradermal tranexamic acid injections to prevent post-inflammatory hyperpigmentation after solar lentigo removal with a Q-switched 532-nm Nd:YAG laser. (Abstract)

Intradermal tranexamic acid injections to prevent post-inflammatory hyperpigmentation after solar lentigo removal with a Q-switched 532-nm Nd:YAG laser. Post-inflammatory hyperpigmentation (PIH) after solar lentigo removal using a Q-switched (QS) 532-nm Nd:YAG laser is a cause for concern. This study aimed to evaluate the efficacy and safety of intradermal injections of tranexamic acid (TA) at reducing the risk of PIH after QS 532-nm Nd:YAG laser treatment of solar lentigines.Twenty-five (...) patients with 50 solar lentigines on forearms underwent QS 532-nm Nd:YAG laser treatment. Then, TA (50 mg/mL) was injected randomly into one lesion and 0.9% normal saline was injected intradermally into another lesion. Two blinded dermatologists and a Mexameter® evaluated photographs at baseline, and at weeks 2, 4, 8, and 12.At the end of the study, the mean melanin index (MI) had decreased significantly in both groups. The TA group showed a significant reduction in the mean MI compared

2018 Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology Controlled trial quality: uncertain

4. Protection against summer solar lentigo over-pigmentation with a SPF30 daily cream. (Abstract)

Protection against summer solar lentigo over-pigmentation with a SPF30 daily cream. The aim of this study was to measure lentigines' pigmentation over a long period of time and evaluate if summer over-pigmentation can be avoided by the use a SPF30 day skin cream.Seventeen healthy female volunteers aged 50 and over and presenting lentigines participated in the study from spring to summer. Throughout the study, all subjects applied a SPF30 daily skin cream to only one hand. Color measurements

2018 Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) Controlled trial quality: uncertain

5. Differential morphological and functional features of fibroblasts explanted from Solar Lentigo. (Abstract)

Differential morphological and functional features of fibroblasts explanted from Solar Lentigo. 28211565 2018 08 20 2018 08 20 1365-2133 177 4 2017 10 The British journal of dermatology Br. J. Dermatol. Differential morphological and functional features of fibroblasts explanted from solar lentigo. e109-e111 10.1111/bjd.15386 Goorochurn R R LIBC, Engineering and Cutaneous Biology Laboratory, UMR 1098 INSERM, EFS BFC, University of Bourgogne Franche-Comté, Besançon, France. UMR U978 INSERM (...) Movement physiology Cell Proliferation physiology Fibroblasts pathology Humans Lentigo pathology Models, Biological Sunlight adverse effects 2017 2 18 6 0 2018 8 21 6 0 2017 2 18 6 0 ppublish 28211565 10.1111/bjd.15386

2017 British Journal of Dermatology

6. The Clinical and Histological Effect of a Low-Fluence Q-Switched 1,064-nm Neodymium: Yttrium-Aluminum-Garnet Laser for the Treatment of Melasma and Solar Lentigo in Asians: Prospective, Randomized, and Split-Face Comparative Study. (Abstract)

The Clinical and Histological Effect of a Low-Fluence Q-Switched 1,064-nm Neodymium: Yttrium-Aluminum-Garnet Laser for the Treatment of Melasma and Solar Lentigo in Asians: Prospective, Randomized, and Split-Face Comparative Study. The low-fluence Q-switched 1,064-nm neodymium:yttrium-aluminum-garnet laser (QSNYL) is popular for melasma treatment among Asians.This study was to evaluate the clinical and histological effects of the low-fluence QSNYL for treatment of melasma and solar (...) lentigenes.In this randomized split-face clinical study, 22 patients with melasma or solar lentigo received low-fluence QSNYL weekly for 10 sessions on one cheek. The treatment efficacy was determined by Mexameter skin colorimetry, physician and patient assessment, and by evaluating histological changes.The treated sides had statistically significant reductions in the melanin and erythema indices (EI); 50.0% of melasma and 62.5% of solar lentigo patients had >50% clearance after the final treatment

2017 Dermatologic Surgery Controlled trial quality: uncertain

7. Solar Lentigo

Solar Lentigo Solar Lentigo Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Solar Lentigo Solar Lentigo Aka: Solar Lentigo (...) , Lentigines , Lentigo , Solar Lentigines , Liver Spot From Related Chapters II. Epidemiology Onset over age 30-40 years Most common in Caucasian skin (also seen in asians) III. Pathophysiology Proliferation of basal s, increasing melanization in response to Contrast with which are a result of increased production IV. Signs Characteristics Small s 1-3 cm (up to 5 cm), well circumscribed Light yellow to light brown to dark brown in color (may be variegated) Round or oval with slightly irregular border

2018 FP Notebook

8. Unstable solar lentigo: A defined separate entity. (Abstract)

Unstable solar lentigo: A defined separate entity. An unstable solar lentigo is a solar lentigo with areas of melanocytic hyperplasia not extending past the margin of the lesion. They are discrete, macular, pigmented lesions arising on sun-damaged skin and a subset of typical solar lentigos. Clinically they differ from usual solar lentigines in often being solitary or larger and darker than adjacent solar lentigines. These lesions are of clinical importance as they can arise in close proximity (...) to lentigo maligna and in a single lesion there can be demonstrated changes of solar lentigo, unstable solar lentigo and lentigo maligna. These observations led us to conjecture that unstable solar lentigos could be a precursor lesion to lentigo maligna. In this article we examine the possibility that lentigo maligna can arise within a solar lentigo through an intermediate lesion, the unstable solar lentigo. We propose that the histopathological recognition of this entity will allow for future research

2016 Australasian Journal of Dermatology

9. Biological processes in solar lentigo: insights brought by experimental models. Full Text available with Trip Pro

Biological processes in solar lentigo: insights brought by experimental models. Common in ageing patient, the solar lentigo is a macular hyperpigmented skin lesion that results from chronic exposure to ultraviolet irradiations. Despite sharing numerous features with other pigmented spots, the diagnostic of this benign lesion is well characterized at the tissue level. Recent studies shed lights on several factors and their pathogenic mechanisms involved in the development of the solar lentigo

2016 Experimental Dermatology

10. The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo Full Text available with Trip Pro

The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo Solar lentigo (SL) is a representative photoaging skin disorder. Alteration of the main epidermal constituent cells-keratinocytes and melanocytes-in relation to the photoaged dermal environment or chemokine/cytokine network is suggested as its pathogenesis. Among these, we focused on monocyte chemoattractant protein-1 (MCP-1), as it is known to be associated with tissue aging

2016 International journal of molecular sciences

11. Follow-up of solar lentigo depigmentation with a retinaldehyde-based cream by clinical evaluation and calibrated colour imaging. (Abstract)

Follow-up of solar lentigo depigmentation with a retinaldehyde-based cream by clinical evaluation and calibrated colour imaging. To assess an objective method evaluating the effects of a retinaldehyde-based cream (RA-cream) on solar lentigines; 29 women randomly applied RA-cream on lentigines of one hand and a control cream on the other, once daily for 3 months.A specific method enabling a reliable visualisation of the lesions was proposed, using high-magnification colour-calibrated camera (...) colour-calibrated camera imaging combined with probability map analysis is a fast and precise method to follow lentigo depigmentation.© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2015 Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) Controlled trial quality: uncertain

12. Objective Evaluation of the Effect of Q-Switched Nd:YAG (532 nm) Laser on Solar Lentigo by Using a Colorimeter Full Text available with Trip Pro

Objective Evaluation of the Effect of Q-Switched Nd:YAG (532 nm) Laser on Solar Lentigo by Using a Colorimeter 26082593 2015 06 17 2018 11 13 1013-9087 27 3 2015 Jun Annals of dermatology Ann Dermatol Objective Evaluation of the Effect of Q-Switched Nd:YAG (532 nm) Laser on Solar Lentigo by Using a Colorimeter. 326-8 10.5021/ad.2015.27.3.326 Kim Ji Seok JS Department of Dermatology, Dankook University Medical College, Cheonan, Korea. Nam Chan Hee CH Department of Dermatology, Dankook University

2015 Annals of dermatology

13. Characteristics of keratinocytes in facial solar lentigo with flattened rete ridges: comparison with melasma. (Abstract)

Characteristics of keratinocytes in facial solar lentigo with flattened rete ridges: comparison with melasma. Flattened rete ridges occurring on the face are not uncommon in solar lentigo (SL).To investigate the morphological changes of keratinocytes in facial SL with flattened rete ridges and melasma.In total, 25 patients with facial SL showing flattened rete ridges and 20 patients with melasma, in which rete ridge flattening is also a common feature, were included in the study. Skin biopsies

2015 Clinical & Experimental Dermatology

14. Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars. (Abstract)

in the study cohort. Twenty-one patients had biopsy-confirmed recurrent LM/LMM; the remainder had pigmented actinic keratosis (n = 4) or hyperpigmentation/solar lentigo (n = 5). RCM had sensitivity of 95.24% (95% CI, 76.18-99.88%), specificity of 77.7% (95% CI, 39.99-97.19%), positive predictive value of 90.91% (95% CI, 74.58-97.15%) and negative predictive value of 87.5% (95% CI, 50.04-98.0%). The most common dermoscopic feature observed among patients with recurrent LM/LMM was focal homogeneous (...) Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars. Determining whether repigmentation within or adjacent to lentigo maligna or lentigo maligna melanoma (LM/LMM) scars represents recurrence of melanoma is challenging. The use of reflectance confocal microscopy (RCM) and dermoscopy may aid in differentiating true melanoma recurrence from other causes of repigmentation.To describe the characteristics

2019 Journal of the European Academy of Dermatology and Venereology

15. Histologic Features Associated With an Invasive Component in Lentigo Maligna Lesions. Full Text available with Trip Pro

), subepidermal clefts (OR, 2.8; 95% CI, 1.0-7.9; P = .049), nests (OR, 3.0; 95% CI, 1.1-8.6; P = .04), and a lesser degree of solar elastosis (OR, 0.4; 95% CI, 0.1-1.1; P = .07). A classification and regression tree analysis of the relevant histologic features was able to accurately identify lentigo maligna with an invasive component (LMM) in more than 60% of patients.These findings may be useful in classifying early LM specimens at higher risk of invasion, which may eventually be relevant in identifying (...) Histologic Features Associated With an Invasive Component in Lentigo Maligna Lesions. Lentigo maligna (LM) presents an invasive component in up to 20% of biopsied cases, but to date the histologic features useful in detecting this invasive component have not been described. Some histologic characteristics are hypothesized to contribute to the progression of LM invasion.To identify the histologic characteristics associated with lentigo maligna melanoma (LMM) in patients with LM diagnosed

2019 JAMA dermatology (Chicago, Ill.)

16. Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy

a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Pierre Fabre Dermo Cosmetique: solar lentigos physical Hyperpigmentation therapies cosmetic topical depigmenting product topical Hyperpigmentation therapies Additional relevant MeSH terms: Layout table for MeSH terms Lentigo Hyperpigmentation Melanosis Pigmentation Disorders Skin Diseases (...) Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

17. Solar Lentigo

Solar Lentigo Solar Lentigo Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Solar Lentigo Solar Lentigo Aka: Solar Lentigo (...) , Lentigines , Lentigo , Solar Lentigines , Liver Spot From Related Chapters II. Epidemiology Onset over age 30-40 years Most common in Caucasian skin (also seen in asians) III. Pathophysiology Proliferation of basal s, increasing melanization in response to Contrast with which are a result of increased production IV. Signs Characteristics Small s 1-3 cm (up to 5 cm), well circumscribed Light yellow to light brown to dark brown in color (may be variegated) Round or oval with slightly irregular border

2015 FP Notebook

18. Commentary on a Prospective Trial Comparing Q-Switched Ruby Laser and a Triple Combination Skin-Lightening Cream in the Treatment of Solar Lentigines. (Abstract)

Commentary on a Prospective Trial Comparing Q-Switched Ruby Laser and a Triple Combination Skin-Lightening Cream in the Treatment of Solar Lentigines. 27286414 2017 06 28 2018 12 02 1524-4725 42 7 2016 07 Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Commentary on a Prospective Trial Comparing Q-Switched Ruby Laser and a Triple Combination Skin-Lightening Cream in the Treatment of Solar Lentigines. 858-9 10.1097/DSS (...) .0000000000000792 Schilling Laura M LM Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania Assistant Professor, Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania. Saedi Nazanin N eng Journal Article Comment United States Dermatol Surg 9504371 1076-0512 IM Dermatol Surg. 2016 Jul;42(7):853-7 27341683 Humans Laser Therapy Lasers, Solid-State therapeutic use Lentigo surgery Prospective Studies Skin Cream

2017 Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Controlled trial quality: uncertain

19. Assessment of CRYOBEAUTY MAINS ET DECOLLETE Versus Liquid Nitrogen Cryotherapy, in the Treatment of Solar Lentigines

ET DECOLLETE is the device under evaluation. Liquid nitrogen is a comparator device. Condition or disease Intervention/treatment Phase Solar Lentigo Device: CRYOBEAUTY MAINS ET DECOLLETE Device: Liquid nitrogen Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 30 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single (Outcomes Assessor) Primary Purpose: Treatment Official Title (...) conceived to treat solar lentigo. One side left, or right of neckline and/or hands is attributed to this device according to randomization protocol. Device: CRYOBEAUTY MAINS ET DECOLLETE The intervention lasts up to 6.5 s. The device will be applied on spots <6 mm which are previously selected by the investigator team. Active Comparator: Liquid nitrogen Liquid nitrogen is a classic cryotherapy device. One side, either left or right of neckline and/or hands are attributed to this device according

2017 Clinical Trials

20. Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream

Exclusion Criteria: Biopsy shows invasive melanoma inside lentigo maligna lesion prior treatment Porphyria or solar dermatitis Allergy for photosensitizer (5-aminolaevulinic acid) used in study Pregnant or breastfeeding patients Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov (...) Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2016 Clinical Trials

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